Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of melanotan ii powder cas 121062-08-6 in China. Welcome to wholesale bulk high quality melanotan ii powder cas 121062-08-6 for sale here from our factory. Good service and reasonable price are available.
Melanotan II powder(MT-2) is a laboratory-made chemical similar to hormones in human body. Melanotan peptide has been proved to have melanin production ( tanning ) and yang-strengthening effects on human beings. Melanotan, CAS 121062-08-6, is a white peptide powder. Also known as α- Melanocyte stimulating hormone (α-MSH) is an endogenous peptide with strong melanocyte stimulating hormone activity. It binds to the melanocyte stimulating hormone receptor subtype MC1R and activates melanocytes to produce melanin under normal physiological conditions through the regulation of the hypothalamic pituitary adrenal axis. It may have specific optical properties, such as fluorescence and absorbance. These properties may be related to the structure and amino acid sequence of peptides. It is an artificially synthesized peptide hormone that simulates the regulatory mechanism of skin pigments in the human body. The main purpose is to regulate and deepen the pigmentation of the skin, resulting in a deeper brownish color.
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Melanotan Ii COA
Skin Tanning and Protection
It is primarily known for its ability to stimulate melanin production in the skin. Melanin is a pigment that gives skin its color and also acts as a natural sunscreen, protecting the skin from the harmful effects of ultraviolet (UV) radiation. By promoting tanning, Melanotan II can help individuals achieve a darker skin tone while potentially reducing the risk of skin cancer. However, it's important to note that the use of Melanotan II for this purpose is controversial and not approved for human use in many countries due to safety concerns.
Potential Therapeutic Applications
Although it is not currently approved for medical use, research suggests that it may have therapeutic benefits in certain conditions. For instance, some studies have investigated its potential use in the treatment of sexual dysfunction, specifically in males with erectile dysfunction. Melanotan II has been shown to exert a dose-dependent stimulatory effect on erections by triggering erectile events and reducing the latency period for the first erectile event. However, these findings are still preliminary, and further research is needed to confirm the safety and effectiveness of Melanotan II for this purpose.
Experimental Uses
In experimental settings, it has also been studied for its potential neuroprotective and neuroregenerative effects. For instance, it has been shown to promote peripheral nerve regeneration and enhance functional recovery after nerve injury in animal models. Additionally, Melanotan II has been investigated for its ability to reduce food intake and body weight, as well as its effects on thermogenesis in mice. These experimental findings suggest that Melanotan II may have potential therapeutic applications in the treatment of obesity and related metabolic disorders, but these uses are still under investigation.
It's crucial to emphasize that the use of Melanotan II for any of the above-mentioned purposes is currently experimental and not approved for human use. The safety and effectiveness of this compound have not been fully evaluated in clinical trials, and its long-term effects are unknown. Therefore, it's strongly advised against using Melanotan II without proper medical supervision and approval.
In conclusion, Melanotan II is a peptide hormone with diverse physiological effects that are currently being investigated for potential therapeutic applications. However, due to safety concerns and lack of clinical approval, its use for any medical purpose is not recommended at this time.
The synthesis of pure melanotan using chemical synthesis requires a series of chemical reaction steps and appropriate protective groups to protect the amino and carboxyl groups of amino acids. The following is a possible synthesis step and chemical equation:
Amino acid pretreatment：Treat the required amino acids with alkali to remove protective groups and obtain amino acids with free amino groups.
Condensation reaction：Dissolve the treated amino acids in an organic solvent (such as DMF), add a condensation agent (such as DIC) and a catalyst (such as HOBt), and stir at room temperature for several hours to days to complete the condensation reaction. This reaction requires nitrogen protection to prevent the impact of water oxidation.
Deprotection reaction：After the condensation reaction is completed, add deprotection reagents (such as TFA) and stir at room temperature for several hours to days to complete the deprotection reaction. This reaction also requires nitrogen protection.
Cleaning reaction：After the deprotection reaction is completed, add an appropriate amount of water and organic solvent (such as DMF), stir evenly, let it stand for layering, discard the water layer, and wash repeatedly to remove residual deprotection reagents and other impurities.
Cyclization reaction：Dissolve the cleaned product in an organic solvent (such as DMF), add a cyclizing agent (such as CDI), and stir at room temperature for several hours to days to complete the cyclization reaction. This reaction also requires nitrogen protection.
