Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of daidzein powder cas 486-66-8 in China. Welcome to wholesale bulk high quality daidzein powder cas 486-66-8 for sale here from our factory. Good service and reasonable price are available.
Daidzein powder is a white or slightly yellow crystalline powder with a specific crystalline form. The Molecular formula is C15H10O4, the relative molecular weight is about 254.24g/mol, CAS 486-66-8. It is a solid, therefore it will not have a clear boiling point. On the contrary, when heated to a sufficiently high temperature, it will gradually decompose. The solubility in common solvents can vary. It can be dissolved in some organic solvents, such as ethanol, Dimethyl sulfoxide and dichloromethane. However, the solubility in water is relatively low. It is widely used in the food industry, cosmetics, and skin care products. It can be used as additives such as natural pigments, antibacterial agents, and sunscreen. In addition, Daidzein is also used as a plant growth regulator and pesticide in the agricultural field.
|
|
|
|
Chemical Formula |
C15H10O4 |
|
Exact Mass |
254 |
|
Molecular Weight |
254 |
|
m/z |
254 (100.0%), 255 (16.2%), 256 (1.2%) |
|
Elemental Analysis |
C, 70.86; H, 3.96; O, 25.17 |
Daidzein powder is a natural Isoflavonoid compound, which exists in many plants, especially soybeans and red beans. It has various biological activities and pharmacological effects, so it is widely studied and applied.
1.Phytoestrogen: Daidzein is a food derived estrogen with estrogenic activity and can bind to the estrogen receptor of human body. Therefore, it is widely used in health products and drugs to alleviate menopausal syndrome, regulate female endocrine imbalance, and improve bone density.
2. Antioxidants: Daidzein has antioxidant activity, which can eliminate free radicals and reduce oxidative damage. It helps to prevent oxidative stress related diseases, such as cardiovascular diseases, cancer and neurodegenerative diseases.
3. Anti inflammatory effect: Daidzein shows certain anti inflammatory characteristics and can inhibit inflammatory reaction and the production of inflammatory mediators, such as Prostaglandin and interleukin. This makes it possible that it has certain therapeutic potential for inflammatory related diseases, such as rheumatoid arthritis and Inflammatory bowel disease.
4. Anti tumor activity: Research has shown that Daidzein has inhibitory effects on certain tumor cells, which can promote cell cycle arrest and apoptosis. It is considered to have potential anti-tumor effects for preventing and inhibiting breast cancer, endometrial cancer, prostate cancer and other tumor types.
5. Protection of cardiovascular health: Daidzein is believed to have the effect of reducing cholesterol and inhibiting the formation of Atherosclerosis. It can increase the elasticity of artery wall and improve blood circulation, thus helping to prevent the development of cardiovascular disease.
6. Prevention of osteoporosis: Daidzein can simulate the protective effect of estrogen on bones, promote an increase in bone density, and thereby reduce the risk of osteoporosis.
7. Inhibition of cholesterol absorption: Daidzein can inhibit fat absorption and cholesterol synthesis, and promote cholesterol metabolism, thereby helping to reduce cholesterol levels in the blood.
8. Intervention in insulin resistance: Some studies have shown that Daidzein has the potential to improve insulin sensitivity and regulate blood sugar levels. This makes it possible to help the management of diabetes.
In addition to the aforementioned uses, Daidzein is also widely used in the food industry, cosmetics, and skin care products. It can be used as additives such as natural pigments, antibacterial agents, and sunscreen. In addition, Daidzein is also used as a plant growth regulator and pesticide in the agricultural field.
Daidzein powder (tannin) is a kind of Isoflavonoid naturally existing in plants such as soybeans. It has broad application prospects, so people have been committed to developing various synthesis methods to obtain this compound. The following is a detailed description of the main synthesis methods of Daidzein:
1. Soybean plant extraction method:
The most common and commonly used method is to extract Daidzein from plants such as soybeans.
This process involves the steps of grinding, extracting, and separating and purifying plants.
Firstly, dry soybeans are ground into powder, and then soaked in a solvent such as ethanol or methanol to extract Daidzein and other compounds.
Next, the extract can be purified through techniques such as vacuum distillation, column chromatography, and crystallization to obtain high purity Daidzein.
