Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 2,2-dibromo-2-cyanoacetamide cas 10222-01-2 in China. Welcome to wholesale bulk high quality 2,2-dibromo-2-cyanoacetamide cas 10222-01-2 for sale here from our factory. Good service and reasonable price are available.
2,2-Dibromo-2-cyanoacetamide (DBNPA) is a white crystalline powder that is stable and non volatile at room temperature. It has a musty and pungent odor. Soluble in general organic solvents such as methanol, ethanol, acetone, and slightly soluble in water. The storage environment should be kept away from strong oxidizing agents and strong alkalis. It can effectively kill fungi that cause plant wilt and is a common broad-spectrum fungicide used for industrial mold prevention and sterilization.
Due to its non oxidizing properties, it is not easy to damage membrane components during sterilization, making it very friendly to membrane components with high precision. Its prominent feature is its dual advantages of rapid hydrolysis in the environment and efficient action at low doses. DBNPA is commonly used to prevent the growth and reproduction of bacteria and algae in papermaking, industrial circulating cooling water, lubricants for metal processing, pulp, wood, coatings, and plywood. It can also be used as a slime control agent and is widely used in pulp and circulating cooling water systems in paper mills. As a broad-spectrum and efficient fungicide, it can quickly penetrate the cell membrane of microorganisms and act on certain protein groups, causing the normal redox process of cells to stop, leading to cell death. At the same time, its branches can selectively brominate or oxidize special enzyme metabolites of microorganisms, ultimately leading to microbial death.

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Chemical Formula |
C3H2Br2N2O |
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Exact Mass |
240 |
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Molecular Weight |
242 |
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m/z |
242 (100.0%), 240 (51.4%), 244 (48.6%), 243 (3.2%), 241 (1.7%), 245 (1.6%) |
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Elemental Analysis |
C, 14.90; H, 0.83; Br, 66.07; N, 11.58; O, 6.61 |
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Melting point |
Melting point 122-125 ° C (lit.) |
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Boiling point |
Boiling point 123-126 ° C |
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Density |
2.3846 (rough estimate) |
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Storage conditions |
insert atmosphere, 2-8 ° C |
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solubility alcohol |
solublesoluble 40 parts of solvent |
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Acidity coefficient ( pKa ) |
11.72 ± 0.50 (predicted) |
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Refractive index |
1.6220 (estimated) |
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Industrial Circulating Water Treatment: Bactericidal and Algaecidal Agent
2,2-Dibromo-2-cyanoacetamide is one of the most widely used non-oxidizing biocides in industrial circulating water systems. It can rapidly penetrate microbial cell walls, damage enzyme systems and nucleic acid structures, and efficiently kill common waterborne microorganisms such as bacteria, fungi and algae.
Meanwhile, it effectively removes biofilm from the surfaces of pipelines and heat exchangers, improving heat transfer efficiency and reducing equipment corrosion risks.Its outstanding advantages include fast degradation in water, low residue, environmental friendliness and no long-term cumulative pollution. It also has good compatibility with commonly used scale inhibitors and corrosion inhibitors. Widely applied in circulating cooling water systems in petrochemical, power, steel, chemical and other industries, it is a key agent ensuring continuous production.


Papermaking Industry: Preservation of White Water and Pulp
In papermaking, pulp and white water systems are highly susceptible to microbial growth, leading to slime, deposits, web breaks, pinholes in paper and equipment clogging. DBNPA can rapidly inhibit microbial proliferation and control slime formation without generating foam, and does not affect paper strength or brightness.
It decomposes quickly in alkaline white water systems without interfering with subsequent papermaking and sizing processes. It also reduces odor and spoilage, extends the recycling cycle of white water, and enhances the operational stability of paper machines, making it an important preservative in modern papermaking processes.