Purification reaction：After the cyclization reaction is completed, column chromatography is performed to obtain purified Melanotan. The specific steps include drying the reaction solution and dissolving it in an appropriate amount of organic solvent (such as ether), adding an appropriate amount of silica gel, mixing evenly, and performing column chromatography separation. When the eluent flows through the column, different components will flow out at different speeds, and each component will be collected for testing and purity analysis.
Freeze-drying：Dissolve the purified Melanotan in an appropriate amount of organic solvent (such as ether), add an appropriate amount of glycine, mix well, and perform freeze-drying treatment. During the freeze-drying process, water will be removed from the solution, resulting in a dry Melanotan solid.
The following are some chemical equations for synthesizing Melanotan Ii Powder using chemical synthesis method:
R1-NH2+R2-COOH → R1-NH-CO-R2
R3 protective group → R3-H
R4-H+R5-COOH → R4-CO-R5
R6-NH2+R7-COOH → R6-NH-CO-R7
R8-NH2+R9-COOH → R8-NH-CO-R9
Among them, R1, R2, R3, R4, R5, R6, R7, R8, and R9 represent different amino acid groups, respectively; The protective group represents the protective group. The above chemical equations are only schematic diagrams, and the actual synthesis process may vary depending on specific operations and experimental conditions.
In summary, the synthesis of melanotan peptide using chemical synthesis requires multiple chemical reaction and purification steps, and the reaction conditions and operating processes of each step need to be strictly controlled to ensure the purity and yield of the final product. At the same time, it is necessary to pay attention to the use of safe and environmentally friendly reagents and solvents, and comply with relevant safety operating regulations.
Adverse reactions
Skin reactions
Skin reactions are the most common adverse reactions, mainly including the following:
Excessive pigmentation: Melanotan peptide promotes melanin production, which may lead to excessive skin pigmentation, uneven pigmentation spots or freckles.
Neoplastic nevi: It has been reported that patients may develop atypical melanocytic naevi after using Melanotan peptide, which may pose a risk of malignant transformation.
In situ melanoma: In rare cases, the use of Melanotan peptide may be associated with the occurrence of melanoma in situ.
Skin allergies: Some patients may experience skin allergic reactions such as itching, erythema, rash, etc.
Cardiovascular system response
Melanotan peptide may have adverse effects on the cardiovascular system, including the following:
Elevated blood pressure: Melanotan peptide may activate the sympathetic nervous system, leading to an increase in blood pressure.
Increased heart rate: Some patients may experience an increase in heart rate, especially shortly after injection.
Facial flushing: Melanotan peptide may cause facial flushing, which is associated with elevated blood pressure and increased heart rate.
Digestive system response
Nausea: Nausea is the most common digestive system adverse reaction of Melanotan peptide, typically occurring within hours after injection and lasting for several hours to days.
Decreased appetite: Although Melanotan peptide has an appetite suppressing effect, some patients may experience decreased appetite, leading to weight loss.
Vomiting: A small number of patients may experience vomiting, especially when the dosage is too high or the injection speed is too fast.
Diarrhea: Some patients may experience diarrhea, which may be related to the stimulating effect of Melanotan peptide on the gastrointestinal tract.
Neurological response
Headache: Headache is a common neurological adverse reaction of Melanotan peptide, typically mild to moderate and lasting for several hours to days.
Dizziness: Some patients may experience dizziness, especially shortly after injection.
Fatigue: A small number of patients may experience fatigue, which may be related to the inhibitory effect of Melanotan peptide on the central nervous system.
Emotional fluctuations: Some patients may experience emotional fluctuations such as anxiety, depression, etc.
Risk factors
Dose and treatment duration
The higher the dose and the longer the treatment duration, the higher the incidence of adverse reactions. Suggest starting from 0.25mg/day, with weekly increments not exceeding 0.25mg, and a maximum dose not exceeding 1mg/day.
Product purity and source
Illegal channel products may contain impurities or incorrect doses, increasing the risk of allergies and infections. Preparations approved by FDA or EMA should be selected.
Individual difference
gene polymorphism (such as MC1 receptor sensitivity) and basic diseases (such as hypertension and diabetes) may affect the type and severity of adverse reactions.
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