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Lactoferrin capsules are dietary supplements with lactoferrin as the main active ingredient, usually extracted and prepared from cow's milk. Its preparation process mainly includes the following steps.
Raw material selection:Select fresh and pollution-free cow's milk as raw material to ensure the activity and purity of lactoferrin.
Extraction and Purification:Lactoferrin was separated and purified from milk by techniques such as ultrafiltration, ion-exchange chromatography and affinity chromatography. Modern processes often adopt multi-stage purification steps to enhance the purity and activity of lactoferrin.
Formula design:The purified lactoferrin is mixed with excipients (such as microcrystalline cellulose, magnesium stearate, etc.) to prepare capsule dosage forms. The selection of excipients needs to take into account their influence on the stability of lactoferrin.
Formulation process:The mixture is made into capsules by using techniques such as wet granulation, dry granulation or direct tablet pressing. Capsule shells are usually made of gelatin or plant-based materials to ensure the safety and stability of the product.
Quality control:Content determination, microbiological testing, heavy metal testing, etc. are carried out on the finished products to ensure that they meet the quality standards.
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Lactoferrin powder COA
Antiviral effect
Lactoferrin capsules is a dietary supplement with Lactoferrin (LF) as the main active ingredient. Lactoferrin is a non-heme iron-binding glycoprotein widely present in the milk and other secretions of mammals. It has broad-spectrum antiviral activity and can inhibit the infection and replication of viruses through multiple mechanisms.
The Antiviral Mechanism of Lactoferrin
Block virus adsorption and invasion
Binding to proteins on the surface of viruses or host cells: Lactoferrin can bind to glycoproteins on the surface of viruses or receptors on the surface of host cells, preventing the binding of viruses to host cells and thereby inhibiting the adsorption and invasion of viruses into cells.
Binding to heparan sulfate proteoglycan (HSPG) in cells: Lactoferrin can bind to HSPG on the cell membrane surface, forming a local high-concentration protective layer of lactoferrin on the cell surface, which blocks the binding of viruses to cells.
Inhibit virus replication
Inhibiting the synthesis of viral RNA/DNA: Lactoferrin can enter cells and interfere with the synthesis of viral RNA or DNA, thereby inhibiting viral replication.
Inhibiting the expression of viral proteins: Lactoferrin can inhibit the expression of viral proteins, preventing the assembly and release of viral particles.
Regulate the immune response
Enhancing the activity of natural killer cells (NK cells) : Lactoferrin can activate NK cells and enhance their killing effect on virus-infected cells.
Promoting the secretion of interferon and other cytokines: Lactoferrin can promote the secretion of antiviral cytokines such as interferon and enhance the body's antiviral immune response.
Iron chelating effect
Depriving the virus of the iron needed for replication: Lactoferrin is an efficient iron-binding protein that can deprive the virus of the iron needed for replication, thereby inhibiting the replication of the virus.
The inhibitory effect of lactoferrin on various viruses
Inhibitory effect on SARS-CoV-2: Studies have shown that lactoferrin can inhibit SARS-CoV-2 infection of host cells and reduce the spread and proliferation of the virus in the body. Among patients infected with the novel coronavirus, the expression level of lactoferrin was significantly upregulated, suggesting that it plays an important role in antiviral defense.
Clinical trial: A study on patients with mild to moderate COVID-19 showed that patients taking lactoferrin recovered their clinical symptoms more quickly, with significantly reduced inflammatory parameters such as serum ferritin and IL-6 levels, and a significantly shortened time for SARS-CoV-2 RNA to turn negative.
Inhibitory effects on subtypes such as H1N1, H3N2, and H5N1: Lactoferrin can inhibit the adsorption and invasion of influenza viruses and reduce the replication of viruses within cells.
Animal experiments: In mouse models, lactoferrin can significantly alleviate lung inflammation and pathological damage caused by influenza virus infection.
Inhibitory effect on rotavirus: Lactoferrin can alleviate the symptoms of diarrhea and vomiting caused by rotavirus infection and shorten the course of the disease.
Mechanism research: Lactoferrin can inhibit the binding of rotavirus to host cells, prevent the virus from entering the cells, and suppress the replication of the virus within the cells.
Inhibitory effects on HSV-1 and HSV-2: Lactoferrin can inhibit the replication of herpes simplex virus and reduce the release of viral particles.
Clinical research: A study on herpangina in children shows that oral administration of this product can significantly improve the therapeutic effect, shorten the time for fever reduction and symptom relief.
Inhibitory effects on HIV, HCV, enteroviruses, etc. : Lactoferrin can also inhibit the infection and replication of various viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and enteroviruses.
Application of Lactoferrin Capsules in Antiviral Therapy
Prevent viral infection
Boosting immunity: This product can regulate the function of the immune system, enhance the body's antiviral ability, and reduce the risk of viral infection.
Daily health care: For people with low immunity, such as infants, the elderly, and pregnant women, taking an appropriate amount of this product can help prevent viral infections.
Adjuvant treatment for viral infections
Relieve symptoms: In the early stage of viral infection, this product can inhibit viral replication, reducing the severity and duration of symptoms.
Shorten the course of the disease: This product can promote physical recovery and shorten the course of viral infection.
Application for Special groups
Infants and young children: Lactoferrin is an important component in breast milk. For infants and young children who cannot be breastfed, taking this product can help enhance immunity and prevent viral infections.
The elderly: The elderly have relatively weak immunity and are more prone to viral infections. This capsule can enhance its antiviral ability and reduce the risk of infection.
