2-Hydroxyethanesulphonic Acid, also known as ethylene glycol monosulfate, is an organic compound. Molecular formula C2H6O4S, CAS 107-36-8, molecular weight 138.13. It is a white or slightly yellow crystalline powder. Easy to dissolve in water, slightly soluble in alcohol, acetone, and benzene. Under conditions of strong acid, strong alkali, or heating, hydrolysis or decomposition may occur. It can be used as a plant growth regulator or an ingredient in pesticide formulations. Plant growth regulators are a special type of chemical used to regulate plant growth and development. Pesticides are chemicals used to prevent and control agricultural pests and diseases. It is an organic sulfur compound widely distributed in animals and some red algae. It can be used as an anionic detergent and has anti settling activity on the glans penis. As a supplier of 2-hydroxyethyl sulfonic acid, our high-quality products have received widespread praise in the Japanese market.
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Chemical Formula |
C2H6O4S |
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Exact Mass |
126 |
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Molecular Weight |
126 |
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m/z |
126 (100.0%), 128 (4.5%), 127 (2.2%) |
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Elemental Analysis |
C, 19.05; H, 4.80; O, 50.74; S, 25.42 |
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Melting point |
< 25 ° C |
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Density |
1.344 (estimate) |
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Storage conditions |
sealed in dry, 2-8 ° C |
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solubility alcohol |
solublesoluble 40 parts of solvent |
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Acidity coefficient ( pKa ) |
1.39 ± 0.50 (predicted) |
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Flash point |
120 ° f |
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Vapor density |
5.21 (vs air) |
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Refractive index |
N20 / D 1.472 (lit.) |
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2-Hydroxyethanesulphonic Acid, also known as ethylene glycol monosulfate, has various potential applications in biomedical research.
1. Drug design and discovery: In the process of drug development, it can be used as a lead compound or synthetic raw material for drugs. Due to its specific chemical structure, this compound may have affinity for certain biological targets, making it a candidate material for developing new drugs.
2. Biosensors: In the field of biosensors, active substances that can be used as sensitive components for detecting biomolecules or ions. By combining with specific biomolecules, this compound can change its conductivity or fluorescence properties, thereby achieving high sensitivity detection of biomolecules.
3. Biological imaging: In biological imaging technology, it can be used as a component of fluorescent probes or magnetic resonance imaging agents. By combining with specific biomolecules, this compound can generate fluorescent signals or alter magnetic resonance signals, providing detailed information about biological tissues or cells.
4. Cell culture and tissue engineering: In cell culture and tissue engineering, it can serve as a supporting matrix or scaffold material for cell growth. This compound can provide the physical and chemical environment required by cells, promoting cell proliferation and differentiation.
5. Biological analysis and detection: can be used as a reagent in biological analysis to detect specific components or indicators in biological samples. For example, it can be used together with other reagents in experiments such as immunoassay, enzyme activity detection, or nucleic acid analysis.
6. Water treatment: can be used as a water treatment agent to remove harmful substances and impurities from water. It can combine with heavy metal ions, organic pollutants, etc. in water to remove pollutants through precipitation, adsorption, or ion exchange, achieving the goal of purifying and treating water.
7. Soil remediation: In soil remediation, it can be used to extract heavy metal ions from soil, such as lead, mercury, cadmium, etc. By combining with heavy metal ions and extracting them from the soil, the risk of soil pollution can be reduced and the soil ecological environment can be protected.
8. Industrial wastewater treatment: The large amount of wastewater generated during industrial production often contains a large amount of harmful substances and heavy metal ions. It can be used as a treatment agent in industrial wastewater treatment, removing harmful substances from wastewater through adsorption, precipitation, or ion exchange technologies to meet discharge standards or reuse conditions.
2-Hydroxyethanesulphonic acid, also known as hydroxyethyl sulfonic acid, is an organic sulfur compound with hydroxyl and ethyl groups. It has many unique properties and is widely used in various fields.
Chemical Industry Applications
(1) Catalysts, stabilizers, and reaction intermediates
As a compound with strong acidity, it can be used as a catalyst, stabilizer, and reaction intermediate in the chemical industry.
In the process of organic synthesis, it plays an important role, such as in the synthesis of certain drugs, dyes, and plastics.
