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CAS 38304-91-5 Minoxidil
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CAS 38304-91-5 Minoxidil

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Molecular formula:C9H15N5O
Molecular weight:209.25
Melting point:272-274 °C (dec.)(lit.)
Boiling point:348.61°C (rough estimate)
Density:1.1651 (rough estimate)

Minoxidil powder was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure. 

Minoxidil powder is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp.

Minoxidil powder is a potassium channel agonist. It contains the chemical structure of nitric oxide), a blood vessel dilator, and may be a nitric oxide agonist. This appears to explain its vasodilatory effects, but may also be linked to minoxidil's ability to stimulate hair growth and treat hair loss. Since minoxidil is a nitric oxide-related compound, it was suspected to act via activation of guanylate cyclase, an enzyme involved in vasodilation.

Functon

1. Minoxidil powder needs to be applied once or twice daily for hair to be maintained. 
2. For maximum effect, the solution should be in contact with the scalp for hours before being washed out. It does not seem capable of reducing DHT or the enzyme responsible for its accumulation around the hair follicle, 5-aliha reductase, which are the main causes of male pattern baldness in genetically susceptible individuals. Therefore, when treatment is stopped, the DHT already accumlated around the follicle has its expected effect, and the follicle usually shrinks again and eventually dies.
3.Minoxidil powder can promote hair regrowth,slow or stop hair loss and treat high blood pressure.

Function of Minoxidil

ChemNMR 1H Estimation

HNMR of Minoxidil

ChemNMR 13C Estimation

HNMR of Minoxidil

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