Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of thiazole cas 288-47-1 in China. Welcome to wholesale bulk high quality thiazole cas 288-47-1 for sale here from our factory. Good service and reasonable price are available.
Thiazole is a colorless to pale yellow transparent liquid with typical aromatic heterocyclic compound characteristics. It has a stable chemical structure and many reactive sites, making it versatile for a variety of organic reactions like electrophilic substitution, nucleophilic substitution, alkylation, and coordination complex formation. Its structure is highly adaptable, making it one of the most widely used core molecular frameworks in high-end fine chemical synthesis.
With Bloomtechz's mature cross-border chemical supply chain, we've been deeply involved in the global fine chemical export market for years and are familiar with import regulations and customs clearance standards in regions like Europe, North America, Southeast Asia, and South America. We can provide customers with one-stop compliant shipping and delivery services. Considering the physicochemical properties of this raw material, we offer customized packaging solutions that are sealed, light-proof, moisture-proof, and leak-proof to effectively prevent issues like evaporation, leakage, contamination, and purity loss during storage and transport, ensuring consistent quality throughout long-distance shipping.
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Chemical Formula |
C3H3NS |
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Exact Mass |
85 |
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Molecular Weight |
85 |
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m/z |
85 (100.0%), 87 (4.5%), 86 (3.2%) |
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Elemental Analysis |
C, 42.33; H, 3.55; N, 16.45; S, 37.66 |
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As an important organic synthesis reagent, it has a wide range of applications in drug synthesis, dye manufacturing, rubber promoter production, and film coloring agents. Its derivatives such as sulfathiazle and vitamin B1 are important components in pharmaceuticals and physiologically active substances. In terms of synthesis, traditional thiazle synthesis methods mainly adopt a multi-step synthesis method, which achieves synthesis through the conversion between functional groups. However, with the development of green chemistry, researchers have begun to explore the use of one-step synthesis methods for thiazle compounds to improve synthesis efficiency and reduce environmental pollution.
Thiazole itself has no direct use, but its derivatives are widely used in the production of pharmaceuticals (sulfathiazole), rubber products (rubber vulcanization accelerators M and Z), and high-temperature resistant synthetic polymer materials (polybenzothiazole).
Research and application in the field of medicine
Thiazle compounds have shown great development value as drugs, and many of them have been used in clinical treatment of various diseases, playing an important role in ensuring human health. There are numerous active pharmaceutical research works related to thiazle compounds, which have shown broad application prospects in fields such as antibacterial, antifungal, anti tuberculosis, anticancer, antiviral, anti-inflammatory and analgesic, hypoglycemic, antiepileptic, antiparasitic, and antioxidant.
1) Antibacterial drugs:
Thiazle compounds are one of the most widely used anti infective drugs in clinical practice, and a large number of drugs have been used in clinical practice, such as synthetic antibiotics (quinolones, sulfonamides, etc.) and antibiotics (penicillins, cephalosporins, macrolides, etc.). However, in recent years, drug resistance has become a global issue, with frequent occurrences of drug-resistant strains and increased resistance of pathogens. For example, the outbreak of "superbugs" and "deadly E. coli" in 2010 resulted in low efficacy of existing drugs, leading to an increase in bacterial infection mortality rates and posing a serious threat to human health.
There is an urgent need to develop new structures of antibacterial drugs. A large number of literature shows that azole compounds, such as the most extensively studied triazole, imidazole, carbazole, and easily synthesized and highly active azole, have great potential for development in the field of antibacterial agents. Thiazle, as an electronic isomer of triazole, imidazole, imidazole, etc., has become a new member in the research and development of antibacterial drugs, and is also one of the most active fields. Especially, 2-aminothiazole, as an electronic isomer of other active groups, can improve lipid solubility and pharmacokinetic properties.
So far, numerous antibacterial drugs containing thiazle rings have been used in clinical practice, such as Cefdinir, Ceftibuten, Cefuroxime, Monozoxime salt, etc., which have good inhibitory effects on Gram positive bacteria, especially on Gram negative bacteria. Plays an important role in treating bacterial infections.
The widespread use of thiazle antibiotics has led to frequent occurrence of pathogen resistance, and there is an urgent need to develop new structural thiazle compounds. Twelve thiazle derivatives containing adamantane structures exhibit strong inhibitory activity against Gram positive bacteria, Gram negative bacteria, and fungi.
Especially its ability to inhibit bacterial strains such as micrococcus, Staphylococcus aureus, and Salmonella is superior to first-line drugs such as streptomycin and ampicillin. Thiazoline compounds are highly favored for their broad antibacterial spectrum and excellent activity against Gram positive bacteria, and their related structural modifications have received attention. Thiazolines modified with chlorothiazole exhibit moderate inhibitory activity against methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, and Escherichia coli, while their activity against Staphylococcus aureus is comparable to that of the clinical drug ampicillin.
