Paeonol (link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/paeonol-powder-cas-552-41-0.html),Chemical Name 2'-hydroxy-4'-methoxyacetophenone, it is a natural organic compound with the chemical formula C9H10O3. Cortex Moutan is the dried root bark of Paeonia suffruticosa Andr., a plant in the Ranunculaceae family, and is one of the commonly used traditional Chinese medicines in clinical practice. As the main medicinal component of paeonol, paeonol has received more and more attention in recent years, and a lot of research results have been made on its physical and chemical properties, pharmacological effects, detection and extraction.
pharmacological effect:
Paeonol has certain potential value in the development and application of functional health products, but there is still a lack of systematic and in-depth toxicological safety evaluation data. In this study, the effects of paeonol on the acute toxicity of nematodes and the indicators of locomotor behavior, feeding behavior and reproductive ability were detected, and the toxicological safety evaluation data were provided for the development and utilization of paeonol-related functional health products. C. elegans movement behavior is an index reflecting the basic functions of its body system. It is easy to operate, high sensitivity, easy to observe, low cost and short cycle. The head swing frequency and body bending frequency of nematodes are often used as indicators to analyze its movement behavior; Feeding behavior can reflect whether the feeding of nematodes is affected by exogenous drugs, and changes in reproductive ability reflect the effects of exogenous drugs on the reproductive and physiological functions of nematodes.
Experiments have shown that paeonol at a concentration of 100 and 200 mg / L treated nematodes for 24 hours, there was no acute toxic effect; paeonol can improve the ability of the nematodes to swing their heads and bend their bodies, and improve the activity of the body. 100 mg / L L paeonol has the best effect. Paeonol has no effect on the energy intake of nematodes. It can be ruled out that paeonol affects physiological functions by reducing the frequency of nematode swallowing, thereby reducing the energy restriction of food intake. Paeonol No effect on fertility indicates that the nematodes were still healthy during the period of action. Paeonol has no toxic effect on nematodes, and can significantly improve the motility of nematodes, which has a certain potential application value in the development and application of functional health products.
Nature:
It has analgesic, anti-inflammatory, antipyretic and anti-allergic effects. For pain caused by physical or chemical factors such as tail pressure and acetic acid, paeonol has obvious analgesic effect. Paeonol has obvious inhibitory effect on the inflammatory response caused by carrageenan, egg white, formaldehyde, histamine, 5-HT, bradykinin, xylene and endotoxin. Paeonol has obvious antipyretic effect on the rise in body temperature caused by typhoid vaccine and triple vaccine. It has inhibitory effect on type II, III, and IV allergies.
Principle of action:
It has sedative, hypnotic, antibacterial, anti-inflammatory, anti-oxidant, and blood pressure-lowering effects. In terms of cosmetics: Paeonol can inhibit the generation of O2- free radicals in cells, whiten the skin, restore and fade the pigment deposited in the skin, reduce stasis and spots, reduce inflammation, reduce swelling and relieve pain, anti-allergy, anti-virus and other effects. It has a good therapeutic and health care effect on stains, muscle pain, itchy skin, psoriasis, shingles, and eczema. In addition, it has a good effect in toothpaste, gargle, tooth powder, and toothache water.
1. History of traditional medicinal use:
Paeonol was first used in traditional Chinese medicine. In ancient China, Chuanxiong was widely used to treat ailments such as dysmenorrhea, vasodilation and rheumatism. Although people have long known that Chuanxiong has medicinal value, the study of its active ingredients did not make significant progress until the 20th century.
2. Extraction and identification:
In the early 20th century, scientists began to conduct in-depth research on Chuanxiong to determine the active ingredients. According to reports, in 1939, Japanese researchers successfully extracted Paeonol from Rhizoma Chuanxiong for the first time, and identified its chemical structure. They named the substance "Peonol".
3. Chemical research:
In the ensuing decades, researchers conducted extensive chemical studies on Paeonol. Through methods such as synthesis, extraction and separation, they have continuously gained an in-depth understanding of the properties, structure and activity of Paeonol.
4. Pharmacology and efficacy research:
Pharmacological and pharmacodynamic studies on Paeonol have shown that it has a variety of biological activities, including antioxidant, anti-inflammatory, antibacterial, and antitumor effects. These studies provide a scientific basis for the clinical application of Paeonol.
5. Clinical research and application:
The clinical application of Paeonol has also gradually received attention. Studies have shown that Paeonol can be used to treat cardiovascular diseases, inflammatory diseases and nervous system diseases. In addition, Paeonol has also been developed as a raw material for cosmetics and health products.
Although the discovery history of Paeonol is relatively short, due to its wide range of biological activities and potential clinical application prospects, its research is still ongoing.
Paeonol molecular structure analysis:
1. Structural features:
Paeonol belongs to the class of acetophenones and has a benzene ring and an acetone group. Its molecular formula is C9H10O3, and its relative molecular mass is 166.17 g/mol.
2. Molecular structure:
The main structural features of Paeonol are as follows:
- Benzene ring: Paeonol molecule contains a six-membered benzene ring, which consists of 6 carbon atoms and 5 hydrogen atoms. A hydroxyl group and a methoxy group are attached to the 2' and 4' positions on the benzene ring, respectively.
- Acetone group: Paeonol molecule contains an acetone group, which is a combination of a ketone group and two methyl groups. This group is attached at position 1 of the benzene ring.
3. Functional group:
The functional groups in Paeonol molecules include hydroxyl (-OH) and methoxy (-OCH3). The presence of hydroxyl and methoxy groups endows Paeonol with many of its active and pharmacological properties.
4. Optical activity:
Paeonol is a chiral molecule and stereoisomers may exist. Its optical activity can be determined by measuring optical rotation.
5. X-ray crystal structure:
X-ray diffraction studies of Paeonol show that its crystal structure is monoclinic.
6. Molecular model:
Through computational chemistry methods, a three-dimensional molecular model of Paeonol can be established. These models can be used to study its interaction with other molecules, pharmacodynamic mechanism, etc.
Generally speaking, the molecular structure of Paeonol is mainly characterized by benzene ring and acetone group, and has functional groups such as hydroxyl and methoxy. These structural features endow Paeonol with many interesting chemical properties and biological activities.