Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of mbth hydrochloride hydrate cas 149022-15-1 in China. Welcome to wholesale bulk high quality mbth hydrochloride hydrate cas 149022-15-1 for sale here from our factory. Good service and reasonable price are available.
MBTH hydrochloride hydrate, usually a white crystal or powdery solid, CAS 149022-15-1, molecular formula C8H10ClN3S. Salt compounds have high solubility in water, and solubility may be affected by factors such as temperature, solvent type, and compound purity. MBTH is a commonly used reagent for photometric determination of fatty aldehydes. In photometric analysis, MBTH reacts with fatty aldehydes to form purple hydrazone compounds, which have the ability to absorb light at specific wavelengths. By measuring the absorbance of the reaction product, the concentration of fatty aldehydes can be indirectly determined.
This method has the advantages of high sensitivity, easy operation, and accurate results, and has therefore been widely used in fields such as organic chemistry and biochemistry. MBTH also has other potential application values. For example, in the photography industry, MBTH can be used for developing color correction; In the hairdressing industry, MBTH can be used for dyeing and coloring hair. In addition, MBTH may also play an important role in other areas not explicitly mentioned, which requires further research and exploration.
|
|
|
|
Chemical Formula |
C8H12ClN3OS |
|
Exact Mass |
233 |
|
Molecular Weight |
234 |
|
m/z |
233 (100.0%), 235(32.0%), 234 (8.7%), 235 |
|
Elemental Analysis |
C, 41.11; H, 5.18;Cl, 15.17; N, 17.98; O,6.85; S, 13.72 |
3-methyl-2-benzothiazolone hydrazone hydrochloride hydrate (MBTH hydrochloride hydrate), as a multifunctional chemical reagent, has demonstrated its wide application value in multiple fields.
1. Determination of fatty aldehydes by photometric method
MBTH plays an important role in the photometric determination of fatty aldehydes. In photometric analysis, MBTH can react with fatty aldehydes to generate purple hydrazone compounds. This purple compound has significant absorption ability at specific wavelengths, and by measuring its absorbance, the concentration of fatty aldehydes can be indirectly determined. This method is highly favored for its high sensitivity, easy operation, and accurate results, and is widely used in research and experiments in fields such as organic chemistry and biochemistry.
2. Determine the hexosamine in viscous polysaccharides
Mucopolysaccharides are complex organic compounds composed of hexosamines, pentosamines, and acidic heteropolysaccharides. MBTH also performs well in determining the content of hexosamines in polysaccharides. By reacting with hexosamines in mucopolysaccharides, MBTH can generate purple hydrazone compounds, which also exhibit light absorbing properties. By measuring its absorbance using photometry, the concentration of hexosamine can be accurately calculated. This method is particularly important in the fields of biomedical and pharmaceutical analysis, helping scientists better understand the composition and metabolic processes of polysaccharides in living organisms.
3. Determination of trace selenium in environmental samples by photometric method
Selenium is a crucial trace element for the growth and development of organisms, but its high concentration may have toxic effects on organisms. Therefore, accurate determination of trace selenium in environmental samples is of great significance for environmental monitoring and protection. MBTH has also played a crucial role in this field. MBTH makes the determination of selenium simple and accurate by reacting with selenium to generate purple hydrazone compounds.
This method not only has high sensitivity, but also is easy to operate and the results are reliable, so it has been widely used in the field of environmental monitoring.
Determination of trace selenium
Selenium is a trace element that has significant impacts on the environment and living organisms. Moderate amounts of selenium are beneficial for living organisms, but excessive amounts may result in toxicity. Therefore, accurate determination of selenium content in environmental samples is crucial for environmental monitoring and protection. MBTH, as a photometric reagent, can react with selenium to generate purple hydrazone compounds with absorption properties.
By measuring the absorbance of the compound, the concentration of selenium can be indirectly determined, thereby achieving accurate detection of trace selenium in environmental samples. This method has been widely applied in the field of environmental monitoring, which helps to assess the pollution status of selenium in the environment and provides scientific basis for formulating corresponding protection measures.