Fungal infections are a common clinical disease, and there are many antifungal drugs currently used in clinical practice. However, azole antifungal drugs such as imidazole: Tioconazole, Oxyconazole, Sulconazole, triazole: Fluconazole, itraconazole, Terconazole, etc. are widely used first-line drugs for the treatment of fungal infections in clinical practice, and are also one of the areas with the most research and development achievements in antifungal drugs. In recent years, there has been an increasing amount of research and development work on thiazle compounds as antifungal drugs.
3) Antituberculous thiazle compounds:
Tuberculosis is a infectious diseases with high mortality caused by Mycobacterium tuberculosis. There are dozens of antituberculosis drugs used clinically, such as Rifampicin, which have high bactericidal activity. However, with the frequent occurrence of drug-resistant strains and adverse reactions of clinical drugs such as gastrointestinal reactions and liver damage, the efficacy of existing anti tuberculosis drugs has decreased and their toxic side effects have been significant, limiting their clinical application.
Therefore, new types of anti tuberculosis drugs need to be developed. New nitrogen-containing aromatic heterocyclic compounds, represented by thiazle compounds, have been extensively and deeply studied against Mycobacterium tuberculosis. Azole compounds such as thiazle, triazole, and diazole have lipid solubility coefficients similar to the cell wall of Mycobacterium tuberculosis, which can interfere with cell wall formation and inhibit bacterial growth. Triazole thiol thiazle 24 has excellent anti tuberculosis ability, with a MIC value of 8g/mL.
4) Anticancer thiazle compounds:
Cancer has become one of the serious threats to human health, and the development of anti-cancer drugs has received widespread attention.
Becoming one of the most extensively researched fields in the world of medicine. Although there are various anti-cancer drugs used in clinical practice, the frequent occurrence and diversity of cancer, as well as the high toxicity and low selectivity of anti-cancer drugs, make existing clinical drugs far from meeting the demand for medication. The development of new anti-cancer drugs is still an urgent and important issue for pharmaceutical chemists. Zolazole compounds are one of the important directions in the development of anticancer drugs. Various thiazle compounds such as Pamicogrel (27, Pamicogrel) and Tiazofurine (28, Tiazofurine) have been successfully used in clinical practice and play an important role in cancer treatment.
In recent years, the research and development of thiazle based anticancer drugs mainly includes three aspects:
Firstly, we aim to modify the structure of existing anti-cancer drugs in order to obtain drugs with low side effects and better anti-cancer effects;
Secondly, utilizing computer technology and splicing principles to develop new structures of thiophene compounds, introducing other drug consortia to assemble into new structures of anti-cancer compounds, with the hope of discovering active lead compounds and opening up new paths for anti-cancer drug development;
The third method is to utilize the amino sulfur heteroatoms in the thiazole ring, as well as the electron rich aromatic structure and metal coordination, to form an integrated complex, in order to obtain supramolecular drugs with ideal anti-cancer effects.
5) Antiviral thiazole compounds:Viral infections such as viral hepatitis B, AIDS and SARS are infectious diseases that seriously affect human health. Due to the extremely complex mechanism of action between viruses and host cells, most antiviral drugs exert their efficacy by causing toxicity to both host cells and normal cells in the human body.
In recent years, the outbreaks of various new viruses such as avian influenza virus, atypical pneumonia virus, as well as the new variant gonorrhea virus (H041) that appeared in Japan in 2011 and the new Bunia virus that appeared in China.
Have posed great challenges to existing antiviral drugs, and the development of new antiviral drugs is urgent. In recent years, azole compounds have achieved many important results in the field of antiviral therapy, especially the anti HIV drug Ritonavir (44, Ritonavir). Therefore, thiazle compounds have become one of the hotspots in the field of antiviral drugs, and constructing new structures of antiviral drugs with thiazle rings has become an important method for antiviral drug development.
6) Antiinflammatory and analgesic thiazle compounds:Inflammation is a defense mechanism of the body, often manifested clinically as redness, swelling, and pain.
The drugs used for early treatment of inflammation are corticosteroid antibiotics, but long-term use of these antibiotics can lead to dependence on the body and can easily cause a decline in adrenal cortex function. Therefore, nonsteroidal anti-inflammatory drugs with better anti-inflammatory effects have become a focus of research and development in the field of anti-inflammatory drugs, and have achieved gratifying results in anti-inflammatory, antipyretic, and analgesic effects.
