D Chiro Inositol Powder (DCI Powder) is a naturally occurring isomer of inositol and belongs to the vitamin B complex. It plays a crucial role in regulating insulin signaling and metabolic balance. As a white, water-soluble powder, it is commonly used in dietary supplements and is mainly targeted at metabolic diseases such as insulin resistance, polycystic ovary syndrome (PCOS), and type 2 diabetes.
DCI is one of the stereoisomers of inositol. In the body, it acts as the second messenger of insulin, helping to enhance the sensitivity of cells to insulin and promoting glucose uptake, thereby lowering blood sugar levels. Studies have shown that the level of D-chiro-inositol in patients with PCOS is usually low. Supplementing DCI can improve hormonal imbalance, promote ovulation, and reduce hyperandrogenic symptoms (such as acne and hirsutism). In addition, it can support lipid metabolism and reduce the risk of cardiovascular diseases.
The common supplementary dosage is 600-1200mg per day. It is usually used in combination with another form of inositol (such as Myo-inositol) to optimize the effect. The DCI powder has good safety and tolerance, but high doses may cause mild gastrointestinal discomfort. It is recommended to use under the guidance of a doctor or a nutritionist, especially for women planning to conceive, diabetic patients, or people with metabolic syndrome.
|
|
|
D Chiro Inositol Powder COA
D Chiro Inositol powder is a compound with multiple biological activities and has shown extensive application prospects in the fields of medicine, health supplements, and functional foods. The following are its core application areas and specific mechanisms of action:
Treatment of Metabolic Diseases: Improving Insulin Resistance and Glycemic Regulation
D-chiro-inositol (DCI) is a key second messenger in insulin signal transduction. By accelerating the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, it promotes non-oxidative and oxidative metabolism of glucose, thereby reducing insulin resistance. Its mechanism of action includes:
Simulating the effect of insulin: DCI can replace the function of insulin, enhance the body's uptake and utilization of glucose, and reduce high blood sugar and circulating insulin levels.
Regulating hormone balance: In patients with polycystic ovary syndrome (PCOS), DCI can lower serum androgen levels, improve ovulation function and menstrual disorders.
Clinical research support:
At a dose of 50 mg/kg, DCI can enhance glucose tolerance in mice fed a high-fat diet and reduce liver lipid accumulation.
At a dose of 150 mg/kg, it can alleviate liver damage and fibrosis in rats with bile stasis models, achieving this through improving bile acid secretion and reducing oxidative stress.
Women's Health Management: PCOS and Fertility Support
Due to its properties of improving insulin resistance and hormone balance, DCI has become a popular component in the treatment of PCOS:
Recovery of ovulation function: DCI regulates the signal transmission of follicle-stimulating hormone (FSH), promoting follicle development and ovulation, and increasing the conception rate.
Improvement of menstrual disorders: Clinical trials have shown that DCI supplementation can significantly improve the regularity of menstrual cycles in patients with PCOS.
Product development case:
Korean Aimekeong Health uses Mediterranean sea bean extract to develop a high-purity DCI product with a purity of >95% and high stability, which can be applied to solid drinks, tablets and capsules.
The American Swanson Company launched the "Chirositol" compound supplement, each tablet containing 90 mg DCI and 3.6 mg manganese sulfate, and the recommended dose is twice a day, one tablet each time.
Anti-tumor adjuvant therapy: Inhibiting cancer cell growth
DCI exhibits anti-tumor potential by regulating cellular metabolism and signaling pathways:
Breast cancer inhibition: At concentrations of 1-40 mM, DCI can inhibit the growth of breast cancer cells MDA-MB-231 and reduce tumor volume.
Mechanism study: DCI may inhibit the proliferation and migration of tumor cells by interfering with the PKCε-PI3K/AKT pathway.
Animal experiment verification: In xenograft tumor models, doses of 500-1000 mg/kg can significantly inhibit tumor growth and prolong survival.
