Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 6-methylcoumarin cas 92-48-8 in China. Welcome to wholesale bulk high quality 6-methylcoumarin cas 92-48-8 for sale here from our factory. Good service and reasonable price are available.
6-Methylcoumarin is a synthetic organic compound with the chemical formula C₁₀H₈O₂ and CAS number 92-48-8. It is a white crystalline solid with a coconut-like or delicate fig-like sweet odor, making it valuable as a fragrance ingredient in cosmetics, perfumes, and flavorings. It is approved for use as a food additive in various countries, employed in the formulation of coconut, vanilla, and caramel-type scents.
Beyond its applications in the fragrance and flavor industry, it exhibits interesting biological properties. It demonstrates anti-inflammatory activity and has been studied for its pharmacological effects. Research using Caco-2 cell models indicates that it has high intestinal permeability, suggesting it can be absorbed effectively when ingested. However, it is important to note that it is classified with certain safety warnings due to its potential to cause skin irritation and allergic reactions, with designations such as "Xn" (harmful) and specific hazard statements under regulatory guidelines.
|
|
|
|
Chemical Formula |
C10H8O2 |
|
Exact Mass |
160 |
|
Molecular Weight |
160 |
|
m/z |
160 (100.0%), 161 (10.8%) |
|
Elemental Analysis |
C, 74.99; H, 5.03; O, 19.98 |
6-Methylcoumarin, with the chemical formula C ₁₀ H ₈ O ₂, is an important organic compound and belongs to the coumarin class of derivatives. It has demonstrated extensive application value in multiple fields due to its unique chemical structure and properties.
Fragrance and essence
Preparation of coconut essence: it has a sweet smell like coconut, and is an important raw material for preparation of coconut essence. In the food industry, it is widely used to prepare coconut flavored candies, ice cream, beverages, and other foods, adding a strong coconut aroma to these products and enhancing consumers' consumption experience.
Preparation of vanilla essence: In addition to coconut flavor, it can also be used to prepare vanilla essence. Its unique aroma and vanilla aroma complement each other, making the vanilla essence more realistic and lasting. This essence is widely used in baking food, dairy products, candy and other fields.
Preparation of caramel essence: It can also be used to prepare caramel essence to add caramel aroma and flavor to food. This essence is widely used in candy, chocolate, drinks and other foods, making these products more attractive and delicious.
Application of other food essence: In addition to the above three flavors, this substance can also be used to prepare other food essence, such as pineapple, coffee and other flavors. These essence provide a wealth of choices for the food industry and meet consumers' needs for diversified foods.
Enhancing the milk and bean aroma of cigarettes: It also has important applications in the tobacco industry. It is used to prepare milk flavor and bean flavor base modules and essence for cigarettes. By mixing them in specific weight portions, it can effectively highlight the milk flavor and bean flavor of cigarettes and improve the smoke quality of cigarettes. This application not only enriches the taste and flavor of cigarettes, but also meets consumers' demand for high-quality cigarettes.
Improving the smoking experience of cigarettes: In addition to enhancing the aroma quality of cigarettes, it can also be used to improve the smoking experience of cigarettes. By compounding with other spice ingredients, it can adjust the smoke concentration, softness and other indicators of cigarettes, making them easier to smoke and more comfortable to taste.
Preparation of perfume essence: 6-methylcoumarin has unique fragrance and stability, and is one of the important raw materials for preparation of perfume essence. It can be used in combination with other spice ingredients to form a perfume essence with rich, realistic and lasting fragrance. This essence is widely used in various perfume to bring consumers a pleasant smell experience.
Prepare skin care essence: In addition to perfume, it can also be used to prepare skin care essence.
Adding an appropriate amount of essence of the substance to skin care products can give the products pleasant fragrance and improve the consumer experience. At the same time, this essence also has certain antioxidant and anti-inflammatory effects, which helps to protect skin health.
Application of other cosmetics essence: It can also be used to prepare other kinds of cosmetics essence, such as shampoo, bath gel, etc. These essence provide a wealth of choices for the cosmetics industry and meet the needs of consumers for diversified cosmetics.
As an intermediate in the synthesis of fragrances, it plays an important role in the field of fragrance synthesis. It can be used as an intermediate for the synthesis of other coumarin derivatives, which can be chemically modified through oxidation, reduction, esterification and other reactions to obtain coumarin derivatives with different structures and properties. These derivatives have broad application prospects in the spice industry.
Improving the performance of spices: Through chemical modification, the aroma quality, stability, and other properties of the substance and its derivatives can be improved. For example, by introducing different functional groups, the volatility, solubility, and other indicators of spices can be adjusted, making them more suitable for different application scenarios. This modification research provides new ideas and methods for the development of the spice industry.
