5-Methoxysalicylic Acid CAS 2612-02-4

The use of 5-MeOSA with spermine enhances the sensitivity and resolution of MALDI-MS analysis, making it possible to detect and differentiate oligonucleotides with high accuracy.

The presence of spermine in the matrix improves the electrical conductivity of the crystal formed during the MALDI process. This conductivity is crucial for the efficient desorption and ionization of analytes, leading to better mass spectrometry results.

The matrix formed by 5-MeOSA and spermine is compatible with a wide range of oligonucleotides, including those with different lengths, base compositions, and modifications. This makes it a versatile tool for oligonucleotide analysis.

The use of this matrix combination can help reduce background noise in the mass spectrometry spectrum, making it easier to identify and quantify the analytes of interest.

5-MeOSA exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase (COX-1/COX-2), reducing prostaglandin E2 (PGE2) synthesis, and blocking inflammatory signaling pathways (NF - κ B, MAPK); The anti-inflammatory activity is superior to aspirin and salicylic acid, and the irritation is lower.
Synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs): 5-methoxysalicylate/amide derivatives are synthesized by esterification, amidation, and condensation of 5-meOSA, which are used for the treatment of rheumatoid arthritis, osteoarthritis, gout, and postoperative pain;

The analgesic effect is twice that of aspirin, the anti-inflammatory effect is 1.8 times that of aspirin, and the gastrointestinal irritation is reduced by 50%.
Skin anti-inflammatory external medication: 5 MeOSA is directly used as an active ingredient for the treatment of dermatitis, eczema, acne, psoriasis, and UV sunburn; Inhibit skin inflammation, reduce redness, swelling, itching, promote skin repair, reduce pigmentation, mild and non irritating, suitable for sensitive skin.
Oral anti-inflammatory preparations: used for the treatment of oral ulcers, gingivitis, and periodontitis, inhibiting oral bacteria, reducing inflammatory pain, and promoting mucosal repair.

5-MeOSA is an efficient mucosal absorption enhancer that can reversibly disrupt the tight junctions between mucosal epithelial cells, increase cell membrane fluidity, and inhibit drug efflux transporters (P-gp), significantly improving the efficiency of drug transdermal, mucosal, and intestinal absorption.
Rectal administration promotes absorption: When used in combination with drugs such as cefoxitin sodium, bleomycin, insulin, etc., it significantly improves the rectal absorption efficiency of drugs (2-5 times higher), increases lymphatic transport, and reduces first pass effects.

It is used for the development of rectal administration formulations for antibiotics, peptides, and protein drugs.
Transdermal administration to promote absorption: it is added to transdermal patches, gel, and creams to improve the skin permeability of drugs (3 – 10 times), prolong the action time, and reduce the dosage of drugs. It is used for transdermal preparations of analgesia, hormones, and antihypertensive drugs.
Oral medication promotes absorption: When used in combination with poorly soluble drugs and drugs with low bioavailability, it enhances intestinal absorption, improves bioavailability, and reduces individual differences.

5-MeOSA exerts hypoglycemic, lipid-lowering, and metabolic syndrome improving effects by activating the AMPK pathway, inhibiting hepatic gluconeogenesis, promoting peripheral tissue glucose uptake, and improving insulin resistance.
Treatment of type 2 diabetes: reduce fasting blood glucose (15% – 20%), improve insulin sensitivity, reduce insulin level, and reduce liver glycogen output; No risk of hypoglycemia, non-toxic to liver and kidney, suitable for diabetes patients with obesity/hyperlipidemia.
Metabolic syndrome intervention: reduce triglycerides, total cholesterol, increase HDL-C, reduce visceral fat deposition, and improve vascular endothelial function.

5-Methoxysalicylic Acid directly scavenges free radicals (superoxide anions, hydroxyl radicals, lipid peroxides), enhances endogenous antioxidant enzyme (SOD, GSH-PX, CAT) activity, reduces MDA content, alleviates oxidative stress damage, and inhibits liver cell inflammation and fibrosis.
Liver injury protection: Used as an adjuvant therapy for drug-induced liver injury, alcoholic fatty liver, viral hepatitis, and liver fibrosis, reducing liver cell damage, lowering transaminase levels, improving liver function, and delaying the progression of liver fibrosis.
Neuroprotection: Inhibits oxidative stress in nerve cells, reduces neuronal apoptosis, improves cognitive function, and is used as an adjuvant therapy for Alzheimer's disease, Parkinson's disease, and stroke.

Antibacterial drugs: have moderate inhibitory activity (MIC=32-128 μ g/mL) against Staphylococcus aureus, Escherichia coli, Salmonella, Propionibacterium acnes, and Candida albicans, and are used for the treatment of skin infections, oral infections, and vaginitis.
Antithrombotic drugs: inhibit platelet aggregation, reduce blood viscosity, improve microcirculation, used as adjuvant therapy for thrombotic diseases and cardiovascular and cerebrovascular diseases.
Antiallergic drugs: inhibit histamine release, block allergic signaling pathways, alleviate allergic reactions, used for the treatment of allergic dermatitis, urticaria, and allergic rhinitis.

Inhibition of tyrosinase activity: competitively binds to the active site of tyrosinase, blocks the key step of melanin synthesis, with an inhibition rate of ≥ 90% (concentration 2%), and the effect is twice that of salicylic acid and 1.5 times that of nicotinamide.
Blocking melanin transport: Inhibiting the transport of melanosomes to stratum corneum cells and reducing epidermal melanin deposition.
Accelerate melanin metabolism: promote the metabolism of the stratum corneum, accelerate the shedding of melanin containing dead skin cells, and fade pigmentation and acne scars.
Antioxidant and anti darkening: Clearing free radicals, inhibiting UV induced oxidative stress, reducing pigmentation, brightening skin tone, and improving dullness and yellowing.