MOTS-C peptide, a chemical product called a "12S rRNA C-type mitochondrial open reading frame" peptide. The molecular weight of MOTSC is approximately 3kDa. It is a hydrophobic peptide, which means it does not like to come into contact with water and is more soluble in organic solvents. It is believed to have various biochemical activities, including regulating energy metabolism, enhancing insulin sensitivity, promoting mitochondrial function, and anti-aging. It has various biochemical activities and stability, and is widely distributed in the human body. It is considered to have potential therapeutic effects, but more research is still needed to determine its mechanism of action and clinical application prospects. Shaanxi BLOOM Tech Co., Ltd has mots c peptide for sale. If you need mots c peptide buy and would like to know the mots c peptide price, please send us an email.
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MOTS c COA
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MOTS c, also known as the mitochondrial-derived mots-c peptide, is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA). It has garnered significant attention for its potential applications in various fields due to its diverse biological functions.
Application: MOTSc has been shown to promote metabolic homeostasis and reduce obesity and insulin resistance. It achieves this by accelerating glucose uptake and enhancing insulin sensitivity.
Research Findings: Studies have demonstrated that MOTSc treatment significantly reduces fasting blood glucose levels and improves insulin sensitivity in diabetic rat models. Product also shows potential in ameliorating cardiac and vascular dysfunction associated with diabetes, making it a promising therapeutic target for diabetes-related complications.
Cardioprotective Effects
Application: MOTSc exhibits cardioprotective properties by reducing myocardial damage and improving cardiac function.
Research Findings: Research has indicated that product treatment can alleviate myocardial fibrosis, improve mitochondrial function, and restore cardiac contractility in diabetic rats. The mechanism involves modulation of signaling pathways such as the CCN1/ERK1/2/EGR1 pathway, which plays a crucial role in cardiac remodeling and dysfunction.
Application: MOTSc has been implicated in enhancing exercise performance, increasing lifespan, and improving overall health in aging individuals.
Research Findings: Studies in mice have shown that product administration can improve exercise capacity, balance, and metabolic parameters in both young and aged mice. In particular, product treatment increased the lifespan of aged mice and improved their metabolic profile, suggesting its potential role in anti-aging therapies.
Treatment of Non-Alcoholic Fatty Liver Disease (NASH)
Application: MOTSc has been identified as a potential therapeutic agent for NASH by alleviating mitochondrial stress and metabolic disturbances.
Research Findings: Recent research has demonstrated that productinteracts with the anti-apoptotic protein Bcl-2, increasing its stability and inhibiting its ubiquitination. This interaction leads to improved mitochondrial function and reduced hepatic fat accumulation, inflammation, and fibrosis in NASH models.
Application: MOTSc is also used as a scientific research tool and chemical reagent in various experimental settings.
Details: MOTSc is available as a white crystalline powder with a high purity (98-102%) and is stored under specific conditions (e.g., shade, dryness, and sealing). It is used in fields such as biochemistry, pharmacology, and molecular biology for studying mitochondrial function, metabolic regulation, and related diseases.
Synthesis Method
Amino acid activation: First, activate the amino acids required by MOTSC, such as using N,N'-dicyclohexylcarbodiimide (DCC) or similar activators.
Ligation reaction: link the activated amino acids to form the peptde chain of MOTSC. The ligation reaction can be performed using catalysts such as N-hydroxybenzimide (HOBt) and dimethylaminopyrimidine (DMAP).
Deprotection group: removal of protection group, such as removal of methylbenzyl (Mtr) protection group, to expose other unreacted functional groups.
Adjust the PH: adjust the pH value of the MOTS-C peptide chain to meet the requirements of its optimum pH value (4-5).
Purification and characterization: Purify and characterize the synthesized MOTSC by column chromatography, high performance liquid chromatography and other methods, such as nuclear magnetic resonance (NMR), mass spectrometry and other techniques.
