Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of l-carnitine powder cas 541-15-1 in China. Welcome to wholesale bulk high quality l-carnitine powder cas 541-15-1 for sale here from our factory. Good service and reasonable price are available.
L-Carnitine powder, abbreviated as lclt or carnitine, the main component of L-carnitine, is an amino acid that promotes the conversion of fat into energy. The two specifications we produce are L-carnitine liquid and powder. L carnitine pure is white crystal or white transparent fine powder. Carnitine is very soluble in water to form a carnitine solution. It is also soluble in ethanol and methanol, slightly soluble in acetone, but insoluble in ether, benzene, chloroform, and ethyl acetate. Pure lclt powder is easy to absorb moisture, has good water solubility and water absorption, and can withstand high temperatures above 200 ℃. Red meat is the main source of L-carnitine powder, which can also be synthesized by the human body to meet physiological needs. It is not a real vitamin, but a substance similar to vitamins. It has many physiological functions such as fat oxidative decomposition, weight loss, and anti-fatigue.
L-Carnitine Powder COA
The powder of L-Carnitine Powder is used in many aspects. 1. In terms of infant food, L-carnitine has certain functions in maintaining infant life and promoting some physiological processes of infant development. For infants, carnitine has become a conditionally essential nutrient. An appropriate supplement of exogenous carnitine is conducive to the normal growth and development of infants. The content of L-carnitine in breast milk is high, and infants mainly rely on breast milk to supply the required L-carnitine.
4. Important nutritional supplements for the human body: with the increase of age, the content of L-carnitine in the body is decreasing. Human beings need to supplement L-carnitine Diabetic patients, renal function patients, mental workers, manual workers, because of the waste of many, the body's consumption of L-carnitine is large, easily lead to the lack of L-carnitine, need long-term supplements.
5. It is also an energy substance for sperm maturation and has the function of improving the number and vitality of sperm. L-carnitine has many functional groups and can be used as organic synthetic raw materials. For example, carnitine can be used to synthesize chiral 3-hydroxytetrahydrofuran. L-carnitine internal salt has a strong hygroscopic ability and has been added to cosmetics as a moisturizer.
L-carnitine belongs to the zwitterionic group. When the pH is neutral, L-carnitine exists in the form of lactones and has good stability. Unlike ordinary amino acids, L-carnitine does not carry an amino group, but carries a positively charged quaternary ammonium group, which is not affected by pH conditions. Moreover, the chelation process can occur not only on its carboxyl group to form a quaternary ring, but also on the hydroxyl and carboxyl groups to form a hexagonal ring. Therefore, it can form various stable chelates with many metal ions, such as copper, zinc, manganese, magnesium, calcium, etc. The possible structures are shown in the following figure. In practical use, Due to its strong hygroscopicity and tendency to clump at room temperature, L-carnitine is usually prepared into non hygroscopic salts using this principle, such as calcium and magnesium salts of L-carnitine tartaric acid, L-carnitine fumarate, and acetyl L-carnitine galactose. There are also studies on L-carnitine whey salts, which are convenient for storage, transportation, and packaging.
The carboxyl group on L-carnitine can undergo a substitution reaction with halogenated hydrocarbons, hydroxyl groups, or amine groups under certain conditions. This reaction is reversible, and when multiple groups are present at the same time, it preferentially reacts with more active groups. For example, when L-carnitine reacts with 2-hydroxyethylamine, it preferentially reacts with amine groups
The carboxyl groups on L-carnitine can be reduced to hydroxyl groups using reducing agents such as sodium borohydride and sodium triacetoxyborohydride.
The hydroxyl groups on L-carnitine can undergo nucleophilic substitution reactions with carboxylic acids and their derivatives to form ester groups. When using acyl chloride for the reaction, attention should be paid to the selection of solvents. Traditionally, trifluoroacetic acid has been used as a solvent to achieve good results. In order to save costs, many studies have used anhydrous acetic acid, propionic acid, and ethyl acetate as solvents, such as the acylation reaction between L-carnitine and propionyl chloride, It can be carried out under the conditions of using dry propionic acid as the solvent and p-toluenesulfonic acid as the catalyst.
The hydroxyl groups on L-carnitine can also react with nitric acid to form organic nitrates.
