Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ketone ester drops in China. Welcome to wholesale bulk high quality ketone ester drops for sale here from our factory. Good service and reasonable price are available.
Ketone ester drops, as the core form of exogenous ketone body supplements, combine β - hydroxybutyric acid (BHB) with 1,3-butanediol through a unique chemical esterification technique to form ketone precursor that can be directly absorbed by the human body. This biotechnology breakthrough originated from the US Department of Defense's Metabolic Advantage Program, which aims to provide soldiers with efficient energy sources to cope with extreme environments. In 2015, Oxford University and H.V.M.N. jointly launched the first commercial product, marking the official entry of ketoester drops into the consumer market.
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Currently, the global market has exceeded 625 million US dollars and is expected to reach 1.084 billion US dollars by 2032, with a compound annual growth rate of 6.4%. Its application scenarios have expanded from elite sports to cognitive enhancement, metabolic disease management, and anti-aging fields, becoming a "phenomenal product" in the field of health technology. As a breakthrough product in the field of exogenous ketone body supplements, it is reshaping the nutritional supplement market with a compound annual growth rate of 23%.
| Product Name | Ketone Ester Drops | ketone Ester Powder |
| Product Type | liquid | Powder |
| Product Purity | ≥99% | ≥99% |
| Product Form | For external use | For external use |
Ketone Ester COA
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| Certificate of Analysis | ||
| Compound name | Ketone Ester | |
| Grade | Pharmaceutical grade | |
| CAS No. | 1208313-97-6 | |
| Quantity | 337.3kg | |
| Packaging standard | 25kg/drum | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090036 | |
| MFG | Jan 9th 2025 | |
| EXP | Jan 8th 2028 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.38% |
| Loss on drying | ≤1.0% | 0.28% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.45% |
| Total microbial count | ≤750cfu/g | 90 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 400ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Ketone ester drops, as the core form of exogenous ketone body supplements, combine β - hydroxybutyric acid (BHB) with 1,3-butanediol through chemical esterification technology to form ketone body precursors that can be directly absorbed by the human body. Since the first commercial product was launched in 2015, its clinical validation has covered multiple fields such as exercise performance, cognitive function, metabolic disease management, and anti-aging, becoming a research hotspot in the field of metabolic technology.
1. Energy optimization for endurance sports
In the field of endurance sports, its core value lies in its ability to rapidly increase blood ketone concentration. Oxford University research shows that 25 grams of ketoester drops can break the peak blood ketone concentration of 1.5 mmol/L within 15 minutes, which is 300% more efficient than traditional ketosalt supplements. This characteristic makes it a "secret weapon" for high-intensity endurance athletes such as the Tour de France cycling team and triathletes. For example, after supplementing with 25 grams of ketoester drops in the changing area, triathletes increased their second stage cycling power output by 11%, while reducing lactate accumulation by 41%, significantly prolonging the duration of exercise.
2. Synthetic metabolic support for strength training
The beneficial effect of strength training comes from its synergistic effect with proteins. Research has shown that when combined with whey protein, the activation of the mTOR signaling pathway is enhanced by 2.8 times, and muscle protein synthesis rate is increased by 19%. In addition, after ACL reconstruction surgery, patients supplemented with ketoester drops showed a 43% reduction in muscle atrophy rate, indicating its potential in anti catabolic metabolism. This discovery provides a new nutritional strategy for athletes' recovery after injury.
3. Revolutionary improvement in recovery efficiency
Recovery after exercise is another focus of clinical application. A single 25g supplementation can accelerate muscle glycogen synthesis by 55%, while reducing AMPK phosphorylation levels by 62% and decreasing the incidence of delayed onset muscle soreness (DOMS). This "clean energy" mode not only accelerates recovery, but also reduces the risk of overtraining, becoming a standard configuration for professional athletes' post match recovery.
