Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of sincalide injection in China. Welcome to wholesale bulk high quality sincalide injection for sale here from our factory. Good service and reasonable price are available.
Sincalide (CAS: 20184-48-5) is a synthetic octapeptide compound. It appears as white crystalline powder with good water solubility, which suits the preparation of liquid injections. This peptide maintains stable molecular structure and biological activity when stored in sealed, cool and dark conditions; exposure to high temperature and excessive humidity will lead to activity loss and quality decline. As a synthetic cholecystokinin octapeptide diagnostic agent that precisely replicates the physiological actions of endogenous CCK, sincalide injection acts as a key pharmaceutical preparation for examining pancreatobiliary function. Delivered via intravenous administration, it takes effect quickly and strongly triggers gallbladder contraction. Combined with ultrasonography and radiography, it allows clinicians to thoroughly evaluate gallbladder function. Meanwhile, it helps collect bile specimens to support subsequent component analysis and related clinical tests.
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Sincalide COA
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| Certificate of Analysis | ||
| Compound name | Sincalide | |
| Grade | Pharmaceutical grade | |
| CAS No. | 25126-32-3 | |
| Quantity | 39g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula | C49H62N10O16S3 | |
| Exact Mass | 1142.35 | |
| Molecular Weight | 1143.27 | |
| m/z | 1142.35(100.0%), 1143.35(53.0%), 1144.36(13.8%), 1144.35(13.6%), 1145.35(7.2%), 1143.35(3.7%), 1144.35(3.3%), 1143.35(2.4%), 1145.36(2.3%), 1144.35(2.0%), 1146.35(1.9%), 1145.36(1.7%), 1144.35(1.3%) | |
| Elemental Analysis | C,51.48; H,5.47; N,12.25; O,22.39; S,8.41 | |
Sincalide is an essential injectable diagnostic preparation that is widely adopted for clinical diagnosis and functional assessment of various hepatobiliary and pancreatic disorders.It exerts a distinct pharmacological action capable of triggering rapid, stable and robust gallbladder contraction.
A core property that has made it a staple tool and gained extensive recognition in gastroenterology, medical imaging and many other relevant clinical specialties.When put side by side with conventional testing methods such as the fatty meal stimulation test, sincalide offers far more consistent and predictable detection outcomes, greatly shortened examination duration and superior operational convenience. It successfully compensates for the inherent limitations of traditional detection means, including unstable individual responses and prolonged testing time, and thus has become an indispensable reagent in routine clinical practice.
Gallbladder-Related Applications
(1) Application in Evaluating Gallbladder Contractile Function
One of the core applications of sincalide injection is the dynamic evaluation of gallbladder contractile function. It is widely compatible with various imaging modalities including ultrasonography, cholecystography, and radionuclide imaging, representing a key clinical tool for identifying abnormal gallbladder function. Its primary uses cover the diagnosis and assessment of various gallbladder disorders, such as screening and confirmation of suspected chronic cholecystitis, gallbladder contractile dysfunction, and adenomyomatosis. Following intravenous administration, it evokes physiological gallbladder contraction, allowing observation of contraction amplitude, rhythm, and time to peak response to determine functional normality.
For patients with gallbladder polyps or cholelithiasis, this product is used for preoperative gallbladder function assessment to clarify contractile reserve, providing critical evidence for patient selection in gallbladder-preserving surgery and avoiding postoperative complications due to severely impaired gallbladder function. Additionally, it replaces the traditional fat meal test in scenarios requiring precise, reproducible results free from interindividual digestive variations and dietary influences, especially for patients with insufficient fasting time, weak digestive function, or inability to tolerate a fat meal.
Compared with the fat meal, peak contraction is achieved within 5–15 minutes after intravenous injection, with faster and more stable responses, effectively improving diagnostic efficiency and accuracy while reducing errors caused by variable fat meal digestion and absorption. For patients fasting for more than 24 hours, it can empty gallbladder bile prior to imaging, enhancing visualization and aiding detection of minor lesions.
