Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of carnosine liquid in China. Welcome to wholesale bulk high quality carnosine liquid for sale here from our factory. Good service and reasonable price are available.
Carnosine Liquid is a high-purity aqueous solution of β-alanine-L-histidine developed by Bloomtechz specifically for high-end skincare and functional nutritional supplements. Utilizing a patented enzymatic synthesis process, it achieves a purity of >99.5% for the L-isomer, eliminating interference with biological activity caused by D-isomer impurities at the source. This liquid form perfectly preserves carnosine's three core benefits-anti-glycation, antioxidant, and metal ion chelation-while addressing the production challenges associated with traditional powdered ingredients, such as slow dissolution and susceptibility to moisture absorption and caking. It can be added directly to formulations and is suitable for continuous production processes of serums, creams, and functional beverages.
Our Products Form
Carnosine COA
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| Certificate of Analysis | ||
| Compound name | Carnosine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 305-84-0 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090055 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.88% |
| Loss on drying | ≤1.0% | 0.54% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.66% |
| Single impurity | <0.8% | 0.63% |
| Total microbial count | ≤750cfu/g | 637 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 655ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Application Case Studies
Dermocosmetics: Multi-Target Anti-Aging Architecture
Bloomtechz L-Carnosine Liquid operates as a cornerstone active in advanced dermocosmetic formulations, delivering dual-pathway intervention against both oxidative stress and glycation-induced aging. Its exceptional water solubility (~323 g/L at 20°C) enables seamless incorporation into the aqueous phase of O/W emulsions, hydrogel masks, and lightweight serums without requiring solubilizers or co-solvents. In anti-aging cream systems, L-Carnosine Liquid at 1-3% active concentration synergizes powerfully with niacinamide to establish a dual anti-glycation and melanin-inhibition matrix, effectively targeting yellowing and dullness associated with AGE accumulation. When combined with ergothioneine, it creates a top-tier antioxidant defense network that addresses both photoaging and glycation aging simultaneously.
For intensive repair formulations, pairing with bifida ferment lysate and panthenol delivers comprehensive overnight recovery for stressed,熬夜-compromised skin barriers. Clinical ex vivo studies demonstrate that topical L-Carnosine formulations can reduce CML and pentosidine (key AGE markers) by up to 150% in the epidermis and 136% in the reticular dermis, validating its profound anti-glycation efficacy at the tissue level. The liquid format eliminates the dissolution step required for powder forms, reducing processing time and minimizing the risk of peptide degradation during manufacturing.
Sports Nutrition: pH Buffering & Recovery Optimization
In the sports nutrition sector, Bloomtechz L-Carnosine Liquid serves as a direct-acting intramuscular pH buffer, complementing β-alanine supplementation protocols by providing immediate carnosine availability without requiring endogenous synthesis.
When formulated into pre-workout beverages or intra-workout hydration solutions at 0.5-2% concentration, it synergizes with creatine monohydrate and electrolyte systems to enhance buffering capacity, delay the onset of muscular acidosis, and sustain peak power output during high-intensity anaerobic efforts. For post-exercise recovery shakes, L-Carnosine Liquid combined with branched-chain amino acids (BCAAs) and tart cherry extract creates a comprehensive recovery matrix that addresses both metabolic acidosis and exercise-induced inflammation. Its stability across a broad pH range (3.0-9.0) and thermal resilience (>90% activity retention after 1 hour at 120°C) make it uniquely suited for hot-fill beverage processing and pasteurized liquid supplement manufacturing.
The liquid format also offers significant formulation advantages over powder forms in ready-to-drink (RTD) products, eliminating sedimentation issues and ensuring uniform dosing throughout the product's shelf life.
