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Compound Fipronil and Praziquantel Spot On Solution,Chinese generic name: Compound non prednisolone praziquantel drops, is a parasite repellent drug designed specifically for cats both in vitro and in vivo.The drug is presented in the form of drops, as a colorless to yellow or orange red solution, and is used topically to achieve synchronous control of parasites both inside and outside the body.
Its core components include four active substances - Fipronil is a broad-spectrum insecticide of the phenylpyrazole class, which interferes with the function of gamma aminobutyric acid (GABA) receptors in the central nervous system of insects, leading to nerve signal transduction blockade and ultimately causing insect death. S-Methylene is an insect growth regulator (IGR) that simulates the action of juvenile hormones, inhibits flea egg hatching and larval development, and breaks the life cycle of parasites. Acetylaminoavermectin is a macrocyclic lactone antiparasitic drug that activates chloride ion channels in invertebrate nerve cells, causing parasite paralysis and death. Praziquantel is a derivative of pyrazine and isoquinoline, which has a potent killing effect on tapeworms and flukes. It achieves deworming by destroying the cuticle of the parasite, inducing muscle spasms, and immune attacks.
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Compound Fipronil and Praziquantel Spot On Solution COA
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| Certificate of Analysis | ||
| Compound name | Compound Fipronil and Praziquantel | |
| Grade | Pharmaceutical grade | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.49% |
| Loss on drying | ≤1.0% | 0.32% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.90% |
| Single impurity | <0.8% | 0.47% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Compound Fipronil and Praziquantel Spot On Solution is an in vitro deworming medication designed specifically for cats. Its core use is to prevent and treat external parasite infections (fleas, ticks) and internal parasite infections (gastrointestinal nematodes, tapeworms) in cats, and to assist in the treatment of allergic dermatitis caused by fleas.
Core use: Dual function of prevention and treatment
Prevention and control of ectoparasites
Adult flea killing: Compound Fipronil and Praziquantel rapidly kills adult fleas on the surface of cats through gastric toxicity, contact killing, and weak internal suction.
Egg and larval blockage: Methoxyphene penetrates the flea egg wall or is absorbed into the egg by the adult, inhibiting embryonic development and larval hatching. Experiments have shown that its inhibition rate on flea eggs is over 98%, cutting off the transmission chain from the source.
Environmental control: Drugs are stored in cat sebaceous glands and continuously released onto the skin surface, forming a long-term protective barrier with a residual effect period of up to 4-6 weeks.
Direct killing: Compound Fipronil and Praziquantel has a strong contact killing effect on ticks, causing them to become paralyzed and fall off by interfering with nerve conduction.
Preventing attachment: The protective layer formed by drugs on the surface of cats can reduce the probability of tick attachment and lower the risk of infection.
Internal parasite treatment
Gastrointestinal nematodes
Ascaris and hookworm: Acetylaminoavermectin promotes GABA release, interferes with nematode neuromuscular signal transmission, and leads to parasite paralysis and excretion.
Insect repellent spectrum: covering common nematodes in cats such as roundworms, lion roundworms, and narrow headed hookworms, with a single administration effective rate of over 95%.
Taenia infection
Killing of Adults and Larvae: Praziquantel increases the permeability of insect cell membranes, triggers calcium ion influx, causes muscle rigidity and contraction, and destroys the cortex to expose antigens, activating host immune attack.
Broad spectrum: Effective against canine tapeworms such as Taenia solium, Taenia solium, and Echinococcus granulosus, covering the entire life cycle of tapeworms (adults, larvae, cysticercus).
Secondary symptom control
Flea allergic dermatitis (FAD)
Allergen reduction: By rapidly killing fleas, the sustained stimulation of allergens in flea saliva is reduced.
Inflammation relief: Reduce skin redness, hair loss, and secondary bacterial infections caused by flea bites.
Anemia prevention
Schistosomiasis control: The potent killing effect of praziquantel on schistosomiasis can prevent chronic anemia caused by schistosomiasis infection.
Tick borne disease blocking: reduces the risk of blood parasitic diseases such as Babesiosis transmitted by ticks.
Clinical application scenarios and target population
Multi Pet Family
Cross infection prevention: After a single cat is infected with fleas or ticks, it can be transmitted to other pets through the environment or direct contact. Compound Fipronil And Praziquantel Spot On Solution can synchronously control the parasitic load of all cats and reduce the risk of transmission within the household.
Case: In a family of three cats, an outdoor cat was infected with fleas, and an untreated indoor cat developed flea bite symptoms within 2 weeks. After using the product, the flea population in the whole house decreased by 90% within 4 weeks.
Outdoor activity cat
High exposure risk: Cats that frequently go out or come into contact with other animals have a significantly increased probability of contracting fleas, ticks, and internal parasites.
Data support: Research shows that the flea infection rate of outdoor cats is 3.2 times higher than that of indoor cats, and the tick infection rate is 5.7 times higher. Monthly use of compound drops can reduce the risk of infection by 82%.
