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2-Methoxy-5-Nitrophenol Sodium Salt (5-Nitroguaiacol sodium), CAS 67233-85-6, Molecular formula C7H6NNaO4, orange red or jujube red plate-like crystals, with naphthalene woody aroma, melting point 105-106 ℃ (free acid). Easy to dissolve in water, soluble in organic solvents such as ethanol and acetone. It is the most important component of sodium nitrophenolate, which can quickly penetrate into the plant body after being absorbed by roots, stems, and leaves, promote cell protoplast flow, improve cell vitality, and accelerate plant growth and development. Widely applicable to various crops, and can be applied at any time from sowing to harvesting. It can be used for soaking, watering, spreading flower buds, and foliar spraying. It has the effects of breaking dormancy, promoting root and seedling strength, early flowering, promoting fertilization and fruiting, preserving flowers and fruits, improving quality, increasing yield, and enhancing stress resistance.
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Chemical Formula |
C7H6NNaO4 |
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Exact Mass |
191 |
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Molecular Weight |
191 |
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m/z |
191 (100.0%), 192 (7.6%) |
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Elemental Analysis |
C, 43.99; H, 3.16; N, 7.33; Na, 12.03; O, 33.49 |
2-methoxy-5-nitrophenol sodium salt is an organic compound with broad application prospects, especially showing significant effects in livestock and fisheries. As a cell activator, it can effectively promote the growth and development of animals and plants, improve yield and quality. It is a jujube red flaky crystal with a naphthalene woody aroma and a melting point of approximately 105-106 ℃. It is easily soluble in water and soluble in organic solvents such as methanol, ethanol, acetone, etc. These properties make them widely applicable in animal fisheries.
Animal Husbandry
Improve feed utilization efficiency:
After being used in combination with feed, the utilization rate of feed can be significantly improved. It enhances the ability of animals to digest and absorb feed by promoting the activity of digestive enzymes in their bodies, thereby improving the conversion rate of feed. This can not only reduce the waste of feed, but also lower the cost of farming.
Promote animal growth and development:
Has a significant growth promoting effect. It can promote the synthesis and secretion of hormones in animals, accelerating their growth and development speed. For example, in the pig farming industry, the use of feed can significantly increase the daily weight gain and feed return rate of pigs.
Enhance animal immunity:
It can also enhance the immune system of animals. It enhances the animal's disease resistance by promoting the proliferation and differentiation of immune cells in the body, increasing their activity. In animal husbandry, the use of feed can reduce the incidence rate and mortality of animals and improve the efficiency of breeding.
Improve the quality of livestock products:
It can also improve the quality of livestock products. It improves the nutritional content and taste of animal products by promoting the metabolism of fat and protein in the animal body. For example, in the chicken industry, using feed containing this substance can significantly improve the quality and yield of eggs.
Pig farming:
A certain pig farm added an appropriate amount of this substance to its feed. After a period of observation, it was found that the daily weight gain of pigs increased by about 15%, and the feed return rate increased by about 10%. At the same time, the disease resistance of pigs has also been significantly enhanced, and the incidence rate and mortality have decreased.
Chicken farming:
A certain chicken farm added this substance to its feed, and after a period of observation, it was found that the quality and yield of eggs had improved. The eggshell of an egg is harder, the yolk is brighter in color, and the taste is more delicious. At the same time, the disease resistance of chickens has also been significantly enhanced, and the incidence rate and mortality have declined.
Cattle farming:
A certain cattle farm added this substance to its feed, and after a period of observation, it was found that the growth and development rate of cattle was significantly accelerated, and weight gain was significant. At the same time, the meat quality of cattle has also been improved, with more tender and juicy meat and a better taste.
Fishery industry
Promote the growth and development of fish:
It is also widely used in the fishing industry. It can promote the synthesis and secretion of hormones in fish, accelerating their growth and development rate. During the breeding process, the use of this substance in feed can significantly improve the growth and survival rates of fish.
Improve the stress resistance of fish:
It can also improve the stress resistance of fish. It enhances the adaptability of fish to adverse environments by promoting the activity of antioxidant enzymes in their bodies. During the breeding process, using feed containing this substance can reduce the stress response and mortality rate of fish, and improve breeding efficiency.
Breeding tilapia:
A certain tilapia farm added this substance to its feed, and after a period of observation, it was found that the growth rate and disease resistance of tilapia were enhanced. At the same time, the body shape of tilapia is more symmetrical and beautiful, and its market competitiveness has been enhanced.