Metalworking Fluids: Antiseptic and Antifungal Agent
Water-based cutting fluids, emulsions, rolling fluids and other metalworking fluids are prone to microbial contamination during use, resulting in odor, stratification and failure. As a highly effective preservative, DBNPA inhibits the growth of bacteria and fungi at low concentrations, extending the service life of working fluids and reducing replacement frequency.It acts fast without damaging lubricating or anti-rust components, causes no corrosion to metal workpieces, and is compatible with various water-soluble processing fluid systems. It is widely used in machinery manufacturing, automotive parts processing and other fields.
Oilfield Water Treatment and Water Injection Systems
Oilfield reinjection water and fracturing fluids often contain harmful microorganisms such as sulfate-reducing bacteria and iron bacteria, which can easily cause pipeline corrosion, hydrogen sulfide generation and formation plugging. DBNPA can efficiently kill such bacteria, control biofouling and corrosion hazards, and ensure unobstructed water injection systems.Meanwhile, its degradation products are formation-friendly and do not cause secondary pollution. Suitable for water treatment processes in offshore and onshore oilfields, it plays an important role in improving oil recovery efficiency and reducing maintenance costs.
Preservation of Coatings, Adhesives and Daily Chemical Products
In water-based coatings, latexes, adhesives, printing inks and other products, DBNPA can be used as a preservative and antifungal agent to prevent mold, deterioration and odor during storage and use, maintaining stable product performance.Due to its broad-spectrum bactericidal activity, rapid action, low toxicity and easy degradability, it is also used in small amounts in some detergent and cleaning product formulations to enhance microbial resistance and shelf life.
Application as an Organic Synthesis Intermediate
In the field of fine chemicals, DBNPA can also serve as an organic synthesis intermediate, participating in bromination, amidation and other reactions for the preparation of active compounds such as pharmaceuticals and pesticides.The bromine atom and cyano group in its molecular structure exhibit high reactivity, allowing it to act as a versatile synthetic building block in the construction of drug molecules and heterocyclic compounds.

The detailed steps for the synthesis method of 2,2-Dibromo-2-cyanoacetamide are as follows:
Add 16.8 grams of cyanoacetamide to a 500m1 four necked bottle. Cyanoacetamide is an organic compound that contains cyanide and acetamide groups in its molecular structure. In this reaction, cyanoacetamide is used as the starting material to synthesize the desired target product.
Add 200ml of crystallization mother liquor in Example 1. The mother liquor in this step is the product from the previous synthesis process, which contains the crystals of the desired target product. The purpose of adding mother liquor is to provide an environment conducive to generating the target product, thereby helping to improve the yield and quality of the product.
Place the reaction bottle in a water bath and cool it to below 20 ℃. Cooling in a water bath is to control the reaction temperature and ensure that the reaction takes place under the set temperature conditions.
Add 32 grams of bromine under stirring, about 20 minutes to complete. Bromine is a halogen compound with strong oxidizing properties. In this reaction, bromine is used as an oxidant to oxidize cyanoacetamide. Under stirring conditions, gradually add bromine to the reaction system to ensure the continuity and uniformity of the reaction.
Add 179 grams of 10% sodium hypochlorite solution dropwise, and continue stirring for 15 minutes after adding. Sodium hypochlorite is a strong oxidant with bactericidal and disinfection effects. In this reaction, the role of sodium hypochlorite is to further oxidize cyanoacetamide, ensuring complete conversion to the target product. During the process of adding sodium hypochlorite solution dropwise, the dropwise acceleration should be controlled to avoid excessive or insufficient oxidation.
Filter and precipitate. This step is to separate the generated solid precipitate, i.e. the target product, from the reaction solution. By filtering, the solid and liquid are separated to obtain a pure target product.
Wash and precipitate twice with 50m1 water. This step is to wash the solid sediment and remove the mother liquor and unreacted substances attached to the surface. By washing with water, the target product can be made more pure.
Dry at 60 ℃ to obtain 45.5 grams of finished product. This step is to dry the solid product at a specified temperature in order to remove any remaining moisture and obtain the dried finished product. In this example, the drying temperature is 60 ℃, but the specific drying temperature may vary depending on different reaction conditions.
The yield is 94.0%, and the mother liquor is recycled. This step is to calculate the yield of the target product after completing the above operation. The yield is the ratio of the actual weight of the target product obtained to the theoretically achievable weight of the target product. In this example, the yield is 94.0%. The recycling of mother liquor is to increase production and reduce costs, by recycling the mother liquor from the reaction bottle and reusing it for the next batch of reactions.
The beneficial effect of this method is reflected in the use of cheap sodium hypochlorite as an oxidant, which fully utilizes bromine and reduces the cost of raw materials; The bromination reaction is almost quantitatively carried out, the product synthesis yield is improved, and the mother liquor can be recycled.