Dietary regulation strategy
Lactoferrin capsules, as nutritional supplements for immune regulation and iron metabolism optimization, have bioavailability and clinical efficacy closely related to diet. Reasonable dietary regulation can not only enhance the absorption efficiency of lactoferrin, but also reduce the risk of adverse reactions. The following is a detailed explanation from four aspects: dietary coordination, taboo combinations, nutritional fortification, and dietary plans for special groups.
Dietary synergy Strategies for Promoting Lactoferrin Absorption
Mechanism: Vitamin C can reduce Fe³⁺ to Fe²⁺, promoting the stability of the lactoferrin-iron complex and increasing the iron absorption rate by 30%-40%.
Recommended food:
Citrus fruits: such as oranges (containing 53 milligrams of vitamin C per 100 grams), pomelos (38 milligrams per 100 grams).
Berries: Strawberries (59 mg /100 g), kiwis (93 mg /100 g).
Vegetables: Red pepper (128 mg /100 g), broccoli (89 mg /100 g).
It is recommended to consume 200 to 300 milligrams of vitamin C daily, which is equivalent to one orange and 100 grams of broccoli. It can be taken twice a day, before and after meals.
Mechanism: Lactoferrin needs to bind to the lactoferrin receptor (LfR) on the intestinal mucosa to be absorbed, and insufficient protein intake will reduce the expression of the receptor.
Recommended food:
Animal protein: egg (6 grams per piece), milk (3 grams per 100 milliliters), fish (18 grams per 100 grams).
Plant protein: Tofu (8g / 100g), chickpeas (19g / 100g).
Suggestion: Daily protein intake should be calculated based on body weight (1.0-1.2 grams per kilogram). For example, a 60-kilogram adult needs to consume 60-72 grams.
Mechanism: Lactoferrin can inhibit pathogenic bacteria, and probiotics can regulate the intestinal flora. The combination of the two can improve the intestinal microenvironment and enhance the bioavailability of lactoferrin.
Recommended food:
Fermented dairy products: yogurt (containing Lactobacillus bulgaricus and Streptococcus thermophilus), kefir (containing various lactic acid bacteria).
Fermented vegetables: kimchi (containing Lactobacillus plantarum), kombucha (containing acetic acid bacteria).
It is recommended to consume 100 to 200 grams of fermented dairy products or 30 to 50 grams of fermented vegetables daily.
Dietary Restrictions to Avoid
Mechanism: Calcium and phosphorus can form insoluble complexes with lactoferrin, reducing the absorption rate.
Forbidden foods:
High-calcium foods: milk (120 mg /100 ml), cheese (700 mg /100 g), almonds (264 mg /100 g).
High-phosphorus foods: nuts (such as almonds 570 milligrams per 100 grams), whole grains (such as oats 362 milligrams per 100 grams).
Suggestion: Avoid eating the above-mentioned foods within one hour before and after taking this product. You can replace milk with yogurt (which has a higher calcium absorption rate).
Mechanism: Tannic acid can combine with lactoferrin to form a precipitate, reducing bioavailability.
Forbidden foods:
Tea types: Black tea (containing 20%-30% tannic acid), green tea (10%-15%).
Fruits: Persimmons (with tannic acid content as high as 4%), grapes (1%-2%).
Suggestion: Avoid drinking tea within 2 hours before and after taking this product. Do not eat more than one persimmon a day.
Mechanism: Fat can delay gastric emptying and reduce the absorption efficiency of lactoferrin in the intestinal tract.
Forbidden foods:
Fried foods: Fried chicken (15%-20% fat content), French fries (12%-15%).
Animal offal: Pig liver (fat content 3%-5%), fat intestine (18%-20%).
It is recommended that during the period of taking this product, the daily fat intake should not exceed 30% of the total calories (for example, in a 2000-calorie diet, the fat intake should not exceed 67 grams).
Nutritional Fortification and Dietary Combination Plans
Intensive diet for patients with iron deficiency anemia
Plan: This capsules (200 mg/day) + Vitamin C (200 mg/day) + heme iron (such as 100 grams of pork liver/week).
Example:
Breakfast: 1 egg + 1 orange + whole wheat bread.
Lunch: Stir-fried pork liver with spinach (50 grams of pork liver) + broccoli.
Dinner: 100 grams of yogurt + 1 kiwi fruit.
Dietary adjustments for people with weakened immunity
Plan: This capsules (300 mg/day) + Probiotics (200 g/day of fermented dairy products) + zinc (such as 100 g/week of oysters).
Example:
Breakfast: 100 grams of yogurt + 10 grams of nuts.
Lunch: 100 grams of salmon + brown rice.
Dinner: 50 grams of tofu soup and kimchi.
Dietary plans for people with abnormal intestinal function
Plan: This capsules (150 mg/day) + low FODMAP diet (such as 50 grams of oats/day) + Turmeric (anti-inflammatory).
Example:
Breakfast: Oatmeal + 1 banana.
Lunch: 100 grams of chicken breast + steamed pumpkin.
Dinner: 100 grams of yogurt + 1 gram of turmeric powder.
The dietary regulation of lactoferrin capsules should follow the principle of "synergistic enhancement and avoidance of inhibition". By rationally combining vitamin C, high-quality protein and probiotics, the absorption efficiency can be improved, while avoiding foods high in calcium, phosphorus and tannic acid. Special groups of people need to adjust their diet plans according to their physiological characteristics to ensure balanced nutrition and safe medication. Long-term users are advised to monitor their blood routine, iron metabolism and liver and kidney functions every three months, and adjust their diet and medication strategies in a timely manner.
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