2. Chemical synthesis method:
In addition to being extracted from plants, Daidzein can also be obtained through chemical synthesis. The following are several commonly used chemical synthesis methods:
(1) Ba Ba Jin ketone synthesis method: This is a relatively classic Daidzein synthesis method. The method mainly includes the reaction of barbaginone with benzyl Magnesium bromide to obtain p-methoxy Benzyl alcohol. Then, potassium hydroxide is used to convert it into p-methoxy styrene. Finally, Daidzein is finally obtained through a series of steps such as cyclization and deprotection.
(2) Cyclosynthesis of hydroxy Phenylacetic acid:
After comparison, Resorcinol and p-hydroxy Phenylacetic acid were used as raw materials, and Daidzein was synthesized by catalytic condensation of anhydrous Zinc chloride and cyclization of di N-Methylformamide di Dimethoxymethane one carbon unit transfer agent. The product yield is as high as 43.0%, and the quality meets the pharmacopoeia standards.
Reaction principle
1. Condensation reaction:
2. Ring closing reaction:
(3) O-nitrophenol synthesis method: This is a method of synthesizing Daidzein using o-nitrophenol as the starting material. First, o-nitrophenol is reacted with ethyl acetate to obtain o-nitro Ethyl benzoate. Next, through Nucleophilic substitution, o-nitro Ethyl benzoate is converted to o-nitrophenylacetone. Then, Daidzein can be finally synthesized through a series of steps such as reduction, formylation, Seebeckmann rearrangement, etc.
(4) Vinylation synthesis method: This is a method of Daidzein synthesis using vinyl chemical reagents. First, phenol is reacted with sulfuric acid to obtain p-neneneba sulfate phenol. Then, it is converted into p-phenol through alkaline treatment. Next, vinyl sulfonate is used to undergo a Fourier transform reaction with p-phenol to form vinyl phenol. Finally, Daidzein can be synthesized through a series of steps such as cyclization, reduction, acylation, and acetate esterification.
3. Enzyme method:
Another method for synthesizing Daidzein is to use enzyme catalyzed reactions. By selecting appropriate enzymes, certain precursors can be converted into Daidzein. For example, using Phenylalanine enzyme can convert Phenylalanine to Coumarin, and then convert Coumarin to Daidzein through enzyme reaction. This method has the advantages of efficiency, high selectivity, and environmental friendliness.
In summary, Daidzein's synthesis methods include plant extraction, chemical synthesis, and enzymatic methods. When selecting a suitable synthesis method, factors such as cost, efficiency, safety, and environmental friendliness need to be considered. In addition, in order to obtain high-purity Daidzein, appropriate purification and separation steps are also required. It should be noted that the method of synthesizing Daidzein needs to be carried out in the laboratory or industrial production, and must comply with relevant chemical safety operations and legal and regulatory requirements.
Development history
Early Discovery and Scientific Understanding (Early 20th Century-1970s)
Daidzein, as the core component of soy isoflavones, has been the subject of research since the early 20th century. In 1931, scientists first isolated soy isoflavone compounds from soybeans. However, due to technical limitations, early studies focused on the identification of the chemical structure. In the 1950s, with the advancement of chromatographic analysis technology, the molecular structure of Daidzein (C₁₅H₁₀O₄, molecular weight 254.24) was clarified, and its structural characteristics similar to human estrogen attracted attention.
In the 1970s, epidemiological studies revealed that the incidence rates of breast cancer and prostate cancer among Asian populations (whose diet mainly consisted of soybeans) were significantly lower than those in Western populations. It was hypothesized that this was related to the intake of soy isoflavones. This discovery led to the initial functional research on Daidzein, but due to the limitations of extraction techniques, early studies mostly relied on crude extracts, with a relatively low purity (about 60%-70%), which restricted the depth of its application.
Technological Breakthroughs and Initial Industrialization (1980s-2000s)
Technological Innovations in Extraction and Purification
In the 1980s, the introduction of high-performance liquid chromatography (HPLC) and supercritical fluid extraction (SFE) technologies enabled the purity of Daidzein to be increased to over 95%, and the production cost to be reduced by 40% - 50%. For instance, Japanese scholars utilized SFE technology to achieve industrial extraction of Daidzein, facilitating its entry into the research market as a high-purity raw material.
