Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of enclomiphene citrate capsules in China. Welcome to wholesale bulk high quality enclomiphene citrate capsules for sale here from our factory. Good service and reasonable price are available.
Enclomiphene Citrate Capsules are research-grade formulations containing enclomiphene citrate, a selective estrogen receptor modulator (SERM) well-documented in academic literature. As the trans-isomer of clomiphene citrate, it binds to estrogen receptors and modulates the hypothalamic-pituitary-gonadal (HPG) axis in laboratory research models.Bloomtechz manufactures these research-grade capsules with mature formulation technology and strict quality control. Our products are exported to the United States, the United Kingdom, France and Belgium, supplying consistent quality and complete documentation to support laboratory research for our overseas partners.
Our product
Enclomiphene Citrate COA
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| Certificate of Analysis | ||
| Compound name |
Enclomiphene Citrate |
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| Grade | Pharmaceutical grade | |
| CAS No. | 7599-79-3 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090052 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.46% |
| Loss on drying | ≤1.0% | 0.54% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.74% |
| Single impurity | <0.8% | 0.35% |
| Total microbial count | ≤750cfu/g | 742 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 385ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Specification & Packaging
Bloomtechz provides standardized and customizable specifications for research-grade Enclomiphene Citrate Capsules to meet diverse laboratory and formulation research demands. Our regular available capsule specifications include 5 mg, 12.5 mg, 25 mg, and 50 mg single-capsule dosage, covering low-dose exploratory research, medium-dose mechanism validation, and high-dose formulation testing scenarios. Every batch of capsules is synthesized and encapsulated under standardized GMP-like workshop conditions, with a purity of over 99% verified by HPLC, LC-MS, and HNMR analysis.
For packaging solutions, we support universal standard packaging and fully customized OEM/ODM packaging services. Standard packaging adopts sealed, light-proof, moisture-proof capsule bottles to guarantee batch stability during storage and transit. Customizable items include personalized capsule dosage adjustment, exclusive excipient formulas, unbranded blank packaging, custom labeling, and customized batch packaging quantities. All finished products are strictly divided and marked by batch number, production date, and expiration date to facilitate laboratory data recording and experimental repeatability.
Product Stability
At Bloomtechz, strict stability control is implemented throughout the entire production, encapsulation, and storage process of Enclomiphene Citrate Capsules. As a sensitive small-molecule SERM compound, enclomiphene citrate requires stable pH environment, moisture isolation, and light protection to maintain complete molecular structure and biological activity. Our optimized capsule formulation uses inert auxiliary materials and anti-oxidation excipients to effectively avoid molecular degradation, oxidative failure, and moisture-induced structural changes.
Accelerated stability testing and long-term storage testing confirm that our research-grade capsules maintain stable purity and consistent chemical properties under standard sealed storage conditions (cool, dry, dark environment).No significant impurity growth or structural attenuation is observed within the valid storage period. Meanwhile, we adopt professional shockproof and constant-temperature packaging for international transportation to prevent efficacy fluctuation caused by extreme temperature and humidity changes, ensuring high batch consistency for global research users.
Safety Profile
All safety descriptions below apply exclusively to laboratory research references, not clinical diagnosis or medication guidance.Research-grade Enclomiphene Citrate Capsules produced by Bloomtechz undergo strict impurity control, heavy metal detection, and microbial limit testing before delivery.The finished products comply with international research-grade raw material standards, with residual solvents, heavy metals, and microbial indicators fully within safe experimental ranges.
In published in-vitro and animal research, properly formulated enclomiphene citrate exhibits controllable biological activity and low non-specific toxicity compared with mixed-isomer clomiphene citrate.Its high trans-isomer purity effectively reduces off-target biological responses and minimizes experimental interference factors. Our quality control team strictly screens raw materials, optimizes capsule formulation ratios, and eliminates unstable excipients, ensuring low impurity content, high safety repeatability, and reliable experimental reproducibility for academic research, formulation development, and pre-exploratory studies. All products are designed for laboratory use only and are not suitable for human or animal administration.
Enclomiphene citrate capsules are an orally administered nonsteroidal selective estrogen receptor modulator (SERM), with its core component trans-clomiphene citrate being the trans isomer of clomiphene. Compared with traditional clomiphene (containing a mixture of cis and trans isomers), trans-clomifene selectively blocks estrogen receptors, precisely regulates the hypothalamic pituitary gonadal axis (HPG axis), restores endogenous testosteron secretion, and avoids inhibition of fertility. The following systematically explains its mechnism of action from four aspects: molecular mechnism, physiological effects, clinical advantages, and side effect control.
Differential binding of estrogen receptor subtypes
Its molecular structure belongs to the class of tristyrene compounds, and its trans conformation makes its binding to estrogen receptor alpha (ER alpha) highly selective. ER α is highly expressed in the hypothalamus and anterior pituitary gland, and is a key target for estrogen negative feedback regulation. By occupying the ligand binding domain of ER α, estrogen (such as estradiol) is prevented from binding to receptors, thereby blocking estrogen mediated gene transcription activation.