L-carnitine is widely present in nature, with high levels of carnitine in muscle tissue. Animal experiments have found that the concentration of L-carnitine in the adrenal gland is the highest, followed by the heart, bones, muscles, adipose tissue, and liver. Free L-carnitine is excreted through urine. The human body requires carnitine through dietary intake and/or endogenous synthesis. The human liver and kidneys use lysine and methionine as raw materials to synthesize carnitine, while requiring the assistance of VC, niacin, VB6, and iron. VC is essential for the biosynthesis of Carnitine Powder, and among all nutritional cofactors, VC has the greatest impact on the rate of carnitine biosynthesis. There is experimental evidence that the biosynthesis rate of carnitine in the kidneys of vitamin deficient guinea pigs decreases by 8-10 times, and the heart and skeletal muscles are particularly sensitive to this. The concentration of carnitine in the aforementioned tissues of animals lacking VC decreased by 50%. Iron is also required in the response that requires VC, and the concentration of carnitine in the liver and heart tissues of pregnant mice with iron deficiency is significantly reduced.
Solubility
L-Carnitine Powder, as an important nutritional supplement, its solubility plays a key role in the application process of the product. The following will elaborate in detail on its solubility from aspects such as solubility characteristics, influencing factors, practical applications and precautions.
Solubility Characteristics
Readily soluble in water
This powder has an extremely high solubility in water. Its water solubility can reach 250g/100g (at 20℃), that is, 250 grams of L-carnitine can be dissolved in every 100 grams of water. This characteristic gives it a significant advantage when preparing liquid preparations, as it can be rapidly and completely dispersed in water to form a uniform and stable solution.
High solubility ensures that L-carnitine can be rapidly absorbed by the human body, enhancing its bioavailability. This is particularly important for people who need to replenish L-carnitine quickly, such as athletes and fitness enthusiasts.
Readily soluble in organic solvents
In addition to water, this powder is also readily soluble in organic solvents such as ethanol and methanol. This characteristic makes L-carnitine have potential application value in the preparation of new drug delivery systems such as solid dispersions and microspheres, which helps to improve the bioavailability and stability of drugs.
In certain specific application scenarios, such as in organic synthesis reactions, L-carnitine may also be used as a catalyst or solvent, and its good solubility in organic solvents makes it possible.
Insoluble in specific solvents
Although this powder has good solubility in most solvents, it is almost insoluble in specific solvents such as acetone and ethyl acetate. This feature needs to be taken into account when preparing certain special dosage forms or conducting specific chemical reactions to avoid adverse effects of solubility issues on product performance or reaction efficiency.
Factors Affecting Solubility
The solubility of this powder is affected by multiple factors, mainly including the following points:
Temperature
Generally speaking, increasing the dissolution temperature can accelerate the dissolution rate and enhance the solubility. However, excessively high temperatures may also lead to drug degradation or deterioration. Therefore, in actual operation, the appropriate dissolution temperature should be selected based on the stability and solubility of the drug.
Solvent properties
The polarity, dielectric constant and other properties of different solvents have a significant influence on the solubility of the powder. Choosing the appropriate solvent is the key to optimizing solubility.
Drug purity and particle size
The higher the purity of a drug and the finer its particles are, the better its solubility is usually. Therefore, when preparing this powder, the purity of the raw materials should be strictly controlled, and the particle size should be optimized through appropriate grinding, screening and other technological means.
Considerations in Practical Application
In practical applications, the solubility of this powder has a significant impact on the preparation, storage and use of the product. The following are some specific considerations:
Preparation of preparations
The high solubility of this powder makes it more convenient and flexible when preparing liquid preparations such as oral liquids and beverages. By adjusting the solvent and excipients, the performance and stability of the preparation can be optimized to meet the needs of different populations.
Storage conditions
This powder is highly hygroscopic. When exposed to air, it will deliquesce and may even liquefy. Therefore, during storage, it is necessary to pay attention to moisture-proofing, avoiding light and keeping it sealed to prevent changes in solubility or deterioration of the drug.
Usage method
For people who need to quickly replenish L-carnitine, they can choose to take oral liquid or beverage and other liquid preparations prepared with this powder. When taking it, the dosage and administration time can be adjusted according to personal taste and needs to achieve the best effect.
Precautions
When using this powder, the following points also need to be noted:
Avoid contact with oxidants
This powder should be kept away from oxidants and other harmful substances to prevent chemical reactions that could render the drug ineffective or produce harmful substances.
Follow the doctor's advice or instructions
When using this powder, follow the doctor's advice or the recommended dosage and usage method in the product manual to avoid adverse reactions caused by excessive or improper use.
Pay attention to individual differences
The tolerance and response of different groups of people to this powder may vary. If any discomfort or allergic reaction occurs during use, stop using it immediately and consult a doctor.
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