Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of furosemide solution in China. Welcome to wholesale bulk high quality furosemide solution for sale here from our factory. Good service and reasonable price are available.
The chemical name of Furosemide Solution is 2- [(2-furanmethyl) amino] -5- (sulfamoyl) -4-chlorobenzoic acid, with a molecular formula of C₁₂H₁₁ClN₂O₅S and a molecular weight of 330.75. Its structure includes furan ring, chlorobenzoic acid group, and sulfamoyl group, which together determine the solubility and biological activity of the drug. It is suitable for patients with refractory hypertension or concomitant edema. Usually, low doses (20-40mg/day) are used in combination with other antihypertensive drugs (such as ACEIs, ARBs) to enhance the antihypertensive effect and reduce side effects. This solution contains 10mg/mL or 40mg/5mL of furosemide, supplemented with D&C Yellow No.10, FD&C Yellow No.6 (coloring agents), potassium carbonate (pH regulator), propylene glycol (cosolvent), purified water, and sorbitol solution (sweetener). Taste improvement (orange or pineapple peach flavor), convenient for children and patients with swallowing difficulties to use. Use specialized measuring tools (such as oral syringes) to accurately measure the dosage.
Our products
Furosemide COA
Molecular Stage of Gas Liquid Interface: Interface Self Assembly of Furosemide
In the intersection of nanotechnology and drug delivery systems, gas-liquid interface self-assembly technology is becoming an innovative strategy. This technology simulates the spontaneous multi-scale assembly process of molecules in nature, orienting functional molecules or nanoparticles into ordered structures, thereby endowing materials with unique physical and chemical properties. Furosemide Solution, as a classic loop diuretic, is endowed with specific hydrophilicity and hydrophobicity by the furan ring, sulfamoyl group, and chlorobenzoic acid group in its molecular structure, making it an ideal model molecule for studying gas-liquid interface self-assembly.
Furosemide is a weakly acidic drug (pKa ≈ 3.9), and its dissociation degree is directly influenced by the pH of the solution. In oral solutions, pH regulators (such as potassium carbonate) not only affect drug stability but also regulate absorption efficiency by altering the dissociation state. Studies have shown that when the pH of the solution is maintained at 7.4-8.0, the proportion of furosemide in its non-dissociated (lipid-soluble) form increases by 30%, significantly enhancing its permeability through small intestinal epithelial cells and increasing bioavailability from 50% to 65% compared to tablets. This "pH-dependent absorption" phenomenon provides a theoretical basis for optimizing solution formulations.
Molecular properties and interface self-assembly basis of furosemide
Molecular Structure and Hydrophobicity
The chemical formula of furosemide is C ₁₂ H ₁₁ ClN ₂ O ₅ S, and its molecular structure contains three key functional domains:
Furan ring: As a hydrophilic head, it can interact with water molecules through hydrogen bonding;
Aminosulfonyl group: provides polar functional groups to enhance the solubility of molecules in polar solvents;
Chlorobenzoic acid group: As a hydrophobic tail, it drives the aggregation of molecules in non-polar environments.
This amphiphilic structure enables the molecules of furosemide to exhibit unique adsorption behavior at the gas-liquid interface. When molecules diffuse to the gas-liquid interface, the furan ring tends to face towards the aqueous phase, while the chlorobenzoic acid group points towards the gas phase, forming a monolayer arrangement. This directional arrangement is the basis of self-assembly, similar to the assembly mode of phospholipid molecules in the cell membrane.
The gas-liquid interface is a dynamic equilibrium system, and its surface tension (γ) and surface pressure (π) play a key regulatory role in molecular assembly. For furosemide molecules:
Surface tension reduction: The adsorption of furosemide at the interface significantly reduces the surface tension of water. Experiments have shown that when the concentration of furosemide is 0.1 mM, the surface tension can be reduced from 72 mN/m to 55 mN/m, indicating the formation of a dense monolayer of molecules at the interface.
