Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of decapeptide-12 cream in China. Welcome to wholesale bulk high quality decapeptide-12 cream for sale here from our factory. Good service and reasonable price are available.
Decapeptide-12 cream, as a "dark horse" in the field of cosmetic raw materials in recent years, has demonstrated outstanding efficacy in whitening, spot removal, anti-aging, and skin repair due to its unique molecular structure and multi-target mechanism of action. It achieves comprehensive intervention from the molecular level to the tissue level by precisely regulating the melanin generation pathway, activating the skin repair signaling network, and optimizing the active ingredient delivery system, becoming one of the core components in high-end skincare formulas.
DecaPeptide-12 COA
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| Certificate of Analysis | ||
| Compound name | DecaPeptide-12 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 137665-91-9 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.49% |
| Loss on drying | ≤1.0% | 0.32% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.90% |
| Single impurity | <0.8% | 0.47% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Molecular properties and functional basis
It is a short peptide chain composed of 10 amino acids with a molecular weight of 1395.52 Da, which combines the permeation advantages of small molecule peptides with the targeting properties of biologically active peptides.
Its molecular structure contains tyrosine (Tyr) and tryptophan (Trp) residues, which can competitively bind to the active site of tyrosinase by simulating the benzene ring structure of tyrosine, directly blocking the key step of melanin synthesis.
In addition, the charge distribution and spatial conformation enable it to efficiently penetrate the stratum corneum of the skin, targeting melanocytes and fibroblasts, laying the foundation for its multifunctional function.
Decapeptide-12 cream, as a star ingredient in the field of cosmetic raw materials, has shown significant advantages in whitening, freckle removal, anti-aging, and skin barrier repair due to its unique dual mechanism of action - targeted inhibition of melanin production and activation of skin repair pathways. Its mechanism of action involves multiple levels such as enzyme activity regulation, gene expression intervention, cell signaling, and skin structure remodeling, forming a multidimensional intervention network from molecules to tissues.
Tyrosinase inhibition: precise blockade of melanin synthesis
1. Competitive binding of tyrosinase active site
Tyrosinase is a key rate limiting enzyme in melanin synthesis, and its active center contains two copper ion (Cu ² ⁺) binding sites, responsible for catalyzing the conversion of tyrosine to dopaquinone. By simulating the benzene ring structure of tyrosine through the residues of tyrosine (Tyr) and tryptophan (Trp) in its molecular structure, it competes with the C-terminal residue of tyrosinase to directly block the enzyme's contact with the substrate.
The experimental data showed that the inhibition constant (Kd) of mushroom tyrosinase was 61.1 μ M, and the half maximal inhibitory concentration (IC50) was 40 μ M, indicating its high inhibitory ability. In human melanocyte experiments, treatment with Decapeptide-12 at a concentration of 100 μ M for 7 days resulted in a 43% decrease in melanin content without affecting cell proliferation, confirming its safety and effectiveness.
2. Multi target inhibition of melanin production pathway
In addition to directly inhibiting tyrosinase activity, it can also achieve long-lasting whitening by regulating signaling pathways related to melanin production. Research has shown that this peptide can downregulate the expression of microphthalmia related transcription factor (MITF), which is a core regulatory factor for melanocyte differentiation and tyrosinase gene expression.
By inhibiting MITF, the expression of key melanin synthesis enzymes such as tyrosinase and TRP-1 (tyrosinase related protein 1) is indirectly reduced, forming a "dual inhibition" mechanism. In addition, it can inhibit the binding of α - MSH (melanocyte stimulating hormone) and MC1R (melanocortin 1 receptor), block the upstream signal transduction of melanin production, and further consolidate its whitening effect.
3. Clinical validation: Improvement of melasma and photoaging
In a double-blind controlled trial for 30 Asian women, after 8 weeks of use of the cream containing 0.01% Decrepeptide-12, the area of chloasma was reduced by 31% on average, and the intensity of pigment was reduced by 27%. The effect was equivalent to that of 4% hydroquinone cream, but the irritation was significantly reduced (15% of the hydroquinone group had erythema and scaling).
Another open trial targeting patients with photoaging showed that after using the compound formula (containing antioxidants and fruit acids) for 3 months, 38.5% of patients' photoaging grading decreased from grade III to grade I, and the arrangement of elastic fibers in the dermis layer significantly improved, proving that it has both whitening and anti-aging effects.
Sirtuin family activation: the core driver of skin repair and anti-aging
1. Biological functions of Sirtuins
Sirtuins (SIRT1-7) are a class of NAD ⁺ - dependent histone deacetylases, known as "longevity proteins," that play critical roles in cellular metabolism, DNA repair, inflammation regulation, and aging processes. Among them, SIRT1 can promote collagen synthesis and inhibit the activity of matrix metalloproteinases (MMPs), thereby improving skin elasticity; SIRT3 reduces oxidative stress and delays cellular aging by regulating mitochondrial function; SIRT6 is involved in DNA damage repair and maintains genomic stability.