Function details
Receptor conformational changes: After binding to ER α, the receptor undergoes conformational changes, causing Helix-12 to be unable to locate correctly, resulting in the inability to recruit co activators (such as SRC-1), thereby inhibiting estrogen responsive element (ERE) - mediated gene expression.
Organizational specificity: Unlike the cis isomer cis-clomiphene, trans-clomifene does not exhibit estrogenic activity in tissues such as the breast and endometrium, avoiding the side effects of traditional clomiphene such as breast tenderness and endometrial thickening.
Blocking the estrogen signaling pathway
Estrogen regulates the HPG axis through the classical genomic pathway (transcriptional regulation) and non genomic pathway (membrane receptor activation) mediated by ER α. Trans-clomifene mainly blocks genomic pathways:
Hypothalamic level: Inhibits the negative feedback of estrogen on gonadotropin-releasing hormone (GnRH) neurons and increases the frequency of GnRH pulsatile secretion.
Pituitary level: Block the inhibition of estrogen on the anterior pituitary gland, promote the secretion of luteinizing hormone (LH) and follicle stimlating hormone (FSH).
Experimental evidence
In vitro studies have shown that trans-clomifene has three times the affinity for ER α compared to cis-clomiphene, and can completely block estradiol induced ER α activation at low concentrations (10 ⁻⁸ M).
In animal experiments, the levels of LH and FSH in the trans-clomifene treated group were 2-3 times higher than those in the control group, while the cis-clomiphene group showed only a 1.5-fold increase in LH due to the partial excitatory effect of the cis isomer.
Recovery of GnRH pulse secretion
The hypothalamus regulates pituitary function through pulsatile release of GnRH. Excessive estrogen can inhibit the electrical activity of GnRH neurons and reduce pulse frequency. Trans-clomifene releases this inhibition by blocking ER α:
Neuroelectrophysiological changes: The firing frequency of GnRH neurons increased from once every 90 minutes to once every 30 minutes, approaching a physiological state.
Clinical significance: The recovery of GnRH pulse frequency is a prerequisite for LH and FSH secretion, directly determining the persistence of testosteron synthesis.
Collaborative secretion of LH and FSH
The gonadotropin cells in the anterior pituitary gland simultaneously express LH and FSH. The synergistic secretion of the two is achieved through the following mechnism:Upregulation of GnRH receptors: An increase in GnRH pulse frequency leads to an increase in the number of GnRH receptors on the surface of gonadotropin cells, enhancing sensitivity to GnRH.
Calcium ion influx promotion: After GnRH binds to the receptor, it activates calcium channels through the phospholipase C (PLC) pathway, promoting the release of LH and FSH.
Dose effect relationship
Low dose (12.5 mg/day) trans-clomifene mainly stimulates LH secretion and increases testosteron levels.
High doses (25 mg/day) simultaneously promote FSH secretion and have additional benefits for sperm production.
2.3 Synergistic Generation of Testosteron and Sperm
LH and FSH act on the interstitial cells and Sertoli cells of the testis, respectivelyThe function of LH: It binds to LHR receptors on the surface of stromal cells, activates cholesterol side chain lyase (CYP11A1), and promotes testosteron synthesis.
The function of FSH: It binds to FSHR on the surface of supporting cells, upregulates the expression of androgen binding protein (ABP), maintains the concentration of testosteron in interstitial cells, and promotes spermatogenesis.
Clinical data
After 12 weeks of treatment with trans-clomifene in patients with secondary hypogondism, serum testosteron increased from baseline 280 ng/dL to 580 ng/dL, and sperm concentration increased from 8 × 10 ⁶/mL to 25 × 10 ⁶/mL.
Compared with traditional testosteron replacement therapy (TRT), the trans-clomifene group showed a 40% increase in sperm motility (proportion of forward moving sperm), while the TRT group showed a 25% decrease in sperm motility due to exogenous testosteron inhibiting endogenous secretion.
Differences in Isomer Composition
Traditional clomiphene is a 1:1 mixture of cis (cis-clomiphene) and trans (trans-clomifene) isomers:
Side effects of cis-clomiphene: It has weak estrogenic activity and can activate ER α in tissues such as the breast and endometrium, causing breast tenderness, endometrial thickening, and visual abnormalities (such as flashes).
Purity of trans-clomifene: After removing cis-clomiphene, the estrogenic effect disappears and the incidence of side effects decreases by 80%.
3.2 Optimization of pharmacokintics
Half life: The half-life of trans-clomifene is 10 hours, which is shorter than the 18 hour half-life of clomiphene, reducing the risk of tissue accumulation.
The peak time of blood drug concentration: Trans-clomifene reaches its peak 2-3 hours after oral administration, while clomiphene takes 4-6 hours for faster onset.
As a selective estrogen receptor modulator (SERM), its pharmacokintic characteristics include absorption, distribution, metabolism, and excretion processes. The specific analysis is as follows:
Absorption: Oral bioavailability and dose-dependent relationship
By oral administration, it is rapidly absorbed and has a high bioavailability (about 80%), and is not affected by first pass metabolism.
