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L-aspartic acid powder, white crystalline powder, odorless, often left-handed optical. Stable under normal temperature and pressure, it is a natural product and non-toxic. It exists in tobacco leaves and smoke. Soluble in hot water, acid, alkali and salt solutions, insoluble in ethanol and ether. It is used as a synthetic sweetener, medically to treat heart disease, as a liver function promoter, an ammonia antidote, a fatigue eliminator, and an amino acid infusion component.
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Chemical Formula |
C4H7NO4 |
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Exact Mass |
133 |
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Molecular Weight |
133 |
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m/z |
133 (100.0%), 134 (4.3%) |
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Elemental Analysis |
C, 36.10; H, 5.30; N, 10.52; O, 48.08 |
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In the prior art, the preparation methods of L-aspartic acid powder mainly include microbial fermentation, fumarate enzyme conversion and chemical synthesis. The microbial fermentation method is used to prepare L-aspartic acid, with low acid production and conversion rate, long cycle, many by-products, and complex extraction process, Under strong acidic condition (about ph1), it can be converted to fumaric acid; The separated and purified fumaric acid is converted into aspartic acid under the action of aspartic acid enzyme and excess ammonia.
After the reaction solution neutralizes the excess ammonia with sulfuric acid, the product l-aspartic acid is separated and purified. In this method, the isomerization of maleic acid into fumaric acid is carried out under strong acidic conditions, which is highly corrosive to equipment. The wastewater generated in this process is strong acid, poor biochemical property, and difficult to treat. Moreover, fumaric acid is converted through enzyme, The produced wastewater contains sulfur and nitrogen.
The invention provides a preparation method of L-aspartic acid powder to solve the technical problems existing in the well-known technology, which comprises the following steps:
Step a: put fumaric acid and ammonia into a reactor to react to obtain ammonium fumarate solution;
Step b: continuously flow the product obtained in step a through the packed bioreactor at a certain space speed;
Step c: control the conversion rate in step b to be greater than 90% to obtain the conversion solution;
Step d: gradually add 1mol/l of hydrogen chloride into the conversion solution obtained in step c, adjust the ph value to 1.5-2.8, and let it stand for crystallization;
Step e: take out the crystals in step d, wash and dry to obtain crude L-aspartic acid;
Step f: recrystallize the crude product in step e and vacuum dry it at 60-85 ℃ to obtain the finished L-aspartic acid powder.
Furthermore, the ammonium fumarate solution in step a shall be stored at 30-40 ℃ after being prepared.
Furthermore, the packed bioreactor in step b is obtained by loading the immobilized e.coli containing aspartase.
Furthermore, the solution standing temperature in step d should be kept at 0-5 ℃, and the standing time should not be less than 12 hours.
Furthermore, the drying temperature after washing in step e is 80-120 ℃, and the solution selected for recrystallization of crude products in step f is dilute ammonia.
The invention has the following advantages and positive effects:
The preparation method of L-aspartic acid proposed by the invention uses fumaric acid and ammonia to prepare L-aspartic acid under the action of mold. The produced wastewater has low acidity and simple treatment. At the same time, the immobilized e.coli containing aspartase is used as the catalyst, and the ammonium fumarate solution flows through the immobilized e.coli containing aspartase Coli's packed bioreactor, the impurities in the conversion solution obtained are less, that is, the by-products of L-aspartic acid obtained in the subsequent steps are greatly reduced, and the extraction process is relatively simple.
The preparation method of L-aspartic acid of the invention is described in detail as follows:
Example 1
The invention relates to a preparation method of L-aspartic acid .
The technical scheme adopted by the invention to solve the technical problems existing in the well-known technology is: a preparation method of L-aspartic acid, including the following steps:
Step a: put fumaric acid and ammonia into a reactor to react to obtain ammonium fumarate solution;
Step b: continuously flow the product obtained in step a through the packed bioreactor at a certain space speed;
Step c: control the conversion rate in step b to be greater than 90% to obtain the conversion solution;
Step d: gradually add 1mol/l of hydrogen chloride into the conversion solution obtained in step c, adjust the ph value to 1.5, and crystallize when standing;
Step e: take out the crystals in step d, wash and dry to obtain crude L-aspartic acid;
Step f: recrystallize the crude product in step e and vacuum dry it at 60 ℃ to obtain the finished L-aspartic acid.
Detailed explanation of the action of L-Aspartic Acid
L-aspartic acid is an essential acidic amino acid for the human body, playing an indispensable role in core energy metabolism and an important substance for maintaining energy homeostasis in the body. It can directly participate in the intracellular tricarboxylic acid cycle as a key metabolic intermediate, assisting mitochondria in energy conversion, efficiently converting nutrients into ATP that can be utilized by cells, effectively alleviating fatigue caused by insufficient energy supply, and improving cellular energy supply efficiency, especially suitable for people with high physical exertion or fast metabolic rates.
