Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of syn ake cream in China. Welcome to wholesale bulk high quality syn ake cream for sale here from our factory. Good service and reasonable price are available.
Syn Ake Cream is an anti-wrinkle repair cream formulated with a Syn Ake peptide complex, made using Bloomtechz's high-purity biomimetic peptide ingredients. The formula employs a gentle emulsification system that stabilizes and delivers the active Syn Ake peptides to targeted sites in the epidermis, where they reversibly regulate local neuromuscular signal transmission to smooth out dynamic wrinkles. Leveraging its proprietary peptide synthesis production line and comprehensive quality control system, Bloomtechz conducts batch-by-batch testing of raw material purity, peptide activity, and formulation stability. The company provides complete quality inspection reports to support customers in formulation optimization and sample evaluation, offering stable and reliable raw materials and technical support for brands looking to develop effective anti-wrinkle face creams.
Our Products Form
Dipeptide diaminobutyroyl benzylamide diacetate COA
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| Certificate of Analysis | ||
| Compound name | Dipeptide diaminobutyroyl benzylamide diacetate | |
| Grade | Pharmaceutical grade | |
| CAS No. | 823202-99-9 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090085 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.85% |
| Loss on drying | ≤1.0% | 0.32% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.63% |
| Single impurity | <0.8% | 0.57% |
| Total microbial count | ≤750cfu/g | 533 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 577ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Product Overview
Syn Ake Cream is a premium skincare formulation whose core mechanism is neurotransmitter-regulated anti-aging. Its key active ingredient is the dipeptide diaminobutyroylbenzylamide diacetate, commonly known in the industry as SYN-AKE.
Its molecular structure mimics the key active fragment of the Waglerin-1 protein found in the venom of the Malaysian mangrove viper (Trimeresurus wagleri). By competitively antagonizing nicotinic acetylcholine receptors at the neuromuscular junction, reversibly blocking the acetylcholine-mediated depolarization of the postsynaptic membrane, thereby inhibiting excessive contraction of facial expression muscles and reducing the formation of dynamic wrinkles caused by repetitive muscle movements.As a professional source manufacturer of cosmetic ingredients, Bloomtechz has long provided high-purity, highly stable SYN-AKE raw materials to end-user brands of Syn Ake Cream.
The purity of our raw materials, as tested by HPLC, is ≥95%; the molecular weight, confirmed by mass spectrometry, is exactly consistent with the theoretical value of 495.58 Da;and batch-to-batch variations are controlled within industry standards, laying a solid foundation for the consistent efficacy of end products.
The formulation of Syn Ake Cream typically employs an emulsion structure, such as water-in-oil (W/O) or oil-in-water (O/W).In addition to the core active peptide, it combines moisturizing agents such as hyaluronic acid, glycerin, and butylene glycol; skin barrier-repairing ingredients like ceramides and squalane; and antioxidants such as tocopherol and ascorbic acid derivatives, forming a triple anti-aging synergistic system of "neuro-regulation + moisturizing repair + antioxidant protection."
The target consumer group for this product consists of individuals aged 25 and older who are experiencing early dynamic wrinkles (such as crow's feet, forehead lines, and glabellar lines) and the initial appearance of static wrinkles.It is particularly suitable for consumers whose wrinkles have deepened due to expressive facial movements but who do not wish to undergo invasive anti-aging procedures such as Botox injections. Bloomtechz provides partner brands with recommendations on ingredient combinations and support for formulation stability testing. Our experienced technical support team will recommend the appropriate SYN-AKE concentration (typically 0.005%–0.05%) and ingredient combinations based on the brand's product positioning and target audience, helping brands achieve the optimal balance between efficacy and cost.
Application Scenarios and Usage Instructions
Syn Ake Cream is primarily designed to improve and prevent dynamic facial wrinkles.
It is particularly effective at targeting lines caused by repeated contraction of facial muscles, such as crow's feet around the eyes, forehead lines, and the "V-shaped" lines between the eyebrows. For daily use, consumers are advised to apply an appropriate amount of the product evenly to the face after cleansing and toning, focusing on areas with visible wrinkles. Gently massage with the pads of the fingers until absorbed. Use once in the morning and once in the evening; improvements in wrinkle depth and skin smoothness can be observed after continuous use for at least 28 days. Some brands formulate Syn Ake Cream as a spot treatment or eye cream for intensive care of specific areas.This formulation design increases the concentration of active ingredients in the target area, enhancing localized efficacy. When collaborating with brand clients,
Bloomtechz recommends the optimal SYN-AKE dosage and formulation combinations based on the brand's product positioning and formulation design, ensuring consistent efficacy across different formulations.In professional beauty settings, Syn Ake Cream can serve as a core product in non-invasive anti-aging treatments, used in conjunction with facial massage, iontophoresis devices, and other beauty techniques. Through physical penetration-enhancing technologies such as microcurrent and ultrasound delivery, the transdermal absorption efficiency of SYN-AKE can be improved, increasing its concentration in the dermis and at neuromuscular junctions to enhance immediate anti-wrinkle effects.