Cognitive function: from acute enhancement to chronic protection
1. The neural mechanism of acute cognitive enhancement
Under simulated high-altitude environment (PO ₂=120mmHg), 25 grams of ketoester drops can improve the accuracy of working memory testing by 27% and shorten reaction time by 0.3 seconds. The mechanism involves BHB as a signaling molecule regulating the neurotransmitter system:
NMDA receptor regulation: By inhibiting excessive activation of NMDA receptors, the frequency of epileptic seizures is reduced by 67%, while enhancing GABAergic neurotransmission and improving anxiety like behavior.
Upregulation of BDNF expression: activates HDAC inhibitor activity, promotes BDNF gene expression in the hippocampus, and increases neuronal synaptic density by 300%.
2. Intervention for chronic neurodegenerative diseases
In the Alzheimer's disease model, daily intake of 12 grams of ketoester drops for 6 consecutive weeks can increase hippocampal glucose metabolism rate by 18% and improve MMSE score by 4.2 points. The BIKE pilot study conducted by the Buck Aging Institute further validated its potential in humans: after supplementation in healthy individuals aged 65 and above, MoCA scores increased by 1.2 points and functional test response times were shortened by 120ms. These findings provide new directions for early intervention in neurodegenerative diseases.
Metabolic disease management: from blood glucose control to cardiovascular protection
1. Blood glucose regulation in type 2 diabetes
Blood glucose control is achieved by reducing insulin secretion and enhancing insulin sensitivity. Research has shown that consuming 12 grams 15 minutes before a meal can reduce postprandial blood glucose peak by 29% and improve insulin sensitivity index (HOMA-IR) by 0.8 units. The long-term follow-up of the Buck Aging Institute found that daily supplementation in healthy elderly people can reduce fasting blood glucose by 0.5mmol/L and improve insulin resistance.
2. Reversal of non-alcoholic fatty liver disease
In NAFLD patients, after 8 weeks of intervention, liver fat content decreased by 31% and ALT levels decreased by 24U/L. Its mechanism is related to activating the AMPK/PPAR α pathway and promoting fatty acid β oxidation.
This discovery provides a new strategy for non pharmacological interventions for metabolic syndrome.
3. Comprehensive protection of the cardiovascular system
The protective effect on the cardiovascular system is reflected in multiple levels:
Reduced arterial stiffness: A single 25g supplement can reduce pulse wave velocity (PWV) by 0.5m/s and improve vascular elasticity.
Enhanced plaque stability: In patients with coronary heart disease, combined treatment with ticagrelor can increase the effective rate of electrocardiogram to 81.63%, and significantly reduce the levels of myocardial enzyme spectrum indicators (such as cTnT and CK-MB).
Inhibition of inflammatory reaction: reduce the level of C-reactive protein (CRP) by 37%, and reduce the risk of atherosclerosis.
Anti aging research: from animal models to human clinical practice
1. Breakthrough discovery in aging mouse model
A leading study by the Buck Institute showed that a ketogenic diet can extend the healthy lifespan of aging mice by 15%, improve memory, and reduce inflammation. However, it is difficult for humans to adhere to a strict ketogenic diet in the long term, making ketone ester drops an ideal alternative.
2. BIKE Pilot Study: The World's First BD-AcAc 2 Anti Aging Human Trial
The BIKE study, launched in 2023, recruited 30 healthy individuals aged 65 and above for a 12 week double-blind randomized controlled trial. Preliminary results show that:
Improved metabolic flexibility: respiratory exchange rate (RER) decreased by 0.05, and fat oxidation ability was enhanced.
Muscle function improvement: chair sitting posture test time shortened by 0.8 seconds, grip strength increased by 2.3kg.
Cognitive performance optimization: MoCA score increased by 1.2 points, and response time for functional testing was shortened by 120ms.
3. TAKEOFF Study: Expanding to Elderly Frailty Population
Based on the success of BIKE research, the Buck Research Institute has applied for funding to expand the trial scale and plans to recruit 180 individuals at risk of age-related frailty to participate in the TAKEOFF study. This study will focus on the effects of ketoesters on the immune system, muscle function, and metabolism, and analyze the most advanced biomarkers in geriatric science.
