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Advance Technology Support Hinokitiol CAS 499-44-5 Cosmetic Grade Raw Material Powder

Advance Technology Support Hinokitiol CAS 499-44-5 Cosmetic Grade Raw Material Powder

Product Code: BM-2-3-002
Name: Hinokitiol
CAS: 499-44-5
Molecular formula: C10H12O2
MW: 164.2
EINECS No.: 207-880-7
Enterprise standard: HPLC>98.0%, GC-MS
HS code: Need confirm
Main market: Germany, Australia, USA, Indonesia, Brazil, UK etc.
Manufacturer: BLOOM TECH Weifang Factory
Technology service: R&D Dept.-2
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Hinokitiol powder colorless, prismatic crystal (recrystallized from absolute ethanol), insoluble in water. The chemical name is 2-hydroxy-4- (1-methylacetaldehyde) and other six step reaction synthesis. The hydroxynitrile is synthesized from isopropyl cyclohexanone or isopropyl cyclohexenyl) -2.4,6-cycloheptene-1-one with molecular formula of croh202 and molecular weight of ketone, and then transformed into isopropyl Cycloheptanone, which is oxidized, brominated and 164.2. Sabineol is a kind of monoterpenoid natural compound with zhuophenone skeleton, which is obtained by Japanese scientist Anderson by dehydrobromination from the tree trunk of Taiwan juniper. It is extracted by the reaction of bromocycloheptanone with - organic compounds. It belongs to the catalytic hydrogenation of trophenol to obtain cyclopentadiene and isopropyl bromoketone compounds under the action of potassium hydroxide. Hinokitiol has good antimicrobial properties, moisture and the effect of preventing pest. It is a plant components with high security and can be as antibacterial, pest control. It has the strong sterilization ability, good fragrance and effect. It can kill bacteria and microbacteria in the air, prevent pests from encroaching on the human body and inhibit human pathogenic bacteria.

Produnct Introduction

Additional information of chemical compound:

Chemical Formula

C10H12O2

Exact Mass

164

Molecular Weight

164

Elemental Analysis

H, 3.09; O, 65.31; P, 31.61

Melting point

50 to 52 ° C (lit.)

Boiling point

140 °C10 mm Hg(lit.)

Density

1.0041 (Rough estimate)

Flash point

190 °C

Vapor density

5.21 (vs air)

Refractive index

1.5190 (Estimate)

Hinokitiol powder 499-44-5

Manufacturing Information

In the field of chemical synthesis, improving the yield and purity of target products has always been the goal pursued by researchers and engineers. This not only affects the quality and cost of the product, but also directly impacts production efficiency and environmental protection. Especially in the context of increasingly scarce resources, how to efficiently and sustainably utilize raw materials and reduce the generation of by-products has become an urgent problem to be solved in the chemical industry.

 

Research on the Method and Yield of Preparing High Purity Juniperus Powder from Celeron Ketone

(1) Method Overview and Challenges

Celerenone is a natural compound with a unique aroma, widely used in fields such as spices, food, and medicine. Through epoxidation and potassium hydroxide treatment, it can be converted into high-purity juniper alcohol powder. However, this process also faces challenges such as the generation of by-products and the difficulty of separation and purification.

(2) Yield research and optimization strategy

In order to improve the yield and purity of quercetin, researchers have conducted extensive yield studies. They reduce the generation of by-products and increase the yield of the target product by optimizing reaction conditions such as temperature, pressure, catalyst type and dosage, as well as improving separation and purification techniques.

In terms of optimizing reaction conditions

 

 

Researchers have found that selecting appropriate catalysts and reaction temperatures is crucial for improving yields. By comparing the catalytic effects of different catalysts, it was found that certain specific catalysts can significantly improve the reaction rate and yield of the target product. Meanwhile, by adjusting the reaction temperature and time, the reaction process can be further controlled to reduce the generation of by-products.

In terms of improving separation and purification technology

 

 

Researchers have adopted advanced separation techniques (such as distillation, extraction, etc.) and purification methods (such as recrystallization, column chromatography, etc.) to effectively remove by-products and impurities and improve the purity of the target product. The application of these technologies not only improves product quality, but also reduces production costs and environmental pollution.

Example of synthesis technology for 1,4-dioxane
1,4-dioxane, as an important organic solvent and chemical raw material, has a wide range of applications in the chemical industry. Here are some common methods for synthesizing 1,4-dioxane and their characteristics:

(1) Ethylene glycol dehydration method:

 

 

Ethylene glycol is dehydrated under acid catalysis to form 1,4-dioxane. This method has readily available raw materials and low prices, but some by-products such as acetaldehyde may be generated during the reaction process, which need to be removed through subsequent processing. In addition, the selection and regeneration of acid catalysts are also key factors affecting the cost and efficiency of this method.

(2) Diethylene glycol dehydration cyclization method:

 

 

Diethylene glycol undergoes dehydration cyclization reaction under the action of catalyst to generate 1,4-dioxane. This method can utilize the by-product diethylene glycol from the production process of ethylene glycol as raw material to achieve effective utilization of resources. However, the selection and regeneration of catalysts are also issues that require attention. In addition, the disposal of waste generated during the reaction process is also an issue that needs to be taken seriously.

(3) Chloroethoxyethanol reacts with strong bases:

 

 

Chloroethoxyethanol reacts with hydroxides of alkali metals or alkaline earth metals to form 1,4-dioxane. This method has low raw material costs and simple reaction equipment, making it easy for industrial production. However, some toxic and harmful by-products and waste may be generated during the reaction process, and effective treatment measures need to be taken to reduce pollution and damage to the environment.

