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Mar. 31th 2025
Pregabalin powder ( lyrica ), also known as prostaglandin, is mainly pregabalin, chemical name (s) - 3-aminomethyl-5-methylcaproic acid. As a professional manufacturer of pregabalin, we also provide the specifications of pregabalin crystal on the basis of pregabalin, which not only improves the professional attitude of our scientific researchers, It also reflects our understanding and mastery of the product. As an antiepileptic drug, it is mainly used to treat postherpetic neuralgia in clinic. In addition, pregabalin can also be used for sleep. After the above introduction and the details below, if you want to know where to buy prabalin? Please give your trust to professional technicians. We are a manufacturer of pregabalin, with professional laboratories and researchers who have worked in the laboratory for more than ten years. Due to our good service and transaction record, we have won the trust of many customers. The pregabalin market has also been promoted in many countries, such as Saudi Arabia, the United Arab Emirates, Australia, Canada and so on. Please leave your information. We are happy to use the most professional technology to provide you with one-to-one service.
Additional information of chemical compound: Melting point 194-196 ° C, Specific rotation D23 + 10.52 ° (C = 1.06 in water), Boiling point 274.0 ± 23.0 ° C (predicted), Density 0.997 ± 0.06 g / cm3 (predicted), Flash point 9 ℃, Storage condition 2-8 ° C, Solubility deionized water: ≥ 10mg / ml, Acidity coefficient (PKA) 4.23 ± 0.10 (predicted), Form white powder, InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N
Pregalin is a synthetic GABA analogue with the molecular formula C8H17NO2. Its chemical structure is related to GABA( γ- Aminobutyric acid is a six membered ring with six carbon atoms and one nitrogen atom, containing both an amino methyl group and a carboxyl group. In the molecular structure of Pregabalin, there is a double bond between the carbon and nitrogen atoms, which gives this six membered ring a certain degree of unsaturation. In addition, the pregarin molecule also contains a free carboxyl group and an amino group, making it highly polar.
The molecular structure characteristics of Pregabalin give it some unique pharmacological properties. Firstly, the molecular structure of pregarin is similar to that of GABA, allowing it to bind to GABA receptors and exert its pharmacological effects. Secondly, the amino methyl and carboxyl groups in pregarin molecules are polar groups, which makes them highly soluble in water, facilitating drug absorption and distribution. In addition, the double bonds and unsaturation in pregarin molecules give them a certain degree of stability, which can resist the attack of free radicals and ensure the stability of their pharmacological effects.
Lyrica's molecular structure analysis also indicates the presence of a chiral center in its molecule. This means that Lyrica has two different stereoisomers, namely the left-handed and right-handed isomers. Among them, left-handed bodies have high pharmacological activity, while right-handed bodies have almost no pharmacological activity. Therefore, chiral separation is required in the production process of Lyrica to ensure that the obtained product is a left-handed enantiomer.
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Pregabalin powder is a γ-aminobutyric acid (GABA) analogue, similar in structure and action to gabapentin, with anti-epileptic, analgesic and anti-anxiety activities. The mechanism of antiepileptic action of pregabalin is still unclear. In laboratory studies, pregabalin showed anticonvulsant activity in various epileptic models; The activity profile of animal models was similar to that of gabapentin, but pregabalin was 3-10 times as active as gabapentin. One of the pregabalin side effects is peripheral edema and prolonged PR interval.
The following is a simplified synthesis route for Ppregabalin Powder, please note that this is not an actual method of industrial production, but rather used to illustrate the concept.
Objective: To reduce 3-aminopropanol (3-aminopropanol) by hydrogenation.
Reaction conditions: In the presence of catalysts (such as platinum, palladium, etc.), hydrogen gas is used for hydrogenation reduction.
H2NCH2CN+2H2+{catalyst → H2NCH2CH2CH2OH
Purpose: To convert 3-aminopropanol into corresponding esters in preparation for subsequent cyclization reactions.
Reaction conditions: The reaction between acyl chloride (such as acetyl chloride, propionic acid chloride, etc.) or carboxylic acid and alcohol is usually carried out under alkaline conditions.
H2NCH2CH2CH2OH+(CH3CO) 2O+catalyst → CH3COOCH2CH2CH2NH2+CH3COOH
Purpose: To convert esters into compounds containing the core structure of It . Due to the complex structure of pregabalin, this step may involve multiple reactions and the formation of intermediates.
Reaction conditions: This step may require specific catalysts, temperature and pressure, as well as possible protective steps to ensure the correct conversion of functional groups.
Hypothetical intermediate steps: For simplicity, we assume the existence of an intermediate that is a precursor to the pregabalin structure, but may lack certain functional groups or have different protective groups.
CH3COOCH2CH2CH2NH2+Catalyst → Intermediate
Intermediate+catalyst → Pregabalin like structure
Objective: To modify the functional groups of pregabalin analogues to obtain the final pregabalin structure.