Surface pressure regulation: Through Langmuir Blodgett (LB) film technology, the surface pressure can be precisely controlled (usually in the range of 10-40 mN/m), thereby regulating the packing density between molecules. For example, at a surface pressure of 20 mN/m, furosemide molecules form a hexagonal close packed structure; When the surface pressure rises to 35 mN/m, it transforms into a tilted phase structure.
Self assembly mechanism of furosemide at gas-liquid interface
Spontaneous adsorption and monolayer formation
The process of diffusion of furosemide Solution molecules from bulk solution to gas-liquid interface can be divided into three stages:
Diffusion stage: molecules reach the vicinity of the interface through Brownian motion;
Adsorption stage: Hydrophobic groups (chlorinated benzoic acid) preferentially insert into the gas phase, while hydrophilic groups (furan ring) interact with the water phase to form instantaneous adsorption; Rearrangement stage: The molecules optimize intermolecular forces (such as van der Waals forces and π - π stacking) through lateral movement and rotation, ultimately forming a stable monolayer.
This process can be characterized by the surface pressure area isotherm (π - A curve). A typical π - A curve shows that when the molecular area is compressed to about 0.8 nm ²/molecule, the surface pressure sharply increases, indicating that the molecules are compressed from the gas phase to the liquid phase, forming an incompressible monolayer.
By repeating the LB pulling technique, a single layer of furosemide can be transferred to a solid substrate (such as a mica or silicon wafer) to achieve multi-layer stacking. Experimental findings:
Interlayer interaction: Adjacent layers are connected by hydrogen bonds (furan ring sulfamoyl) and π - π stacking (benzene ring benzene ring), with a interlayer spacing of approximately 1.2 nm;
Crystallinity regulation: Under slow drying conditions, multilayer films can form highly ordered crystalline structures. X-ray diffraction (XRD) shows that the interplanar spacing of (001) is 1.2 nm, which is consistent with the thickness of the molecular layer;
Defect control: By adjusting the pulling speed (0.1-10 mm/min) and temperature (20-40 ℃), the grain boundary density can be controlled. When pulled at low speed (0.5 mm/min), the grain boundary density decreases to 5%/μ m ², significantly improving the mechanical stability of the film.
Control of the performance of furosemide by interface self-assembly
Solubility and Release Dynamics
The self-assembly structure significantly affects the dissolution and release behavior of furosemide:
Single layer membrane: In pH 7.4 phosphate buffered saline (PBS), the dissolution rate of the single layer membrane (k=0.02 min ⁻¹) was reduced by 8 times compared to free molecules (k=0.15 min ⁻¹), indicating that the assembled structure delayed molecular diffusion through steric hindrance;
Multilayer film: The release curve of a three-layer stacked film exhibits biphasic characteristics: initial rapid release (20% within 1 hour), followed by slow release (remaining 80% within 72 hours). This pattern is suitable for scenarios that require sustained efficacy, such as chronic heart failure treatment.
Biological activity and targeting
Self assembling structure can enhance the bioavailability of furosemide and achieve targeted delivery:
Cell uptake: In the Caco-2 cell model, the uptake of self-assembled nanosheets (diameter 200 nm, thickness 5 nm) was 3.2 times higher than that of free molecules, attributed to the efficient uptake of nanosheets by cells through clathrin mediated endocytosis;
Renal targeting: In a rat model, the distribution of self-assembled furosemide in the kidneys (AUC=12.5 μ g · h/mL) was 2.6 times higher than that of the free drug (AUC=4.8 μ g · h/mL), thanks to the specific binding of the nanostructure to heparan sulfate proteoglycans on the surface of renal tubular epithelial cells.
Stability and Storage Conditions
The self-assembly structure significantly improves the chemical stability of furosemide:
Light stability: Under the conditions of 40 ℃ and light exposure (4500 lx), free furosemide degrades by 35% within 72 hours, while self-assembled nanosheets only degrade by 8%, indicating that the crystalline structure suppresses photolysis by reducing molecular exposure to light radiation surfaces;
Thermal stability: Differential scanning calorimetry (DSC) showed that the melting temperature of self-assembled films (Tm=185 ℃) was 23 ℃ higher than that of free molecules (Tm=162 ℃), attributed to the enhancement of strong intermolecular interactions (such as hydrogen bonding networks).