Liver protection: Alleviating cholestasis and fibrosis
DCI protects liver health by improving bile acid metabolism and antioxidant stress:
Biliary stasis alleviation: DCI can enhance bile acid secretion, reduce oxidative stress, lower serum ALT and AST levels, and alleviate bile duct hyperplasia and liver parenchymal necrosis.
Anti-fibrotic effect: In liver cirrhosis models, DCI inhibits the activation of hepatic stellate cells, reduces collagen deposition, and delays the fibrotic process.
Dosage reference: Oral administration of 150 mg/kg once daily for 2 weeks can significantly improve liver pathological indicators.
Antioxidation and Anti-inflammation: Delaying aging and chronic disease management
DCI exerts antioxidant and anti-inflammatory effects by eliminating free radicals and regulating inflammatory factors:
Free radical scavenging: DCI exhibits high antioxidant activity against superoxide anion, hydrogen peroxide, and hydroxyl radicals, protecting cells from oxidative damage.
Inflammatory factor regulation: DCI can reduce the expression of pro-inflammatory factors (such as NF-κB, TNF-α), alleviating chronic inflammatory responses.
Application potential: In atherosclerosis, hyperuricemia, and neurodegenerative diseases, the antioxidant and anti-inflammatory effects of DCI may delay disease progression.
Market Applications and Product Development Trends
Health supplement field: As a dietary supplement, DCI is often combined with Myo-inositol (MYO) in a 40:1 ratio to improve metabolic syndrome and PCOS.
Functional foods: Due to its good solubility and slightly sweet taste, DCI can be added to beverages, energy bars, and other products to enhance health value.
Pharmaceutical intermediates: High-purity DCI (≥98%) can be used to develop innovative drugs for treating diabetes, PCOS, and cancer.
Process optimization: Natural extraction methods (such as carob and kudzu root) and enzyme catalytic technology have become mainstream, improving yield and purity, and reducing costs.
The discovery and research history of D-Chiro-Inositol (D- enantiomeric inositol, abbreviated as DCI) is an important chapter in the exploration of the functions of the inositol family by the scientific community. Its discovery can be traced back to the mid-19th century, but the key breakthrough that revealed its biological activity occurred in the latter half of the 20th century. Here is the detailed history of DCI from its discovery to its functional research:
The Early Discovery of Inositol: Establishing the Foundation (1850-1950)
The first isolation of inositol
In 1850, German doctor Johann Joseph Scherer isolated a polyhydroxy alcohol from muscle tissue and named it "Inositol". This discovery laid the foundation for subsequent research, but the specific structure and function of inositol were not clear at that time.
The discovery of inositol isomers
In 1887, scientist Maquenne discovered that inositol was not a single compound but existed in multiple isomers. By 1964, Eisenberg and Bolden further confirmed that tissues such as testes and prostates contained free forms of Myo-inositol (muscle inositol), and the concentration of inositol in semen was three times that of plasma. This discovery suggested the potential role of inositol in the reproductive system.
The first extraction of DCI
In 1951, researcher Peter S. L. Stent isolated DCI from carob tree seeds. This groundbreaking work revealed the uniqueness of DCI as a member of the inositol family, but its physiological function remained to be explored.
Revealing the Biological Functions of DCI: From Structure to Mechanism (1970-1990)
The key role of insulin signal transduction
In 1979, Dr. Larner, the director of the Pharmaceutical College of Virginia University, discovered that DCI was an important component of the insulin second messenger. This discovery revealed the core role of DCI in insulin signal transduction: DCI accelerated the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, promoting non-oxidative and oxidative metabolism of glucose, thereby reducing insulin resistance.
The association of DCI with metabolic syndrome
In the 1990s, it was confirmed that the level of DCI in the human body was closely related to metabolic health. For example, patients with type 2 diabetes had extremely low levels of DCI in their blood and significantly higher concentrations in urine, suggesting that metabolic disorders led to the loss of DCI, thereby exacerbating insulin resistance. This discovery provided a theoretical basis for DCI as a therapeutic target for metabolic diseases.
