Scopolamine butylbromide(link: https://www.bloomtechz.com/synthetic-chemical/api-researching-only/scopolamine-butylbromide-cas-149-64-4.html is an organic compound with the chemical formula C21H30BrNO4 and a molecular weight of 440.3804 g/mol. The compound is a white crystalline powder, almost insoluble in water, it can also form corresponding solutions in some organic solvents, and easily soluble in ethanol, chloroform and benzene. is an ionic compound that has a different ionization constant in water. Among them, the ionization constant of the N(CH3)3 group on the acetylcholine receptor is 9.4×10-5; and the ionization constant of the Br- ion is 7.3×10-17. It belongs to the class of acetylcholine receptor antagonists, and can relax smooth muscle and reduce the secretion of secretions by blocking the action of M1-M5 acetylcholine receptors.
Various chemical properties of Scopolamine butylbromide will be introduced in detail below.
1. Thermal stability:
Scopolamine butylbromide is relatively stable at room temperature, but it is easy to decompose under conditions such as high temperature, humidity and light. Therefore, care should be taken to avoid the influence of these conditions during preparation, storage and use.
2. Spectral properties:
Scopolamine butylbromide has the characteristics of absorbing ultraviolet and infrared rays. The main absorption wavelength in the ultraviolet region is 220-240 nm. The infrared spectrum shows N-H stretching vibration (3323 cm-1), C=O stretching vibration (1690 cm-1), C-O-C stretching vibration (1090 cm-1) and other characteristic peaks.
3. Stability:
Scopolamine butylbromide is relatively stable at room temperature, but it is easy to decompose under conditions such as high temperature, humidity and light. Therefore, care should be taken to avoid the influence of these conditions during preparation, storage and use.
4. Solubility:
Scopolamine butylbromide is practically insoluble in water and readily soluble in ethanol, chloroform and benzene. Such as methanol, ethanol, etc.
Scopolamine butylbromide has good solubility and can be dissolved in various solvents. The following is the solubility data of Scopolamine butylbromide in some common solvents:
Water: 1 g of Scopolamine butylbromide can be dissolved in about 10 ml of water;
Ethanol: 1 g of Scopolamine butylbromide can be dissolved in about 3 ml of ethanol;
Methanol: 1 g of Scopolamine butylbromide is soluble in about 4 ml of methanol;
Dimethyl sulfoxide (DMSO): 1 g of Scopolamine butylbromide can be dissolved in about 5 mL of DMSO.
It should be noted that in some cases, the solubility of Scopolamine butylbromide may be affected by other factors, such as temperature, pH, etc. Therefore, when making pharmaceutical preparations and applications, it is necessary to make appropriate adjustments according to specific conditions to obtain the best results.
5. Ion number constant:
Scopolamine butylbromide is an ionic compound with a different ionization constant in water. Among them, the ionization constant of the N(CH3)3 group on the acetylcholine receptor is 9.4×10-5; and the ionization constant of the Br- ion is 7.3×10-17.
5.1. Ionization constant: The ionization constant of Scopolamine butylbromide is pKa=8.3, which indicates that it has strong alkalinity in aqueous solution and can react with acid to form corresponding salts.
5.2. Degree of dissociation: The degree of dissociation of Scopolamine butylbromide is affected by pH. Scopolamine butylbromide dissociates less at lower pH (acidic environment) and higher at higher pH (basic environment). For example, Scopolamine butylbromide dissociates about 6.5% at pH=7.4 (under physiological conditions).
In general, Scopolamine butylbromide is a compound with ionic properties, and its ionization is often used to describe its chemical behavior and physical properties in aqueous solution.
In summary, Scopolamine butylbromide is a white crystalline powder with UV and IR absorbing properties. It plays an important role in smooth muscle and secretion regulation, but it is easy to decompose under conditions such as high temperature, humidity and light, so it needs to pay attention to storage and use conditions.
In 1893, German pharmacist Wilhelm Täufert extracted an organic compound called atropin from foxglove. Atropin is a potent anticholinergic drug that has typical anticholinergic effects such as inhibition of the heart and respiratory organs.
In 1894, British pharmacist Skinton Burns (Henry Hallett Dale) discovered a neurotransmitter called choline when studying the mechanism of action of atropin, which is the physiological process of controlling muscle contraction and secretion in the human body. important substance.
Since then, in the process of anticholinergic tests on various drugs, scientists have successively discovered many anticholinergic drugs similar to atropin, including Scopolamine butylbromide.
In 1900, German pharmacist Heinrich Lefler synthesized Scopolamine for the first time, but did not find it to have good clinical application value. Until 1917, the German pharmacist Krusman took over the research work of Rifingold, and improved the synthesis method according to the chemical structure of Scopolamine, and successfully prepared Scopolamine butylbromide. Since then, the drug has spread rapidly in Germany and has become an important drug for treating gastrointestinal diseases and other diseases.
With the in-depth research on the mechanism of action of Scopolamine butylbromide, its scope of application is also expanding. For example, it can be used as an adjuvant to narcotic drugs, which can reduce the side effects of vomiting and dry mouth. In addition, in terms of the motor system, Scopolamine butylbromide can relieve pain and discomfort caused by motor system diseases such as muscle spasms and ankylosing spondylitis.
In general, Scopolamine butylbromide is a long-established and widely used anticholinergic drug, which originated from the research on atropin at the end of the 19th century. After years of hard work by scientists, it has gradually become known and used by people.