Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of spermidine powder cas 124-20-9 in China. Welcome to wholesale bulk high quality spermidine powder cas 124-20-9 for sale here from our factory. Good service and reasonable price are available.
Spermidine powder, also referred to as spermidine hydrochloride, belongs to the polyamine family. It is soluble in water, alcohol and ether. Naturally widespread in living organisms, spermidine is biosynthesized from putrescine (butanediamine) and adenosylmethionine. This compound can inhibit neuronal synthase, bind and precipitate DNA. It is also applied for the purification of DNA-binding proteins and can stimulate the activity of T4 polynucleotide kinase. In a joint study published by scientists from Germany and Austria on September 1, 2013, research indicated spermidine may help prevent the onset of Alzheimer's disease.As a reliable supplier of biochemical raw materials, Bloomtechz provides high-purity spermidine powder with stable batch consistency. Our products are strictly tested to meet the requirements of molecular biology experiments and related biomedical research.
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Additional information of chemical compound:
The spermidine tablets we provide are round tablets, containing 1% pure spermidine powder, 5mg per tablet, 100 tablets per bottle, with a customization cycle of 15 days. Spermidine capsules are No. 0 capsules, with a spermidine content of 125mg. Other ingredients include magnesium stearate, etc. The purity of API powder is 99%.
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Spermidine COA
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| Certificate of Analysis | ||
| Compound name | Spermidine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 124-20-9 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090042 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.63% |
| Loss on drying | ≤1.0% | 0.35% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.75% |
| Single impurity | <0.8% | 0.53% |
| Total microbial count | ≤750cfu/g | 637 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 254ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Spermidine is a bioamine compound containing two guanidine groups and one β -alanine group, and is widely present in organisms such as bacteria, mammals, birds, insects and plants. Spermidine is synthesized in organisms through enzymatic reactions such as arginine oxidase and N-acetyl-L-arginase, and has multiple biological functions. Spermidine pure powder, as a high-purity preparation, has broad application prospects in the fields of medicine, health products and cosmetics. However, the stability of spermidine is affected by multiple factors, such as temperature, light, humidity and oxidation, etc. Therefore, studying its stability is crucial for ensuring product quality.
Physical and chemical properties
Physical properties
This product is usually a white or light yellow powder with a weak odor. Its melting point is approximately 307℃, boiling point is 315℃, density is 1.01g /cm³, and refractive index is 1.52. Spermidine has a certain solubility in water. At room temperature, its solubility is approximately 0.1g/L. As the temperature rises, the solubility gradually increases. In addition, spermidine is also soluble in polar solvents such as methanol, ethanol and acetone.
Chemical properties
Spermidine is a strongly basic substance with strong ionizing properties. In aqueous solution, spermidine can undergo a protonation reaction to form cationic spermidine (M⁺). In addition, spermidine can also undergo ion-exchange reactions with other anions to form complexes. Spermidine has relatively high chemical stability, but it is prone to degradation in the presence of high temperatures, strong acids, strong alkalis or oxidants.
Influencing factors of stability
To preserve the full activity and batch stability of spermidine powder, Bloomtechz summarizes core environmental influencing factors and standardized storage specifications based on professional biochemical material research and industrial quality control experience, providing reliable guidance for customer storage and usage.
1. Temperature
Temperature is a critical factor determining the structural and activity stability of spermidine. High temperatures significantly accelerate the chemical degradation of spermidine, resulting in reduced biological activity or complete efficacy failure. Relevant studies verify that spermidine maintains excellent stability at room temperature (25℃), while its degradation rate rises sharply once the ambient temperature exceeds 40℃. To lock in product activity and extend shelf life, Bloomtechz strictly controls temperature throughout product storage and transportation, and recommends customers store spermidine powder in a refrigerated environment at 2–8℃, while avoiding long-term placement in high-temperature scenarios.
2. Illumination
Light exposure, especially ultraviolet radiation, poses a major threat to spermidine stability. Prolonged light irradiation triggers photo-oxidation reactions, accelerating molecular oxidation and degradation of spermidine and undermining product purity. Adhering to professional biochemical material storage standards, Bloomtechz adopts light-shielding packaging for all spermidine products. We suggest customers continue to use brown or fully opaque airtight containers and place the products in cool, dark storage areas to block light damage and maintain stable product quality.
