Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of cetrorelix acetate injection in China. Welcome to wholesale bulk high quality cetrorelix acetate injection for sale here from our factory. Good service and reasonable price are available.
Cetrorelix Acetate Injection is a synthetic decapeptide that belongs to the class of gonadotropin-releasing hormone (GnRH) antagonists. It competitively binds to receptors on the pituitary cell membrane with endogenous GnRH, thereby inhibiting pituitary secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH), and this inhibitory effect is dose-dependent. GnRH typically binds to GnRH receptors on the surface of pituitary gonadotropin cells, stimulating the secretion of LH and FSH. Acetic acid cetuximab has a similar structure to GnRH and can competitively bind to these receptors, thereby blocking the action of GnRH. It can inhibit pituitary secretion of LH and FSH by blocking the action of GnRH. This inhibitory effect appears rapidly after medication, and continuous treatment can maintain the inhibitory effect.
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Cetorelix COA
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| Certificate of Analysis | ||
| Compound name | Cetrorelix Acetate | |
| Grade | Pharmaceutical grade | |
| CAS No. | 145672-81-7 | |
| Quantity | 15g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.47% |
| Loss on drying | ≤1.0% | 0.29% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.55% |
| Total microbial count | ≤750cfu/g | 127 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 400ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula | C70H92ClN17O14 | |
| Exact Mass | 1429.67 | |
| Molecular Weight | 1431.06 | |
| m/z | 1429.67 (100.0%), 1430.67 (75.7%), 1431.67 (32.0%), 1431.68 (28.3%), 1432.67 (24.2%), 1433.67 (9.0%), 1430.67 (6.3%), 1432.68 (6.1%), 1431.67 (4.5%), 1431.67 (2.9%), 1434.68 (2.2%), 1432.68 (2.2%), 1432.66 (1.9%), 1432.67 (1.8%), 1433.67 (1.5%), 1433.68 (1.3%), 1430.68 (1.1%) | |
| Elemental Analysis | C, 58.75; H, 6.48; Cl, 2.48; N, 16.64; O, 15.65 | |
Assisted reproductive technology (ART) has brought hope for fertility to many infertile patients, among which in vitro fertilization embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI) are widely used. Among these technologies, precise control of ovulation is a key link that directly affects the success rate and safety of treatment. Cetrorelix Acetate Injection, as a gonadotropin-releasing hormone (GnRH) antagonist, plays an important role in ovulation control in assisted reproductive technology. Assisted reproductive technology (ART) has brought hope for fertility to many infertile patients, among which in vitro fertilization embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI) are widely used. Among these technologies, precise control of ovulation is a key link that directly affects the success rate and safety of treatment. This injection plays an important role in ovulation control in assisted reproductive technology as a gonadotropin-releasing hormone (GnRH) antagonist.
Pharmacological effects of Cetrorelix Acetate
Cetrorelix Acetate is a synthetic decapeptide that belongs to the GnRH antagonist class. GnRH is a hormone secreted by the hypothalamus that binds to the GnRH receptor on the membrane of anterior pituitary cells, stimulating the pituitary gland to secrete luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH and FSH play a crucial role in the female reproductive cycle, with LH peak triggering egg maturation and ovulation, while FSH promotes follicle development and estrogen synthesis.
It can competitively bind to receptors on the pituitary cell membrane with endogenous GnRH, thereby blocking the stimulating effect of GnRH on the pituitary gland and inhibiting the secretion of LH and FSH. This inhibitory effect is dose-dependent, meaning that the higher the drug dosage, the stronger the inhibitory effect on LH and FSH secretion. Unlike GnRH agonists, it does not have an initial stimulatory effect and can rapidly produce inhibitory effects after medication, and continuous treatment can maintain this inhibitory effect.
During the natural menstrual cycle, follicle development to a certain stage triggers LH peaks, leading to egg maturation and ovulation. However, in the controlled ovarian stimulation (COS) process of assisted reproductive technology, premature LH peak can lead to premature rupture of follicles, resulting in decreased egg quality or inability to obtain a sufficient number of mature eggs, thereby reducing fertilization and pregnancy rates. Cetrorelix Acetate Injection can delay the appearance of LH peak by inhibiting LH secretion, ensuring that follicles reach optimal maturity under the control of doctors and providing high-quality eggs for subsequent egg retrieval and in vitro fertilization.