Especially, thiazle nonsteroidal anti-inflammatory compounds have attracted widespread attention and attracted many scientific workers to devote themselves to the research and development of thiazle anti-inflammatory and analgesic drugs.
The research and development of thiazle compounds as anti-inflammatory and analgesic drugs mainly includes two aspects: one is the modification of existing clinical anti-inflammatory and analgesic drugs with thiazle rings, such as the azole anti-inflammatory and analgesic drugs meloxicam and Sudoxicam (49 Sudoxicam) obtained by modifying piroxicam, which have the advantages of high efficacy and low toxicity; The second approach is to introduce other anti-inflammatory and analgesic functional groups centered around thiazle to construct new structures of anti-inflammatory and analgesic drugs, such as clinical drugs Fanetizole (50) and Fentiazac (51).
7) Hypoglycemic thiazle compounds:
With the improvement of living standards, the incidence rate of obesity is getting higher and higher, and diabetes patients tend to be younger, which has attracted great attention. Many related work is devoted to the research and development of hypoglycemic drugs. The existing hypoglycemic drugs mainly include sulfonylureas, biguanides, phenylalanine, thiazolidinediones, etc,
Among them, thiazolidinedione drugs, as insulin sensitizers, are one of the most widely used hypoglycemic drugs in clinical practice, with advantages such as good efficacy, high bioavailability, and minimal drug interactions.
The success of thiazolidinedione hypoglycemic drugs has encouraged scientists to research and develop more effective thiazle hypoglycemic drugs. There are numerous related literature works, many of which mainly target catalytic enzymes that affect carbohydrate metabolism and construct new thiazle hypoglycemic compounds with excellent affinity centered around the thiazle ring.
8) Antiepileptic drugs:
Thiazole compounds are currently used clinically to treat epilepsy, such as ethylsuccinimide and phenytoin sodium.
However, they have the disadvantages of unclear efficacy and high neurotoxicity, which limits their clinical use. In recent years, azole based antiepileptic drugs have attracted widespread attention due to their superior lipid solubility, good pharmacokinetic properties, and minimal toxic side effects. Thiazle based antiepileptic compounds have become an important breakthrough in the research and development of antiepileptic drugs.
9) Antiparasitic thiazle compounds:
Parasites such as Plasmodium, Toxoplasma gondii, Schistosoma, etc. pose a serious threat to human health and livestock and poultry production.
The resulting human and animal parasitic diseases are a widely distributed, diverse, and severely harmful class of diseases worldwide. It has a wide range of infectious sources and diverse transmission routes, and the susceptible population is mostly elderly and children, which brings many difficulties to the development of antiparasitic drugs. And with the abuse of existing antiparasitic drugs leading to increased parasite resistance, there is an urgent need to develop new antiparasitic drugs. Thiazle antiparasitic drugs such as nilidazole and metronidazole play an important role in clinical practice, and the success of thiazle antiparasitic drugs has encouraged many scientists to develop new thiazle antiparasitic compounds.
Application and research in the field of pesticides
Thiazle compounds, as pesticides, have been widely used in the agricultural field due to their excellent herbicidal activity, efficient plant growth regulation, and low toxicity bactericidal and insecticidal effects. They have made outstanding contributions to promoting the development of animal husbandry and forestry and ensuring crop harvests. Therefore, the research and development of thiazle pesticides have received widespread attention, and many efficient, low toxicity, and economical pesticides have been developed, such as fungicides Thifluzamide (76, Thifluzamide), Ethaboxam (77, Ethaboxam), Metthiophanate (78, Methanovax), and herbicide Chlorpyriprole (79, Mefenacet).
Applications and research in the field of materials
The thiazle ring is a five membered aromatic heterocyclic structure containing electron rich amino sulfur heteroatoms and conjugated systems, exhibiting strong intramolecular electron transfer properties. This structure enables thiazle compounds to exhibit many unique properties and has broad potential applications in the field of materials. At present, the research on thiazle compounds as emerging organic materials has involved multiple fields such as dyes, corrosion-resistant materials, nonlinear optical materials, optoelectronic materials, etc.
Biological dyes
Biological stain is a type of selective coloring agent for special substances in cells, such as nucleic acids, proteins, lipids, etc. It is widely used in the fields of biology and medicine, often used to label special structures such as muscle fibers and organelles, and is one of the basic tools for biological and medical research. Thiazoles, as biological dyes, are widely used in the field of life sciences due to their strong nucleic acid affinity and strong fluorescence properties when embedded in nucleic acids. Especially in recent years, thiazle compounds have attracted much attention in the field of DNA staining agents due to their low internal fluorescence, good chemical stability, and high molar extinction coefficient.