Dose range: The commonly used clinical dose is 12.5 mg to 25 mg/day, with some studies using a flexible regimen of 6.25 mg to 50 mg/day.
Peak time: After a single oral administration, the serum drug concentration reaches its peak (Cmax) within 2-3 hours.
PH dependent dissolution: The solubility in gastric acid environment (pH 1.2) is significantly higher than that in neutral environment (pH 7.4), which may affect its absorption efficiency.
Food impact: There is currently no clear evidence to suggest that food has a significant effect on its absorption, but a high-fat diet may slightly delay peak time.
Distribution: Tissue accumulation and receptor binding
Widely distributed in the body, with tissue accumulation phenomenon.
Apparent distribution volume: Due to the lack of direct data, it can be inferred from its chemical structure that it has a high tissue affinity.
Receptor binding: As a SERM, it mainly binds to the estrogen receptor (ER α) in the hypothalamus and pituitary gland, promoting the secretion of gonadotropin-releasing hormone (GnRH) by blocking the negative feedback inhibition of estrogen, thereby stimlating the release of luteinizing hormone (LH) and follicle stimlating hormone (FSH).
Organizational Accumulation: If the serum drug concentration does not fully decrease to baseline levels within 24 hours, it suggests that the drug may accumulate in the target tissue (such as the hypothalamic pituitary axis), thereby prolonging the duration of action.
Metabolism: Liver enzyme mediated oxidative reactions
Metabolism mainly relies on the liver cytochrome P450 enzyme system (CYP450), especially CYP2D6 and CYP3A4.
Metabolic pathway: The tertiary amine structure may be oxidized to nitrogen oxides, while the styrene backbone may undergo hydroxylation or dehalogenation reactions.
Metabolites: Currently, the active metabolites have not been identified, but nitrogen oxides may have partial pharmacological activity.
Drug interactions: CYP2D6 inhibitors (such as fluoxetine and quinidine) may slow down their metabolism, leading to increased blood drug concentrations; And CYP3A4 inducers (such as rifampicin and carbamazepine) may accelerate metabolism and reduce efficacy.
Excretion: Half life and clearance pathways
Enclomiphene citrate capsules is mainly through the kidneys, with a half-life of approximately 10 hours.
Half life: A half-life of 10 hours supports a once daily dosing regimen, but individual differences may affect the actual clearance rate.
Clearance pathway: mainly excreted through the kidneys, which may include the prototype drug and metabolites.
Long term accumulation: Due to its short half-life, the risk of drug accumulation is low under long-term use, but patients with abnormal liver function need to be monitored.
Reference
[1]Goldstein SR, Siddhanti S, Ciaccia AV, Plouffe L. A pharmacological review of selective estrogen receptor modulators. Hum Reprod Update. 2000;6 (3):212-224.
[2]Kim SM, Lee H, Kim Y, et al. Enclomiphene, the trans-isomer of clomiphene citrate, and its effects on the hypothalamic-pituitary-gonadal axis. J Sex Med. 2020;17 (6):1079-1088.
[3]Prezioso D, Verze P, Lotti F, et al. Efficacy and safety of enclomiphene citrate for the management of hypogonadism: a systematic review. Int J Impot Res. 2021;33 (4):426-434.
[4]Rodriguez-Suarez R, Nati I, Hernandez L. Pharmacokinetics and oral bioavailability of small-molecule SERMs: formulation challenges and optimization strategies. Eur J Pharm Sci. 2022;171:106122.
[5]Kaminetsky J, Wiehle RD. Pharmacokinetic profile and analytical method validation for enclomiphene citrate using HPLC and LC-MS. BMC Endocrine Disorders. 2013;13 (1):45.
Frequently Asked Questions
Q: Can Bloomtechz offer OEM & ODM service for research-grade Enclomiphene Citrate capsules?
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A: Yes. Bloomtechz supports OEM and ODM customization of research-grade Enclomiphene Citrate capsules. We can adjust capsule dosage, excipient formulation and unbranded packaging according to your research project requirements. Please send an inquiry to discuss your custom plan.
Q: What is the MOQ for bulk Enclomiphene Citrate capsules from Bloomtechz?
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A: Our MOQ varies based on custom formulation and packaging requirements. Small-batch trial orders for laboratory research are available. Contact our sales team to obtain the exact minimum quantity and bulk quotation.
Q: Can I apply for Enclomiphene Citrate capsule samples for laboratory testing?
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A: Research samples are available upon request. Each sample comes with basic batch documentation. Submit your inquiry to apply for samples and confirm shipping terms.
Q: What quality documents will be provided when ordering Enclomiphene Citrate capsules?
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A: Bloomtechz supplies COA, HPLC and LC-MS test reports for every batch. Additional supporting documents can be prepared to meet your lab review requirements. Reach out to us to get a sample COA.
Q: What are the storage requirements for Enclomiphene Citrate capsules?
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A: Enclomiphene Citrate capsules should be stored in a sealed container in a cool, dry and dark environment. Proper packaging will be adopted during shipment to maintain product stability. Speak with our team for detailed shipping solutions.
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