Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of dehydroacetic acid powder cas 520-45-6 in China. Welcome to wholesale bulk high quality dehydroacetic acid powder cas 520-45-6 for sale here from our factory. Good service and reasonable price are available.
Dehydroacetic acid powder (DHA) is an organic compound. It is in the form of a white crystalline powder and has a odorless or faint special odor. The solubility in water is low, but it can be dissolved in many organic solvents, such as ethanol, acetone, Dimethyl sulfoxide, etc. It is a stable compound that is relatively stable at room temperature and not easily volatile. However, it decomposes and loses activity at high temperatures. It is easy to burn at high temperatures and can be used as a fuel. Its combustion products include carbon dioxide, water, and some toxic gases. It has a certain degree of hygroscopicity and may undergo changes in crystal structure after moisture absorption. It is an acidic compound with a carboxyl group. It can undergo esterification, dehydration, Nucleophilic addition and other chemical reactions.
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Chemical Formula |
C8H8O4 |
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Exact Mass |
168 |
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Molecular Weight |
168 |
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m/z |
168 (100.0%), 169 (8.7%) |
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Elemental Analysis |
C, 57.14; H, 4.80; O, 38.06 |
Used as an intermediate in organic synthesis; Paste of vinyl acetate lotion, vinyl acrylate lotion and other resin lotion, as well as paste of polyvinyl alcohol, Carboxymethyl cellulose, starch, bone glue and other mixtures; Recently, it has been widely used in fields such as adhesives, mosquito repellent incense, feed, shampoo, and toothpaste; As the product has inhibitory effect on mold, yeast and Gram bacillus, it is used in medicine, cosmetics and food as a mildew inhibitor and preservative. According to GB2760-1996, it can be used in Fermented bean curd, assorted Pickled vegetables and raw orange juice. Widely used in industries such as cosmetics, food, and pesticides.
Cosmetics:
Dehydroacetic acid powder is widely used as a preservative and antibacterial agent in cosmetics. Due to its excellent broad-spectrum antimicrobial activity, it can effectively inhibit the growth of bacteria, fungi and molds that easily contaminate cosmetics, thereby extending the shelf life of cosmetics and preventing microbial contamination. It is mild and low-irritating, suitable for long-term addition to skincare products, makeup, shampoo, shower gel, and other daily cosmetic products without affecting the product's texture and efficacy.
Food:
DHA can be used as a food preservative and antiseptic. With strong antimicrobial effects against common food-borne microorganisms, it can inhibit the growth and reproduction of bacteria, yeasts and molds in food, effectively extending the shelf life of food and maintaining the original flavor and quality of food. It is commonly used in foods such as pastries, bread, jam, and seasonings, and meets international food safety standards when used in specified dosages.
Pesticides:
DHA, as a broad-spectrum fungicide and insecticide, is widely applied in the agricultural field. It can effectively control a variety of fungi, bacteria, and pests on crops, inhibit the spread of crop diseases and insect pests, reduce crop damage, and further improve crop yield and quality. It is non-toxic to crops and environmentally friendly, suitable for green agricultural production.
Water treatment:
DHA can be used for disinfection and anti-corrosion in water treatment processes. It has strong bactericidal and antimicrobial properties, which can quickly kill bacteria, algae and other microorganisms in water, degrade harmful substances, purify water quality, and avoid microbial reproduction causing pipeline blockage and corrosion, making water safer and cleaner for use.
Fabric anti-corrosion:
DHA can be used for anti-corrosion treatment of fabrics and textiles. Spraying or soaking DHA treatment agent into the fabric can make it adhere firmly to the fabric fibers, effectively inhibiting the growth of bacteria and mold on the fabric surface, preventing fabric mildew, odor and damage, and improving the antibacterial performance and service life of the fabric.
Dye industry:
DHA, as an important intermediate in organic synthesis, has wide applications in the dye industry. It has stable chemical properties and can be used as a key raw material to synthesize various dyes, pigments and other organic compounds. These products have bright colors and good color fastness, providing reliable support for the dyeing processes of fabrics and other materials.
Packaging materials:
DHA can be used for anti-corrosion treatment of plastics and packaging materials. Adding an appropriate amount of DHA to plastic products or packaging materials during production can inhibit the growth and reproduction of microorganisms on the material surface, prevent the materials from mildewing and aging due to microbial contamination, and extend their service life.
Other applications:
DHA also has a wide range of other applications, such as coatings, adhesives, rubber products, and other fields. Adding DHA to these products can enhance their stability, improve anti-corrosion and antibacterial properties, prevent product deterioration caused by microbial erosion, and extend the service life of the products.