Exploring new aroma types: With the continuous changes and upgrades in consumer demand for spices, the development of new spices has become one of the important directions of the spice industry. As a compound with a unique chemical structure, it provides new possibilities for the development of novel fragrances. By modifying and transforming its structure, it is possible to explore spice compounds with new aroma types to meet the new needs of consumers.
Developing multifunctional fragrances: In addition to having fragrance, this substance and its derivatives may also have other biological activities or functional properties. For example, they may have antioxidant, anti-inflammatory, antibacterial and other effects. By conducting in-depth research on the biological activities of these compounds, multifunctional fragrances with multiple functions can be developed, injecting new vitality into the development of the fragrance industry
Initially identified for its pleasant coconut-like aroma, 6-Methylcoumarin emerged as a valuable synthetic fragrance. Early studies focused on optimizing its synthesis routes, with research exploring various precursors and catalysts to enhance yield and purity. The compound's inclusion in the list of permitted food additives by regulatory bodies like China's GB 2760 underscored its safety and utility in flavorings, particularly for coconut, vanilla, and caramel notes.
In the realm of organic synthesis, it served as a pivotal intermediate. Researchers investigated its reactivity, leading to the development of derivatives with enhanced biological activities. For instance, studies demonstrated its potential as an anti-inflammatory agent, with experiments showing its high permeability across intestinal barriers, suggesting possible oral bioavailability.
The advent of advanced analytical techniques, such as ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), enabled precise quantification in complex matrices. This advancement was crucial for quality control in fragrance formulations and for studying its pharmacokinetic properties.
Moreover, the role in photobiology was explored, with research indicating its minimal phototoxicity in cellular models, distinguishing it from certain photoactive coumarins. This property expanded its applications in sunscreens and other photoprotective formulations.
Recent studies have also delved into its potential as an adjuvant in cancer therapy. For example, research demonstrated its synergistic effects with paclitaxel in inhibiting esophageal cancer cell growth, highlighting its therapeutic potential when combined with conventional chemotherapeutics.
Overall, the research history of this substance indicates that it has evolved from a simple spice ingredient to a multifunctional compound, with applications covering cosmetics, pharmacology, and oncology. The ongoing research continues to reveal new aspects of its utility, ensuring its relevance in different scientific fields.
Frequently Asked Questions
Answer: Because it exists in a "twin crystal form". There are two crystal forms of 6-methylcoumarin: the alpha form has a melting point of 90 ° C and the beta form has a melting point of 82 ° C. Commercial products are usually labeled as 73-76 ° C, depending on the crystallization conditions and crystal form ratio. This polymorphic phenomenon affects its solubility and stability, and requires special attention in pharmaceutical formulations.
Answer: Yes! It can be perfectly encapsulated by cucurbitacin [8] urea (CB [8]) to form a host guest complex. After packaging, its fluorescence emission peak undergoes a significant red shift, and both quantum yield and fluorescence lifetime increase. What's even more amazing is that at a low temperature of 77K, it can emit phosphorescence even though it wasn't originally phosphorescent. This change in photophysical properties makes it suitable for constructing supramolecular catalytic reactors.
3.Why are there two terms for its storage temperature: "-20 ° C frozen" and "room temperature"?
Answer: This is a balance between "long-term stability" and "short-term convenience". AbMole and other strict suppliers suggest that powders can be stored for 3 years at -20 ° C and 2 years at 4 ° C; Most suppliers indicate that it should be stored at room temperature, cool, and dry. Compromise suggestion: If not in use for a long time, refrigerate at 2-8 ° C; If used frequently in the short term, keep in a dry and cool place. The key is shading and sealing, as it is sensitive to light exposure.
Answer: It is a typical example of "concentration determines taste". When it is below 50 ppm, it has a sweet and pleasant flavor similar to vanilla; When it exceeds 50 ppm, it will turn into an almost bitter taste. This concentration dependent taste reversal makes its application in food essence require precise control of dosage. The overall aroma is described as "sweet coconut, vanilla, creamy, with a powdery floral note".
Answer: It is a confirmed allergen exposed to light. In the 2012 report of the European Union Scientific Committee on Consumer Safety, 6-methylcoumarin was labeled as a "light contact allergen identified in humans". The historical problem stems from its widespread use in sunscreen products - after application, exposure to sunlight can cause phototoxic reactions such as burning sensation and erythema, often occurring within a few hours of contact, and as a photoallergen, it is unstable on the skin, making diagnosis difficult.
Hot Tags: 6-methylcoumarin cas 92-48-8, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, DIMETHYLPHOSPHINE OXIDE, Synthetic Chemical, 2 6 Pyridinedicarboxylic acid, 3 Phenyltoluene, 3 methyl 4 piperidone, 3 Nitrobenzaldehyde 99