It should be noted that MOTSC is a complex polypeptide compound, and the synthetic route needs to go through multiple steps, and requires strict experimental conditions and technical operations. In addition, in order to ensure the quality and purity of the synthesized product, sufficient purification and characterization analysis are required.
Chemical synthesis methods
Liquid phase synthesis (SPS)
Liquid phase synthesis is an early developed synthesis method, including stepwise coupling reactions and segment coupling reactions. In the synthesis of MOTSc, liquid-phase synthesis can be carried out through the following steps:
Firstly, protect the amino acids in the MOTSc sequence to prevent unnecessary reactions during the synthesis process. Common protective groups include tert butoxycarbonyl (Boc) and 9-fluorenylmethoxycarbonyl (Fmoc).
According to the amino acid sequence of MOTSc, gradually couple amino acids from the C-terminus. In each step of coupling, coupling agents (such as 1-hydroxybenzotriazole, HOBt) are added to prevent racemization and improve coupling efficiency.
After each coupling reaction, the intermediate needs to be separated and purified to remove unreacted amino acids and by-products.
Repeat the above steps to gradually extend the peptde chain until the full-length synthesis of MOTSc is completed.
Finally, remove all protective groups and purify the synthesized MOTSc to obtain high-purity products.
The liquid-phase synthesis method is suitable for the synthesis of small peptids (<10 amino acids), but for peptids like MOTSc with 16 amino acids, the synthesis steps are cumbersome, time-consuming, and costly. In addition, as the peptde size increases, the solubility of fragments will become the main issue for conjugation.
Solid phase synthesis (SPPS)
Solid phase synthesis is currently the preferred method for synthesizing small and medium-sized peptids (<50 amino acids), and it is also the mainpathway for MOTSc chemical synthesis. The basic steps of solid-phase synthesis include:
Resin selection and pretreatment: Select suitable solid-phase carriers (such as Wang resin, Rink resin, etc.) and perform pretreatment to introduce appropriate linking groups.
Amino acid coupling: A covalent bond is formed between the carboxyl group of the first amino acid at the C-terminus and the connecting group on the resin. Then, the amino acid bound to the solid-phase carrier is deprotected and serves as an amino donor, forming an amide bond with an excess of another activated carboxyl group to extend the peptde chain. During the coupling process, it is also necessary to add coupling agents to improve efficiency.
Washing and deprotection: After each coupling reaction, the resin needs to be washed to remove unreacted amino acids and coupling agents. Then, remove the protective groups on the amino acids to prepare for the next step of coupling.
Peptde chain extension and purification: Repeat the above steps to gradually extend the peptde chain until the full-length synthesis of MOTSc is completed. Finally, the peptde chain is cleaved from the resin and purified..
The solid-phase synthesis method has the advantages of high automation, high synthesis efficiency, and high product purity. However, each cycle reaction requires a large amount of reagents, generates a large amount of waste liquid, and requires expensive preparation chromatography to remove impurities with similar structures in the later stage, further increasing production costs.
Chemical Properties
Amino acid composition: MOTSC is a polypeptide composed of several amino acids, and its amino acid sequence can be obtained through gene coding.
Chemical structure: The chemical structure of MOTSC is determined by its amino acid sequence, which is usually analyzed and characterized by techniques such as mass spectrometry.
Solubility: MOTSC is a hydrophobic polypeptde, not easily soluble in water, but more easily soluble in organic solvents such as methanol and ethanol.
PH stability: The stability of MOTSC is affected by the pH value, and its optimum pH value is 4-5.
Oxidation-reduction properties: MOTSC may be affected by oxidation-reduction reactions, resulting in changes in its biochemical activity.
In summary, MOTSC is a peptde compound composed of amino acids, which has chemical properties such as hydrophobicity, pH stability, and possible influence by redox reactions. These chemical properties have a certain influence on its biochemical activity, stability and pharmacological properties.
The current understanding of the reaction properties of the chemical product polypeptide MOTSC is still relatively limited, but some reaction properties can be inferred based on its chemical structure and amino acid composition, including:
1. Amino acid reaction: Mots-c Peptide contains multiple amino acids, and reactions between amino acids may occur, such as acylation and condensation.