2. The regulatory effect of Decapeptide-12 on Sirtuins
Experiments have shown that Decapeptide-12 (100 μ M, 72 hour treatment) can significantly upregulate the transcription levels of SIRT1, SIRT3, SIRT6, and SIRT7 in human neonatal keratinocytes without causing cytotoxicity. Further research has found that the peptide indirectly enhances Sirtuins activity by activating the AMPK (adenosine monophosphate activated protein kinase) signaling pathway, increasing intracellular NAD ⁺ levels. In the artificial skin model, Decapeptide-12 promotes the secretion of type I and III collagen by fibroblasts, while inhibiting the expression of MMP-1 (collagenase), resulting in a 29% increase in collagen content and an 18% increase in elastic fiber density, significantly improving skin structure.
3. Clinical evidence of anti-aging
A randomized controlled trial involving 60 subjects showed that after using an eye cream containing 0.01% Decapeptide-12 cream for 12 weeks, the depth of wrinkles around the eyes decreased by 14%, the skin tightness increased by 19%, and there were no irritating reactions. Organizational analysis shows that collagen fibers in the dermis are arranged more tightly and the elastic fiber network structure is more complete, proving that it reverses skin aging at the cellular level.
Skin Type-Specific Application Guide
Oily & Acne-Prone Skin: Oil-Control, Hyperpigmentation Inhibition, Fade Acne Marks & Dullness
Core Skin Concerns
Oily acne-prone cutis features overactive sebaceous glands, resulting in persistent excess sebum and enlarged pores. Recurring breakouts frequently trigger post-inflammatory hyperpigmentation, namely red and dark acne marks. Additionally, oxidized sebum causes overall yellowish facial dullness. Tolerance levels vary widely among people with this cutis type; potent brightening ingredients such as high-concentration acids, 377 and high-dose niacinamide often trigger breakouts, redness, stinging and barrier damage, trapping cutis in a vicious cycle of "brightening treatments ruining cutis condition".
Product Matching Benefits
It formulated for oily acne-prone cutis mostly adopts a lightweight oil-in-water emulsification system. Its thin, hydrating texture absorbs rapidly upon application without adding extra sebum burden, effectively preventing closed comedones and breakouts. The core ingredient Decapeptide-12 not only targets melanin synthesis to fade old dark acne marks, but also downregulates cutaneous inflammatory factors to soothe residual red inflammation from pimples, tackling inflammatory hyperpigmentation at its source. Compared with conventional brightening actives, peptides are mild and non-irritating, without exfoliating stratum corneum or compromising the skin barrier, supporting long-term stable brightening for oily acne-prone complexions.
Dry, Sensitive & Barrier-Impaired Skin: Repair & Brighten, Gentle Skin Renewal
Core Skin Concerns
Dry sensitive cutis is characterized by a fragile cutis barrier and poor moisture retention, prone to chronic flakiness, redness and itchy irritation with minimal resistance to external aggressors. This cutis type rarely tolerates any potent brightening actives. Chronic dehydration and nutrient deficiency lead to lackluster, uneven cutis tone; pigmentation worsens drastically during seasonal transitions or environmental stress, creating a dilemma: dull cutis cannot bear brightening treatments, while brightening products induce allergic reactions.
Product Matching Benefits
It abandons irritating brightening mechanisms and centers on mild peptides with zero exfoliating effects, leaving fragile cutis barriers intact. Its base is infused with repairing and moisturizing ingredients including squalane, panthenol and ceramides. While suppressing melanin and correcting dry yellow dullness, it fills gaps within the cutis barrier and boosts moisture retention, delivering triple benefits: brightening, barrier repair and hydration. It simultaneously alleviates general and localized dullness in dry sensitive cutis, repairs compromised barriers and elevates cutaneous tolerance.
Mature Skin: Antioxidation & Melanin Suppression, Reverse Photoaging Dullness
Core Skin Concerns
Mature skin exhibits slowed metabolism and diminished self-repair capacity. Prolonged UV exposure and accumulated free radicals induce photoaging, manifesting as overall sallow dullness, superficial age spots and sun spots, accompanied by sagging and increased fine lines. Conventional moisturizing creams fail to resolve pigmentation, while traditional brightening products lack anti-aging repairing efficacy, failing to meet the multi-dimensional skincare demands of mature complexions.
Product Matching Benefits
Decapeptide-12 boasts powerful melanin-inhibiting and brightening properties while scavenging superficial cutaneous free radicals, slowing photoaging-related pigment accumulation and stopping existing spots from darkening and new spots from forming. The cream's nourishing texture caters to mature cutis's dehydrated, nutrient-deprived state, delivering long-lasting hydration to refine rough, depleted cutis texture. It combines three core functions: brightening, antioxidant anti-aging and deep moisturization, precisely addressing photoaging dullness, pigmented spots and dryness unique to mature cutis.
Tolerant Normal Skin: Daily Stabilization, Clear & Even Complexion
Core Skin Concerns
Normal and combination cutis features intact barriers and robust tolerance with no persistent severe cutis issues. However, late nights, daily commuter UV radiation and environmental pollution frequently trigger temporary dullness, yellow discoloration on the T-zone and uneven localized tone. Such cutis requires mild, long-acting brightening stabilizing products to sustain a clear complexion.