(2) Electroplating additives
In the electroplating industry, it can be used as an electroplating additive, which helps improve the electroplating effect and enhance the electroplating quality.
(3) Surfactant
This substance or its salts (such as sodium hydroxyethyl sulfonate) have excellent solubility and stability, and can be used as surfactants.
They can increase the stability of the formula, enhance the cleaning power of hard water, and are gentle on the skin.
These characteristics make them widely applicable in soap and shampoo formulations for home care, industrial and public facilities, and personal care markets.
(4) Metal corrosion inhibitors and buffering agents
Can be used as a metal corrosion inhibitor to protect metal surfaces from corrosion damage.
At the same time, it can also serve as a buffering agent to adjust the pH of the solution.
Biology and Medical Applications
(1) Synthesis intermediates of bioactive substances
In the fields of biology and medicine, it can be used as a synthetic intermediate for bioactive substances.
For example, it can participate in the synthesis of drugs such as hormones and antibiotics.
(2) Biological dyes and biomarkers
It is also used as a biological dye and biomarker for studying the structure and function of biomolecules.
(3) Pharmaceutical raw materials
This substance or its derivatives can be used as raw materials for the preparation of drugs.
For example, sodium hydroxyethyl sulfonate has pharmacological effects such as anti-inflammatory, analgesic, and anti allergic effects, and can be used to prepare eye drops, skin medications, injections, etc.
Daily life applications
(1) Cosmetics and personal care products
In daily life, it can be used as an ingredient in cosmetics and personal care products.
It can be used as a dispersant and stabilizer to prepare cream, lotion, shampoo and other cosmetics, so that the product is uniform in texture and easy to apply.
Meanwhile, due to its good solubility and surface activity characteristics, it can also be used as an ingredient in detergents and cleaning agents for cleaning and decontamination.
(2) Detergent
The substance and its salts (such as sodium hydroxyethyl sulfonate) are mild and high foam surfactants, which can be used to prepare various detergents.
Such as laundry detergent, dishwashing liquid, etc., have excellent washing performance and skin affinity.
Other industrial applications
(1) Plastic, rubber, fiber, and coating industries
In industries such as plastics, rubber, fibers, coatings, etc., this substance or its salts can be used as dispersants and stabilizers.
They help improve the processing performance of these materials and the quality of the final product.
(2) Paper industry
In the papermaking industry, this substance or its salts can be used as papermaking additives.
They help improve the physical and chemical properties of paper and enhance its quality.
(3) Pesticide emulsifier
This substance or its salts can also be used to prepare pesticide emulsifiers.
They help improve the dispersibility and stability of pesticides, thereby increasing their utilization and control effectiveness.
Application examples
(1) Drug synthesis
In the process of drug synthesis, 2-hydroxyethyl sulfonic acid can serve as an important reaction intermediate.
For example, it can participate in the synthesis of compounds with specific pharmacological activities, which have broad application value in the field of medicine.
(2) Preparation of dyes
It can also be used to prepare dyes.
By reacting with specific reactants, dyes with specific colors and properties can be synthesized, which have a wide range of applications in fields such as textiles and printing.
(3) Personal care product formula
In personal care product formulas, it can be one of the important ingredients.
It can provide excellent stability and dispersibility, making the product easier to apply and absorb.
Meanwhile, due to its gentle nature, it can also be used to prepare various products suitable for sensitive skin.
(4) Electroplating solution formula
In the electroplating solution formula, it can be used as one of the important additives.
It can improve the performance of the plating solution, enhance the uniformity and adhesion of the plating layer.
At the same time, 2-hydroxyethanesulphonic acid can also reduce energy consumption and waste emissions during the electroplating process, improving the environmental performance of the electroplating process.
(5) Detergent formula
In detergent formulations, this substance or its salts can serve as important surfactant components.
They can provide excellent decontamination performance and foam stability, making detergent more efficient and easy to use.
Meanwhile, due to their mild nature and affinity for the skin, they can also be used to prepare various mild detergents.
(6) Pesticide emulsifier formula
In pesticide emulsifier formulations, this substance or its salts can serve as important emulsifier components.
They can improve the dispersibility and stability of pesticides, making them easier to spray and absorb.
At the same time, they can also reduce the loss and waste of pesticides, improve the utilization rate and control effect of pesticides.