2. Oxidation reaction: MOTSC may be affected by oxidation reactions, such as oxidation, peroxidation, etc., resulting in changes in its biochemical activity.
3. Hydrolysis reaction: MOTSC contains multiple hydrophilic amino acids, which may undergo hydrolysis reaction in water, thereby degrading its structure and biochemical activity.
4. Radioactive reactions: MOTSC may contain some isotopes that are prone to radioactive reactions, such as hydrogen, carbon, nitrogen, etc., so they may be affected by radioactive reactions.
In conclusion, the reaction properties of the chemical product polypeptide MOTSC may be affected by factors such as its chemical structure, amino acid composition, and environment, and more research is needed to gain an in-depth understanding of its reaction properties and the impact on its biochemical activity.
Motsc, as a bioactive peptde derived from mitochondrial DNA, has multiple physiological functions and potential application prospects. The following is a detailed explanation of its application prospects:
1.Treatment of metabolic diseases
Obesity and diabetes
It can improve obesity and insulin resistance, providing new ideas for the treatment of these metabolic diseases. By regulating mitochondrial metabolic pathways, it is also possible to reduce fat accumulation, improve insulin sensitivity, and help control blood sugar and weight.
Non alcoholic fatty liver (NASH)
Research has shown that this substance can alleviate the progression of non-alcoholic fatty liver disease. By increasing the stability of Bcl-2 protein and inhibiting ubiquitination, it can also inhibit the development of NASH, alleviate hepatic steatosis, inhibit larger lipid droplet deposition, and improve mitochondrial mediated metabolic disorders.
2.Cancer Treatment and Prevention
It may play an important role in cancer. Although the specific mechanism is not fully understood, studies have shown that exogenous MOTSc therapy can inhibit the growth and proliferation of certain cancer cells. Therefore, it is expected to become a new target or adjuvant therapy for cancer treatment.
3.Exercise and anti-aging
Sports adaptability
It can act as a potential mitochondrial signal, mediating the mitochondrial excitation response induced by exercise, thereby stimulating physiological adaptation and improving exercise tolerance. This is of great significance for athletes and sports enthusiasts, as it helps improve athletic performance and promote physical recovery.
Anti-aging
It also has anti-aging effects. By regulating cellular metabolism and reducing oxidative damage, MOTSc can delay the process of cellular aging and protect cells from damage. This is of great significance for extending human lifespan and improving the quality of life.
4.Other potential applications
It may also have other potential applications, such as improving cardiovascular health, regulating immune function, etc. These application prospects require further research and validation to support.
5.Precautions
- Although it has multiple application prospects, mots-c peptide safety and effectiveness in the human body still need further research and verification.
- When using the substance or its related products, relevant laws, regulations, and operating procedures should be strictly followed to ensure the accuracy and safety of the experiment.
Frequently Asked Questions
What are the side effects of MOTS-c peptide?
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However, among people who claim to purchase MOTS-c online, there are many reported side effects, including increased heart rate or heart palpitations, injection site irritation, insomnia, and fever. There is also no data available on what happens with long-term use of MOTS-c.
Does MOTS-c increase testosterone?
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MOTS-c administration increases these hormones, suggesting that MOTS-c may stimulate the reproductive axis. Our results reveal that MOTS-c plays a role in the central regulation of reproduction, as well as causes increased LH, FSH and testosterone release.
How long does it take to see results from MOTS-c?
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How long does it take to see results? Some patients may start to notice improvements in energy and metabolism within a few weeks of starting MOTS-C therapy. However, consistent use over time is key to experiencing the full range of benefits.
Does MOTS-c build muscle?
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The molecular analysis revealed a novel, important signaling pathway of MOTS-c. Taken together, this research shows MOTS-c improves not only metabolic function but also muscle mass. We previously proposed that MOTS-c acts as an exercise mimetic hormone.
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