Product Matching Benefits
Decapeptide-12 cream is an ideal daily brightening stabilizer for healthy cutis. Its mild formulation is suitable for long-term use without cutaneous burden, continuously inhibiting melanin formation and preventing pigment buildup. It rectifies dullness triggered by irregular schedules and external irritants, maintaining lasting fair, translucent cutis.
Delivery system optimization: nanotechnology that breaks through the skin barrier
1. Liposome encapsulation technology
The molecular weight is 1395.52 Da, and although it has a certain transdermal ability, its bioavailability can be further enhanced by liposome encapsulation. Liposomes are composed of phospholipid bilayers, similar in structure to skin cell membranes, and can directly deliver active substances to keratinocytes or melanocytes through fusion. The experiment shows that the transdermal absorption rate of liposome coated cream is 3.2 times higher than that of ordinary cream, and the retention amount in the skin stratum corneum is 2.8 times higher, and the active substance is continuously released for 12 hours.
2. Nanostructured lipid carriers (NLC)
NLC uses a mixed matrix of solid and liquid lipids to further enhance its stability. In the 40 ℃ accelerated test, the active substance retention rate (92%) of the NLC formula group was significantly higher than that of the ordinary cream (78%), and the penetration depth in the skin increased by 40%. In addition, the sustained-release properties of NLC can reduce the waste of active substances in the epidermal layer and lower the risk of irritation.
3. Micro needle SMT technology
For deep pigmentation (such as melasma), microneedle patches can directly deliver it to the dermis layer. Animal experiments showed that the skin melanin content of the microneedle group was 39% lower than that of the cream group, and the depth of action could reach the dermal papilla layer. This technology breaks through the stratum corneum barrier through physical puncture, forming microchannels that allow active substances to bypass the epidermal barrier and reach the target site, significantly improving treatment efficacy.
1. Preparation of Decapeptide-12 via Solid-Phase Peptide Synthesis (SPPS)
Decapeptide-12 is synthesized by the Fmoc solid-phase peptide synthesis method, using Rink-amide resin as the solid support. Amino acids are coupled sequentially from the C-terminus to the N-terminus. Side chains of amino acids are protected with protecting groups such as t-Bu, Boc and Pbf to prevent side reactions. Each synthesis cycle consists of three steps:
Deprotection: Fmoc groups are removed with 20% piperidine in DMF. The mixture is bubbled with nitrogen for 5 minutes, followed by 5 washes with DMF.
Coupling: Amino acid carboxyl groups are activated by TBTU/DIEA, then coupled with amino groups on the resin. The system is rinsed 3 times with DMF afterwards.
Iteration: The above procedures are repeated until all 10 amino acid residues are fully assembled.
2. Purification and Lyophilization
The crude peptide is purified by reversed-phase HPLC with an acetonitrile-water gradient elution system, and the main peak fraction is collected. The structure is identified by mass spectrometry (MS) and nuclear magnetic resonance (NMR), with the final purity reaching no less than 98%.
The purified solution is desalted via dialysis and then freeze-dried to yield Decapeptide-12 as a white powder. The product shall be stored at -20 °C away from light.
3. Preparation of Cream Formulation
Weigh Decapeptide-12 powder at a dosage of 0.1%–1.0%, add deionized water, and stir at 40 °C until fully dissolved for later use. Heat the oil phase (stearic acid, cetyl alcohol, glyceryl stearate) to 75 °C for melting; dissolve the water phase (glycerin, sodium hyaluronate, preservatives) at the same temperature. Combine the two phases and perform high-speed emulsification for 30 minutes. Cool the mixture to 45 °C, add the prepared peptide solution and homogenize for 15 minutes. After cooling down to room temperature, Decapeptide-12 cream is obtained.
1. Research and Development Background (Early 2000s)
In the early 2000s, hydroquinone, a conventional skin whitening agent, faced limitations in clinical application due to its cytotoxicity and tendency to cause irreversible pigmentation such as ochronosis. The dermatology research team at Stanford University focused on developing non-cytotoxic and reversible tyrosinase inhibitors for the treatment of problematic skin conditions including melasma and post-inflammatory hyperpigmentation.
2. Molecular Screening and Discovery (2005–2009)
The team adopted high-throughput peptide library screening technology to target tyrosinase, the rate-limiting enzyme in melanin synthesis, and competitively block its active sites. In 2009, Abu Ubeid and colleagues published a study in the Journal of Investigative Dermatology, identifying a decapeptide with the amino acid sequence Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr, which was named Decapeptide-12. This peptide delivers potent tyrosinase inhibitory activity, 5.5 to 17 times stronger than hydroquinone, without causing damage to melanocytes.
3. Patenting and Commercialization (Post-2010)
The peptide was subsequently patented and launched by Envy Medical under the brand name Lumixyl. It was first introduced to professional medical aesthetics channels and later expanded into the mainstream beauty and personal care market. Thanks to its high efficacy and low irritation, Decapeptide-12 has gradually become a core raw material for whitening and anti-aging skincare products worldwide.
FAQ
What is the use of Decapeptide-12?
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Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation.
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