Potential applications of other pollutants
Although MBTH is mainly used for the determination of selenium in environmental monitoring, its detection principle based on photometry also provides possibilities for the detection of other pollutants. In the future, with the deepening of research and the development of technology, MBTH may expand to the detection of more environmental pollutants, such as heavy metals, organic pollutants, etc. This will further enhance the application value of MBTH in environmental monitoring and protection.
Function in environmental monitoring
Optimization of Environmental Monitoring Methods
The application of MBTH hydrochloride hydrate in environmental monitoring is not limited to direct pollutant detection, but can also promote the optimization and improvement of environmental monitoring methods. For example, by studying the combined application of MBTH with other reagents or technologies, more sensitive, accurate, and convenient environmental monitoring methods can be developed. The application of these methods will help improve the efficiency and accuracy of environmental monitoring, providing stronger technical support for environmental protection.
Development of environmental protection policies and standards
The application results of MBTH in environmental monitoring are of great significance for the formulation of environmental protection policies and standards. Through precise detection and analysis of pollutants in the environment using chemical reagents such as MBTH, comprehensive information on the types, concentrations, and distribution ranges of pollutants can be obtained. These pieces of information serve as the foundation for formulating environmental protection policies, setting pollutant emission standards, and evaluating environmental quality.
Therefore, the application of MBTH in environmental monitoring helps to promote the scientific formulation and effective implementation of environmental protection policies and standards.
Enhance public awareness of environmental protection
The application results of MBTH in environmental monitoring can also be communicated to the public through open and transparent means, thereby enhancing public awareness of environmental protection.
By means of media promotion, popular science education, and other means, the importance of environmental monitoring and the role of chemical reagents such as MBTH can be popularized to the public, which can make the public more concerned about environmental issues and actively participate in environmental protection actions. This will help create a good atmosphere for the whole society to participate in environmental protection and promote the sustainable development of environmental protection.
Industrial and Material Testing Applications
Hydrated MBTH Hydrochloride serves as the standard chromogenic reagent for spectrophotometric determination of residual aldehydes in the materials industry. Relying on a condensation-oxidation color development system, it is widely applied in quality control across the full industrial chains of polymers, textiles, leather, packaging and building materials. Featuring a straightforward testing workflow and low limit of detection, it complies with eco-material compliance testing standards worldwide.
In the industries of artificial wood panels, coatings and adhesives, this reagent acts as the core raw material for detecting free formaldehyde in wood panels, water-based adhesives and phenolic resins.
Free formaldehyde released from urea-formaldehyde adhesives during panel manufacturing directly determines the environmental protection grade of finished products. The MBTH spectrophotometric method enables rapid quantification of formaldehyde concentrations in panel extracts, supporting factory inspection for E0 and E1 grade panels.
In production workshops for coatings and sealants, it is also deployed for online monitoring of liquid-phase aldehyde levels in waste gas and intermediate raw materials, allowing real-time formula adjustment to reduce aldehyde emissions and meet the national standard limits for indoor decorative materials.
It boasts mature applications in textiles and leather, catering to safety testing of eco-textiles and finished leather goods. Free formaldehyde may remain in printed and dyed fabrics, tanning auxiliaries and color fixing agents for composite leather.
After aqueous extraction, MBTH colorimetry is used for quantitative analysis, enabling environmental screening of children's clothing, home textiles and sofa leather to eliminate export compliance risks arising from excessive formaldehyde levels. Meanwhile, it can simultaneously measure the total content of low-carbon aldehydes such as acetaldehyde in processing auxiliaries to control malodorous volatile aldehyde pollutants.
This reagent is also indispensable for testing food-contact plastics and paper packaging materials. Aldehydes may migrate from plastic lunch boxes, composite films and laminated paper packaging when exposed to food at high temperatures. After extraction via immersion in water or food-simulating solvents, MBTH colorimetry quantifies migrated aldehyde content in line with food packaging safety control specifications, preventing risks of aldehyde contaminant migration.