Overall, DHA, as a multifunctional organic compound, is widely used in cosmetics, food, pesticides, pharmaceuticals, and other industrial fields. It plays an important role in anti-corrosion, antibacterial, preservation, and increasing product stability. With the continuous development of science and technology, the application field of DHA will continue to expand.
DHA is widely found in many deep-sea fish oils, as well as in marine algae and some terrestrial plants. DHA is an ω-3 unsaturated fatty acid and an essential fatty acid for the body.
Deep-sea fish oil
DHA is abundant in deep-sea fish, especially those rich in fat, such as salmon, tuna, mackerel, etc.
Marine algae
Certain marine algae are also an important source of DHA. These algae produce DHA through photosynthesis, which is then ingested by marine organisms such as fish.
Land plants
Although the content of DHA in land plants is relatively low, some plant oils (such as flaxseed oil, walnut oil, etc.) contain precursors of omega-3 fatty acids, which can be partially converted into DHA in the human body.
DHA is an omega-3 unsaturated fatty acid with multiple double bonds in its chemical structure, which makes DHA have unique biological activity.
Omega-3 unsaturated fatty acids are essential for human health. They can reduce the risk of cardiovascular disease, promote brain development and vision health, etc.
Essential for brain development
DHA is an important component of brain cell membranes and plays a key role in the structural and functional development of the brain. Especially during the fetal and infant periods, the intake of DHA is particularly important for the development of the brain and nervous system.
Promote healthy vision
DHA is also an important component of the retina and helps maintain normal visual function.
Reduce the risk of cardiovascular disease
A moderate intake of DHA can reduce the levels of triglycerides and cholesterol in the blood, thereby reducing the risk of cardiovascular disease.
People of different ages and health conditions have different requirements for DHA. Generally speaking, adults are recommended to consume a moderate amount of ω-3 unsaturated fatty acids, including a certain amount of DHA, every day.
For pregnant and lactating women, since the fetus and infant have a higher demand for DHA, they are advised to add DHA-rich foods to their diet or supplement with a proper amount of DHA preparations.
Dehydroacetic Acid Powder (DHA), a white crystalline powder with odorless and weakly acidic properties, is a versatile pyrone derivative widely used in food preservation, daily chemicals, and pharmaceuticals. Its discovery and development history spans over 150 years, closely intertwined with the advancement of organic synthesis chemistry and the growing demand for safe antimicrobial agents. The compound was first prepared and reported in 1866 by German chemist Geuther, who isolated this crystalline substance from the decomposition products of acetoacetic ester, though he only determined its empirical formula (C₈H₈O₄) without clarifying its specific molecular structure or potential applications.
In the following decades, chemists worldwide conducted in-depth research on DHA's structure. In 1891, J. Norman Collie proposed an initial structural formula, and subsequent studies by Ostwald and other scholars further explored its chemical properties, with Ostwald identifying it as a weak acid and proposing an alternative structural hypothesis. However, the correct molecular structure of DHA was not definitively confirmed until the mid-20th century; in 1952, Jerome A. Berson published a landmark study in the Journal of the American Chemical Society, accurately elucidating its structure as 3-acetyl-6-methyl-2,3-dihydro-pyran-2,4-dione, laying a solid foundation for its subsequent application research.
A critical turning point came in 1947, when G.H. Coleman and P.A. Woff discovered DHA's significant antimicrobial and antifungal properties, unlocking its practical value. In 1949, the United States officially approved DHA as a food preservative, marking its entry into industrial applications. Japan began widespread use of DHA in the 1970s, while China listed it as a new food additive in 1998 after rigorous evaluation, recognizing its role in food mildew prevention and preservation. Meanwhile, industrial synthesis processes continued to advance: early production relied on the Claisen condensation of ethyl acetoacetate, and later, the base-catalyzed dimerization of diketene became the mainstream method, with subsequent purification technologies (such as vacuum distillation with activated charcoal) improving product purity to over 99.9%.
Today, DHA is recognized by the FAO and WHO as a safe preservative, with applications expanding to cosmetics, pharmaceuticals, and agriculture. From an obscure laboratory product to a globally used industrial raw material, DHA's discovery and development reflect the synergy of basic chemical research and industrial demand, cementing its status in modern fine chemical industries.
