Milbemycin Oxime Powder is a broad-spectrum antiparasitic drug, belonging to the macrocyclic lactone class, mainly used for the prevention and treatment of parasitic infections in pets (such as dogs and cats) both inside and outside the body. The appearance is usually white to light yellow powder, odorless or slightly bitter, easily soluble in organic solvents, and slightly soluble in water. It activates glutamate gated chloride ion channels in parasite neuromuscular cells, causing a large influx of chloride ions and triggering neuromuscular hyperpolarization, ultimately leading to parasite paralysis and death. Highly effective against both larvae and adults of nematodes (such as heartworms, roundworms, and hookworms) and arthropods (such as fleas and mites). It can simultaneously prevent and treat multiple parasites both inside and outside the body, and has low toxicity to mammals, making it suitable for long-term preventive use. Drugs metabolize quickly in animal bodies, reducing the risk of environmental pollution.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
Our products

Milbemycin Oxime Powder

Milbemycin Oxime Tablets
![]() |
![]() |


![]() |
![]() |
Milbemycin Oxime COA


Milbemycin Oxime Powder is a broad-spectrum antiparasitic drug belonging to the macrocyclic lactone class. Since its emergence in the 1980s, it has become one of the core drugs for preventing and treating parasitic infections in dogs in veterinary medicine. Its unique pharmacological mechanism, high efficiency, and safety make it widely used in the prevention and treatment of internal and external parasites in dogs, especially in the prevention of heartworm worms, treatment of intestinal nematodes, and control of external parasites.
Clinical application of cats and dogs

Prevention of Lymphatic Filariasis
Dirofilaria is a fatal disease caused by the canine heartworm (Dirofilaria immitis), transmitted by mosquitoes. The larvae develop into adults in dogs and parasitize the pulmonary artery and right ventricle, causing pulmonary hypertension, heart failure, and even death. Milbeixime is one of the FDA approved heartworm prophylaxis drugs, with the following effects:
Killing microfilament larvae: Milbeixime can eliminate microfilament larvae (L1 stage) of heartworm worms in the blood, blocking their development into adults.
Inhibition of adult reproduction: High doses may have a partial killing effect on adult heartworms, but usually require the combination of other drugs (such as moxifloxacin) to completely eliminate the adults.
Prevention of Lymphatic Filariasis
Prevention of infection: Regular administration (once a month) can maintain drug concentration and prevent new infections.
Clinical advantages:
High Safety: Compared to Ivermectin, Milberoxime is safer for sensitive breeds such as Collie due to its lower risk of neurotoxicity for dogs with multidrug resistance gene (MDR1) mutations.
Strong compatibility: It can be used in combination with insecticides such as Praziquantel to prevent heartworms and other parasites.


Treatment of intestinal nematodes
Milberoxime has a highly effective killing effect on common intestinal nematodes in dogs, including:
Ascaris: Toxocara canis, Toxascaris leonina.
Hookworms: Ancylostoma caninum and A. Braziliense.
Whipworm: Trichuris vulpis, a fox hair nematode.
Eye worm: In some cases, it can be used as an adjuvant treatment for canine roundworm (Thelazia callipieda) infection.
Stage of action: Milbeixime is effective against both adult and larval nematodes (L4 stage), but it should be noted that it does not directly kill the eggs, so regular administration is necessary to prevent reinfection.
External parasite control
Milbemycin Oxime Powder has an indirect control effect on some ectoparasites, mainly through the following pathways:
Flea control: Milberoxime can kill flea larvae and pupae, but it needs to be combined with topical insecticides (such as non prednisolone) to thoroughly eliminate adult insects.
Mite treatment: It has a certain therapeutic effect on Sarcoptes scabiei, Otodectes cynotis, and Demodex canis mites, but usually needs to be used in combination with other drugs (such as ivermectin, moxifloxacin) or local treatment.
Tick prevention: Milberoxime has no direct killing effect on ticks, but can reduce the risk of disease transmission after tick bites (such as Lyme disease).


Other purposes
Combination therapy: Milbeixime is often used in combination with praziquantel to form a compound preparation, which can prevent heartworm worms, treat intestinal nematodes and tapeworms.
Postoperative prevention: In areas with high incidence of heartworm infection, preoperative administration of milberoxime to dogs can reduce the risk of heartworm microfilamentemia caused by stress during surgery.
Comparison with other drugs
Comparison with Ivermectin
| Characteristic | Milbemycin Oxime | Ivermectin |
| Heartworm prevention | Efficient and highly secure | Efficient, but use with caution for Collies |
| Intestinal nematodes | Better effect on hookworms and whipworms | Better effect on roundworms |
| Ectoparasite | Indirect control of mites and fleas | Stronger direct killing effect on mites |
| Neurotoxicity risk | low | High (especially MDR1 mutant dogs) |
Comparison with Moxibustin
Moxidectin is another commonly used heartworm preventive medication, characterized by:
Long lasting effect
Moxifloxacin has a longer residual period and can be administered every 6 months.
Insecticidal spectrum
Moxifloxacin has a stronger direct killing effect on ticks and mites.
Safety
Milbeixime has lower acute toxicity and is more suitable for puppies and sensitive dogs.
Meet the refined pet-keeping needs
Milbemycin Oxime Powder is a new type of semi-synthetic macrolide anthelmintic drug. With its precise mechanism of action and high efficacy while being low in toxicity, it has become a core tool for pet health management in the era of refined pet care. Its application value lies not only in the broad-spectrum prevention and control of parasites, but also in the deep adaptation to special pet groups, multi-pet families, and complex parasite infection scenarios, meeting the high requirements of modern pet owners for safety, convenience, and comprehensiveness.




