Proparacaine Hydrochloride CAS 5875-06-9

Proparacaine hydrochloride CAS 5875-06-9, also known as proparacaine hcl, chemical name 3-amino-4-propoxybenzoic acid-2- ( ethylamino ) ethyl ester monochloride, white powder. it chemical formula C16H27ClN2O3, CAS 5875-06-9, relative molecular weight 330.85 g/mol. Exists in the form of crystals, usually in the form of white crystalline powder. Soluble in water and ethanol. It has a relatively high solubility in water and can form a transparent solution. The pH value is usually between 4 and 6. It is a local anesthetic commonly used in ophthalmic surgeries and examinations. Only for local use and not suitable for general anesthesia or other forms of anesthesia. When using Proparacaine hcl, it is necessary to follow the doctor's advice and prescription, as well as relevant drug usage guidelines and safety precautions. It has multiple uses in the field of biological reagents, including cell culture, neuroscience research, organ transplantation and preservation, animal experiments, and muscle relaxation. It plays an important role in these fields, providing convenience and support for life science research and experiments.

Melting point 182.0-183.3 , Storage conditions: insert atmosphere, store in freezer, under - 20 ° C, Acidity coefficient (PKA) 3.2 (at 25 ℃), Maximum wavelength( λ max)300nm(MeOH)(lit.), Dangerous goods sign xn, Hazard category code 20 / 21 / 22-36-43, Safety instructions 26-36, WGK Germany 3, RTECS No, dg3065000

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It is a drug commonly used for local anesthesia in ophthalmic surgeries. The following is a possible method description for synthesizing Proparacaine hydrochloride in the laboratory:

The synthesis of Product typically involves two main steps. Firstly, 1,3-propanediamine reacts with 4-aminobutyric acid to produce N-acetyl-4-aminobutyric acid. Secondly, N-acetyl-4-aminobutyric acid was Transesterification with p-nitroanisole to obtain Propacaine hydrochloride.

The crystal of proparacaine hydrochloride was prepared by dissolving promecaine hydrochloride in 30 8 ( TC ), d C 5 linear fatty alcohol, acetonitrile, and mixed solvent of ethanol and ethyl acetate, ethanol and acetone. Promecaine hydrochloride should be completely dissolved in the solvent, but the temperature and concentration of dissolution is not limited, the preferred promecaine hydrochloride completely dissolved in the solvent mentioned above, saturated solution in the reflux state. After the procaine hydrochloride was completely dissolved, it was crystallized from high temperature cooling, and the crystallization temperature was-20 25. C, cooling rate of 40 ' C / hour or less, preferably room temperature natural cooling crystallization. Finally, crystalline promecaine hydrochloride was separated by suction filtration. Proparacain inhibits the migration and adhesion of corneal epithelial cells by changing the actin cytoskeleton. Proparacaine, like bupivacaine or Chemicalbook lidocaine, can anesthetize the spinal cord, lose motor function, muscle motor perception and injury sensation. Intrathecal procaine anesthesia is stronger for sensory than for motor ability.

Propafenone hydrochloride is a powerful and widely used local anesthetic that plays a crucial role in medical practice and scientific research due to its excellent anesthetic effect and safety. The following is a detailed explanation of its various uses:

Ophthalmic surgery and examination

 

In the field of ophthalmology, this local anesthetic is particularly widely used. Firstly, it is an indispensable anesthetic in ophthalmic surgery. Whether it is complex corneal transplantation surgery, delicate cataract extraction surgery, or highly skilled vitrectomy surgery, it can quickly produce anesthetic effects, ensuring painless operation during the surgical process. This not only reduces the patient's pain, but also improves the accuracy and safety of the surgery.

In addition, this anesthetic also plays an important role in ophthalmic examinations such as intraocular pressure measurement and corneal scraping. By rapidly anesthetizing the eye tissue, it makes these examination processes more comfortable and safe, thereby improving patient cooperation and examination accuracy. Especially in intraocular pressure measurement, it can reduce patients' tension and avoid fluctuations in intraocular pressure caused by pain stimuli, thereby ensuring the accuracy of measurement results.