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Dehydroacetic acid powder (DHA) is an important organic compound with the chemical formula C₈H₈O₄ and a molecular weight of 168.15. In its solid form, it is a white or pale yellow crystalline powder, odorless and tasteless, with a melting point range of 108°C to 111°C and a boiling point of approximately 270°C. These physical properties provide the foundation for its stability in various industrial applications.
From a chemical structure perspective, dihydroxyacetone belongs to a pyranone derivative. The carbonyl and double bond in its molecular structure endow it with unique chemical reactivity. It has a relatively low solubility in water, but exhibits good solubility in organic solvents such as benzene, ether, acetone, and hot ethanol. This solubility property enables it to be flexibly applied in different polar solvent systems during formulation design.
The most notable chemical property of dihydroxyacetic acid is its potent antibacterial ability. As a broad-spectrum preservative, it exhibits excellent inhibitory effects on molds, yeasts, and bacteria, with the inhibitory effect on molds being particularly prominent. Its antibacterial mechanism mainly achieves through destroying the integrity of microbial cell membranes, inhibiting intracellular enzyme activities, and interfering with energy metabolism processes. Experimental data shows that the minimum inhibitory concentration (MIC) of dihydroxyacetic acid for common food spoilage bacteria is significantly lower than that of traditional preservatives such as sodium benzoate. For example, the inhibitory effect on certain molds can reach 2-10 times that of sodium benzoate.
The chemical stability of this compound is manifested in several aspects:
pH adaptability: Its antibacterial activity remains effective under both acidic and alkaline conditions. Although its aqueous solution stability decreases as pH increases (pH > 9), it still maintains stable activity within the common pH range for food processing (pH 3 - 8).
Thermal stability: Dehydroacetic acid is not easily decomposed during high-temperature processing (such as baking, sterilization). Its aqueous solution can remain stable when heated at 120°C for 2 hours. This characteristic makes it particularly suitable for food systems that require high-temperature processing.
Light stability: It is insensitive to light under normal storage conditions and can maintain its activity for a long time without the need for special light-blocking packaging.
In terms of chemical reactivity, dehydroacetic acid exhibits certain esterification reaction activity and can undergo ester exchange reactions with alcohols to form ester derivatives. The carboxylic acid group in its molecule gives it weak acidity, with a pKa value of approximately 4.75, and it can react with bases to form corresponding salts (such as sodium dehydroacetic acid). These salts usually have better water solubility and antibacterial activity, and are more widely used in the food industry.
From a safety perspective, dihydroxyacetic acid is a low-toxic compound. The oral LD50 for rats is 500mg/kg body weight, making it a practically non-toxic substance. Its metabolites are mainly excreted through urine and will not accumulate in the human body at the recommended dosage. However, long-term excessive intake may cause irritation to the gastrointestinal tract. Therefore, various national regulations strictly limit its usage scope and maximum residue levels.
For instance, the new version of the "Food Safety National Standard - Use Standards of Food Additives" (GB 2760-2024) in China stipulates that dihydroxyacetic acid and its sodium salt shall not be used in butter, starch products, bread, and other foods. The maximum usage amount in pickled vegetables is adjusted to 0.3g/kg.
In the field of applied chemistry, dihydrogen phosphate powder is widely used in various industries such as food, feed, cosmetics, coatings and leather products due to its excellent anti-corrosion properties and stability. In the food industry, it is often used for the preservation of products like fermented bean curd, pickles, and jam, effectively extending the shelf life; in the cosmetics sector, its low irritation and broad-spectrum antibacterial properties make it an ideal preservative for products like eyeliner pens and lipsticks; adding dihydrogen phosphate to packaging materials can prevent microbial contamination and ensure product quality and safety.
FAQ
Is dehydroacetic acid safe for skin?
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In its raw form, Dehydroacetic Acid appears as a white crystalline powder that is odorless. Further, it is a safe ingredient and is well tolerated by most skin types.
What is dehydroacetic acid?
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Dehydroacetic acid (DHA) is defined as an important biologically active compound known for its antimicrobial activities and as a powerful antiseptic agent in aqueous mediums.
Is dehydroacetic acid good for your hair?
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Products need preserving, and Dehydroacetic acid is a mild preservative widely used in both haircare and cosmetics. It prevents products from deteriorating and becoming contaminated, by stopping the growth and reproduction of microorganisms.
What is the origin of dehydroacetic acid?
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Origin of Dehydroacetic Acid: Dehydroacetic acid is synthesized through the reaction of diketene and acetic acid. Diketene, a highly reactive compound, reacts with acetic acid under controlled conditions to form Dehydroacetic acid.
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