3-Nitro-1,2,4-triazole CAS 24807-55-4

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 3-nitro-1,2,4-triazole cas 24807-55-4 in China. Welcome to wholesale bulk high quality 3-nitro-1,2,4-triazole cas 24807-55-4 for sale here from our factory. Good service and reasonable price are available.

3-Nitro-1,2,4-triazole, with the molecular formula C₂H₂N₄O₂ and a relative molecular weight of 122.06, is a high-performance, multifunctional organic energetic compound. The product is normally a white crystal or crystalline powder, solid at room temperature, insoluble in water, and compatible with various organic solvents. As a source factory brand, Bloomtechz has been deeply involved in the fine chemicals field for over a decade, with mature synthesis production lines and a complete quality control system.

We can precisely control the crystal form and purity of the product, strictly monitor all physical and chemical indicators, eliminate batch differences, and fully ensure product quality stability. Relying on many years of overseas trade experience, we are familiar with chemical export standards and logistics regulations in various countries, and can provide one-stop services such as customized packaging, compliant customs declaration, and full traceability.

3-Nitro-1,2,4-triazole is an organic compound containing nitro groups, widely used in organic synthesis, chemical industry, agriculture, and other fields. It can also be used to synthesize various resins, which are widely used in coatings, adhesives, and plastics.

1. Synthetic phenolic resin:

Phenolic resin is a polymer synthesized by condensation reaction of phenolic and aldehyde compounds, which has excellent heat resistance, corrosion resistance, and insulation performance. 3 Nitro-1,2,4-triazole can be used as a modifier for synthesizing phenolic resins, improving their brittleness and impact resistance, toughness, and processability.

2. Synthetic polyurethane resin: Polyurethane resin is a polymer material with excellent wear resistance, flexibility, and impact resistance, widely used in coatings, adhesives, leather finishing agents, and other fields. 3 Nitro-1,2,4-triazole can be used as a crosslinking agent for synthesizing polyurethane resin, which can improve the hardness and wear resistance of the resin.

3. Synthetic epoxy resin: Epoxy resin is a polymer material with excellent adhesion, wear resistance, and chemical corrosion resistance, widely used in coatings, adhesives, electronic packaging materials, and other fields. 3 Nitro-1,2,4-triazole can be used as a modifier for synthesizing epoxy resin, which can improve the toughness and heat resistance of epoxy resin.

4. Synthetic polyimide resin: Polyimide resin is a polymer material with excellent heat resistance, corrosion resistance, and insulation properties, widely used in fields such as wires and cables, electronic devices, etc. 3 Nitro-1,2,4-triazole can be used as an intermediate for synthesizing polyimide resins and can synthesize various types of polyimide resins.

5. Organic synthesis intermediate: 3 Nitro-1,2,4-triazole can be used as an important intermediate in organic synthesis for synthesizing other organic compounds. For example, 3 nitro-1,2,4-triazole can be converted into 3-amino-1,2,4-triazole through a reduction reaction, leading to the synthesis of various drugs, dyes, and resins.

6. Agricultural chemicals: 3 Nitro-1,2,4-triazole can be used to synthesize various agricultural chemicals, such as fungicides, herbicides, and plant growth regulators. These agricultural chemicals can be used to control crop diseases and pests, increase crop yield, and improve crop quality.

In summary, 3 Nitro-1,2,4-triazole has a wide range of applications in the synthesis of resins, which can improve and enhance the performance and processability of resins, and is widely used in fields such as coatings, adhesives, plastics, etc.

The research on hypoxic cell radiosensitizers is an important direction in the field of tumor therapy, aimed at improving the efficacy of radiotherapy in hypoxic areas within tumors. In this field, it stands out due to its unique chemical structure and biological activity, becoming a highly anticipated research object. Experimental data shows that compared with traditional hypoxic cell radiosensitizers such as Misonidazole (MISO), this compound exhibits a more significant sensitizing effect in vitro experiments, that is, they can achieve the same tumor killing effect at lower radiation doses. This is of great significance for reducing the burden of treatment on patients and minimizing damage to normal tissues.

More importantly, the compound exhibits lower toxicity while enhancing radiation sensitivity. This characteristic makes these compounds safer in the drug development process, reducing the risk of treatment interruption or failure caused by drug side effects. In order to further optimize the performance of such compounds, scientists have successfully synthesized a series of new compounds by introducing functional groups such as N ^ I-acetylhydroxamic acid side chains through complex chemical synthesis strategies. These derivatives not only retain their original sensitizing effect, but also reduce toxicity to a certain extent, providing the possibility of achieving efficient and low toxicity tumor radiosensitization therapy.

In addition, by conducting in-depth research on the structure activity relationship of these new compounds, scientists are expected to reveal the specific mechanism by which the compounds enhance radiation sensitivity, providing theoretical support for the development of more precise and effective tumor treatment strategies. Meanwhile, with the continuous deepening of research on tumor microenvironment, hypoxia mechanism, and drug action mechanism, the application prospects of such compounds in tumor treatment will be even broader, bringing new hope to cancer patients.

It is an organic compound containing nitro groups, which has wide applications in organic synthesis and chemical industry. The following are two routes for laboratory synthesis of 3-Nitro-1,2,4-triazole and their corresponding chemical equations.

