Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of coluracetam powder cas 135463-81-9 in China. Welcome to wholesale bulk high quality coluracetam powder cas 135463-81-9 for sale here from our factory. Good service and reasonable price are available.
Coluracetam powder is a nootropic compound belonging to the racetam class, characterized by its fine, crystalline structure and high purity when synthesized for research purposes. It is chemically designated as (2-oxo-1-pyrrolidinyl) acetamide and is known for its potential to modulate cholinergic systems, particularly through high-affinity choline uptake (HACU) enhancement, which may support cognitive processes. The powder is typically white to off-white, water-soluble, and stable under standard laboratory conditions, making it suitable for in vitro and in vivo studies. Research suggests it may exhibit neuroprotective properties and influence synaptic plasticity, though its precise mechanisms remain under investigation. Coluracetam powder is often utilized in neurological studies to explore its effects on memory, learning, and potential applications in neurodegenerative conditions. Proper handling and storage are essential to maintain its integrity, as exposure to moisture or extreme temperatures may degrade its quality. Its low molecular weight and bioavailability make it a subject of interest for further pharmacological exploration.
|
|
|
Coluracetam COA
The synthesis methods of Coluracetam powder mainly include the following:
Method 1:
A synthesis method using phenylacetylene as the raw material: The method includes reacting phenylacetylene with succinic anhydride to generate phenylacetylene anhydride, and then reacting it with quinoline to obtain the target product Coluracetam. The specific steps are as follows:
(1) React phenylacetylene and succinic anhydride in the presence of anhydrous hydrogen chloride at 100 ℃ for 6 hours to obtain phenylacetylene anhydride.
(2) React phenylacetylene anhydride with quinoline in the presence of phosphorus oxychloride at 80 ℃ for 3 hours to obtain crude Coluracetam.
(3) Recrystallize crude Coloracetam with methanol to obtain pure Coloracetam.
This method has mild reaction conditions and high yield, making it the main method for industrial production of Coloracetam.
Method 2:
The synthesis method using 3-cyanopyridine as raw material: This method uses 3-cyanopyridine as raw material and obtains the target product Coluracetam through several steps of reaction. The specific steps are as follows:
(1) 3-Cyanopyridine and sulfoxide chloride were reacted with triethylamine at 60 ℃ for 4 hours to obtain 3-carboxypyridine.
(2) 3-Carboxypyridine and phosphorus oxychloride were reacted with triethylamine at 50 ℃ for 2 hours to obtain 2-cyanoquinoline-3-carboxylic anhydride.
(3) React 2-cyanoquinoline-3-carboxylic anhydride with methanol in the presence of sulfuric acid at 60 ℃ for 2 hours to obtain crude Coluracetam.
(4) Recrystallize crude Coloracetam with methanol to obtain pure Coloracetam.
This method has a high yield, but the raw material cost is high, and it requires the use of highly toxic sulfoxide chloride and phosphorus oxychloride, so it is not suitable for industrial production.
Method 3:
The synthesis method using 3-ethyl formate quinoline as raw material: This method uses 3-ethyl formate quinoline as raw material and obtains the target product Coluracetam through several steps of reaction. The specific steps are as follows:
(1) 3-Carboxyquinoline anhydride was obtained by reacting 3-ethyl formate quinoline with thionyl chloride in the presence of triethylamine at 60 ℃ for 4 hours.
(2) React 3-carboxyquinolinic anhydride with methanol in the presence of sulfuric acid at 60 ℃ for 2 hours to obtain crude Coluracetam.
(3) Recrystallize crude Coloracetam with methanol to obtain pure Coloracetam.
This method has a high yield, but the raw material cost is high, and it requires the use of highly toxic sulfoxide chloride and phosphorus oxychloride, so it is not suitable for industrial production.
The above three synthesis methods all require strict control of reaction conditions and raw material purity to ensure the quality and safety of Coloracetam. In addition, in industrial production, it is necessary to consider factors such as production efficiency and cost, and choose appropriate synthesis methods and process conditions.