Hinokitiol synthesis CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd

In summary, improving the yield and purity of the target product in the chemical synthesis process is a complex and meticulous task. By optimizing reaction conditions, improving feed ratios, using efficient catalysts, enhancing separation and purification techniques, and applying green chemistry concepts, the yield and purity of the target product can be effectively improved while reducing production costs and environmental pollution. At the same time, targeted research and optimization are needed for specific synthesis goals and product characteristics to achieve more efficient and sustainable chemical synthesis processes.

Usage

Hinokitiol powder, also known as β- Southwest tin rosin phenol is a natural organic compound mainly found in Japanese cypress wood. It has various potential uses, including antibacterial, antioxidant, anti-inflammatory, anti-tumor, neuroprotective, etc.

1. Antibacterial effect:

 

Hinokitiol exhibits broad-spectrum antibacterial activity and can inhibit the growth of various bacteria and fungi. It also showed significant inhibitory effect on some common pathogenic bacteria, such as Staphylococcus aureus, Escherichia coli and Candida albicans. Therefore, Hinokitiol is widely used in fields such as skincare, oral care products, disinfectants, and medical devices to help prevent and treat infections.

Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd

Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd

2. Antioxidant effect:

 

Hinokitiol has significant antioxidant activity, which can neutralize free radicals and reduce oxidative stress damage. This makes it have potential application value in preventing cell oxidative damage and skincare. Hinokitiol is added to cosmetics and skincare products as a natural antioxidant that helps protect the skin from environmental factors and ultraviolet radiation.

 

3. Anti inflammatory effects:

 

Hinokitiol has inhibitory effects on various inflammatory reactions. It can inhibit the production of inflammatory mediators and the activation of inflammatory signaling pathways, thereby alleviating inflammatory symptoms. This makes Hinokitiol show potential efficacy in the treatment of inflammatory skin diseases, arthritis and Inflammatory bowel disease.

Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd
 
Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd

4. Antitumor effect:

 

Hinokitiol exhibits certain anti-tumor activity and can inhibit the growth and spread of cancer cells. It affects the proliferation of cancer cells and regulates cell cycle through various mechanisms. Hinokitiol also has inhibitory effects on tumor angiogenesis and metastasis. Although research on Hinokitiol as an anti-tumor drug is still in its early stages, it has shown broad potential and is considered a promising candidate drug.

5. Neuroprotective effects:

 

Hinokitiol shows a certain neuroprotective effect, which can alleviate the symptoms of neurodegenerative diseases. It protects nerve cells from damage by inhibiting oxidative stress, reducing neuroinflammation, and promoting the survival of nerve cells. This makes Hinokitiol have potential clinical application prospects in the treatment of Nervous system disease such as Alzheimer's disease, Parkinson's disease and stroke.

Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd
 
Hinokitiol uses CAS 499-44-5 | Shaanxi BLOOM Tech Co., Ltd

6. Other potential uses:

 

In addition to the main uses mentioned above, Hinokitiol also exhibits some other potential biological activities. It has been reported to have anti diabetes, anti allergy and anti muscular atrophy effects. In addition, Hinokitiol is also used in fields such as wood preservatives, spices, and sunscreen.

Discovering History

Hinokitiol powder was discovered by Japanese chemist Tetsuo Nozoe in 1936. It was isolated from the essential oil of the heartwood of Chamaecyparis taiwanensis, and the compound finally got its name. Hinokitiol is xxx identified non benzene aromatic compounds. The compound has a seven square molecular structure and was first synthesized by Ralph Raphael in 1951. Due to its iron chelating activity, cyprinol is known as an Iron Man molecule in scientific media, which is ironic because Tetsuo is translated as Iron Man in English Taiwan cypress is native to East Asian countries, especially Japan and Taiwan. Sophora wood alcohol has also been found in other trees of the cypress family, including Thuja plicata Donn ex D. Don, which is commonly found in the Pacific Northwest.

The wood rich in juniper phenol was used by the ancient Japanese to build buildings with a long history, such as Japan's national treasure Golden Hall, which is one of the buildings of Chūson-ji complex in Iwate Prefecture County. It protects it from insects, wood rotting fungi, and mold for up to 840 years. In addition, some ancient and famous Buddhist temples and shrines use trees, which later became known to contain cypress phenols. Since xxx in 2000, the biological characteristics of cyprinol have become a research hotspot, with a focus on its biological characteristics. The resistance of cypress trees to wood decay is the main reason for studying their chemical composition and identifying substances responsible for these characteristics.

Future Directions

► Nanotechnology

Encapsulating hinokitiol in chitosan nanoparticles enhances skin penetration. A 2022 study reported a 3-fold increase in bioavailability compared to free hinokitiol.

► Drug Development

Combining hinokitiol with antibiotics (e.g., ciprofloxacin) shows synergistic effects against biofilms. A 1:1 ratio reduced Pseudomonas aeruginosa biofilm mass by 90% in vitro.

► Sustainable Agriculture

Genetically modified crops expressing hinokitiol biosynthesis pathways could reduce pesticide use. Early trials in tobacco plants demonstrated a 60% decline in aphid infestation.

Hinokitiol powder exemplifies the convergence of natural chemistry and industrial innovation. Its broad-spectrum antimicrobial activity, coupled with low toxicity, positions it as a cornerstone of green chemistry. While challenges in cost and stability persist, advancements in synthesis and formulation promise to expand its applications. As industries prioritize sustainability, hinokitiol is poised to play a pivotal role in shaping the future of eco-friendly materials and therapeutics.

We are constantly engaged in the development of new products to improve our corporate goals and to design and produce Advance Technology Support Hinokitiol CAS 499-44-5 Cosmetic Grade Raw Material Powder for our customers according to their requirements. We will promote industrial systematization, product diversification, and provide better and more comprehensive services to customers. Our company has been adhering to the customer-oriented, technology first principle, to provide customers with reasonable products, quality service.

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