I. Guardians of Special Pet Groups
Dogs of breeds such as Collie are highly sensitive to avermectin-based drugs due to genetic defects. Traditional deworming medications can easily cause neurotoxic reactions. However, milbemycin, due to its inability to penetrate the blood-brain barrier, has become a safe alternative for these pets. The chronic toxicity test showed that continuous administration at 3mg/kg body weight per day did not cause any abnormalities. Pregnant female dogs using it throughout their pregnancy also had no risk of teratogenesis or miscarriage, ensuring the safety of the young pets during their development period. For kittens over 6 weeks old, milbemycin can precisely control the dosage, preventing heartworm infection while avoiding the risk of drug overdose, providing early protection for the growth of the young pets.
II. Cross-infection prevention firewall for multi-dog and multi-cat households
In multi-dog and multi-cat living environments, the risk of parasite transmission increases exponentially. Mirbefloxin achieves its peak concentration in adipose tissue 4-8 hours after oral administration, forming a 30-day efficacy barrier that effectively blocks the reproduction chain of external parasites such as fleas and mites. Its compound formulation (such as Mirbefloxin + Praziquantel) can simultaneously kill tapeworms and flukes and other complex parasites, reducing the risk of medication omission due to the alternate use of different drugs. Clinical data shows that administering once a month can reduce the infection rate of pet parasites by 92% in households, significantly lowering the risk of human-dog co-infection.
III. Precise Attack Weapons for Complex Infection Scenarios
For the special situation where pets have been infected with heartworms, Milbemycin Oxime inhibits the activity of microfilariae, reducing the risk of thrombosis during treatment. When combined with Ivermectin, this regimen can increase the clearance rate of heartworm larvae to 98%, while reducing the toxic reactions caused by excessive dosage of a single drug. For deep-seated parasitic mites such as scabies mites and ear mites, Milbemycin Oxime can penetrate the epidermal keratin layer and reach the hair follicle roots, killing over 95% of the parasites within 72 hours, alleviating severe itching and skin damage in pets. In the context of an increasingly severe issue of drug resistance in deworming, the combined formulation of Milbemycin Oxime and Chlorfenapyr shows a powerful killing effect against resistant fleas, breaking through the traditional drug efficacy bottleneck.
IV. Expert in Dose Control for Precise Medication Administration
Mirbeox powder can be precisely dosed according to the pet's weight, allowing for dose adjustments at the 0.1mg/kg level. This enables differentiated needs to be met for pets from young to old, and for small to large dogs. Its pharmacokinetic characteristics support a once-monthly dosing schedule, with 90% of the drug excreted in the feces as the original form within 48 hours, reducing the burden on the liver. For pets with abnormal liver function, Mirbeox does not significantly affect indicators such as GOT and GPT, making it a preferred long-term medication option for pets with chronic diseases.
V. Strategic Choices for Preventive Health Management
Starting the preventive administration of milbemycin oxime one month before the active season of mosquitoes can block the infection window period of heartworms, with a protection rate of over 99%. When combined with mosquito repellents, this scheme forms a "internal killing + external prevention" dual barrier, significantly reducing the risk of exposure for pets. For the parasite eradication after the adoption of stray animals, the broad-spectrum killing characteristics of milbemycin oxime can handle multiple infections such as roundworms, hookworms, and fleas in one go, shortening the isolation observation period, and accelerating the integration of pets into the family.
Milbexon powder, through its molecular-level precise action mechanism, has established a three-dimensional protection system of "safety barrier - precise attack - long-term prevention" in the field of pet parasite control. Its inclusiveness for special groups, adaptability to complex scenarios, and control over medication precision make it an indispensable health management tool in the era of refined pet care. As pet healthcare moves towards individualized and preventive directions, the application scenarios of Milbexon will continue to expand, providing more scientific solutions for pet health.
FAQ
1. Question: Milbemycin is an ingredient of agricultural insecticides. Why can it be used for pet deworming?
Answer: The mechanism of its deworming effect lies in highly selectively activating the glutamate-gated chloride channels in parasites, causing their neural and muscle hyperpolarization and paralysis, ultimately leading to death. This channel has different distribution and functions in mammals, and the drug is difficult to pass through the blood-brain barrier of dogs and cats. Therefore, when reaching the deworming concentration, it is extremely safe for the host. This reflects the classic pharmacological principle of "poison is dose" and the subtle differences in target selectivity.
2. Question: How stable is the powder raw material? Why are most commercially available products in the form of pre-formulations?
Answer: Mirepetinol raw material is sensitive to light, oxygen and humidity. Especially when in powder form, it has a larger surface area and is more prone to photolysis and oxidative degradation, thus losing its efficacy. Commercial pre-formulations (such as tablets and drops) have significantly enhanced stability through techniques such as microencapsulation, the addition of antioxidants, and packaging in a light-protected container. This explains why pet owners find it difficult to safely use the raw material directly.
3. Question: Besides common parasites, what special pests does it have unique value for?
Answer: Milbemycin is currently an oral medication with outstanding efficacy against "ear mites" in dogs and cats. Its lipophilicity enables it to distribute to the lipid layer of the skin and be secreted into the ear canal through the sebaceous glands. Without directly applying the medication to the ear canal, it can achieve systemic treatment, providing a convenient and efficient solution for deep or stubborn ear mite infections. This characteristic is particularly prominent among similar drugs.
Hot Tags: milbemycin oxime powder, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, benzocaine 200mesh, Chlorhexidine Diacetate CAS 56 95 1, Octreotide Acetate Powder, articaine hydrochloride powder, Cryptotanshinone, 1 5 Dimethylhexylamine











