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Butaphosphan, chemically known as ethane-1,2-diyl bis(dihydrogen phosphate), is an organic phosphorus compound with the molecular formula C₂H₈O₆P₂. It is a colorless to slightly yellowish, viscous liquid that is highly soluble in water, facilitating its formulation into injectable solutions. The stability of butaphosphan in aqueous solutions makes it suitable for parenteral administration, ensuring reliable delivery and bioavailability.
Butaphosphan injection is a veterinary pharmaceutical agent widely used to enhance metabolic function, support energy production, and improve overall health in livestock and companion animals. It is a phosphorus compound that plays a critical role in energy metabolism, bone formation, and cellular repair.
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Additional information of chemical compound:
| Product Name | Butaphosphan Powder | Butaphosphan Injection | |
| Product Type | Powder | Injection | |
| Product Purity | >95% | >95% | |
| Product Specifications | 1g; 10g; 100g; 1kg | 10%/100ml;20%/100ml | |
| Product Form | Organic Synthesis | Injection | |
Butaphosphan COA
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| Certificate of Analysis | ||
| Compound name | Butaphosphan | |
| Grade | Pharmaceutical grade | |
| CAS No. | 17316-67-5 | |
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| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White to off-white | Conformed |
| Water content | ≤5.0% | 0.11% |
| Loss on drying | ≤1.0% | 0.23% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | >95%% | 99.98% |
| Single impurity | <0.8% | 0.17% |
| Total microbial count | ≤750cfu/g | 30 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 200ppm |
| Storage | -80°C, 2 years; -20°C, 1 year (Sealed storage, away from moisture) | |
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| Shaanxi Chuzhan is a technology enterprise specializing in the research and development, production of chemicals and equipment customization services, providing OEM/ODM full-chain solutions. We offer flexible full-process customized services, from formula research and development to equipment selection, all can be deeply adapted according to customer requirements. Support full-cycle technical collaboration from small-scale trials, medium-scale trials to large-scale production, equipped with a professional engineering team to provide process optimization suggestions, and can customize packaging labels according to the brand requirements of customers. | ||
| Chemical Formula | C7H18NO2P |
| Exact Mass | 179.11 |
| Molecular Weight | 179.20 |
| m/z | 179.11 (100.0%), 180.11 (7.6%) |
| Elemental Analysis | C, 46.92; H, 10.13; N, 7.82; O, 17.86; P, 17.28 |
Introduction
Butaphosphan injection is a vital tool in veterinary medicine, particularly in the management of metabolic disorders, energy deficiencies, and nutritional imbalances in animals. It is a water-soluble organic phosphorus compound that serves as a precursor to high-energy phosphate bonds, such as adenosine triphosphate (ATP), thereby supporting cellular energy metabolism. Additionally, butaphosphan plays a role in bone mineralization, nerve function, and the synthesis of nucleic acids and phospholipids. Its applications span various species, including cattle, pigs, horses, poultry, dogs, and cats, making it a versatile therapeutic option in veterinary practice.
Pharmacological Properties and Mechanisms of Action
Chemical Structure and Bioavailability
Butaphosphan, chemically known as ethane-1,2-diyl bis(dihydrogen phosphate), is a water-soluble compound. Its solubility allows for easy formulation into injectable solutions, ensuring rapid absorption and bioavailability when administered intramuscularly or intravenously. This quick uptake is essential for providing timely support during acute conditions or periods of high metabolic demand.
Regulation of Cellular Energy Metabolism and Improvement of ATP Synthesis Efficiency
Disturbance of energy metabolism serves as the core inducement of postpartum debilitation, stress-induced fatigue, subclinical ketosis and slow recovery after illness in animals. Butaphosphan positively modulates key pathways of glucose and lipid metabolism and optimizes the operational efficiency of the tricarboxylic acid cycle. On the one hand, it facilitates hepatic gluconeogenesis, accelerates glucose production, increases reserves of hepatic glycogen and muscle glycogen, and establishes an energy reservoir that can be rapidly mobilized by the organism.
On the other hand, it promotes the conversion of ADP to ATP, elevates tissue ATP levels, reduces AMP accumulation, and improves energy supply to skeletal muscle, myocardium and smooth muscle.
For peripartum dairy cows and parturient dams, massive mobilization of body fat readily generates excessive ketone bodies and triggers metabolic acidosis. Butaphosphan accelerates normal oxidative decomposition of fat, reduces accumulation of free fatty acids and ketone bodies, and assists in the prevention and control of subclinical ketosis. Meanwhile, it speeds up metabolic clearance of lactic acid produced by exercise, alleviates muscular fatigue, and relieves clinical signs including listlessness, difficulty standing and parturient asthenia.
Modulation of Insulin Signaling Pathway to Promote Feed Intake and Anabolism
Butaphosphan upregulates the expression of insulin receptor substrate-related genes, improves insulin sensitivity of the organism, and moderately increases circulating insulin levels. Insulin is a pivotal hormone regulating appetite and nutrient anabolism. Enhanced insulin signaling improves gastrointestinal peristalsis and secretion of digestive glands, effectively alleviating reduced feed intake during stress, postpartum period and illness.
In terms of anabolic metabolism, the agent facilitates amino acid transport and protein biosynthesis and reduces the intensity of catabolism.Administration in young animals, weak livestock and convalescent animals improves protein deposition efficiency and alleviates growth retardation and dysplasia. For breeding stock, it ameliorates body condition, optimizes reproductive performance, shortens the postpartum anestrus interval of female animals and improves semen quality of male animals. This pathway realizes "promoting feed intake and accelerating nutrient deposition" at the source and enhances feed conversion efficiency.