Standardized compliant sales service system
Bloomtechz has full qualifications for handling, producing, storing, and exporting hazardous chemicals. We've built a standardized, regulated, auditable, and traceable compliant sales service system, covering everything from customer inquiries, demand coordination, and order signing to qualification verification, inventory control, and invoice delivery. The whole process is compliant and controllable, eliminating any compliance risks. We're one of the few thiazole raw material brands in the world that can legally handle mass production, custom manufacturing, cross-border sales, and specialized hazardous chemical transportation.
For customers across different industries, scales, and application stages, Bloomtechz has built a tiered and differentiated sales and service model to precisely match customer procurement needs, eliminating resource waste and standard mismatches. For university laboratories, CRO research institutions, new drug R&D teams, and fine chemical experimental units, it opens research-grade small order sales channels, supports procurement of milliliter,
hundred-milliliter, and small-sized samples, with rapid delivery and comprehensive documentation to meet early experimental screening, process tuning, formulation development,
and data benchmarking needs, eliminating the need for customers to stockpile large quantities and reducing R&D costs; For small and medium-sized pesticide enterprises, fine chemical processing plants, and daily chemical and fragrance manufacturers, it provides industrial-grade conventional bulk sales services, stable supply of 98% and 99% purity standard products, suitable for conventional production and formulation blending, offering high cost-performance and stable batch sizes; For large pharmaceutical companies, high-end new materials companies,
listed chemical manufacturers, and cross-border brand traders, we provide high-purity batch sales and annual price-locking and supply assurance services. Long-term strategic cooperation agreements can be signed to lock in annual capacity, stabilize supply prices, prioritize production scheduling and delivery, eliminate issues such as market price fluctuations, raw material shortages, and supply interruptions during peak seasons, and ensure continuous and stable operation of production lines.
One-on-one dedicated sales consultant service, with precise full-process coordination
All partner clients are equipped with dedicated sales consultants and technical engineers working together, providing 7×24 hour consultation services and one-on-one follow-up throughout the entire order process. Before sales, based on the customer's product usage, process standards, usage scenarios, and procurement volume, we can accurately recommend suitable purity, specifications, packaging, and transportation solutions, offering free technical consultation, parameter interpretation, compliance Q&A, and solution optimization services;
During sales, real-time synchronization of production progress, quality inspection data, outbound status, and logistics nodes is provided, promptly responding to customer needs adjustments, parameter changes, delivery delays, and other issues; After-sales continuous follow-up on product user experience, answering various questions such as storage, compatibility, process adaptation, and compliant usage, ensuring an efficient, smooth, and worry-free procurement process throughout the process.
It also supports flexible cooperation models, covering spot procurement, custom production, OEM manufacturing, capacity reservation, and long-term exclusive sales, adapting to customers' diverse cooperation needs.
Frequently Asked Questions
Can small-sample orders enjoy the full set of technical documents that mass production orders do?
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Yes. Most suppliers only provide complete documentation for large orders, but Bloomtechz applies the same quality control standards for all thiazole orders. Even for milliliter or kilogram-level sample orders, we can provide a full set of documents including COA, MSDS, and chromatographic reports, meeting customer needs for experimental archiving, formula filing, and preliminary project reviews.
Does long-term purchasing support locking specific batch parameter ranges?
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Yes, we offer exclusive parameter-locking services. Thiazole, as a volatile heterocyclic material, can experience slight batch-to-batch fluctuations. For long-term clients, we can lock key parameter ranges, strictly controlling moisture, residual impurities, and consistency of distillation fractions, ensuring stable process adaptability for pharmaceutical synthesis and pesticide intermediate mass production, and avoiding frequent adjustments.
During peak seasons with tight capacity, can production be reserved in advance to ensure supply?
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Yes, free production reservation is available. Bloomtechz has a dedicated thiazole distillation line and routinely maintains a safe inventory. For customer stocking plans, capacity can be locked in advance, with no order displacement or delivery delays during peak seasons. A dedicated sales representative tracks order progress and provides real-time updates on production and shipping.
Can low-impurity thiazole customized distillation services be provided?
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Yes. For high-end synthesis and precision experimental scenarios, we can perform secondary deep distillation customizations, specifically removing trace sulfides and residual alcohol impurities. This differs from general industrial- or reagent-grade products on the market and meets high-purity fine synthesis R&D requirements.
How can export of thiazole avoid the risk of hazardous materials classification errors?
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Bloomtechz has mature hazardous material export experience, with precise classification schemes matching thiazole's physicochemical properties, compliant documentation, and risk explanations. Standardized packaging and labeling effectively reduce the risk of customs inspections, classification disputes, and detainment, ensuring efficient and stable cross-border delivery.
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