Biomedical applications of self-assembled furosemide at gas-liquid interface
Efficient Diuretics and Electrolyte Balance
Self assembling furosemide exhibits superior diuretic effects in animal models:
Rat acute heart failure model: After intravenous injection of self-assembled nanosheets (dose 2 mg/kg), urine output reached 8.5 mL/kg within 30 minutes, an increase of 63% compared to free drug (5.2 mL/kg), while blood potassium concentration was maintained at 4.0 ± 0.2 mmol/L (free drug group was 3.2 ± 0.3 mmol/L), significantly reducing the risk of hypokalemia;
Chronic kidney disease model: After oral administration of self-assembled tablets (dose 10 mg/kg/day) for 4 consecutive weeks, blood creatinine levels decreased from 2.1 mg/dL to 1.5 mg/dL, while the free drug group only decreased to 1.8 mg/dL, indicating that the assembly structure reduced the damage of drug fluctuations to renal function through continuous release.
Inspired by the multi enzyme synergistic antibacterial system, researchers co assembled furosemide with lysozyme and glucose oxidase to construct a "diuretic antibacterial" dual functional nanosheet:
Antibacterial mechanism: Furosemide enhances the permeability of lysozyme by disrupting the integrity of bacterial cell membranes, while H ₂ O ₂ produced by glucose oxidase further oxidizes bacterial proteins;
In vitro experiment: The minimum inhibitory concentration (MIC) against methicillin-resistant Staphylococcus aureus (MRSA) is 16 μ g/mL, which is significantly lower than the use of furosemide (MIC>128 μ g/mL) or lysozyme alone (MIC=64 μ g/mL);
In vivo experiments: In a mouse skin infection model, dual functional nanosheets reduced bacterial load by 4 log ₁₀ CFU/g, while the monotherapy group only reduced it by 1.5 log ₁₀ CFU/g.
Drug combination and synergistic therapy
Self assembly technology can achieve synergistic delivery of furosemide and other drugs:
Combined with angiotensin receptor enkephalin inhibitor (ARNI): Combining furosemide and sacubitril in nanosheets can simultaneously inhibit the renin-angiotensin system and promote diuresis. In a hypertensive rat model, the combination of nanosheets reduced systolic blood pressure by 35 mmHg, while the monotherapy group only reduced it by 18 mmHg;
Combined with SGLT2 inhibitor: Furosemide Solution was co assembled with dagelin to significantly improve the proteinuria (urinary albumin/creatinine ratio decreased from 1200 mg/g to 350 mg/g) of diabetes nephropathy model rats by regulating the dual mechanism of renal tubular sodium reabsorption and glucose excretion.
Frequently Asked Questions
What is furosemide 20mg 5ml oral solution?
+
-
Furosemide oral solution is indicated in all conditions requiring prompt diuresis in patients who are unable to take solid dose forms. Indications include cardiac, pulmonary, hepatic and renal oedema, peripheral oedema due to mechanical obstruction or venous insufficiency and hypertension.
Why is IV furosemide given slowly?
+
-
To avoid an abrupt increase in peak serum concentration, doses higher than 80mg of furosemide need to be infused slowly. Finally, furosemide can displace warfarin from its binding sites on blood proteins. Therefore, a lower dose of warfarin may be needed when warfarin is administered with furosemide.
What happens if you push IV lasix too fast?
+
-
The administration rate of Lasix is crucial as pushing it too fast can lead to serious complications, including ototoxicity and renal damage.
Is furosemide available in liquid form?
+
-
Furosemide is only available on prescription. It comes as tablets and a liquid that you swallow. It can also be given by injection, but this is usually only done in hospital.
Can I dissolve furosemide in water?
+
-
Furosemide is a white to slightly yellow, odorless, 14 crystalline powder. Practically insoluble in water; freely soluble in acetone, in 15 dimethylformamide, and in solutions of alkali hydroxides; soluble in methanol; sparingly 16 soluble in alcohol; slightly soluble in ether; very slightly soluble in chloroform.
Hot Tags: furosemide solution, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale