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Triptorelin (CAS: 57773-63-4, [D-Trp⁶]-LHRH) is a synthetic decapeptide GnRH analog with the molecular formula C₆₄H₈₂N₁₈O₁₃ and a molecular weight of 1311.47 Da. Its structural modification at the 6-position endows the compound with higher receptor affinity and better enzymatic stability than natural GnRH, supporting long-acting pharmacological performance. The pure triptorelin powder is water-soluble and chemically stable under sealed, low-temperature and dry conditions, while high temperature, strong light and extreme pH may cause structural degradation. Proper storage effectively maintains its complete molecular structure and stable biological activity for consistent clinical performance. As a mature and precise endocrine regulating preparation, triptorelin injection 3.75 mg possesses prominent clinical value in multiple therapeutic fields, covering two core application directions: inhibiting premature ovulation for assisted reproduction and suppressing testosterone secretion for tumor intervention.
Products Forms
Triptorelin COA
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| Certificate of Analysis | ||
| Compound name | Triptorelin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 57773-63-4 | |
| Quantity | 30g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090066 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula | C64H82N18O13 | |
| Exact Mass | 1310.63 | |
| Molecular Weight | 1311.47 | |
| m/z | 1310.63 (100.0%), 1311.63 (69.2%), 1312.64 (23.6%), 1311.63 (6.6%), 1313.64 (4.5%), 1312.63 (4.3%), 1312.64 (2.7%), 1313.64 (1.8%), 1313.63 (1.6%) | |
| Elemental Analysis | C, 58.61; H, 6.30; N, 19.22; O, 15.86 | |
In assisted reproductive therapy, it stabilizes the hypothalamic-pituitary-gonadal axis, blocks abnormal LH surges and premature follicle rupture, creates a stable follicular development environment, and ensures smooth and standardized ovulation induction.
In oncological treatment, it effectively reduces serum testosterone levels, eliminates the hormone dependence of advanced prostate cancer, and suppresses tumor proliferation and disease progression. Benefiting from its optimized molecular structure and reliable physicochemical stability, triptarelin achieves accurate, safe and efficient endocrine intervention, serving as a classic long-acting preparation for reproductive regulation and hormone-dependent tumor treatment.
The core regulatory mechanism and clinical value of inhibiting premature ovulation
In assisted reproductive technology, the core requirement of ovulation induction stage is to obtain multiple high-quality follicles that mature synchronously, while the emergence of early ovulation will directly break this goal and bring multiple obstacles to the treatment process.
Triptolide effectively inhibits premature ovulation by precisely balancing the reproductive signaling pathway, which can be analyzed from two core dimensions:
(I)Block premature peak of luteinizing hormone to avoid premature rupture of follicles
The normal rhythm of the hypothalamic pituitary gonadal axis is the core of regulating ovulation. Under normal physiological conditions, the peak of luteinizing hormone appears synchronously with follicle maturation. However, during assisted reproductive ovulation induction, if the hormone rises too early and forms an abnormal peak, it will trigger premature rupture and discharge of follicles, leading to the loss of immature follicles.
Triptolide can gently regulate the secretion function of the pituitary gland, inhibit the premature release of luteinizing hormone, eliminate the core cause of premature rupture of follicles, ensure the continuous development of follicles to maturity within the preset time window, and avoid follicle waste and treatment cycle interruption caused by premature ovulation.
(II)Maintain the synchronicity of follicular development and reduce the risk of ovulation disorders
The occurrence of premature ovulation is often accompanied by asynchronous follicular development, where some follicles mature and are expelled prematurely, while others develop rhythmically, ultimately leading to a shortage of available follicles.
Triptorelin injection 3.75 mg stabilizes the regulatory signals of the reproductive axis.Avoiding the imbalance of follicular development rhythm caused by hormone fluctuations, promoting synchronous growth and maturation of multiple follicles, reducing the probability of premature ovulation from the root, and providing sufficient and high-quality follicle reserves for subsequent egg retrieval.
In conclusion, triptorelin achieves precise and comprehensive regulation of the female reproductive endocrine axis during ovulation induction. By effectively blocking the premature surge of luteinizing hormone, it prevents abnormal follicle rupture and premature ovulation, ensuring that follicles develop steadily within the expected treatment cycle. Meanwhile, it stabilizes overall hormonal rhythm, harmonizes the synchronous development of multiple follicles, and eliminates follicular developmental asynchrony caused by endocrine fluctuations.
This dual regulatory mechanism fundamentally avoids follicle loss, treatment interruption and insufficient available follicle resources.
Accordingly, Triptorelin significantly optimizes the safety, stability and success rate of assisted reproductive ovulation induction, delivering important clinical value for improving egg retrieval efficiency and overall pregnancy outcomes.
The core regulatory mechanism and value of inhibiting testosterone secretion
During the progression of advanced prostate cancer, abnormal secretion of testosterone is the core driving force behind the uncontrolled proliferation of tumor cells and the continuous spread of lesions. The continuous increase in testosterone levels will accelerate the deterioration of the tumor, not only exacerbating various discomforts in the patient's body, but also further increasing the complexity of the disease, posing greater obstacles to clinical intervention. For patients with advanced prostate cancer, testosterone is like a "nutrient supply" for tumor growth.Its sustained excessive secretion provides sufficient support for the proliferation of tumor cells.
Leading to the continuous expansion of the lesion and the extension of the infiltration range, which in turn causes more serious physical discomfort and even threatens the patient's life safety.With its precise regulatory properties,triptorelin injection 3.75 mg act on the transmission pathway of the reproductive axis in the body, achieving scientific regulation of testosterone secretion by precisely balancing relevant signals.It cuts off the hormone support required for tumor progression from the root, inhibits the core cause of tumor deterioration, and lays a solid foundation for subsequent tumor control.Balance the source transmission of testosterone production and reduce hormone synthesis.
The generation and release of testosterone do not occur in isolation, but rely on the orderly regulation and signal transduction of the body's reproductive axis, forming a complete physiological regulatory system.
Due to the impact of advanced prostate cancer, the regulatory function of the reproductive axis is disrupted and imbalanced, and the related transmission signals are abnormally active, resulting in testosterone secretion far exceeding normal levels, forming abnormal accumulation, and continuously providing proliferation power for tumor cells.Triptolide abandons the stiffness of traditional intervention methods and intervenes in the secretion function of the pituitary gland in a gentle and precise manner,
Effectively inhibiting the excessive release of gonadotropin-related signals, cutting off abnormal transmission pathways from the source of testosterone production, gradually reducing the total synthesis and secretion of testosterone, and slowly regulating testosterone levels in the body to an appropriate range that meets the intervention needs of advanced prostate cancer.
It eliminates the core hormone triggers of tumor progression from the root, creating favorable conditions for subsequent tumor control.Stabilize hormone secretion rhythm and avoid tumor stimulation caused by testosterone fluctuations.
The testosterone levels of patients with advanced prostate cancer not only suffer from excessive secretion, but also often fluctuate violently.
This unstable hormone state repeatedly stimulates the proliferation activity of tumor cells, leading to accelerated deterioration of tumor lesions.At the same time, it can also cause various discomforts in the patient's body, such as emotional fluctuations, physical weakness, and local hidden pain.
Triptorelin injection 3.75 mg not only effectively inhibits testosterone secretion and reduces the total amount of hormones, but also precisely regulates the regulatory rhythm of the body's reproductive axis.
Maintains the stability of hormone secretion in the body, avoids drastic fluctuations in testosterone levels, reduces the counter stimulation of tumor cells by hormone fluctuations, and builds a stable and suitable internal environment for subsequent tumor control. At the same time, this stable hormone state can effectively alleviate various physical discomforts caused by hormone disorders, reduce patients' physical burden, and improve their physical comfort and intervention compliance.
References
Zhou Ming, Huang Jian. Clinical efficacy analysis of long-acting triptorelin in sustained testosterone suppression in advanced prostate cancer [J].
Cornford P, Jefferson K, Cole O. Effects of initiating or switching to a six-monthly triptorelin formulation on prostate cancer patient-healthcare interactions and hospital resource use: a real-world, retrospective, non-interventional study[J]. Oncology and Therapy, 2018, 6(2): 173-187.
Shore N D, Shore D M. Triptorelin embonate: a 6-month formulation for prostate cancer[J]. Expert Opinion on Pharmacotherapy, 2010, 11(15): 2569-2578.
TRIPTORELIN(https://drugs.ncats.io/drug/9081Y98W2V)
Triptorelin Injection(https://medlineplus.gov/druginfo/meds/a611047.html/)
Triptorelin(https://en.wikipedia.org/wiki/Triptorelin)
FAQ
Triptorelin is a synthetic and highly active gonadotropin-releasing hormone (GnRH) analog with stable molecular structure and significant hormonal regulation ability. It works by initially stimulating and then persistently inhibiting the secretion of pituitary gonadotropins, thereby effectively reducing the levels of testosterone and estrogen in the body. With its reliable hormone-suppressing activity, triptorelin is widely applied in the clinical treatment of central precocious puberty, prostate cancer, endometriosis and other hormone-dependent diseases, showing continuous and steady therapeutic effects during long-term standardized administration.
This product is mainly given via subcutaneous or intramuscular injection. The dosage and administration cycle need to be adjusted professionally according to different diseases and individual physical conditions, and it must be used under medical supervision.
Triptorelin peptide powder as well as its corresponding finished pharmaceutical preparations demand stringent storage requirements featuring low temperature and light protection. The products must be preserved in a fully sealed and dry environment, while being kept away from high temperatures, intense illumination and excessive humidity. These protective measures effectively prevent molecular structural decomposition and the gradual loss of biological activity. When stored in compliance with standard specifications, the material retains superior chemical stability and intact bioactivity throughout the storage period. Appropriate preservation practices are fundamentally important to sustain its original pharmacological efficacy, prolong the product shelf life, and avert the reduction of therapeutic potency or the generation of extra impurities resulting from inadequate storage management.
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