Coluracetam Powder (CAS number: 135463-81-9), chemical name N - (2,3-dimethyl-5,6,7,8-tetrahydrofurano [2,3-b] quinolin-4-yl) -2- (2-oxopyrrolidin-1-yl) acetamide, belongs to the Sitan class derivatives and is a compound under development with multiple potential uses. The following will elaborate on its purpose:
Scientific research and drug development
Coluracetam has important applications in cognitive function research. Many studies have shown that Coluracetam can improve learning disabilities, memory deficits, and cognitive impairments in rats and mice. For example, in a mouse model induced by AF64A, Coluracetam (0.3-3 mg/kg, orally, once daily for 11 days) significantly improved memory impairment and hippocampal acetylcholine consumption. Similarly, in a rat model, Coluracetam (1-3 mg/kg, orally, once daily for 8 days) also significantly improved cognitive and learning impairments. These research results suggest that Coluracetam may improve cognitive function by increasing the synthesis and release of acetylcholine, enhancing the activity of cholinergic neurons. In addition, the application of Coluracetam in cognitive function research is also reflected in its impact on different cognitive domains. For example, some studies have shown that Coluracetam can improve different types of memory functions such as working memory, spatial memory, and long-term memory. These findings provide important clues for further understanding the mechanism of action and potential applications of Coluracetam.
Research on neurodegenerative diseases
Coluracetam also has potential value in the study of neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc. are usually accompanied by a decline in cognitive function and damage to neurons. Coluracetam may have a positive impact on these diseases by enhancing the activity of cholinergic neurons. For example, in research on Alzheimer's disease, Coluracetam Powder may improve patients' cognitive function by increasing the synthesis and release of acetylcholine. In addition, Coluracetam Powder may also alleviate neuronal damage and death through neuroprotective effects, thereby delaying disease progression. However, further clinical studies are needed to verify the efficacy and safety of Coluracetam Powder in neurodegenerative diseases.
Coluracetam also plays an important role in neurotransmitter and receptor research. Acetylcholine is one of the important neurotransmitters in the central nervous system, which binds to various receptors and exerts different physiological effects. Coluracetam may affect the activity and function of these receptors by increasing the synthesis and release of acetylcholine. For example, some studies have shown that Coluracetam has different effects on M-type cholinergic receptors (M1-M5) and N-type cholinergic receptors (N1-N2). These findings contribute to further understanding the mechanism of action and potential applications of Coluracetam Powder. In addition, Coluracetam Powder may also affect other neurotransmitter systems, such as the dopaminergic system, noradrenergic system, etc., resulting in a wider range of physiological effects.Coluracetam also has practical value in drug interaction and metabolism research. Drug interaction refers to the possible mutual influence between two or more drugs when used simultaneously. Understanding the interactions between Coluracetam Powder and other drugs can help with rational drug use and avoid adverse reactions. In addition, the metabolic research of Coluracetam is also an important part of drug development. Understanding the metabolic pathways and metabolites of Coluracetam in the body can help evaluate its efficacy and safety, and provide a basis for determining drug dosage and formulating administration plans.
Scope of sales channels
Coluracetam, as a derivative of Sitan, belongs to the category of puzzle drugs. Its powder form (Coluracetam Powder) is mainly circulated in the market through specific sales channels. The following will provide a detailed analysis of the sales channel scope from dimensions such as supplier type, sales platform, regional distribution, sales model, and customer base:
Sales Platform and Channel
B2B e-commerce platform
The platform has gathered a large number of chemical raw material suppliers and buyers, providing a broad market space for Coluracetam's international sales. Suppliers post product information (such as purity, packaging specifications, prices, etc.) on the platform, and buyers place orders through inquiry and comparison. The platform provides online payment, logistics tracking and other services to ensure the security and convenience of transactions. High information transparency, convenient transaction process, suitable for small and medium-sized procurement. The platform also provides marketing promotion, data analysis and other services to help suppliers expand their market share.