Neurocognitive & Metabolic Health Formulations
Bloomtechz L-Carnosine Liquid extends its application portfolio into the rapidly expanding neurocognitive and metabolic health segments. In nootropic and brain health supplements, it pairs synergistically with phosphatidylserine, Omega-3 DHA, and B-complex vitamins to support neuronal membrane integrity, mitigate β-amyloid aggregation, and enhance cerebral glucose metabolism.For metabolic health formulations targeting insulin sensitivity and glucose regulation, L-Carnosine Liquid combined with berberine, alpha-lipoic acid,
and chromium picolinate creates a multi-mechanistic approach to glycemic control, leveraging carnosine's ability to modulate GLUT4 translocation and reduce AGE-mediated insulin resistance. In liquid shot and oral spray formats, the pre-dissolved nature of our L-Carnosine Liquid enables rapid absorption through oral mucosa, bypassing first-pass metabolism and delivering faster onset of systemic effects compared to encapsulated powder forms.
Intellectual Property & Patent Landscape
Synthesis Process Patents: The Biocatalytic Revolution
The intellectual property landscape surrounding L-carnosine synthesis has undergone a fundamental paradigm shift, transitioning from legacy chemical methodologies to advanced biocatalytic and fermentation-based platforms. Traditional chemical synthesis routes, historically reliant on hydrazinolysis and acyl chloride condensation, face increasing regulatory scrutiny due to potential hydrazine residue risks and D-isomer contamination, as documented in conventional multi-step chemical protocols. In response, the industry has aggressively pivoted toward enzymatic catalysis and whole-cell fermentation strategies.Recent patent grants demonstrate significant innovation in enzyme engineering,
including directed evolution of DmpA transferase variants (E86V/D259A mutations) that achieve a 3.53-fold increase in catalytic efficiency compared to wild-type enzymes, enabling product concentrations up to 5.36 g/L under mild, green chemistry conditions. Parallel developments include novel L-ligase enzymes from CJ CheilJedang (KR-20240113674-A), thermostable L-carnosine hydrolase mutants (N117E/I169L) from Jining University, and aminopeptidase variants optimized for reverse peptide bond synthesis. Whole-cell fermentation approaches have further advanced through metabolic engineering of E. coli chassis strains, where targeted knockout of endogenous peptidase genes (pepD, pepN, pepA) eliminates product degradation bottlenecks, while upregulation of PRPP biosynthesis pathways enhances L-histidine precursor supply, collectively achieving de novo titers exceeding 14.39 g/L.
Formulation Patents: Stabilization & Synergistic Architectures
Beyond synthesis, extensive patent portfolios protect advanced formulation strategies designed to overcome L-carnosine's inherent hydrolytic instability and maximize therapeutic efficacy. Key innovations include liposomal and phytosome delivery systems-such as L-carnosine-phospholipid complexes dispersed in hyaluronic acid matrices-that significantly enhance transcorneal permeation for ophthalmic applications while maintaining controlled release kinetics. Metal chelation technologies represent another critical IP domain, with patented methods for producing zinc L-carnosine (Polaprezinc) complexes via anhydrous solvent systems that minimize purification complexity and residual solvent content,
as well as carnosine-magnesium complexes designed for transdermal athletic performance enhancement. Synergistic combination patents protect multi-active architectures, including carnosine/branched-chain amino acid formulations for antioxidant support (WO96/36348), carnosine/taurine combinations for inflammatory disorder management (EP0413528), and carnosine/urocanic acid systems for photodermatosis prophylaxis (WO94/21245). Novel derivative patents further expand the chemical space, covering N-acetyl-L-carnosine synthesis via solid-phase carrier methods, cyclic carnosine oligomers with enhanced stability, and carnosine glycoside extracts for injectable pharmaceutical compositions.
reference
Hipkiss, A. R., & Brownson, C. (2000). A possible new role for the anti-ageing peptide carnosine. Cellular and Molecular Life Sciences, 57(5), 747–753.
Pavlin, M., Rossetti, G., De Vivo, M., & Carloni, P. (2015). Carnosine and homocarnosine degradation mechanisms by the human carnosinase enzyme CN1: Insights from multiscale simulations. Biochemistry, 54(48), 7127–7135.