At the same time, it can actively transport metabolic substrates within cells, accelerate the breakdown and excretion of lactate and metabolic waste generated during exercise or metabolic processes, reduce the burden of metabolic product accumulation on body functions, and maintain the smooth operation of the metabolic system.L-aspartic acid has important central nervous system regulatory functions and provides strong support for the normal physiological operation of the brain. As an important precursor of excitatory neurotransmitters, it can participate in the transmission of neural signals in the brain, assist in the rapid transmission of nerve impulses, and maintain the body's concentration, neural response speed, and normal cognitive function.
It has an auxiliary effect on cognitive activities such as learning and memory. In addition, it can balance the metabolic level of brain nerve cells, alleviate the metabolic wear and tear of nerve cells during high-intensity operation, reduce nerve fatigue, assist in maintaining the stability of the central nervous system, and reduce discomfort caused by neurological metabolic disorders.L-aspartic acid plays a crucial role in the process of body synthesis metabolism and substance conversion, providing a material basis for multiple physiological activities. It can serve as an important raw material for the urea cycle, participating in the metabolism and elimination of toxins in the body.
Effectively reducing the burden on the liver during toxin metabolism, maintaining normal physiological functions of the liver, and avoiding the accumulation of toxins that can cause damage to the liver.At the same time, it actively participates in the synthesis of amino acids and nucleotides in the body, providing necessary material support for cell proliferation and differentiation, assisting in the basic repair and renewal of body tissues, and playing an important role in maintaining normal growth and development of the body and repairing minor tissue damage.L-aspartic acid also plays a significant role in endocrine regulation and physical fitness assistance, especially attracting attention from sports enthusiasts.
It can synergistically regulate the secretion and balance of male hormones and growth related factors in the body, providing assistance for the growth, development, and physical fitness improvement of the body, and is often applied in the regulation of sports related functions. In addition, it can optimize the microenvironment of muscle cells, reduce metabolic damage to muscle cells after exercise, relieve muscle soreness, accelerate muscle recovery, help the body quickly recover physical fitness, and improve exercise endurance and performance.
As an essential acidic amino acid for human conditions, L-Aspartic Acid is widely present in human cells, tissues, and various natural foods, and is one of the core substances that maintain normal physiological functioning of the body. Its function runs through multiple key physiological processes such as energy metabolism, neural regulation, synthesis and transformation, and endocrine regulation, combining fundamental and functional aspects.
It has irreplaceable value for human growth and development, functional maintenance, and damage repair. Unlike non essential amino acids, L-aspartic acid is one of the functional amino acids that has attracted much attention in recent years. It needs to be supplemented through diet or self synthesis to meet the demands of active metabolism, excessive physical exertion, or special physiological stages. Its diverse physiological effects work together to provide comprehensive support for cell activity, tissue health, and overall functional stability.
FAQ
What is L-aspartic acid used for?
Protein Synthesis and Structural Integrity: As a fundamental building block, L-Aspartic acid is incorporated into thousands of proteins throughout the body. Its presence influences protein folding, stability, and the active sites of enzymes.
Is L-aspartic acid the same as aspartame?
Aspartame is a dipeptide composed of l-aspartic acid and phenylalanine methyl ester, amino acids found naturally in foods. It is soluble in water and in alcohol, and insoluble in oils and in fats. Aspartame has greater stability in the pH range of 3.0–5.0 (Newsome, 1986; Dziezak, 1986; Wells, 1989).
How much L-aspartic acid should you take daily?
When taken by mouth: Aspartic acid is commonly consumed in foods. D-aspartic acid is possibly safe when used in doses of 3-6 grams daily for up to 3 months. L-aspartic acid is possibly safe when used in doses up to 8 grams daily, short-term.
What are the hazards of L-aspartic acid?
Hazard statement(s) H303 + H313 May be harmful if swallowed or in contact with skin. Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin.
What is another name for L-aspartic acid?
Synonyms: (S)-Aminosuccinic Acid. L-Asparaginic Acid.
Is L-aspartic acid the side chain?
Side chains of L-Asp are often hydrogen bonded to the mainchain NH group to form asx turns or asx motifs (asx means L-Asp or asparagine) that enable the folding of proteins. The asx turn consists of three amino acid residues that form a hydrogen bond from its side chain CO group to the main chain NH group.
What is the difference between aspartic acid and L-Aspartic acid?
Forms and nomenclature:There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L-aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "D-aspartic acid" are more limited.
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