When liaising with brand clients, Bloomtechz's professional sales team provides tailored raw material technical support based on the brand's product formulations and usage scenarios.
This includes recommendations on raw material solubility for different dosage forms and permeation-enhancing formulation strategies, helping brands optimize the product user experience.In post-aesthetic procedure recovery scenarios, Syn Ake Cream can serve as a supplementary skincare product following medical aesthetic treatments such as Botox injections, Thermage, and Ultherapy. Since the skin barrier is particularly fragile after aesthetic procedures, SYN-AKE's reversible antagonistic mechanism does not cause additional skin irritation.At the same time, its neuromodulatory action can prolong the anti-aging effects of these procedures and reduce the recurrence of dynamic wrinkles. Bloomtechz provides customized ingredient solutions for aesthetic clinics and related brands, including recommendations for low-irritation formulations suitable for post-procedure use and stability testing support, helping brands expand into the post-aesthetic care market.
Reference
Pentapharm Ltd. (2006). SYN-AKE: The Synthetic Snake Venom Peptide for Anti-Wrinkle Applications. Basel: Pentapharm Technical Documentation.
DSM Nutritional Products. (2007). SYN-AKE Product Specification and Efficacy Data Sheet. Kaiseraugst: Royal DSM N.V.
Brubaker, J. L., & Henry, J. (2010). "Neuromodulatory Peptides in Cosmetic Dermatology: Mechanisms and Clinical Applications." Journal of Cosmetic Dermatology, 9(3), 212-219.
Wang, X., & Li, Y. (2015). "Comparative Study of Synthetic Snake Venom Peptide and Botulinum Toxin Type A in the Treatment of Dynamic Wrinkles." Dermatologic Surgery, 41(Suppl 1), S85-S92.
Ghochikyan, A. (2026). "Syn-Ake (Waglerin-1 - a snake venom) | Dipeptide Diaminobutyroyl Benzylamide Diacetate." Cosmetic Ingredients Guide.
Frequently Asked Questions
Q1: We'd like to develop an anti-aging product featuring SYN-AKE. How long does it typically take from initial consultation to mass production? What kind of support can you provide?
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Bloomtechz offers a full-cycle, end-to-end service from initial consultation to bulk delivery. The standard process is as follows: ① Initial Consultation (1–3 business days): A dedicated account manager will work one-on-one with you to understand your product positioning, formulation design, and target market; ② Solution Recommendations (3–5 business days): We provide customized ingredient recommendations and formulation solutions based on your product format; ③ Sample Testing (7–10 business days): We supply 1g–10g trial batches of raw materials for laboratory prototyping and stability testing; ④ Bulk Supply (7–15 business days after confirmation): We provide packaging in various sizes ranging from 1kg to 100kg based on order volume, accompanied by a complete quality inspection report. The entire process, from initial consultation to the first batch of mass production, typically takes about 3–4 weeks. In addition, we offer value-added services such as regulatory filing support, compilation of evidence for efficacy claims, and marketing messaging recommendations to help your product reach the market quickly and establish a competitive edge.
Q2: Can SYN-AKE be blended with other anti-aging ingredients? Will there be any conflicts?
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Bloomtechz's technical support team can provide targeted formulation recommendations and stability testing support based on your existing formula. We offer customized formulation solutions for various dosage forms (serums, creams, eye creams, ampoules, etc.) to ensure efficacy and product stability after blending. Additionally, we provide permeation-enhancing formulation solutions, stability test data under different pH conditions, and recommendations for ingredient solubility in various dosage forms to help brands optimize the product user experience.
Q3: How safe is SYN-AKE? Are there any risks of side effects?
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Q4: What is the appropriate dosage for SYN-AKE? Is it very costly?
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Bloomtechz can recommend the optimal dosage and formulation plan based on your product positioning and budget, striking the best balance between efficacy and cost. We offer packaging in various sizes ranging from 1 kg to 100 kg, which can be flexibly adjusted according to order volume, supporting both small-batch trial orders and large-scale procurement. Specific quotes will be calculated individually based on your purchase volume and formulation plan. We provide a transparent pricing structure and detailed cost analysis to help brands maximize efficacy while controlling costs.
Q5: Compared to the Argireline (acetyl hexapeptide-8) we currently use, what are the advantages of SYN-AKE? Is it worth switching?
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When working with brand clients, Bloomtechz's professional sales team recommends the optimal dosage and formulation combinations based on the brand's product positioning and dosage form design, ensuring consistent efficacy across different formulations. If your brand emphasizes selling points such as "rapid wrinkle reduction" or "instant firming," we provide corresponding technical support for the ingredients, including recommendations on solubility for different formulations and formulation combinations to enhance penetration, helping brands optimize the product experience. Additionally, we offer comprehensive efficacy evaluation plans and marketing messaging recommendations to help brands establish a competitive edge in the market.
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