Breakthroughs in Clinical Application of DCI: From Laboratory to Clinic (1999-2010)
A milestone in PCOS treatment
In 1999, Dr. Larner's team discovered that D Chiro Inositol powder could significantly improve the ovulation function and hormone balance of patients with polycystic ovary syndrome (PCOS). PCOS patients often have insulin resistance and excessive androgen levels, and DCI, by regulating hormone levels (such as reducing serum androgen) and restoring the ovulation cycle, became a potential drug for the treatment of PCOS. This discovery promoted the research on the application of DCI in reproductive medicine.
Verification of the mechanism of diabetes management
In the early 2000s, animal experiments confirmed that DCI could enhance glucose tolerance in mice on a high-fat diet and reduce liver lipid accumulation. Further studies showed that DCI regulated lipid metabolism through the PKCε-PI3K/AKT pathway, providing new ideas for the adjunctive treatment of type 2 diabetes.
Discovery of antioxidant and anti-inflammatory functions
Around 2010, researchers found that DCI had strong antioxidant activity against superoxide anion, hydrogen peroxide, and hydroxyl radicals, and could inhibit the expression of pro-inflammatory factors (such as NF-κB, TNF-α). This discovery expanded the application potential of DCI in chronic inflammation and aging-related diseases.
Modern Research and Application Expansion: From Natural Extraction to Industrial Transformation (Since 2010)
Optimization of natural extraction technology
Chinese researchers used roasted buckwheat as the raw material and employed germination extraction and acid hydrolysis techniques to increase the DCI content from 20% to 66%, and to increase the monomer content by approximately 8 times. The argan extract became the main natural source of DCI, and was classified as a natural flavoring agent by regulations, allowing for appropriate addition to functional foods such as chocolate and beverages.
Deepening of clinical research
PCOS treatment: Clinical trials have shown that PCOS patients who supplement 500-1000 mg of DCI daily can significantly improve insulin resistance and ovulation function.
Anti-tumor assistance: DCI can inhibit the growth of breast cancer cells (MDA-MB-231) at concentrations ranging from 1 to 40 mM, and reduce tumor volume.
Liver protection: A dose of 150 mg/kg of DCI can alleviate liver damage and fibrosis in rats with bile stasis models.
Industrialization and market application
DCI powder, as a dietary supplement and pharmaceutical intermediate, has been widely applied in health supplements, functional foods, and drug development. For example, the "Chirositol" compound supplement launched by the US company Swanson contains 90 mg of DCI and 3.6 mg of manganese sulfate per tablet, and the recommended dosage is twice a day, one tablet each time.
FAQ
1. Does it compete with the intracellular transport carrier of another isomer of inositol (Myo-inositol)?
Both may share some sodium-ion-dependent inositol transporters (SMIT). The high-dose single-donor D-enantiomeric inositol may theoretically affect the normal uptake of Myo-inositol, interfering with the latter's regulation of oocyte quality and thyroid function.
2. Besides the insulin signaling pathway, does it function through epigenetic mechanisms?
Preliminary studies suggest that it may act as a precursor of phosphatidylinositol glycan, influencing the synthesis of anchoring proteins, thereby regulating the functions of cell surface receptors related to insulin resistance. This involves a non-classical level of signal regulation.
3. What is the biochemical basis for the varying therapeutic effects on patients with polycystic ovary syndrome (PCOS) caused by different etiologies?
The effect may be highly dependent on the specific phosphorylation status of the insulin receptor substrate (IRS) in the patient and the downstream PI3K activity. For some patients with PCOS who have polymorphisms in the IRS genes or significant chronic inflammation, the improvement in insulin sensitivity may be limited.
4. Could long-term and high-dose use potentially interfere with the liver's gluconeogenesis pathway?
As an insulin sensitizer, it is theoretically possible to enhance the inhibitory effect of insulin on hepatic gluconeogenesis. For individuals with abnormal liver function or marginal glucose regulation ability, the potential risk of hypoglycemia should be monitored.
Hot Tags: d chiro inositol powder, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, larocaine hydrochloride, Medetomidine hydrochloride, paracetamol powder, pure benzocaine powder, tetracaine powder, tetramisole hcl powder