Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of selank injection in China. Welcome to wholesale bulk high quality selank injection for sale here from our factory. Good service and reasonable price are available.
Selank injection is a synthetic heptapeptide with the amino acid sequence Thr Lys Pro Arg Pro Gly Pro, molecular formula C33H57N11O9, and molecular weight 751.87. Its appearance is white powder, purity (HPLC) ≥ 98.0%, acetate content ≤ 12.0%, moisture content ≤ 8.0%, peptide content ≥ 80.0%, endotoxin ≤ 50EU/mg, amino acid composition analysis ≤± 10%. It has certain physical and chemical properties, such as a melting point of 134-136 ° C, a predicted density of 1.53 ± 0.1 g/cm ³, and a predicted acidity coefficient (pKa) of 3.43 ± 0.20. It is an artificially synthesized analog that is a synthetic analog of human tetrapeptides that promote phagocytosis. This synthesis method enables it to be accurately prepared to meet the needs of scientific and clinical research. Through specific chemical synthesis methods, its purity and quality can be controlled, providing a foundation for subsequent research and applications.
Our product
Additional information of chemical compound:
| Product Name | Selank Spray | Selank Powder | Selank Injection |
| Product Type | Spray | Powder | Injection |
| Product Purity | HPLC≥99.0% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable |
Our Product
Selank+. COA
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Certificate of Analysis |
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Compound name |
Selank | |
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CAS No. |
129954-34-3 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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preclinical study
Anxiety disorder model:
In the anxiety disorder model, Selank injection showed significant anti anxiety effects. By simulating different stress conditions and observing changes in animal behavior and physiological indicators, it was found that Selank can improve animal anxiety and regulate neurotransmitter balance. For example, in a chronic stress model, Selank can increase animal exploratory behavior and reduce anxiety related behavioral manifestations.
Cognitive dysfunction model:
In the cognitive impairment model, Selank can improve the cognitive ability of animals. Through testing the learning and memory tasks of animals, it was found that injection of Selank significantly improved their memory performance and accelerated their learning speed. This may be related to Selank's regulation of the neurotransmitter system, promotion of neuronal growth, and synaptic plasticity.
Research on Stress Related Disease Models
Chronic stress model:
In the chronic stress model, Selank can alleviate the damage of stress to the body. As mentioned earlier, in the study of the effects of chronic plantar electrical shock stress on the morphological parameters of rat liver, Selank was able to alleviate stress-induced liver degenerative changes and restore the nuclear cytoplasmic ratio of liver cells. In addition, Selank may also regulate hormone levels and immune function in the body, reducing the overall impact of stress on the body.
Posttraumatic Stress Disorder (PTSD) Model:
Although there is currently relatively little research on Selank in PTSD models, based on its mechanism of anti anxiety and neurotransmitter regulation, it is speculated that Selank may have certain potential in the treatment of PTSD. Future research can further explore the efficacy and mechanism of Selank in PTSD models.
In addition to its protective effect against liver damage caused by chronic stress, Selank may also have potential application value in other liver disease models. For example, in a drug-induced liver injury model, it can be studied whether Selank can alleviate the toxic effects of drugs on the liver and protect the function of liver cells. This requires further research to verify.
Clinical application prospects
Treatment of anxiety disorders
Based on the anti anxiety effect of Selank, it has potential application value in the treatment of anxiety disorders. Anxiety disorder is a common mental illness, and current treatment methods mainly include medication and psychological therapy. Selank, as a new type of anti anxiety medication, may have advantages such as minimal side effects and significant therapeutic effects. Future clinical trials can further evaluate the efficacy and safety of Selank in patients with anxiety disorders.
Improvement of cognitive impairment
For patients with cognitive impairment, such as Alzheimer's disease, mild cognitive impairment, etc., Selank may help improve cognitive function. Selank may improve patients' memory and learning abilities by regulating the neurotransmitter system and promoting neuronal growth. However, current research on Selank in patients with cognitive impairment is relatively limited, and more clinical trials are needed to validate its efficacy.
Treatment of stress-related diseases
Selank injection may have a certain effect in the treatment of stress-related diseases such as chronic fatigue syndrome and post-traumatic stress disorder. By reducing stress responses and regulating physiological functions in the body, Selank may improve patients' symptoms and quality of life. But further research is also needed to confirm its efficacy in these diseases.
Liver protection
For some liver disease patients, such as drug-induced liver injury, alcoholic liver disease, etc., Selank may be used as an adjuvant therapy to protect liver cells and reduce liver damage. Further research is needed to explore its potential application in the treatment of liver diseases.