Regulation of Stress Endocrine Levels to Exert Systemic Anti-Stress Effects
Stimuli such as transportation, temperature fluctuation, parturition, vaccination and pathogen invasion induce continuous secretion of stress hormones including cortisol in animals. High concentrations of cortisol suppress feed intake, accelerate muscle protein breakdown and impair immune function. Butaphosphan reduces plasma cortisol concentration and mitigates metabolic damage caused by chronic stress.
Under stress conditions, oxidative stress in animals rises and cellular lipid peroxidation intensifies. By stabilizing hepatocyte function, butaphosphan enhances hepatic detoxification capacity, lowers accumulation of stress toxins and metabolic wastes, and reduces the release of liver injury markers. In livestock production settings, it can mitigate production decline induced by regrouping stress, heat stress and postpartum stress, reduce risks of pica and sudden death, and maintain metabolic homeostasis of the organism.
Therapeutic Applications
The product is indicated for a variety of conditions in veterinary medicine, including:
Metabolic Disorders and Energy Deficiencies
Convalescence: After illness, surgery, or stress, animals may experience reduced appetite and energy levels. The product can help restore energy metabolism, supporting recovery and promoting a return to normal physiological function.
Anorexia and Cachexia: In animals with chronic diseases or conditions leading to weight loss and muscle wasting, butaphosphan can improve nutrient utilization and energy production, helping to maintain body condition and quality of life.
Nutritional Support
Phosphorus Deficiency: In regions with phosphorus-deficient soils or in animals on phosphorus-restricted diets, the product can provide supplemental phosphorus, preventing deficiencies and supporting overall health.
Growth and Development: In young, growing animals, butaphosphan can support bone mineralization and tissue development, promoting healthy growth and preventing skeletal abnormalities.
Reproductive Health
Gestation and Lactation: During pregnancy and lactation, animals have increased nutrient and energy demands. Butaphosphan injection can support metabolic function, ensuring adequate energy and nutrient supply to the developing fetuses or nursing offspring.
Infertility and Reproductive Disorders: Butaphosphan may play a role in supporting reproductive health by improving energy metabolism and hormonal balance, potentially aiding in the treatment of certain reproductive disorders.
Bone Injuries and Fractures: Butaphosphan can support bone healing and repair by providing phosphorus for hydroxyapatite formation and promoting cellular proliferation and differentiation during the healing process.
Osteoporosis and Rickets: In conditions characterized by bone density loss or improper mineralization, such as osteoporosis or rickets, the product can help restore bone health and prevent further deterioration.
Therapeutic Applications in Veterinary Medicine
Metabolic Disorders and Convalescence:
Butaphosphan is widely used to treat metabolic disorders and support convalescence in animals recovering from illness or surgery. It helps restore energy metabolism, promoting appetite and overall vitality. In cases of anorexia or cachexia, butaphosphan can improve nutrient utilization and energy production, supporting weight maintenance and recovery.
Nutritional Support and Growth Promotion:
In regions with phosphorus-deficient soils or in animals on phosphorus-restricted diets, butaphosphan provides essential phosphorus supplementation.
This is crucial for young, growing animals to support bone mineralization and tissue development, ensuring healthy growth and preventing skeletal abnormalities.
Reproductive Health and Performance:
Butaphosphan plays a significant role in supporting reproductive health. During gestation and lactation, animals have increased nutrient and energy demands. The product ensures adequate energy and nutrient supply to the developing fetuses or nursing offspring, supporting healthy reproductive outcomes and enhancing milk production in lactating animals.
Orthopedic Conditions and Bone Health:
For animals suffering from conditions such as osteoporosis, rickets, or fractures, the product can aid in bone healing and repair. By providing phosphorus for hydroxyapatite formation and promoting cellular proliferation and differentiation, it supports the regeneration of bone tissue and helps restore skeletal integrity.
Practical Considerations and Administration Guidelines
Dosage and Frequency
The dosage and frequency of butaphosphan injection depend on the species, age, weight, and condition of the animal, as well as the severity of the indication. Typical dosages range from 0.1 to 0.5 mL per 10 kg body weight, administered intramuscularly or intravenously, once daily or as directed by a veterinarian. It is essential to follow the manufacturer's instructions and veterinary recommendations to ensure safe and effective use.
Route of Administration
It can be administered intramuscularly or intravenously, depending on the specific product formulation and veterinary guidance. Intramuscular injection is commonly used for convenience and ease of administration, while intravenous injection may be preferred in cases requiring rapid onset of action or when high plasma concentrations are desired.
Precautions and Contraindications
While it is generally well-tolerated, certain precautions and contraindications should be considered. In animals with renal impairment, the excretion of phosphorus may be impaired, leading to hyperphosphatemia. Butaphosphan should be used with caution in these animals, and phosphorus levels should be monitored closely. Additionally, animals with pre-existing hyperphosphatemia should not receive it, as it may exacerbate the condition.
Monitoring and Follow-Up
During treatment with it, animals should be monitored closely for signs of improvement or adverse effects. Regular veterinary check-ups may be necessary to assess response to treatment, adjust dosages if needed, and monitor for potential complications.
FAQ
What is the route of injection for butaphosphan and cyanocobalamin?
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Injection by intravenous, intramuscular or subcutaneous route. This injectable solution is administered according to condition & body weight: In acute disease (To be repeated daily if required).
What is another name for Butaphosphan?
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Butafosfan or Butaphosphan powder raw material is an important ingredient used in many veterinary medicines. It is also known as Vitamin B13 or Vitamin B4, and its CAS number is 17316-67-5.
What is the use of Butaphosphan injection?
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This drug is prescribed for the treatment of many conditions, such as, tetanus, paresis, and metabolic disorders. It is sometimes used to improve muscle performance in animals like racing horses, and it is also used to increase milk production in dairy cows.
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