Furthermore, in quality control for thermal insulation building materials and resin composite production, MBTH is utilized to screen residual aldehydes in curing agents and foaming auxiliaries for rapid differentiation between qualified and unqualified batches. This testing technique requires no large chromatographic equipment, delivers low reagent costs and supports high-throughput sample analysis. Ideal for frequent daily quality inspection in factory laboratories, it is a universal, standardized rapid reagent for trace aldehyde detection throughout the materials sector.
I. Selection of Main Synthetic Routes
For industrial mass production, the methylation-hydrazinolysis-salt formation and hydration route of 2-mercaptobenzothiazole is preferred, featuring readily available raw materials, fewer reaction steps, and low consumption of hazardous reagents such as bromine. The N-methylaniline cyclization method is commonly adopted for laboratory bench-scale trials. Both routes share core procedures: construction of the benzothiazole parent nucleus, introduction of hydrazone groups, hydrochloride salt formation, and hydrated crystallization. The following elaborates on the mainstream industrial process.
II. Methylation of the Parent Nucleus
Using 2-mercaptobenzothiazole as the starting material, sodium hydroxide is added in an aqueous phase to dissolve mercapto groups. Methyl benzenesulfonate, the methylation reagent, is slowly added dropwise at a controlled temperature of 60 °C, followed by 4 hours of reflux to complete N-methyl substitution and generate the intermediate 3-methyl-2-mercaptobenzothiazole.
Upon reaction completion, the solvent is recovered, and crude solids precipitate after cooling. Cold water washing removes inorganic salt impurities. This step determines the purity of the parent nucleus; residual impurities will directly reduce the sensitivity of the subsequent chromogenic reagent.
III. Hydrazone Formation via Condensation with Hydrazine Hydrate
The methylated intermediate is loaded into a reactor, mixed with 80% hydrazine hydrate, and heated to 85–99 °C with temperature holding for 6 hours. Nucleophilic substitution occurs between the thione group and hydrazine to produce crude free 3-methyl-2-benzothiazolinone hydrazone.
A weakly acidic environment is maintained throughout the process to drive the forward reaction. After the reaction, the mixture is diluted with water, cooled and suction-filtered. The filter cake is repeatedly rinsed with water until no residual hydrazine is detected, then dried to obtain free MBTH base, with a yield of approximately 64% for this step.
IV. Hydrochloride Salt Formation and Hydrated Crystallization
Free MBTH base is dispersed in pure water. Equimolar concentrated hydrochloric acid is slowly added dropwise under stirring at room temperature to protonate amino groups and form hydrochloride salt, with white crystals gradually precipitating from the solution.
An ice-water bath is applied for thorough crystallization, followed by washing with cold dilute hydrochloric acid to eliminate unreacted starting materials.
The solids are then mixed with water and heated for recrystallization. The cooling rate is strictly controlled to slowly precipitate the target product MBTH hydrochloride hydrate containing one molecule of crystal water. Vacuum drying is performed under light-shielded and low-temperature conditions to prevent oxidative discoloration and performance degradation of the product.
V. Refinement and Process Optimization
The crude product undergoes secondary recrystallization using an ethanol-water mixed solvent to remove trace organic impurities, inorganic salts and oxidized by-products, raising reagent purity to meet the specifications of spectrophotometry for environmental and material testing.
Process optimization measures include replacing the methylation reagent to lower irritation and adopting continuous crystallization to shorten production cycles. All operations are carried out away from light to avoid spontaneous photooxidation of MBTH, which would impair its color-developing capacity.
The overall yield of the full process ranges from 60% to 65%, suitable for industrial production ranging from kilogram to ton scales. The finished product is a white crystalline powder complying with national standard requirements for testing reagent raw materials.
Hot Tags: mbth hydrochloride hydrate cas 149022-15-1, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Cinchonine, Iridium III chloride, 1 10 Phenanthroline Powder CAS 66 71 7, 6 Aminoquinoxaline CAS 6298 37 9, Tetramethylbenzidine CAS 54827 17 7, 3 4 Difluorophenylboronic acid