Dimethylcarbamoyl chloride (also known as DMF-Cl link:https://www.bloomtechz.com/synthetic-chemical/organic-intermediates/dimethylcarbamoyl-chloride-cas-79-44-7.html), is a liquid at room temperature and is a non-volatile liquid. This means it does not evaporate easily at room temperature and can be stored and handled in liquid form. It is important to note that due to its pungent odor and corrosive nature, proper safety measures need to be taken when using and handling it. Melting and boiling points are approximately 26-28°C and 76-78°C, respectively. This indicates that DMF-Cl has relatively low melting and boiling points, making it easy to handle and manipulate in laboratory and industrial settings. The refractive index (nD) is about 1.454. The index of refraction is a measure of the ability of light to bend as it passes through a substance and is important in determining the propagation and refraction behavior of light. It is an organic compound with many uses.
1. Organic synthesis:
Dimethylcarbamoyl chloride is an important intermediate in organic synthesis. It can be used as a carbamoylating reagent for introducing dimethylcarbamoyl (DMF-CO) into other compounds. By reacting it with aromatic amines or alcohols, the corresponding N,N-dimethylcarbamic acid amide derivatives can be synthesized. In addition, it can also participate in reactions such as esterification, etherification, and acylation for the construction of complex organic molecules.
2. Pharmaceutical manufacturing:
Due to its chemical activity, Dimethylcarbamoyl chloride is widely used in the field of pharmaceutical manufacturing. For example, it can be used to synthesize protective groups in polypeptide drugs, such as the synthetic arginine dimethylcarbamoyl ester (Dde) protective group. In addition, Dimethylcarbamoyl chloride can also be used to synthesize compounds such as 5-aza-2'-deoxyuridine (tiazofurin), which have antitumor and antiviral activities.
3. Pesticide manufacturing:
Dimethylcarbamoyl chloride is widely used in the manufacture of pesticides. For example, it is used as a synthetic fungicide, such as dimethylcarbamoylflurazole (DMFU), for protecting crops from fungi and bacteria. In addition, it can also be used to synthesize other types of pesticide intermediates, such as insecticides and herbicides.
4. Manufacture of dyes and pigments:
Dimethylcarbamoyl chloride can be used as a synthetic intermediate for dyes and pigments. By reacting with aromatic amines, carboxamide dyes with different colors can be obtained. By adjusting substituents and structures, dyes with various colors and application characteristics can be obtained, which are widely used in the fields of textiles, leather, inks and plastics.
5. Surfactant manufacturing:
Dimethylcarbamoyl chloride can also be used to prepare surfactants. Derivatives of Dimethylcarbamoyl chloride can be synthesized and used as surfactants by reacting with fatty alcohols or other amino-containing compounds. These surfactants are used in the preparation of products such as detergents, emulsifiers and lubricants.
6. Chemical analysis:
Dimethylcarbamoyl chloride is also commonly used in chemical analysis. It can be used in derivatization reactions to enhance the detection sensitivity of target compounds in chromatographic analysis. For example, by reacting with amines or alcohols, they are converted into the corresponding N,N-dimethylcarbamate amide derivatives, making them easier to detect in gas or liquid chromatographic analyses.
It should be noted that the uses listed above are only part of Dimethylcarbamoyl chloride, and it has many other applications. In any practical application, when using Dimethylcarbamoyl chloride, it is necessary to follow safe operating procedures and handle it according to specific process conditions and requirements.
Dimethylcarbamoyl chloride (DMF-Cl for short) is an organic compound, and its naming involves the naming rules of chemical formula, structure and functional groups.
1. Chemical formula naming:
The chemical formula is named according to the atomic symbols and relative atomic numbers of the elements contained in the compound to indicate the chemical composition. For Dimethylcarbamoyl chloride, its chemical formula is C3H6ClNO.
2. Structure naming:
Structural nomenclature is the way of naming compounds based on the spatial arrangement of the atoms in the molecule. The structure of Dimethylcarbamoyl chloride can be expressed as: ClC(=O)N(C)C.
3. Functional group naming:
Dimethylcarbamoyl chloride molecule contains multiple functional groups, which need to be named one by one.
- Amine group: The N(C)C part of the molecule represents an amine group, where N represents a nitrogen atom and C represents a carbon atom.
- Acyl group: The C(=O) part of the molecule represents the acyl group, where =O represents the carbonyl group on the acyl group, and C represents the carbon atom in the acyl group.
- Chloro group: Cl in the molecule represents a chlorine atom.