Kittens and elderly cats
Mild deworming plan: Kittens (over 7 weeks old) and elderly cats with weaker immune systems should choose high safety deworming products. The compound drops have undergone strict toxicity testing and have no significant effect on the liver and kidney function of kittens.
Case: A certain animal hospital used it on 20 8-week-old kittens. During the observation period of 30 days, no serious adverse reactions occurred, and the success rate of deworming was 100%.
Pregnant/lactating cats
Safety verification: Clinical trials have shown that the use of compound drops after mid pregnancy has no teratogenic effects on both mother cats and fetuses, and can reduce the risk of infection in kittens through milk.
Medication advice: Use under the guidance of a veterinarian and avoid medication in early pregnancy or one week before delivery.
Medication plan and operating procedures
Dose and frequency
Recommended dosage for weight range, medication tube specifications, administration frequency<2.5kg, 0.3ml single tube once a month, 2.5kg-7.5kg 0.9ml single tube once a month, >7.5kg combination uses multiple tubes once a month
Special Scenario:
High risk environment: such as a stray cat rescue station, medication can be administered every 3 weeks (subject to veterinary evaluation).
Treatment period: once a month for three consecutive months, followed by prevention.
Operation steps
Location selection: Separate the cat's neck and back hair, exposing the skin (non hair area).
Administration method: Drop Compound Fipronil And Praziquantel Spot On Solution vertically to a point on the skin to avoid flowing onto the hair.
Follow up treatment: Wear an Elizabeth ring for 2 hours after administration to prevent licking; Avoid taking a shower within 72 hours.
Precautions
Prohibited for dogs/rabbits: The ingredient concentration is designed specifically for cats and may cause poisoning when used in dogs.
Excessive risk: Do not administer the medication repeatedly, with a minimum interval of 2 weeks.
Skin contact: Wash hands immediately after medication and avoid contact with eyes.
Interactions with other drugs
Synergistic effect
Combined use with vaccines: No significant effect, but it is recommended to have a 7-day interval.
Combination with antibiotics: no drug metabolism competition, can be used synchronously.
Antagonistic effect
Combined use with ivermectin: may increase the risk of neurotoxicity (avoid simultaneous use).
Combined use with saramycin: repeated deworming ingredients resulting in excess (choosing a single ingredient product).
The impact of food
High fat diet: may delay drug absorption, it is recommended to fast for 2 hours before administration.
Dairy products: Calcium containing foods may reduce the bioavailability of praziquantel (avoid simultaneous intake).
Overview of Active Pharmaceutical Ingredient Synthesis
Fipronil is synthesized using 2,6-dichloro-4-(trifluoromethyl)aniline and 3-cyano-5-aminopyrazole as starting materials. High-purity technical material is obtained through condensation, sulfonylation, cyclization and refining.
The reaction conditions are mild with stable yield, and the product exhibits excellent insecticidal activity. Praziquantel adopts the classic tetrahydroisoquinoline cyclization process.
It is prepared via acylation, condensation, catalytic hydrogenation and multi-step cyclization reactions, then purified by recrystallization in alcoholic solvents. The purity of the raw material reaches veterinary pharmaceutical grade and meets the compatibility requirements for compound preparations.
Formulation Process of Compound Spot-on Solution
This topical spot-on solution requires no chemical synthesis and is mainly prepared by physical compatibility and dissolution. Fipronil and praziquantel raw materials are added into a composite solvent system according to the formula ratio, with absolute ethanol and propylene glycol used as the main solvents and penetration enhancers.
The mixture is stirred slowly at room temperature until completely dissolved. Cosolvents, stabilizers and antioxidant components are added sequentially under continuous stirring for homogenization to adjust system viscosity and physicochemical properties.
After standing for impurity removal and filtration through a precision membrane to eliminate particulate contaminants, the solution is aseptically filled and hermetically sealed at a constant temperature.
The overall process is simple to operate with good component compatibility. The finished product features high stability and uniform transdermal absorption, complying with the production and quality control standards for pet topical antiparasitic spot-on preparations.
Molecular level flavor masking technology
Cyclodextrin inclusion: Encapsulate praziquantel into the β - cyclodextrin cavity to reduce bitterness perception.
Ion exchange resin: Fixing drug molecules through electrostatic interactions to block taste buds from coming into contact.
Intelligent drug delivery system
FAQ
What is compound Fipronil spot on?
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Product feature Fipronil is a broad spectrum insecticide for the prevention and treatment of many kinds of insect pests. it is not easy to produce drug resistance, it also have a very strong killing effect on inset pests which have drug resistance for chrysanthemum ester, amino acid ester insecticide.
Is Fipronil spot-on safe for dogs?
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Fipronil spot-on is generally safe and effective for dogs when used as directed, acting as a topically applied insecticide to control fleas, ticks, and chewing lice. It works by staying in the skin's lipids rather than entering the bloodstream, but it should not be used on puppies under 8–10 weeks old or on rabbits.
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