Enterprise official website and direct sales channels
Production oriented enterprises usually display product details, technical parameters, application areas, and contact information through their official websites. The official website may also provide online customer service, sample application and other services to facilitate customer consultation and procurement. Customers can directly contact the company's sales department for bulk procurement or customized services. The direct sales model reduces intermediate links, lowers procurement costs, while ensuring product quality and supply stability.
Industry exhibitions and offline channels
Suppliers showcase their products and expand their customer base through exhibitions such as the China International Chemical Exhibition and the European Biopharmaceutical Raw Materials Exhibition. During the exhibition, suppliers can have face-to-face communication with customers to understand market demand and feedback, while showcasing the strength and image of the enterprise. Establish long-term cooperative relationships with research institutions and pharmaceutical companies, providing services such as sample testing and technical exchanges. Offline cooperation helps establish trust relationships and promote long-term cooperation.
Regional distribution and market coverage
European and American markets
The demand for puzzle drug raw materials in the European and American markets continues to grow, and Coluracetam Powder, as a new type of puzzle drug raw material, has attracted the attention of research institutions and pharmaceutical companies. Suppliers must comply with regulatory requirements in the European and American markets (such as FDA and CE certification) and provide high-quality products and services. At the same time, by participating in industry exhibitions in Europe and America and establishing local sales teams, we aim to expand our market share.
Asian market
The demand for puzzle drug raw materials in the Asian market is also strong, especially in countries such as China, India, and Japan. The demand for Coluracetam Powder is constantly increasing among research institutions and pharmaceutical companies in these countries. Suppliers can quickly enter the market by collaborating with local agents and distributors. At the same time, we provide customized services and technical support to meet the personalized needs of our customers.
Other regions
The demand for puzzle drug raw materials is gradually increasing in Southeast Asia, South America, Africa and other regions. The market potential in these regions is enormous, but suppliers need to understand the local regulatory requirements, market environment, and cultural differences. Expand market share by participating in local exhibitions, establishing sales networks, and other means. At the same time, establish cooperative relationships with local research institutions and pharmaceutical companies to jointly promote market development.
The history of racetam drugs can be traced back to 1964, when Romanian chemist Corneliu Giurgea first synthesized Piracetam, the world's first discovered aphrodisiac drug. The discovery of Piracetam marks the beginning of scientists' systematic research on compounds that can improve cognitive function. The common feature of racetam drugs is that they all contain a 2-pyrrolidone core structure, but different derivatives have changes in their side chains, which affect their pharmacological properties. After Piracetam, scientists have developed various derivatives such as Oxiracetam, Aniracetam, Pramiracetam, etc., each with different mechanisms of action and effects. Coluracetam was discovered in this context, and its structural feature is the presence of a furan quinoline skeleton, which makes it unique in the racetam family.
It was first developed by Mitsubishi Pharmaceutical (now known as Tanabe Mitsubishi Pharmaceutical) in the 1990s under the codename MKC-231. The original intention of its research and development was to find a cognitive enhancer that is more effective than existing racetam drugs, especially in regulating the cholinergic system. It combines 2-pyrrolidone and furan quinoline structures, giving it higher lipid solubility and blood-brain barrier penetration ability. This structural optimization enables it to act more effectively on the central nervous system (CNS). Early studies have found that Coluracetam can significantly enhance high affinity choline uptake (HACU), which is a key step in the synthesis of the neurotransmitter acetylcholine (ACh). This characteristic makes it a potential therapeutic drug for Alzheimer's disease, as the disease is closely related to the degeneration of cholinergic neurons.
Hot Tags: coluracetam powder cas 135463-81-9, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, gs 441524 remdesivir, 3 Nitrobenzonitrile, N N N Trimethylethylenediamine, 3 Phenyltoluene, 2 5 Dihydroxybenzaldehyde, 2 Chloro 4 pyridinecarboxylic acid