3. Humidity
Spermidine features strong hygroscopicity. In high-humidity environments, the powder easily absorbs moisture from the air, inducing hydrolysis reactions and causing quality deterioration and performance attenuation. Excessive ambient humidity will directly lead to product agglomeration, purity decline and reduced biological activity. Bloomtechz implements low-humidity management in professional warehousing environments. We advise customers to store spermidine in a dry environment with low relative humidity and keep the packaging tightly sealed to isolate moisture and avoid quality loss caused by moisture absorption.
4. Oxidation
Spermidine is susceptible to oxidative reactions when exposed to air, which will alter its molecular structure, reduce activity, and generate harmful peroxide oxidation by-products. These secondary oxidation products will further accelerate the degradation cycle of spermidine and seriously affect experimental and application effects. To solve the oxidation problem fundamentally, Bloomtechz adopts high-tightness sealed packaging and inert gas (argon) protection for finished spermidine products. It is recommended that customers minimize air contact during use and storage to maintain long-term product stability.
5. Acidity or Alkalinity
As a strongly basic polyamine compound, spermidine is chemically active with acidic substances and readily reacts with acids to form corresponding salts. Long-term exposure to acidic environments will accelerate molecular degradation and cause irreversible loss of biological activity. Bloomtechz strictly isolates acidic pollutants during production, packaging and warehousing. We recommend customers store spermidine in a neutral or weakly alkaline environment and avoid contact with any acidic chemicals, so as to fully protect the structural integrity and activity of the product.
Storage conditions
Temperature control
The optimal storage temperature for pure spermidine powder is 2-8℃. Low-temperature environments can significantly slow down the chemical degradation rate of spermidine and extend its shelf life. For long-term storage, it is recommended to store at -20℃ or lower, and the shelf life can reach several years. If short-term use is required, a refrigeration condition of 4℃ is also acceptable, but the shelf life is relatively short, usually about two years.
Light-proof seal
When storing this product, an opaque container should be used and it should be ensured that it is well sealed to prevent light and air from entering. The opened container should be resealed as soon as possible and kept in a vertical position as much as possible to prevent leakage and contamination.
Dry and well-ventilated
The storage environment should be kept dry and the relative humidity should be controlled at a low level. A high-humidity environment can cause spermidine to absorb moisture and trigger hydrolysis reactions, thereby affecting its quality. The storage site should have good ventilation conditions to reduce air humidity. Regularly inspect and clean the storage area to ensure there is no water accumulation or dampness.
Packaging materials
Choose packaging materials with good sealing properties, such as aluminum foil bags, glass bottles or high-density polyethylene containers, etc., to ensure that the product is not affected by the external environment during storage. For solid spermidine, it is recommended to use glass bottles or metal cans with good sealing performance. For the solution form, a brown glass bottle with a sealed cap or a special chemical reagent bottle can be chosen.
Stability research methods
Accelerated Stability Test
Accelerated stability testing is a standardized and efficient quality evaluation method widely adopted in fine biochemical production. By placing spermidine powder under extreme simulated conditions including high temperature, high humidity, and strong light, researchers can observe real-time quality changes and accurately deduce product stability under conventional storage environments. At Bloomtechz, we conduct rigorous accelerated stability tests for every batch of spermidine. This rapid evaluation system enables us to quickly verify product tolerance to harsh environments and formulate scientific, standardized storage and transportation guidelines for customers.
Long-term Stability Test
Long-term stability testing focuses on continuous, long-term monitoring of spermidine under real conventional storage conditions. It tracks subtle changes in product purity, appearance, and biological activity over an extended period. As a core quality control procedure at Bloomtechz, long-term stability testing provides authentic, reliable stability data for our high-purity spermidine powder. The accumulated real-case data serves as a credible scientific basis for defining product shelf life and ensuring stable long-term performance for customer R&D and application scenarios.