Triazole sulfonate + HNO₃--> Triazole nitrate + NO₂ + H₂O

Chemical equation:

(1) C₂H₃N₃ + H₂SO₄-->Triazole sulfonate + H₂O

(2) Triazole sulfonate + 2NaOH -->Triazole base+ Na₂SO₄

(3) AgNO₃ --> AgCl + NO₃^-

(4) Triazole base + Cu (NO₃)₂-->Cu (OH)₂ + Triazole nitrate

(5) Cu (OH)₂ --> CuO + H₂O

(6) Na₂SO₄ + H₂SO₄ --> BaSO₄ + Na₂SO₄

(7) Triazole nitrate + NH₃ -->Triazole imine + NH₄NO₃

(8) Triazole imine -->Triazole imine salt (NH₄Cl) -->Triazole imine (NH₄Cl)

(9) Triazole imine (NH₄Cl)+Fe -->C₂H₂N₄O₂ + FeCl₂ + NH₄Cl

Starting material: 1,2,4-triazole

 

 

1

1.

Under anhydrous conditions, mix 1,2,4-triazole with concentrated sulfuric acid, heat to 140-150 ° C, maintain at this temperature for 2-3 hours, and allow 1,2,4-triazole to react with sulfuric acid to form bisulfate.

2

2.

Cool the reaction product to room temperature, add a sodium hydroxide aqueous solution, neutralize the remaining sulfuric acid, and bring the pH value to 7-8.

3

3.

Add silver nitrate to precipitate chloride ions in the solution, and filter to remove silver chloride precipitates.

4

4.

Add sodium hydroxide to the filtrate, adjust the pH value to 9-10, and then add copper nitrate to generate a blue precipitate of copper hydroxide.

 

 

5

5.

Filter to remove copper hydroxide precipitation, concentrate the filtrate to half its volume, add concentrated sulfuric acid to precipitate the salts in the solution, and filter to remove barium sulfate precipitation.

6

6.

Add concentrated ammonia water to the filtrate, adjust the pH value to 9-10, and generate 3-amino-1,2,4-triazole precipitate.

7

7.

Filter to remove the precipitate, dissolve the precipitate with concentrated hydrochloric acid, add appropriate reducing agents such as iron powder, and reduce 3-amino-1,2,4-triazole to 3-nitro-1,2,4-triazole.

As domestic fine chemical production capacity continues to expand, the 3-nitro-1,2,4-triazole market is gradually globalizing. Overseas customers are increasingly demanding product compliance, trade professionalism, and comprehensive after-sales service. However, most domestic manufacturers currently lack their own import-export qualifications and experience in operating in overseas markets, relying on third-party trade agents instead. This causes a lot of issues like too many middlemen, delayed communication, incomplete documents, high customs clearance risks, and disconnected after-sales service. At the same time, many manufacturers aren't familiar with hazardous chemical import standards, environmental access rules, or product certification requirements in different countries, which can easily lead to goods being held, customs clearance failures, or returns and claims, seriously harming customer interests.

With over a decade of hands-on experience in international trade, Bloomtechz has built a mature and comprehensive global trade service system. We have full self-operated import and export rights, so there's no need for third-party agents-factories connect directly with global end customers, cutting out middleman markups, making communication more efficient and costs lower. Our professional foreign trade team is deeply familiar with global markets and well-versed in chemical import regulations, hazardous material transportation rules, customs clearance procedures, and product entry standards across regions like Europe, America, Southeast Asia, the Middle East, and South America.

We can provide clients with a full set of English qualification documents, quality inspection reports, certificates of origin, MSDS safety sheets, and hazardous material compliance documents.Plus, we offer one-stop services including customs declaration, logistics coordination, clearance assistance, and full traceability, minimizing procurement risks for our clients. After years of development, Bloomtechz products are sold to dozens of countries and regions worldwide, and we have established long-term, stable partnerships with many overseas new materials companies, agrochemical enterprises, and research institutions.

Our overseas services are far ahead of peers in terms of professionalism, compliance, and stability. 

The core performance of 3-nitro-1,2,4-triazole products mainly depends on the synthesis process and purification technology. The level of the process directly determines the product's purity, stability, controllability of morphology, and suitability for applications. At present, most manufacturers in the industry are still using traditional synthesis processes that were developed decades ago. These processes have become fixed, and the technology has stagnated, leading to many shortcomings such as low reaction conversion rates, numerous by-products, incomplete purification, high energy consumption, and uncontrollable parameters.

Products made with traditional processes can only meet the basic needs of low-end agricultural chemicals and cannot meet the demanding standards of high-end energetic materials, biopharmaceuticals, precision electrochemical devices, and other advanced fields. The industry also suffers from severe product homogenization, leading to vicious price competition in the low-end market.Bloomtechz has always focused on technological innovation as its core driving force.

The company has set up a dedicated R&D team specializing in process optimization and technology iteration for energetic triazole intermediates, breaking through the technical barriers of traditional processes. 

Their self-developed and upgraded closed-loop catalytic synthesis process significantly improves raw material utilization and product conversion rate by precisely controlling reaction temperature, pressure, catalyst amount, and reaction duration, which reduces the formation of by-products and residual impurities from the source. At the same time, their innovative multi-stage gradient purification and low-temperature controllable crystallization technology allows precise control over crystal growth rate, particle size, and morphology, perfectly addressing industry pain points such as uneven particle size, chaotic crystal shapes, and unstable solubility.

Most importantly, Bloomtechz has achieved precise control over chiral enantiomer ratios. Products with different D-type and L-type compositions can be customized according to clients' needs in pharmacological testing or high-end material synthesis, allowing precise tuning of biological activity and electrochemical performance. This core technological advantage is something most ordinary competitors cannot achieve, completely breaking the bottleneck of technology homogenization in the industry and meeting the demands of the high-end differentiated market.

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