Raloxifene powder is a synthetic nonsteroidal benzothiophene derivative that belongs to the class of selective estrogen receptor modulators (SERMs). As a reliable supplier of raloxifene powder, I am delighted to share with you the various scientific uses and potential benefits of this remarkable compound.
Raloxifene Powder CAS 84449-90-1
Product Code: BM-2-5-047
Eng Name: Raloxifene
CAS number: 84449-90-1
MF.: C28H27NO4S
Molecular weight: 473.58
EINECS number: 686-786-1
HS code: 29349990
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Wuxi Factory
Technology service: R&D Dept.-2
We provide Raloxifene Powder CAS 84449-90-1 please refer to the following website for detailed specifications and product information.
1. Osteoporosis Prevention and Treatment
One of the most well - recognized uses of raloxifene powder is in the prevention and treatment of post - menopausal osteoporosis. After menopause, women experience a significant decrease in estrogen levels, which leads to an imbalance in bone remodeling. Osteoclasts (cells that break down bone) become more active than osteoblasts (cells that build bone), resulting in a net loss of bone mass and increased risk of fractures.
Raloxifene acts on estrogen receptors in bone tissue. It mimics the beneficial effects of estrogen on bone by increasing bone mineral density (BMD). Clinical studies have shown that long - term use of raloxifene can raise BMD in the spine and hip, two areas particularly prone to fractures in post - menopausal women. A meta - analysis of multiple randomized controlled trials indicated that raloxifene treatment significantly reduced the risk of vertebral fractures in post - menopausal women with osteoporosis [1].
2. Breast Cancer Risk Reduction
Raloxifene also plays an important role in reducing the risk of breast cancer, especially in post - menopausal women at high risk. Estrogen can stimulate the growth of breast cancer cells in hormone - receptor - positive breast cancer. Raloxifene, as a SERM, has anti - estrogenic effects in breast tissue.
It binds to estrogen receptors in breast cells, blocking the binding of endogenous estrogen and inhibiting the growth - promoting effects of estrogen on breast cancer cells. The Study of Tamoxifen and Raloxifene (STAR) was a large - scale clinical trial comparing the efficacy of raloxifene and tamoxifen in reducing breast cancer risk. The results showed that raloxifene was as effective as tamoxifen in reducing the risk of invasive breast cancer in post - menopausal women at high risk [2].
3. Cardiovascular Health
There is also evidence suggesting that raloxifene may have beneficial effects on cardiovascular health. It can affect lipid metabolism by reducing low - density lipoprotein cholesterol (LDL - C) levels in the blood. High levels of LDL - C are a major risk factor for cardiovascular diseases such as atherosclerosis and coronary heart disease.
Raloxifene appears to improve the lipid profile by interfering with cholesterol synthesis and absorption in the liver. In addition, it may also have anti - inflammatory and anti - thrombotic effects, which contribute to the overall protection of the cardiovascular system. Some studies have reported a reduced risk of non - fatal myocardial infarction in post - menopausal women taking raloxifene [3].
4. Comparison with Oter Related Compounds
When compared with other compounds in the pharmaceutical market, raloxifene has its own unique advantages. For example, if we compare it with Chlorhexidine Diacetate CAS 56 - 95 - 1, which is mainly used as an antiseptic and disinfectant in oral care and wound management, raloxifene's applications are focused on hormonal and bone - related health issues. While Luteolin Powder CAS 491 - 70 - 3 has antioxidant and anti - inflammatory properties and is often studied for its potential in treating various chronic diseases, raloxifene has a more targeted action on estrogen - related physiological processes. And D - α - Tocopherol Succinate CAS 4345 - 03 - 3, a form of vitamin E with antioxidant functions, raloxifene's mechanism of action is centered around its interaction with estrogen receptors.
5. Our Offer as a Supplier
As a professional raloxifene powder supplier, we are committed to providing high - quality products. Our raloxifene powder is produced in strict accordance with international quality standards and undergoes rigorous quality control procedures. We use advanced manufacturing techniques to ensure the purity and stability of the product.
We understand the importance of reliable supply in the pharmaceutical and research industries. Therefore, we have established a stable production system and a wide - range supply chain to ensure timely delivery of products. Whether you are a pharmaceutical company researching new drug formulations, a research institution conducting pre - clinical studies, or a laboratory in need of high - purity raloxifene powder, we can meet your needs.
If you are interested in our raloxifene powder and would like to discuss procurement details, such as product specifications, pricing, and delivery terms, please feel free to contact us. We look forward to establishing a long - term and mutually beneficial cooperation with you.
References
[1] Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3 - year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA. 1999;282(7):637 - 645.
[2] Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P - 2 trial. JAMA. 2006;295(23):2727 - 2741.
[3] Barret - Connor E, Thompson Jr. DH, Kuller LH, et al. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four - year results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 2002;287(6):733 - 740.