Shrimp farming:
A shrimp farm found that the growth rate and survival rate of shrimp were improved after adding 5-nitroguaiacol sodium to the feed. Meanwhile, the meat of shrimp is also more tender and delicious, receiving widespread praise from consumers.
Improve the quality of aquatic products:
It can also improve the quality of aquatic products. It improves the nutritional content and taste of aquatic products by promoting the metabolism of fat and protein in fish bodies. For example, in the breeding of sea bass, using feed containing this substance can significantly improve the meat quality and taste of sea bass.
Breeding sea bass:
A certain sea bass breeding farm added an appropriate amount of this substance to the feed, and after a period of observation, it was found that the growth rate and survival rate of sea bass were both improved. At the same time, the meat quality of sea bass has also been improved, with more tender and juicy meat and a better taste. In addition, the economic benefits of the breeding farm have also been significantly improved.
2-Methoxy-5-Nitrophenol Sodium Salt, also known as Sodium 2-methoxy-5-nitrophenolate, is a chemical compound with a distinct structure and various applications in the field of chemistry and related industries. This particular salt is formed by the reaction of 2-methoxy-5-nitrophenol with a sodium base, typically sodium hydroxide (NaOH), resulting in the replacement of the phenolic hydrogen with a sodium ion.
Chemically, it possesses a methoxy group (-OCH3) at the 2-position and a nitro group (-NO2) at the 5-position on the phenol ring. The methoxy group imparts some level of electron-donating properties, while the nitro group is electron-withdrawing, leading to a polarized aromatic ring that influences its reactivity and physical properties.
The sodium salt form of this compound enhances its solubility in aqueous solutions compared to its free phenol form. This solubility characteristic is crucial for applications where aqueous-based reactions or formulations are required. Additionally, the sodium salt can facilitate better dispersion and handling in various industrial processes.
In terms of applications, it finds utility in dye synthesis, where it can serve as an intermediate in the preparation of azo dyes due to its aromatic nature and the presence of functional groups suitable for further chemical modifications. It may also be employed in the production of pharmaceuticals, particularly in the synthesis of compounds with nitrophenol moieties known for their biological activities.
Furthermore, this chemical can play a role in the development of explosives and pyrotechnics, benefiting from the nitro group's energetic properties. However, its use in such applications requires strict safety measures due to potential hazards associated with nitro compounds.
In summary, it is a versatile chemical intermediate with unique structural features that enable its application in dye manufacturing, pharmaceutical synthesis, and potentially in the production of explosives and pyrotechnics. Its sodium salt form enhances solubility and ease of handling, making it a valuable component in various chemical processes. However, appropriate safety protocols must be adhered to when handling and disposing of this compound.
According to the basic theory of synthetic reactions, the synthesis route of 5-nitroguaiacol sodium was first determined. Using guaiacol as the raw material, 2-methoxy-5-nitrophenol sodium salt was synthesized through acylation, nitration, and hydrolysis reactions; Then, according to the reaction sequence, each step of the reaction is carefully examined, and the intermediate and target products in the synthesis process are fully analyzed to provide reference for subsequent research.
Firstly, based on preliminary experiments, the key factors affecting the acylation reaction were identified. Then, through orthogonal and single factor experiments, the various factors affecting the reaction were examined in detail to determine the optimal process and optimize the separation process of the product. The direct vacuum distillation method was used to simplify the separation steps, resulting in an improved product yield of around 98% and a purity of over 98%. The infrared analysis confirmed that the synthesized product is acetylguaiacol ester, and a gas chromatography method was established for qualitative and quantitative analysis of the product.
Secondly, based on the preliminary experiment, nitric acid acetic acid was selected as the nitration agent for the nitration reaction. The influencing factors of the nitration reaction were investigated in detail through single factor experiments, and the optimal process conditions were determined. Under the optimal conditions, the yield of 5-nitroacetylguaiacol was 78% and the purity was 99%. The product underwent melting point, thermal analysis, infrared spectroscopy, and high-performance liquid chromatography analysis.
Finally, the main factors affecting the hydrolysis reaction were determined through preliminary experiments, and the optimal process conditions were determined through single factor investigation. Under the optimal process conditions, the yield of 5-nitroguaiacol sodium can reach 83%, and the purity can reach 99%.
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