Biomineralization Regulation: A New Approach for Bone Repair
As a biomineralization regulator: Synergistically promoting bone regeneration with trace elements
2-Hydroxyethylsulfonic acid can integrate inorganic ions such as calcium and phosphorus through chelation, simulating the mineralization process of natural bone. Recent studies have shown that when combined with trace elements such as iron (Fe) and manganese (Mn), it can significantly enhance the bone repair effect:
Experimental Design: The researchers constructed a layered scaffold of mineralized collagen-hydroxyapatite (Col-HA) loaded with Fe/Mn, and compared the osteogenic capabilities of the simple Col-HA scaffold, the Col-FeHA scaffold, the Col-MnHA scaffold, and the Col-FeMnHA scaffold.
Key Findings:
Gene Expression: The scaffolds with Fe/Mn incorporation significantly upregulated the expression of osteogenic-related genes (such as ColI, OPG, Osterix), with the Col-FeMnHA scaffold having the highest gene expression level, indicating a synergistic effect of Fe/Mn.
Cell Behavior: On scaffolds containing Fe/Mn, the in vitro osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) was enhanced, the cell adhesion was tighter, and a clear biological membrane was formed within 7 days, while no such phenomenon was observed on the simple Col-HA scaffold.
In Vivo Repair: After implanting the scaffolds into a mouse cranial defect model, the scaffolds containing Fe/Mn showed higher bone regeneration rate and bone density, and the aggregation of osteoclasts was more significant, indicating that they accelerated repair by regulating the balance of bone remodeling.
As Additives for Scaffold Materials: Optimizing Structure and Function
2-Hydroxyethylsulfonic acid can be used as a modifier for scaffold materials to regulate the mineralization process and improve the biocompatibility and bone conductivity of the scaffolds:
Mineralization mechanism: Traditional collagen mineralization relies on non-collagen proteins (such as osteocalcin), but it is costly and has limited sources. The study used a synthetic analogue of 2-hydroxyethylsulfonic acid (such as polyacrylic acid) to simulate the chelating function of non-collagen proteins, combined with the templating effect of trisodium phosphate, to achieve ordered mineralization within collagen fibers.
Scaffold performance:
Structure: The Col-HA scaffolds prepared by homogenization or unidirectional freeze-thaw technology present a porous or layered structure, among which the layered scaffolds are more conducive to cell migration and nutrient transportation.
Biocompatibility: All scaffolds are non-cytotoxic, and the layered scaffolds containing Fe/Mn significantly promote the proliferation and adhesion of BMSCs, indicating that the scaffold materials derived from 2-hydroxyethylsulfonic acid are suitable for bone tissue engineering.
As a Metabolic Regulator: Participating in the Balance of Bone Metabolism
2-hydroxyethylsulfonic acid is an endogenous metabolite (such as the precursor of taurine), which can affect bone repair by regulating cellular metabolism:
Metabolic pathway: Mammals can convert taurine to 2-hydroxyethylsulfonic acid through enzymatic deamination, which can be detected in plasma and urine. High concentrations of 2-hydroxyethylsulfonic acid are associated with protection against type 2 diabetes.
Potential mechanism:
Calcium regulation: 2-hydroxyethylsulfonic acid may affect intracellular calcium signaling by chelating calcium ions, thereby regulating osteogenic differentiation of BMSCs.
Anti-inflammatory effect: Its derivatives (such as 2-hydroxyethylsulfonic acid sodium) have mild surface activity and may promote bone healing by reducing inflammatory responses.
Industry Trends and Opportunities
Demand for bone tissue engineering: The global bone defect repair market is expected to reach 30 billion US dollars by 2030. 2-hydroxyethylsulfonic acid, as a low-cost and highly effective mineralization regulator, is expected to replace some traditional materials (such as calcium phosphate ceramics).
Personalized medical applications: Combined with 3D printing technology, 2-hydroxyethylsulfonic acid-derived scaffolds can achieve patient-specific repair and meet the treatment needs for complex bone defects.
Interdisciplinary collaboration: Cooperation with fields such as materials science and bioinformatics can further reveal the molecular mechanism of 2-hydroxyethylsulfonic acid in bone metabolism and promote new drug development.
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