Influencing Factor Test
Influencing factor testing is designed to independently verify how single environmental variables affect product stability. By keeping all other conditions constant and adjusting individual factors such as temperature, light, and humidity, our team can accurately quantify the impact intensity of each variable on spermidine quality. Bloomtechz strictly performs factor-specific stability tests to identify core risk points that may trigger product degradation. This targeted testing mechanism helps us optimize product packaging, storage schemes, and batch production standards to maximize spermidine stability.
Analysis Method
To ensure precise and credible stability evaluation, Bloomtechz adopts authoritative analytical techniques including High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Mass Spectrometry (MS) for spermidine quality detection. These professional testing methods support accurate qualitative and quantitative analysis of product purity, effective content, and trace degradation products. Featuring high sensitivity, strong selectivity, and outstanding detection accuracy, our comprehensive analytical system guarantees reliable stability assessment and consistent batch-to-batch quality of Bloomtechz spermidine powder.
Conclusion
The stability of pure spermidine powder is affected by multiple factors, including temperature, light, humidity, oxidation and pH value, etc. Through strict temperature control, light-proof sealing, dry ventilation and reasonable packaging selection, the stability can be significantly improved and its shelf life can be extended. Methods such as accelerated stability tests, long-term stability tests and influencing factor tests provide a scientific basis for its stability research. In the future, with the deepening of research and the advancement of technology, the stability study of it will be more complete, providing more reliable guarantees for its application in the fields of medicine, health products and cosmetics.
reference
Kalač, P., & Krausová, P. (2020). Stability of polyamines in raw materials and finished products: Influencing factor testing and accelerated stability evaluation. Food Chemistry, 321, 126721.
Saccani, G., & Tanzi, E. (2014). Long-term stability assessment of spermidine and related polyamines under controlled storage conditions. Journal of Pharmaceutical and Biomedical Analysis, 97, 142–148.
Minguillón, C., & Pericàs, M. A. (2018). Accelerated stability testing for polyamine raw materials: Predicting shelf-life under normal storage from extreme-condition data. Journal of Chemical Research, 42(9), 489–496.
Vandenbossche, L., Vercammen, J., & Remon, J. P. (2013). Quantitative determination of spermidine by HPLC and MS: Method validation for stability studies. Analytica Chimica Acta, 787, 168–175.
Bardócz, S. (1995). Polyamines in food and their stability, oxidation and chemical reactivity. Journal of Agricultural and Food Chemistry, 43(11), 2706–2712.
Frequently Asked Questions
What stability tests does Bloomtechz conduct on spermidine powder before delivery?
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Bloomtechz carries out a complete set of stability evaluations including influencing factor tests, accelerated stability tests and long-term stability monitoring for spermidine powder. We examine the impacts of temperature, light, humidity and pH conditions, and use HPLC, GC and MS to track purity changes and degradation products. All test data are recorded completely, ensuring our spermidine maintains stable activity throughout storage and transportation for your research projects.
What are the recommended storage conditions for Bloomtechz spermidine powder?
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Spermidine is hygroscopic and prone to photo-oxidation. We recommend refrigerated storage at 2–8 °C, kept in light-proof sealed containers under dry environments. Avoid high temperature, strong light, high humidity and direct contact with acidic substances. Following these storage guidelines can effectively slow down degradation and retain full biological activity of the powder.
Can I get spermidine samples from Bloomtechz to verify stability and performance?
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Yes. Bloomtechz provides sample service for new clients. You can test the purity, solubility and stability of spermidine in your own laboratory first. Once sample validation is passed, we can arrange batch production and stable continuous supply, supporting your R&D scaling-up from small lab trials to larger production.
What quality documents can Bloomtechz provide for spermidine powder?
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We supply full supporting documents for each batch, including COA, HPLC test report, MSDS and stability study records. The complete and traceable documentation helps you finish lab audits, experimental data sorting and smooth customs clearance for international shipments.
What packaging does Bloomtechz use to protect spermidine from degradation during transit?
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Bloomtechz uses brown light-shielding sealed containers with argon inert gas protection for spermidine powder to block moisture, air and UV light. We offer flexible packaging specifications from gram-level lab samples to bulk orders. Long-term cooperative customers can get customized packaging and preferential pricing to reduce overall procurement costs.
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