BD-AcAc 2, as the culmination of metabolic technology, are reshaping the boundaries of human understanding of energy metabolism. From national defense and military to civilian health, from sports performance to disease treatment, its application scenarios continue to expand. With the integration of nanotechnology and gene editing, the next five years will usher in a new era of personalized ketone body supplementation, providing unprecedented precision tools for human health management. However, technological breakthroughs need to go hand in hand with ethical regulation to ensure that this revolutionary product truly serves human welfare.
Product Matrix and Technological Evolution
1. First generation monoester system (2015-2020)
Represented by H.V.M.N. BD-AcAc 2, it adopts a monoester structure of D-BHB and R-1,3-butanediol. Its characteristics are:
Peak blood ketone concentration: 3.8 mmol/L (25g dose)
Absorption time: 15-30 minutes to peak
Limitations: Significant bitterness (threshold 0.03%), needs to be masked by microcapsule embedding technology, but the bioavailability drops to 82%.
2. Second generation diester system (2020-2023)
KetoneAid KE4 pioneered the use of 1,3-butanediol diacetate to achieve diketone release (BHB: AcAc=1:0.7). Clinical data shows that:
ATP generation efficiency: increased by 19%
Gastrointestinal tolerance: Nausea incidence rate of 31% (decreased by 15% compared to monoesters)
Application scenario: Suitable for high-intensity interval training (HIIT) and cognitive intensive tasks.
3. Third generation nanocarrier technology (2024 present)
Regenavita launches NanoKet ™ Adopting a phospholipid bilayer nanostructure, ketone ester drops bonds are encapsulated inside liposomes:
Blood ketone peak time: shortened to 8 minutes
Bioaccumulation: Increased to 94%
Taste optimization: Adding natural Rebaudioside M to achieve zero bitterness
Certification standards: triple certification from WADA, BSCG, and FDA GRAS, with a salt content of less than 0.1g/bottle.
The product, as a new type of nutritional supplement that can directly and rapidly increase ketone body levels in the body through oral administration, have not been discovered overnight. It is a history of scientific exploration spanning nearly a century, interwoven with curiosity about the basic energy metabolism of life, the need to cope with extreme environments, the advancement of military technology, and the wisdom of commercial innovation.
As early as the 1920s, American doctors Russell M. Wilder and others discovered that a high-fat, extremely low carbohydrate diet that simulates hunger can effectively control the onset of refractory epilepsy in children. They first named this diet the "Ketogenic Diet". This marks the first conscious use of ketones by humans to treat diseases. However, the understanding at that time was still at the level of phenomena - the body produces some kind of "alternative fuel" and produces therapeutic effects when it is "sugar deficient". The scientific community still knows very little about the chemical nature, generation pathways, and detailed physiological functions of this' fuel '.
In 1960, it was a decade of breakthrough progress in ketone body research. Scientists led by George F. Cahill Jr. conducted a series of classic hunger experiments, systematically elucidating the complex hormonal and metabolic regulatory network of the human body during fasting.
When insulin levels decrease and glucagon levels increase, adipose tissue will break down in large quantities, releasing fatty acids. After entering the liver, not all fatty acids are oxidized for energy supply, but a considerable portion is converted into three ketone body molecules: acetoacetic acid (AcAc), β - hydroxybutyric acid (BHB), and acetone. The most crucial understanding is that β - hydroxybutyric acid (BHB) is not a "metabolic waste" as previously thought, but a high-quality "clean energy" specially produced by the liver and efficiently utilized by important organs such as the brain, heart, and skeletal muscles. Cahill's research has shown that under long-term hunger, up to 60% -70% of the brain's energy needs can be supplied by BHB, which perfectly explains why humans can maintain clear cognitive function even under long-term fasting.
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