(2) Application in Obtaining Duodenal Bile Samples
By potently stimulating gallbladder contraction, this product promotes the release of concentrated gallbladder bile into the duodenum, allowing collection of segmented bile samples via duodenal drainage for high-quality bile compositional analysis. This application is widely used in the diagnosis and management of multiple biliary tract disorders.
Specifically, it supports the auxiliary diagnosis and etiological analysis of suspected cholesterol gallstones, cholestatic liver diseases, biliary tract infections, and biliary tract tumors. Samples including common bile duct bile (Fraction A), gallbladder bile (Fraction B), and hepatic bile (Fraction C) - particularly the highly concentrated and representative Fraction B - are analyzed for quantitative levels of cholesterol, bile salts, and phospholipids, as well as screened for crystals, parasites, and tumor cells
For patients with cholesterol stones, bile composition analysis identifies lithogenic mechanisms and determines whether bile is supersaturated with cholesterol. In cholestatic liver disease, it helps distinguish hepatocellular from obstructive cholestasis. For biliary infections, bile culture identifies pathogenic bacteria. In biliary tract tumors, cytological examination of bile enables early detection of atypical tumor cells, overcoming the limitation of imaging modalities that cannot directly analyze bile components and supporting clinical decision-making. This application also monitors the efficacy of medical litholytic therapy by comparing bile composition before and after treatment.
Pancreas-Related Applications
(1) Application in Combined Testing of Exocrine Pancreatic Function
Sincalide injection is frequently used in combination with secretin, forming the gold-standard protocol for evaluating exocrine pancreatic function. It is widely applied in the diagnosis and functional assessment of various pancreatic diseases and represents a core clinical method for evaluating pancreatic parenchymal function. Indications include diagnosis and staging of chronic pancreatitis, pancreatic cancer, cystic fibrosis, and postoperative pancreatic insufficiency, especially for screening early subclinical pancreatic dysfunction.
It addresses the limitation of CT, MRI, and other imaging modalities, which only show morphological changes without reflecting secretory function.Secretin primarily acts on pancreatic ductal cells to stimulate water and bicarbonate secretion, while sincalide targets pancreatic acinar cells to induce release of digestive enzymes including amylase, lipase, and proteases.
Combined measurements of secretory volume, bicarbonate concentration and digestive enzyme activity offer a comprehensive assessment that accurately reflects the pancreatic exocrine function. This testing protocol facilitates the etiological diagnosis and classification of various pancreatic diseases, and helps clinicians formulate targeted treatment plans. Specifically, it can guide dosage adjustment of pancreatic enzyme replacement therapy for patients with exocrine insufficiency. Through continuous dynamic monitoring of secretory function, it also supports prognostic evaluation by tracking disease progression and treatment outcomes. Additionally, this method is widely used to examine the functional status of pancreatic grafts after transplantation.
(2) Application in Cytological and Enzymatic Analysis of Duodenal Aspirates
When combined with secretin for exocrine pancreatic function testing, this product assists in obtaining high-quality duodenal aspirates for cytological and enzymatic analysis, primarily used for early screening and differential diagnosis of pancreatic and periampullary diseases. Indications include early screening for pancreatic cancer and periampullary carcinoma, staging of chronic pancreatitis, and differentiation between benign and malignant pancreatic lesions.
In chronic pancreatitis, duodenal aspirates show abundant inflammatory cells and fibrin fragments, with enzymatic analysis revealing reduced amylase and lipase activity, facilitating severity assessment alongside clinical symptoms. In pancreatic or periampullary carcinoma, cytological smears and pathological examination detect atypical tumor cells, and combined with tumor markers such as CA19-9, significantly improves diagnostic sensitivity for early detection and intervention. It also differentiates pancreatic dysfunction caused by chronic pancreatitis versus pancreatic cancer, reducing misdiagnosis and missed diagnosis. This application overcomes limitations of conventional imaging in early pancreatic tumor screening, supporting precise diagnosis and treatment of pancreatic diseases.