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Physical properties
Appearance and Condition: White crystalline powder with a musty pungent odor.
Melting Point and Boiling Point: Melting point is 122-125℃, boiling point is 221.5℃ (760 mmHg).
Solubility:Slightly soluble in water (solubility at 25℃ is approximately 1.5g/100mL), but solubility significantly increases with pH increase.Easy to dissolve in organic solvents such as acetone, polyethylene glycol, benzene, ethanol, etc., and can be miscible with water in any proportion (liquid product).
Density and Refractive Index: Density is 2.451 g/cm³, refractive index is 1.624 (25℃).
Stability:2,2-Dibromo-2-cyanoacetamide aqueous solution is stable under acidic conditions, but easily decomposes under alkaline conditions (pH from 6.7 to 9.7, half-life from 37 hours to 0.11 hours).Heating, ultraviolet light or fluorescence irradiation can accelerate dissolution, but high temperature (such as 250℃) will cause decomposition.
Chemical Properties
Reactivity:In the presence of reducing agents (such as hydrogen sulfide), bromination is deprotonated, generating non-toxic cyan ethylamine, resulting in loss of bactericidal activity.Incompatible substances include bases and strong reducing agents (such as hydrogen sulfide), and avoid dangerous reactions.
Molecular Structure:Chemical formula is C₃H₂Br₂N₂O, molecular weight 241.87.Contains cyano group (-CN) and bromine atom (-Br), giving it strong oxidizing property and bromination ability.
Toxicity and Environmental Impact
Toxicity:Moderate toxicity, inhalation, skin contact or ingestion harmful. Female guinea pigs LD₅₀ is 118mg/kg (refer to acetamide toxicity).When operating, protective equipment must be worn to avoid direct contact.
Environmental Impact:Waste and by-products may be harmful to the environment, need to be properly handled.Avoid mixing with food, alkalis, hydrogen sulfide, and keep away from heat sources and fire sources.
Packaging and Storage
Packaging: Sealed packaging in hard cardboard barrels lined with plastic film, or 25kg bags.
Storage conditions:Cool, dry, well-ventilated, avoid direct sunlight.Store separately from bases, hydrogen sulfide, food to prevent cross-contamination.Storage temperature is recommended to be below 25℃, some products need to be refrigerated (2-8℃).
FAQ
What is the CAS number of 2 2 Dibromo 2 cyanoacetamide?
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2,2-Dibromo-2-cyanoacetamide | 10222-01-2 | Tokyo Chemical Industry (India) Pvt.
What is the mechanism of action of the DBNPA?
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Once inside the cell, DBNPA reacts with these sulfur-containing groups, forming covalent bonds that inactivate enzymes involved in redox equations. This disruption is irreversible and stops energy production, leading to cell death within 5-10 minutes of exposure.
Is DBNPA an oxidizer?
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DBNPA is not an oxidizing biocide and is not a bromine release biocide. DBNPA does act similar to the typical halogen biocides. The solid formulated DBNPA as a tablet is slow release form and not an oxidizer.
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