Corneal pain relief

 

For patients with corneal pain, this local anesthetic also has significant therapeutic effects. Corneal pain is usually caused by corneal ulcers, keratitis, or other corneal lesions, which not only cause great pain to patients but may also affect vision. By locally applying this anesthetic, it can quickly inhibit the transmission of pain signals, alleviate patients' pain, and improve their quality of life. In addition, it can promote the repair and healing of corneal tissue, which helps with the recovery of diseases.

 

Pain relief in animal experiments:
In animal experimental research, this local anesthetic is also commonly used as a pain reliever. Due to the fact that animal experiments often involve surgery or manipulation of animals, these processes may cause pain and discomfort to the animals. Therefore, in order to ensure the accuracy and reliability of experimental results, researchers usually administer this anesthetic to animals to alleviate their pain. This not only helps reduce the pain and discomfort of animals, but also improves the accuracy and scientificity of experiments.

Auxiliary diagnostic testing

 

In the field of ophthalmic diagnosis, this local anesthetic also plays an important role. For example, during precise examinations such as corneal curvature measurement and corneal topography analysis, patients may feel discomfort or pain due to the possibility of slight irritation or touch to the eyes involved in these examination processes. At this point, by administering this anesthetic to the patient in advance, the pain and stimulation during the examination process can be significantly reduced, and the patient's cooperation and accuracy of the examination can be improved. This not only helps doctors to more accurately understand the patient's eye condition, but also provides strong support for subsequent treatment.

Auxiliary diagnostic testing

 

In the field of ophthalmic diagnosis, this local anesthetic also plays an important role. For example, during precise examinations such as corneal curvature measurement and corneal topography analysis, patients may feel discomfort or pain due to the possibility of slight irritation or touch to the eyes involved in these examination processes. At this point, by administering this anesthetic to the patient in advance, the pain and stimulation during the examination process can be significantly reduced, and the patient's cooperation and accuracy of the examination can be improved. This not only helps doctors to more accurately understand the patient's eye condition, but also provides strong support for subsequent treatment.

Ophthalmic research

 

In the field of ophthalmic research, this local anesthetic also has a wide range of application value. By temporarily anesthetizing the eye tissue, it can help researchers observe and study the subtle changes and functional characteristics of the eye structure more deeply. For example, when studying the pathogenesis of corneal diseases, by anesthetizing corneal tissue, researchers can more clearly observe the morphology and arrangement of corneal cells, thereby revealing the pathogenesis of the disease. In addition, when researching new treatment methods, this anesthetic can also provide the necessary painless environment for experiments, ensuring the accuracy and reliability of experimental results.

Skin surgery and cosmetic plastic surgery

 

In addition to the field of ophthalmology, this local anesthetic also has a wide range of applications in skin surgery and cosmetic surgery. In skin surgery, such as skin cutting and suturing, patients may experience severe pain as these operations typically involve cutting and suturing the skin. At this point, by locally applying this anesthetic, it can quickly anesthetize the skin tissue, alleviate the patient's pain, and ensure the smooth progress of the surgery.

In the field of cosmetic surgery, this anesthetic also plays an important role. Whether performing facial plastic surgery, skin filling, or other cosmetic procedures, it can provide patients with a painless treatment environment. This not only improves the comfort and safety of the surgery, but also enables patients to recover to work and life more quickly after the surgery.

Pain management

 

In the field of pain management, this local anesthetic also has broad application prospects. For pain caused by various reasons, such as neuralgia, muscle pain, etc., by locally applying this anesthetic, it can quickly alleviate the patient's pain and improve their quality of life. Especially in patients who require long-term pain management, this anesthetic can provide them with a safe and effective method of pain relief.

Other innovative applications

 

With the continuous advancement of medical technology and the continuous exploration of researchers, the application fields of this local anesthetic are still expanding. For example, in the field of neuroscience research, proparacaine hydrochloride may be used as a tool to study neural transmission mechanisms; In the field of rehabilitation therapy, it may be used to help patients recover damaged nerve and muscle function; In the field of dentistry, it may also be used as a medication to relieve toothache. These innovative applications not only broaden the scope of application of this anesthetic, but also provide more possibilities for medical research and clinical practice.

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