Expanded Application Scenarios
As a highly specific CCK receptor agonist, sincalide injection is widely used in physiological and pathological research on gastrointestinal motility, providing important tool support for studying the pathogenesis of gastrointestinal motility disorders. Its core applications include the evaluation of antroduodenal coordinated motility and pyloric sphincter function, as well as research into the pathogenesis of functional dyspepsia, gastroparesis, and other related disorders.
In scientific research, this product can trigger CCK receptor-mediated physiological responses to observe the contractile rhythm and intensity of gastrointestinal smooth muscle, evaluate antroduodenal coordination, investigate the relaxation and contraction patterns of the pyloric sphincter, and explore the mechanisms underlying gastrointestinal dysmotility. In patients with functional dyspepsia or gastroparesis, it can stimulate gastrointestinal motility to compare interindividual response differences and analyze the association between gastrointestinal hormones (e.g., CCK) and motility disorders, yielding experimental evidence for disease mechanisms.
Furthermore, it is used to study the mechanism of action of gastrointestinal motility-modulating agents by observing their effects on sincalide-stimulated gastrointestinal responses and identifying their molecular targets, supporting the development of prokinetic drugs. These applications extend beyond human studies to animal models, bridging basic and translational research in gastrointestinal motility.
Indications and Contraindications
Sincalide is a synthetic active fragment of cholecystokinin (CCK), specifically CCK-8, primarily used in the diagnosis of gastrointestinal function, including evaluation of pancreatic and gallbladder function, as well as intestinal examination via X-ray (fluoroscopy).
Contraindications: Use is strictly prohibited in individuals with hypersensitivity to sincalide. Safety and efficacy in children and adolescents under 18 years of age have not been established; therefore, use in this population is not recommended.
Information source
Fresenius Kabi, SINCALIDE Guidelines for Use in Special Populations; Kete Bio, Research Progress in Expanded Applications of Sincalide; benchchem.com, Application Notes of Sincalide in Preclinical Models
Articles from Kete Biotechnology Co., Ltd.; product introductions from ChemicalBook
Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues (https://tech.snmjournals.org/content/47/3/210)
Sincalide (intravenous route) (https://www.mayoclinic.org/drugs-supplements/sincalide-intravenous-route/description/drg-20065964)
FAQ
What is the mechanism of action of sincalide?
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When sincalide is administered via intravenous bolus injection, it triggers rapid contraction of the gallbladder, with the contraction reaching its peak effect within 5 to 15 minutes. In contrast, stimulation from a fatty meal induces a gradual gallbladder contraction process, which only achieves the maximum response after roughly 40 minutes. This notable difference in onset and peak time distinguishes the two stimulation methods clearly in clinical application.
What is sincalide used for?
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Sincalide injection serves as a valuable diagnostic adjunct in clinical practice, primarily assisting physicians in identifying a range of functional and organic disorders affecting the gallbladder and pancreas. Beyond hepatobiliary and pancreatic assessment, this injectable agent can also accelerate the evacuation of barium contrast medium within the intestinal tract. By doing so, it effectively shortens the duration of fluoroscopy and X-ray examinations of the digestive tract, thereby reducing patients' overall exposure to ionizing radiation during imaging procedures.
What are the ingredients in sincalide?
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Each single-dose vial of sincalide contains a sterile, nonpyrogenic white lyophilized powder formulated for clinical use. Every vial holds 5 micrograms of active sincalide, along with a series of excipients: 30 mg arginine hydrochloride, 15 mg lysine hydrochloride, 170 mg mannitol, 4 mg methionine, 2 mg pentetic acid, 0.005 mcg polysorbate 20, 9 mg dibasic potassium phosphate and 0.04 mg sodium. All components are precisely proportioned to maintain the stability, purity and safety of the preparation for injection.
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