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4-Butylresorcinol powder is an organic compound with CAS 18979-61-8 and chemical formula C10H13O3. also known as Rucinol, is an active ingredient in a variety of cosmetics. It is a white to light yellow powder or crystal that is opaque in its solid state. The benzene ring and hydroxyl group in its molecular structure determine its high polarity and hydrophilicity. This compound can be soluble in organic solvents such as ethanol, ether, and chloroform, but not in water. This indicates that it has good solubility in organic solvents, while it is almost insoluble in water. This characteristic is caused by the benzene ring and hydroxyl group in its molecular structure. The refractive index is a measure of a substance's ability to refract light, and the higher the refractive index, the stronger the substance's ability to refract light. Used as a whitening and freckle remover in cosmetics, it can inhibit the formation of melanin, thereby fading spots and improving skin color. It has antioxidant effects and can prevent skin cells from being damaged by free radicals, thereby delaying the aging process of the skin. It can be used as a preservative and pigment dispersant to improve the performance and stability of coatings.
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Chemical Formula |
C10H14O2 |
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Exact Mass |
166.22 |
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Molecular Weight |
166.10 |
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m/z |
166.10 (100.0%), 167.10 (10.8%) |
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Elemental Analysis |
C, 72.26; H, 8.49; O, 19.25 |
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Morphological |
powder |
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Color |
white to pale yellow powder. |
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Melting point |
50.0 to 55.0 °C |
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Boiling point |
166 ° C / 7mmHg ( lit. ) |
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Density |
1.092 ± 0.06 g / cm3 ( Predicted ) |
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Storage conditions |
Inert atmosphere |
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solubility alcohol |
solublesoluble 40 parts of solvent |
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Acidity coefficient ( pKa ) |
9.95 ± 0.18 ( Predicted ) |
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At present, there are two main methods for the synthesis of 4-Butylresorcinol powder:
Method 1:
4-Butyl resorcinol was reduced with palladium carbon in methanol. Catalytic hydrogenation is a typical gas liquid solid three-phase heterogeneous reaction. In order to ensure the complete contact of three phases, high temperature and high pressure (15atm) conditions are required, which not only has high energy consumption, but also has the flammable and explosive characteristics of H2 in the system. In case of leakage, there is a huge safety risk, and the cost of using palladium carbon is very high.
Method 2:
Under conditions, 4-butyl resorcinol was reduced with zinc amalgam at 120 ° C. Because the reaction is carried out on the surface of active zinc, new zinc amalgam is needed for each step; High reaction temperature leads to large loss of hydrochloric acid concentration, and concentrated hydrochloric acid needs to be added to maintain acidity; Produce a large amount of pollutants zinc amalgam.
Like the conventional methods reported at present, the above two methods have obvious defects in process amplification. In addition, the traditional reactor reaction and feed reaction release heat and produce a large amount of gas, which has great potential safety hazards and increases the difficulty of process amplification
The method of synthesizing 4-n-butyl resorcinol adopted by our company is:
Weigh 100g of 4-n-butyryl resorcinol and dissolve it in toluene, ice bath to 0 ℃, then slowly add 32g (1.5eq) sodium borohydride in batches, and react at room temperature for 12h after adding; Then inject it into preheating module 1 and preheat it to 80 ℃; Mix 67g Raney nickel and isopropanol into preheating module 2 and preheat to 80 ℃. Then add the above two preheated materials into the reaction module, and the residence time is controlled at 200s. Collect the outflow reaction solution, pour it into ice water to quench, filter out the solid, evaporate most of the toluene, add 330ml of dichloromethane for extraction, evaporate the dichloromethane, and obtain 82G of white solid 4-n-butyl resorcinol, with a yield of 89% and a HPLC purity of 99.3%.
4-Butylresorcinol powder has a wide range of applications in the pharmaceutical field.
1. Antifungal drugs:
4 Butylresorcinol is an effective antifungal drug mainly used for the treatment of skin fungal infections. Its mechanism of action is mainly by disrupting the integrity of fungal cell membranes, thereby inhibiting fungal growth and reproduction. This compound has been widely used to treat fungal diseases such as dermatophytosis and athlete's foot. Compared with other antifungal drugs, 4 Butylresorcinol has stronger antifungal activity and fewer adverse reactions, making it considered a very promising antifungal drug.
2. Anti inflammatory drugs:
4 Butylresorcinol also has anti-inflammatory effects and can be used to treat inflammatory diseases such as arthritis and rheumatoid arthritis. Its anti-inflammatory effect is achieved by inhibiting the release of inflammatory mediators and inhibiting the synthesis of prostaglandins. Compared with other anti-inflammatory drugs, 4 Butylresorcinol has stronger anti-inflammatory effects and fewer adverse reactions, making it one of the first choices for anti-inflammatory drugs.
3. Antitumor drugs:
In recent years, the anti-tumor effect of 4 Butylresorcinol has gradually received attention. Research has shown that this compound can inhibit the growth and diffusion of tumor cells and induce apoptosis of tumor cells. Its anti-tumor effect may be related to the inhibition of signal transduction pathways in tumor cells. Therefore, 4 Butylresorcinol may become a new type of anti-tumor drug for the treatment of various cancers.
4. Treatment of diabetes foot:
Diabetes foot is one of the serious complications of diabetes, which often needs amputation. Research shows that 4 Butylresorcinol can improve the symptoms of diabetes foot, promote wound healing, and improve the quality of life of patients. Its mechanism of action may be related to promoting angiogenesis, promoting cell proliferation, and inhibiting inflammatory reactions. Therefore, 4 Butylresorcinol may become a new drug for the treatment of diabetes foot.
