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CAS 34552-83-5 loperamide hydrochloride
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CAS 34552-83-5 loperamide hydrochloride

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Loperamide hydrochloride is an organic compound with the molecular formula of c29h34cl2n2o2 and molecular weight of 513.51. It is a white or yellowish white powder. It is used as an antidiarrheal drug to treat diarrhea.

Opioid receptors acting on the intestinal wall prevent the release of acetylcholine and prostaglandins, thus inhibiting intestinal peristalsis and prolonging the retention time of intestinal contents. It can increase the tension of anal sphincter, so it can inhibit fecal incontinence and urgency. It can also be used for patients undergoing anorectal surgery. The high affinity with intestinal wall and obvious "first pass metabolism" make it hardly enter the whole blood circulation.

For the symptoms of acute and chronic diarrhea caused by various causes. It can reduce the volume and frequency of defecation and increase the consistency and hardness of stool.

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