Pharmacokinetic characteristics
After subcutaneous injection, the substance has a high bioavailability of approximately 85%. The total plasma clearance rate and renal clearance rate were 1.2ml/min/kg and 0.1ml/min/kg, respectively, with a distribution volume (Vd) of 1.1l/kg. The average terminal half lives after intravenous injection and subcutaneous injection are approximately 12 hours and 30 hours, respectively. The pharmacokinetics of single subcutaneous administration (0.25mg-3mg cetuximab) and continuous daily administration for 14 days showed linearity, providing a basis for dose adjustment in clinical medication.
Specific uses in assisted reproductive technology
In the COS process of assisted reproductive technology, it is usually necessary to use gonadotropins (such as FSH, HMG, etc.) to stimulate the simultaneous development of multiple follicles to increase the number of retrieved eggs. However, the occurrence of endogenous LH peak during follicular development is a potential risk. This substance can effectively prevent premature ovulation and ensure egg retrieval at the appropriate time by inhibiting LH secretion. For example, in in in vitro fertilization embryo transfer therapy, doctors will start using gonadotropins for ovarian stimulation at specific times during the menstrual cycle based on the patient's specific condition. When the diameter of the dominant follicle reaches 14-16mm, inject an injection containing this substance once a day until 24-36 hours before ovulation induction. This can ensure that follicles continue to develop and mature under the action of gonadotropins, while avoiding premature ovulation caused by LH peak.
Reduce the risk of ovarian hyperstimulation syndrome (OHSS)
OHSS is one of the common complications in assisted reproductive technology, mainly manifested as ovarian hyperresponsiveness, causing symptoms such as ascites, pleural effusion, blood concentration, electrolyte imbalance, and even life-threatening in severe cases. The occurrence of OHSS is related to the excessive response of the ovaries to gonadotropins and the stimulation of LH peaks. Cetrorelix Acetate Injection reduces the risk of OHSS by suppressing LH peaks and reducing ovarian overreaction to gonadotropins. Research has shown that compared to GnRH agonist regimens, the use of Cetrorelix antagonist regimens can reduce the incidence of moderate to severe OHSS from 3.2% to 1.1%, significantly improving the safety of treatment.
A stable hormonal environment is crucial for the normal development and maturation of eggs. During ovulation induction, hormone fluctuations caused by LH peak may affect the quality of eggs. It can maintain stable hormone levels, avoid the adverse effects of LH peak, and help improve the quality of eggs. High quality eggs are a key factor in improving fertilization rates and embryo quality, thereby increasing the chances of successful pregnancy. Clinical data shows that using this product can increase the average number of retrieved eggs by 15% -20%, and significantly improve the maturity and quality of eggs.
Reduce the risk of multiple pregnancies
Multiple pregnancy is another important issue of assisted reproductive technology. It not only increases the risk of pregnancy for pregnant women, such as hypertensive disorder during pregnancy, diabetes, postpartum hemorrhage, etc., but also has adverse effects on the health of newborns, such as premature delivery, low birth weight, neonatal asphyxia, etc. It reduces the risk of multiple pregnancies by precisely controlling the development of follicles, thereby reducing the likelihood of multiple follicles maturing simultaneously. This helps to improve the safety of assisted reproductive technology and ensure maternal and infant health.
The receptivity of the endometrium is crucial for embryo implantation. In assisted reproductive technology, stable hormone levels help maintain the good condition of the endometrium and provide a suitable environment for embryo implantation. This substance can improve the receptivity of the endometrium and increase the success rate of embryo implantation by stabilizing hormone levels.
Frequently Asked Questions
What is cetrorelix acetate used for?
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Cetrorelix is used to prevent premature ovulation as part of controlled ovarian stimulation treatment. The content of 1 vial (0.25 mg) is administered once a day every 24 hours. In individual cases, it can also be given twice a day at intervals of 12 hours.
How effective is cetrorelix injection?
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In conclusion, a daily cetrorelix injection (0.25 mg) is able to prevent premature LH surge under the letrozole-FSH protocol but is not fully efficient. The beneficial effect for IUI treatment in terms of pregnancy rate needs to be further elucidated.
What happens after a cetrorelix injection?
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Common side effects include pain, discoloration or redness, or swelling at the injection site. Nausea and headache can also occur. Cetrorelix is an injection that you will give yourself after training from your healthcare provider.
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