Anxiolytic
Selank has anti anxiety properties. In the study on the effects of chronic plantar electrical shock stress on liver morphological parameters in rats, Selank was intraperitoneally injected into Wistar male rats subjected to chronic plantar electrical shock stress at doses of 100, 300, and 1000 μ g/kg, respectively, 15 minutes before each stress. Morphological and morphometric analysis shows that chronic plantar electrical shock stress leads to hepatocyte watery degeneration, increased nuclear cytoplasmic ratio (due to increased nuclear area and decreased cytoplasmic area), focal necrosis, and infiltration of lymphoid tissue cells. Injecting all doses of Selank can alleviate stress-induced degenerative changes. Selank at doses of 300 and 1000 μ g/kg can restore the nuclear cytoplasmic ratio of liver cells, with Selank at a dose of 300 μ g/kg achieving the maximum anti stress effect. This suggests that Selank may exert anti anxiety effects by regulating the function of the nervous system, reducing stress responses.
Improve cognitive function
In relevant studies, Selank has shown sustained pro intellectual effects in clinical trials. For adult rats with disturbances in overall brain activity and biogenic amine levels caused by prenatal hypoxia, injection of Selank (300 mkg/kg, i/p) resulted in a 2-3 fold increase in sensory attention (p<0.01) and a 1.5-fold increase in learning ability (p<0.01). Exploratory activities in open field and hole plate experiments returned to normal, and the balance of 5-hydroxytryptamine and noradrenergic brain system activity was restored. This indicates that Selank can improve the function of the nervous system and have a positive impact on cognitive function.
In the study of cats, the effects of the new heptapeptide anti anxiety drug Selank (300 mg/kg, intravenous) on arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and AP suppression induced by acetylcholine injection were recorded. After 1-3 minutes of injection, Selank reduced AP by 32 ± 4.3%; Within the first 5-10 minutes after injection, the drug also caused an increase of 24 ± 2.8% in cerebral blood flow, which gradually returned to its initial level. Heart rate and respiratory rate were not affected by drug injection, and Selank did not affect acetylcholine induced AP suppression. This indicates that Selank has a certain regulatory effect on the cardiovascular system, which can affect arterial pressure and cerebral blood flow to a certain extent, but will not have a significant impact on heart rate and respiratory rate.
Protective effect on the liver
As mentioned earlier, in the study of the effects of chronic plantar electrical shock stress on the morphological parameters of rat liver, Selank injection can alleviate stress-induced liver degenerative changes and restore the nuclear cytoplasmic ratio of liver cells. This may be due to Selank regulating the stress response in the body, reducing the damage of stress to liver cells, and thus playing a protective role in the liver.
Research and Development Challenges and Future Directions
R&D Challenge
In depth study of the mechanism of action
Although Selank has been found to have multiple pharmacological effects, its specific mechanism of action is not yet fully understood. Further in-depth study of Selank's targets and signaling pathways can help to better understand its pharmacological effects and provide a more scientific basis for clinical applications.
Clinical safety assessment
Before introducing Selank into clinical practice, a comprehensive safety assessment is required. This includes research on the toxicity, immunogenicity, reproductive toxicity, and other aspects of drugs. In addition, it is necessary to determine the appropriate dosage range and administration method to ensure the safety and effectiveness of the drug in the human body.
Interactions with other drugs
In practical clinical applications, Selank may be used simultaneously with other drugs. Therefore, it is necessary to study the interactions between Selank and other drugs to avoid potential adverse drug reactions.
Future direction
Conduct clinical trials
Based on sufficient preliminary research, conduct clinical trials of Selank to evaluate its efficacy and safety in different diseases. Through large-scale clinical trials, verify the clinical application value of Selank and provide a basis for its market launch.
Optimization of drug formulation
At present, Selank mainly exists in the form of injection. In order to facilitate the use of patients and improve the bioavailability of drugs, we can explore and develop other dosage forms, such as oral preparations, nasal sprays, etc.
Combination therapy research
Explore the combination therapy of Selank injection with other drugs to improve treatment efficacy. For example, in the treatment of anxiety disorders, Selank can be used in combination with traditional anti anxiety drugs to achieve a synergistic effect.
Expand application areas
In addition to the currently extensively studied neurological and stress-related diseases, the potential applications of Selank in other fields such as cardiovascular disease and immune system diseases can also be explored.
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