Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of spermidine powder cas 124-20-9 in China. Welcome to wholesale bulk high quality spermidine powder cas 124-20-9 for sale here from our factory. Good service and reasonable price are available.
Spermidine powder, also known as spermidine hydrochloride, is a polyamine. Soluble in water, alcohol and ether. It is widely distributed in organisms and is synthesized by putrescine (butylene diamine) and adenosylmethionine. It can inhibit neuronal synthase, bind and precipitate DNA; It can also be used to purify DNA binding protein and stimulate T4 polynucleotide kinase activity. On September 1st, 2013, scientists from Germany and Austria jointly studied that may prevent the onset of Alzheimer's disease.
Excessive intake of spermidine may cause discomfort symptoms such as headache, nausea and insomnia. It is necessary to strictly follow the doctor's instructions. It is recommended to prioritize obtaining spermidine from food sources such as kelp, mushrooms, and broccoli. If necessary, use supplements under the guidance of a professional doctor.
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Additional information of chemical compound:
The spermidine tablets we provide are round tablets, containing 1% pure spermidine powder, 5mg per tablet, 100 tablets per bottle, with a customization cycle of 15 days. Spermidine capsules are No. 0 capsules, with a spermidine content of 125mg. Other ingredients include magnesium stearate, etc. The purity of API powder is 99%.
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Spermidine COA
Spermidine is a bioamine compound containing two guanidine groups and one β -alanine group, and is widely present in organisms such as bacteria, mammals, birds, insects and plants. Spermidine is synthesized in organisms through enzymatic reactions such as arginine oxidase and N-acetyl-L-arginase, and has multiple biological functions. Spermidine pure powder, as a high-purity preparation, has broad application prospects in the fields of medicine, health products and cosmetics. However, the stability of spermidine is affected by multiple factors, such as temperature, light, humidity and oxidation, etc. Therefore, studying its stability is crucial for ensuring product quality.
Physical and chemical properties
Physical properties
This product is usually a white or light yellow powder with a weak odor. Its melting point is approximately 307℃, boiling point is 315℃, density is 1.01g /cm³, and refractive index is 1.52. Spermidine has a certain solubility in water. At room temperature, its solubility is approximately 0.1g/L. As the temperature rises, the solubility gradually increases. In addition, spermidine is also soluble in polar solvents such as methanol, ethanol and acetone.
Chemical properties
Spermidine is a strongly basic substance with strong ionizing properties. In aqueous solution, spermidine can undergo a protonation reaction to form cationic spermidine (M⁺). In addition, spermidine can also undergo ion-exchange reactions with other anions to form complexes. Spermidine has relatively high chemical stability, but it is prone to degradation in the presence of high temperatures, strong acids, strong alkalis or oxidants.
Influencing factors of stability
Temperature is one of the key factors affecting the stability of this product. High temperatures can accelerate the chemical degradation process of spermidine, leading to a decrease in its activity or even its failure. Studies show that spermidine has good stability at room temperature (25℃), but its degradation rate increases significantly above 40℃. Therefore, when storing, high-temperature environments should be avoided. It is recommended to store at a refrigerated temperature of 2-8℃.
Light exposure is another important factor affecting the stability of spermidine. Long-term exposure to light, especially ultraviolet rays, will accelerate the oxidation and degradation of spermidine. Therefore, when storing, it is necessary to ensure that the container is completely protected from light. Brown or black opaque containers can be used and placed in a cool place.
Spermidine has a strong hygroscopicity. A high-humidity environment will promote its reaction with moisture in the air, leading to a decline in quality. A humid environment may cause spermidine to absorb moisture and trigger hydrolysis reactions, thereby affecting its quality. Therefore, the storage environment should be kept dry and the relative humidity should be controlled at a low level.
Spermidine is prone to oxidation in the air, resulting in structural changes and reduced activity. The oxidation reaction will generate peroxides or other oxidation products, further accelerating the degradation of spermidine. Therefore, when storing, direct contact with air should be avoided. It is recommended to use well-sealed packaging materials and store under the protection of inert gases such as argon.
Spermidine is a strongly basic substance that can react with acids to form the corresponding salts. An acidic environment will accelerate the degradation of spermidine, resulting in a decrease in its activity. Therefore, when storing, direct contact with acidic substances should be avoided, and the pH value of the storage environment should be maintained within the neutral or weakly alkaline range.