Baba, S. P., Amraotkar, A. R., Hoetker, D., Gao, H., Gomes, D., Zhao, J., & Wempe, M. F. (2024). Evaluation of supplementary carnosine accumulation and distribution: An initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial. Amino Acids, 56(1), 1–15.
Han, H., Zhao, Y., Wang, Y., Zhang, Z., Chen, H., & et al. (2026). Heterologous expression of an aminopeptidase in Escherichia coli for cell-free biosynthesis of L-carnosine. International Journal of Biological Macromolecules, 312, 148703.
Suyama, M. (2008). Buffering capacity and taste of carnosine and its methylated compounds. Fisheries Science, 74(1), 193–199.
Frequently Asked Questions
Q1: What is the minimum order quantity (MOQ) and lead time for bulk procurement of Carnosine Liquid?
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A: Our standard minimum order quantity (MOQ) for Carnosine Liquid is 1 kg for trial orders, with bulk commercial supply available in 25 kg drums or customized intermediate bulk containers (IBCs) depending on your production scale. For in-stock specifications, the standard lead time is 5-7 business days following order confirmation. For customized formulations requiring specific pH adjustments, stabilizer modifications, or proprietary packaging, the lead time typically ranges from 15 to 20 business days to accommodate rigorous in-process quality control and stability verification. Bloomtechz maintains robust production capacity and raw material reserves to ensure uninterrupted supply for long-term commercial contracts.
Q2: What is the recommended dosage and optimal pH range for incorporating Carnosine Liquid into cosmetic or nutraceutical formulations?
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A: The optimal incorporation dosage of Carnosine Liquid varies by application: for dermocosmetic formulations (e.g., anti-aging serums, creams), the recommended active concentration ranges from 0.1% to 2.0%; for nutraceutical and sports nutrition beverages, dosage should be calibrated based on target physiological efficacy and regulatory guidelines. Carnosine Liquid exhibits optimal stability and bioactivity within a physiological pH range of 6.8 to 7.4. Our technical support team provides customized formulation guidance to ensure compatibility with your existing ingredient matrix and prevent peptide degradation during processing.
Q3: How does Bloomtechz guarantee batch-to-batch consistency and provide quality documentation for regulatory compliance?
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A: As a specialized source manufacturer of peptide and active ingredients, Bloomtechz enforces strict GMP and ISO22000 quality management protocols across all production stages. Every batch of Carnosine Liquid undergoes comprehensive physicochemical and microbiological testing, including HPLC purity verification, pH validation, heavy metal screening, and microbial limit testing. Upon shipment, clients receive a complete documentation package including a detailed Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and optional third-party verification reports, ensuring full traceability and seamless compliance with international regulatory requirements for target markets.
Q4: What are the recommended storage conditions and shelf life for Carnosine Liquid to maintain potency?
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A: To preserve the structural integrity of the dipeptide bond and prevent hydrolytic degradation, Carnosine Liquid should be stored in a cool, dry environment protected from light, with an optimal storage temperature between 2°C and 8°C for long-term preservation. Under these recommended conditions, the validated shelf life is 24 months from the date of manufacture. Our packaging utilizes opaque, airtight, pharmaceutical-grade containers with optional nitrogen flushing to minimize oxidative exposure, ensuring the product retains its labeled potency throughout its shelf life.
Q5: Does Bloomtechz provide custom synthesis, private labeling, or OEM/ODM services for Carnosine Liquid?
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A: Yes. Beyond supplying standardized high-purity Carnosine Liquid, Bloomtechz offers comprehensive OEM/ODM and custom synthesis services tailored to brand-specific requirements. We can customize solvent systems, stabilizer profiles, concentration levels, and packaging specifications to align with your product positioning. Our dedicated sales and technical teams provide one-on-one consultation from initial R&D prototyping through to commercial-scale production and global logistics coordination, helping you accelerate time-to-market while maintaining the highest standards of product quality and efficacy.
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