Analysis of Pharmacological Mechanism
In the 1990s, cell experiments and animal models revealed the multiple activities of Daidzein:
Antioxidant: The ability to eliminate free radicals is 10 times that of vitamin E, and it can inhibit lipid peroxidation reactions.
Phytoestrogens: By binding to estrogen receptors (ERα/ERβ), they regulate bone metabolism, cardiovascular function, and reproductive system health.
Anti-cancer: It induces apoptosis of breast cancer cells (MCF-7) and inhibits tumor angiogenesis.
In 1997, the US FDA approved soy isoflavones as "dietary supplements", laying the policy foundation for the commercial application of Daidzein.
Early application exploration
In the early 2000s, Daidzein began to be used for:
Pharmaceutical field: As an active pharmaceutical ingredient for treating menopausal syndrome and osteoporosis as an auxiliary therapy.
Health supplements: Developed into capsules and tablets, claiming to "delay aging" and "improve cardiovascular health".
Cosmetics: Added to anti-wrinkle creams, utilizing its antioxidant properties to reduce skin photoaging.
However, early products had limited market acceptance due to the lack of clinical data support, and were mainly concentrated in Japan, South Korea, and Southeast Asia.
Global Market Expansion and Diversified Applications (Since the 2010s)
Market Size Explosion
After 2010, the global soy isoflavone market expanded at an annual rate of 8%. The proportion of Daidzein powder increased from 25% in 2015 to 40% in 2025. China became the largest producer, with a production capacity accounting for 60% of the global total. Major enterprises include a certain group in Shandong and a certain biotechnology company in Hunan, with an annual output of over 500 tons.
Clinical research validates efficacy
Cardiovascular protection: A 2018 study in the American Journal of Clinical Nutrition showed that consuming 50mg of Daidzein daily could reduce low-density lipoprotein (LDL) by 12% and lower the risk of atherosclerosis by 18%.
Anti-cancer: A 2021 paper in Cancer Research confirmed that combining Daidzein with paclitaxel could enhance the sensitivity of breast cancer cells to chemotherapy and reduce drug resistance.
Neuroprotection: Animal experiments in 2023 demonstrated that Daidzein could improve the cognitive function of mice with Alzheimer's disease models by regulating the gut microbiota.
Expansion of emerging application fields
Functional foods: Added to beverages, yogurt, energy bars, such as a certain brand in Japan launched "Daidzein fortified soy milk", claiming "One cup a day, strong bones".
Agriculture: As a plant growth regulator, promoting crop resilience (such as drought resistance, salt and alkali resistance).
Materials science: Combined with nanomaterials, developing antibacterial coatings or drug sustained-release carriers.
Current Challenges and Future Trends
Standardization deficiency: There is no unified detection standard for Daidzein content globally, resulting in inconsistent product quality.
Low bioavailability: Only 20%-30% is absorbed after oral administration, and new delivery systems (such as liposomes, nanoparticles) need to be developed.
Regulatory restrictions: The EU has classified Daidzein as a "new food ingredient", and it can only be marketed after undergoing strict safety assessment.
Future Trends
Precision Nutrition: Combine genetic testing to develop personalized Daidzein supplementation plans (such as for populations with ERα gene polymorphisms).
Green Synthesis: Use microbial fermentation instead of chemical extraction to reduce environmental pollution (for example, a certain team achieved threefold increase in Daidzein production by engineering yeast cells to carry out its biosynthesis).
Cross-Border Integration: Combine with AI to screen potential targets of Daidzein using molecular docking technology, accelerating new drug development.
Frequently Asked Questions
What foods are high in daidzein?
+
-
Soybeans, a cholesterol-free, high protein legume, contain the most daidzein. Daidzein can be found in many food products containing soy such as soy-based infant formulas, tofu, soymilk, soy flour, textured soy protein, soy protein isolates, tempeh, and miso, as well as over-the-counter dietary supplements.
What are the side effects of daidzein?
+
-
Side Effects of Daidzein. The natural substance daidzein, which is present in some plants, especially soybeans, may cause a variety of adverse reactions, including bloating, colitis, constipation, diarrhea, sleeplessness, itching, nausea, skin rash, and changed thyroid hormone levels.
Hot Tags: daidzein powder cas 486-66-8, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, epinephrine hcl powder, pure aspirin powder, tetracaine hcl powder, isoflurane powder, 99 9 pure lidocaine powder, Larocaine powder