Reaction conditions: Depending on the type of functional group required, it may involve reactions such as oxidation, reduction, halogenation, alkylation, etc.
Pregabalin like structure+catalyst → C8H17NO2
Objective: To convert pregabalin into its hydrochloride form to increase its water solubility and stability.
Reaction conditions: Add excess hydrochloric acid to an appropriate solvent, such as ethanol or isopropanol.
Pregabalin+HCl → C8H18N2O
Objective: In the actual synthesis process, it is often necessary to construct the core structure of pregabalin through multi-step reactions, which involves the preparation and separation of a series of intermediates.
Reaction conditions: These reactions may require specific catalysts, temperature, pressure, and reaction time to ensure the efficiency and selectivity of the reaction.
Purpose: Pregabalin has a chiral carbon atom, so its synthesis process requires the introduction and separation of chiral centers.
Method: This is usually achieved by using chiral catalysts, chiral reagents, or chiral separators. For example, a single enantiomer of pregabalin can be prepared through asymmetric synthesis or chiral separation.
Note: Chiral synthesis and separation are complex and intricate processes that require precise control of reaction conditions and operational steps.
Objective: In order to improve the yield, purity, and production efficiency of pregabalin, it is necessary to optimize the synthesis route and process conditions.
Method: This includes screening catalysts, adjusting reaction temperature and time, optimizing solvent selection, etc. In addition, advanced technologies such as continuous flow reactors can also be used to improve production efficiency.
Attention: The optimization process needs to comprehensively consider factors such as cost, environmental friendliness, and product quality.
Purpose: After determining the appropriate synthesis route and process conditions, it is necessary to scale up the synthesis process to industrial production scale and implement strict quality control.
Method: This includes establishing appropriate production processes, selecting appropriate production equipment, and establishing strict quality control standards. In addition, comprehensive analysis and testing of raw materials, intermediates, and final products are required to ensure the quality and safety of the products.
Although the above synthesis route is simplified and hypothetical, it provides a conceptual framework for understanding the basic steps and principles of pregabalin powder synthesis. The actual synthesis route may involve more intermediates and complex reaction conditions. In addition, for large-scale production of pregabalin, more complex and efficient synthesis methods may be adopted in industry.
The molecular structure characteristics of Pregabalin give it some unique pharmacological properties and it has a wide range of applications in the medical field.
1. Molecular Structure Characteristics
The chemical name of it is (S)-3-(aminomethyl)-5-methylhexanoic acid, its molecular formula is C8H17NO2, and its molecular weight is usually 159.23 (some sources also give 145.199, but 159.23 is more common). It is a white to off-white powder or white crystalline powder with a melting point of 194 to 196 °C. In molecular structure, It is characterized as a structural derivative of gamma-aminobutyric acid (GABA), but does not bind directly to GABAA, GABAB, or benzodiazepine receptors.
2. Pharmacological properties
High affinity for the α2-δ site:
It has a high affinity for the α2-δ site (an auxiliary subunit of voltage-gated calcium channels) in the central nervous system. This binding may exert its pharmacologic effects by modulating calcium channel function and reducing the calcium-dependent release of some neurotransmitters.
Analgesic and Anticonvulsant Effects:
Results from studies in transgenic mice and structurally related compounds (e.g., gabapentin) suggest that the analgesic and anticonvulsant effects of It in animal models may be related to its binding to the α2-δ subunit. In vitro studies have also shown that It may be effective in controlling neuropathic pain by modulating calcium channel function and reducing calcium inward flow, with a subsequent reduction in excitatory neurotransmitter release.
Safety And Tolerance:
It has demonstrated a favorable safety and tolerability profile in clinical trials. However, adverse reactions are dose-dependent and may result in higher discontinuation rates. Common adverse reactions include dizziness, drowsiness, dry mouth, edema, blurred vision, and weight gain.
3. Application cases in medical field
Postherpetic neuralgia:
Pregabalin capsule is a commonly used drug for the treatment of postherpetic neuralgia. It reduces pain and improves patients' quality of life by regulating the release of neurotransmitters.
Adjunctive treatment of epilepsy:
It is also used as an adjunctive treatment for partial seizures. By inhibiting the α2-δ subunit of voltage-dependent calcium channels in the central nervous system, Pregabalin reduces neuronal excitability, thereby controlling seizures.
Sciatica:
Clinical studies have shown that It is significantly more effective than the traditional antiepileptic drug carbamazepine in the adjunctive treatment of sciatica. It can reduce the release of excitatory neurotransmitters, effectively control neuropathic pain, and small adverse reactions, well tolerated.
In summary, It has a wide range of application prospects in the medical field by virtue of its unique molecular structure characteristics and pharmacological properties. However, its adverse effects and dose dependence should also be noted when used to ensure patient safety.
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