Storage conditions
Temperature control
The optimal storage temperature for pure spermidine powder is 2-8℃. Low-temperature environments can significantly slow down the chemical degradation rate of spermidine and extend its shelf life. For long-term storage, it is recommended to store at -20℃ or lower, and the shelf life can reach several years. If short-term use is required, a refrigeration condition of 4℃ is also acceptable, but the shelf life is relatively short, usually about two years.
Light-proof seal
When storing this product, an opaque container should be used and it should be ensured that it is well sealed to prevent light and air from entering. The opened container should be resealed as soon as possible and kept in a vertical position as much as possible to prevent leakage and contamination.
Dry and well-ventilated
The storage environment should be kept dry and the relative humidity should be controlled at a low level. A high-humidity environment can cause spermidine to absorb moisture and trigger hydrolysis reactions, thereby affecting its quality. The storage site should have good ventilation conditions to reduce air humidity. Regularly inspect and clean the storage area to ensure there is no water accumulation or dampness.
Packaging materials
Choose packaging materials with good sealing properties, such as aluminum foil bags, glass bottles or high-density polyethylene containers, etc., to ensure that the product is not affected by the external environment during storage. For solid spermidine, it is recommended to use glass bottles or metal cans with good sealing performance. For the solution form, a brown glass bottle with a sealed cap or a special chemical reagent bottle can be chosen.
Stability research methods
Accelerated stability test
Accelerated stability testing is a commonly used stability research method. By storing under extreme conditions such as high temperature, high humidity or strong light, it observes the mass changes and predicts its stability under normal storage conditions. This method can quickly assess its stability and provide a basis for formulating reasonable storage conditions.
Long-term stability test
Long-term stability tests involve long-term monitoring of it under actual storage conditions to observe the changes in its quality over time. This method can provide the stability data of pure spermidine powder under actual storage conditions, offering a scientific basis for determining the validity period of the product.
Influencing factor test
The influence factor test is to study the impact of a single factor (such as temperature, light, humidity, etc.) on the stability of the product. By keeping other factors unchanged, changing the level of a certain factor and observing its quality change, the degree of influence of this factor on its stability can be determined.
Analysis method
The stability study of this product usually employs analytical techniques such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS) to quantitatively and qualitatively analyze its purity, content, and degradation products. These methods have the characteristics of high sensitivity, high selectivity and high accuracy, and can effectively evaluate its stability.
Conclusion
The stability of pure spermidine powder is affected by multiple factors, including temperature, light, humidity, oxidation and pH value, etc. Through strict temperature control, light-proof sealing, dry ventilation and reasonable packaging selection, the stability can be significantly improved and its shelf life can be extended. Methods such as accelerated stability tests, long-term stability tests and influencing factor tests provide a scientific basis for its stability research. In the future, with the deepening of research and the advancement of technology, the stability study of it will be more complete, providing more reliable guarantees for its application in the fields of medicine, health products and cosmetics.
Storage conditions
Temperature control
Recommended temperature: 2-8°C (refrigerated).
Low-temperature storage: Long-term storage can be carried out at -20°C or lower to significantly extend the shelf life.
High temperature influence: High temperatures can accelerate chemical reactions, leading to the degradation of spermidine. Therefore, exposure to environments above 25°C should be avoided.
Lighting management
Light-proof requirements: It must be stored completely away from light to prevent accelerated oxidation and degradation by ultraviolet rays.
Container selection: It is recommended to use brown or black opaque containers and store them in a cool place.
Humidity control
Dry environment: Spermidine is highly hygroscopic. High humidity will promote its reaction with moisture, leading to a decline in quality.
Humidity recommendation: The relative humidity of the storage environment should be controlled at a relatively low level (such as ≤30%).
Sealing measures
Sealed packaging: Packaging materials with good sealing properties (such as aluminum foil bags, glass bottles or high-density polyethylene containers) should be used to prevent moisture and air from entering.
Post-opening handling: After opening, the container should be resealed as soon as possible and kept upright to prevent leakage and contamination.
Other precautions
Isolated storage: Avoid mixed storage with toxic and harmful substances to prevent chemical reactions.
Regular inspection: It is necessary to regularly check the sealing of the storage containers, the temperature control conditions, as well as the appearance and odor of spermidine to ensure there are no abnormal phenomena.
Protective measures: When handling spermidine, personal protective equipment (such as chemical protective goggles, lab coats and gloves) must be worn to prevent skin contact and inhalation.
Summary: Pure spermidine powder should be stored under refrigeration at 2-8°C, away from light, dry and sealed conditions to maintain its stability and activity. Long-term storage can be considered at -20°C or lower temperatures, and it is necessary to strictly follow the requirements of sealed and isolated storage.
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