5. Other uses:
In addition to the aforementioned uses, 4 Butylresorcinol also has other medicinal uses. For example, it can serve as a preventive drug for cardiovascular diseases, with effects such as lowering blood pressure, lowering blood lipids, and preventing platelet aggregation. In addition, it can also be used to treat some neurological diseases, such as Alzheimer's disease, Parkinson's disease, etc. Further research and validation are needed to determine the safety and effectiveness of these uses.
In general, 4-Butylresorcinol has a wide range of applications in the medical field, from antifungal drugs to anti-inflammatory drugs, anti-tumor drugs and treatment of diabetes foot. However, it should be noted that these uses require further validation and confirmation of their safety and effectiveness in clinical trials. In addition, for any new use or application field, sufficient research and testing should be conducted to ensure its safety and effectiveness.
4-Butylresorcinol powder is a derivative of resorcinol, which is usually non-toxic and harmless to the skin after structural changes. However, due to the irritant nature of this ingredient, an allergy test must be conducted before use to avoid skin intolerance. In addition, it is slightly soluble in water and is prone to oxidation and discoloration as a phenolic substance. It is also prone to chelation with metal ions, which limits its application in cosmetics.
(1) Inhibition of melanin production and transfer: It can penetrate deep into the basal layer of the skin and inhibit the production and transfer of melanin. It enhances the degradation ability of tyrosinase, helping to break down and eliminate existing melanin precipitates, thereby achieving the effects of removing yellowing, brightening, whitening and lightening spots.
(2) Powerful whitening effect: According to research, it has a significant inhibitory effect on tyrosinase activity. In the in vitro human tyrosinase assay, its inhibitory effect is 5 times that of hexylresorcinol, 6 times that of phenethyl resorcinol (377), 25 times that of quercetin, 325 times that of arbutin, and 220 times that of hydroquinone. Compared to 377577, it has better penetration, stronger whitening effect, and more thorough spot lightening.
(3) Dimming age spots and acne scars: Long term use can fade age spots and acne scars caused by melanin deposition, making the skin brighter and smoother.
2. Antioxidant effect
(1) Clearing free radicals: It has strong antioxidant capacity and can eliminate free radicals in the body, preventing skin aging.
(2) Preventing UV damage: It can also protect the skin from UV damage and prevent the formation of sunspots and wrinkles.
(3) Reduce skin inflammation: It has anti-inflammatory effects and can alleviate skin inflammation and redness.
(4) Promote wound healing: It can also promote wound healing and reduce scar formation.
(1) Inhibition of bacteria and fungi: It has inhibitory effects on various bacteria and fungi, and can prevent and treat skin infections.
(2) Increasing skin moisture: It can increase the moisture content of the skin, improve dryness and flaking of the skin.
(3) Lock in moisture: It can also lock in moisture on the surface of the skin, keeping it soft and smooth.
(1) Addition ratio: usually added to skin care products as whitening additives, such as whitening essence, whitening facial mask, etc. The addition ratio needs to be adjusted according to the product formula and skin tolerance.
(2) Usage effect: Using skincare products can significantly improve skin dullness, pigmentation, and other problems, making the skin brighter and more even.
What are the side effects of this compound?
Lesions
Skin redness and swelling: When the skin comes into contact with 4-butylresorcinol powder, the stimulating effect of chemical substances may cause local blood vessel dilation, leading to skin redness and swelling.
Itching: Chemical substances stimulate the nerve endings of the skin, which may cause itching and make the patient constantly scratch, further exacerbating skin damage.
Pain: In some cases, 4-butylresorcinol powder may cause a stinging or burning sensation on the skin, usually due to direct damage to skin cells caused by chemicals.
Gastrointestinal damage
Stomach pain: 4-Butylresorcinol stimulates the gastric mucosa, which may cause pain or discomfort in the stomach.
Nausea and vomiting: After ingesting this chemical substance, patients may experience symptoms such as nausea and vomiting due to its irritating effect on the gastrointestinal tract.
Acid reflux: In some cases, 4-butylresorcinol may cause excessive secretion of gastric acid, leading to discomfort symptoms such as acid reflux and heartburn.
Respiratory system damage
Respiratory irritation: Long term exposure to 4-butylresorcinol may cause symptoms such as congestion and edema of the respiratory mucosa, leading to discomfort such as coughing and difficulty breathing.
Tachycardia and blood pressure drop: In some cases, this chemical substance may have an impact on the cardiovascular system, leading to abnormal vital signs such as tachycardia and blood pressure drop.
Dyspnea: Severe respiratory damage may cause life-threatening symptoms such as difficulty breathing and suffocation in patients.
Other potential risks
Allergic reactions: Some patients may experience allergic reactions to the substance, manifested as rash, urticaria, difficulty breathing, and other symptoms. For such patients, the use of cosmetics containing this chemical substance should be immediately stopped and they should seek medical attention for anti allergic treatment.
Photosensitivity: Studies have shown that 4-butylresorcinol may increase skin sensitivity to light. Therefore, after using cosmetics containing this chemical substance, prolonged exposure to sunlight should be avoided as much as possible to reduce the occurrence of photosensitive reactions.
Endocrine disrupting effects: Some chemicals have endocrine disrupting effects and may have an impact on the human endocrine system. Although there is currently insufficient evidence to suggest that 4-butylresorcinol has this effect, it is still necessary to remain vigilant and closely monitor relevant research progress.
We have many years of experience in producing Cosmetic Grade Pure Rucinol 4 Butylresorcinol Powder 4-N-Butylresorcinol 18979-61-8, serving thousands of companies, and rich experience in production and manufacturing. We have independent and perfect product research, design and development capabilities, and can provide customers with suitable products. The company has a united and hard-working team, and adopts the production process route of combining high and new technology at home and abroad, and continues to develop and innovate on this basis.