Decapeptide-12, white powder or liquid. It is a small oligopeptide, which is related to the C-terminal residue of tyrosinase (Kd: 61.1 μ M) Interacting tyrosinase inhibitors. It is a competitive inhibitor of mushroom tyrosinase (IC50:40 µ M). That also increased the transcription of SIRT. It reduces melanin content in melanocytes. It is used to study melanogenesis, aging and inflammation. It is a cosmetic raw material that can inhibit the formation of melanin, lighten the spots, reduce the pigmentation, and even and brighten the skin color. It is developed by researchers in the Department of Dermatology of Stanford University. It is currently a new peptide that has been proven to effectively inhibit the activity of tyrosinase (tyrosinase promotes the excessive generation of melanin, resulting in uneven pigment and black spots, etc.) in the superficial.
|
Chemical Formula |
C65H90N18O17 |
|
Exact Mass |
1395 |
|
Molecular Weight |
1396 |
|
m/z |
1395 (100.0%), 1396 (70.3%), 1397 (24.3%), 1396 (6.6%), 1398 (4.7%), 1397 (4.4%), 1397 (3.5%), 1398 (2.5%), 1398 (1.6%), 1396 (1.0%) |
|
Elemental Analysis |
C, 55.94; H, 6.50; N, 18.07; O, 19.49 |
Customized Bottle Caps & Corks
|
|
|
Decapeptide-12 is a peptide consisting of ten amino acids that has been shown to have various cosmetic and skincare benefits. It is commonly used in skincare products due to its ability to target specific superficial concerns and provide anti-aging effects. Some of the benefits of product include:
Skin Brightening: it can help to even out superficial tone and reduce the appearance of dark spots and hyperpigmentation. It works by inhibiting the production of melanin, which is responsible for superficial color.
Anti-Aging: it can help to reduce the appearance of fine lines and wrinkles by stimulating colla production. Colla is a protein that is essential for maintaining the skin's elasticity and firmness.
Moisturizing: it can help to hydrate the superficial and improve its texture. It works by increasing the production of hyaluronic acid, which is a natural moisturizer that helps to keep the superficial soft and supple.
Anti-Inflammatory: it has anti-inflammatory properties that can help to reduce redness and irritation in the superficial. It works by inhibiting the production of inflammatory molecules that can cause superficial damage.
Protective: It can help to protect the superficial from environmental stressors, such as UV radiation and pollution. It works by stimulating the production of antioxidants, which can help to neutralize harmful free radicals that can cause superficial damage.
Inhibit pigment synthesis: It can reduce the synthesis and deposition of melanin by inhibiting the activity of tyrosinase. Melanin is one of the root causes of pigmentation and spots, so It is widely used in whitening products to help improve superficial tone and uneven superficial tone.
Antioxidant effect: It is an antioxidant that can neutralize free radicals, remove oxides and maintain a normal redox state, helping to protect superficial cells from damage, thereby delaying the occurrence of skin aging.
Stimulate colla synthesis: It can stimulate colla production and regeneration, making the superficial more elastic and firm. At the same time, this peptide can also reduce the signs of aging such as fine lines and wrinkles.
Promote wound healing: Due to its anti-inflammatory and anti-oxidant properties, It is also used in the treatment of burns and wounds to accelerate wound healing.
Antibacterial effect: It also has a certain antibacterial effect, and is also widely used in the field of beauty. For example, it can be added to facial cleansers to remove and prevent pollution.
Fermented skin care: Lumixyl can be used in natural fermented beauty and superficial care products, which are produced through a complex microbial transformation process, which helps to increase the activity of other ingredients and make them more easily absorbed by the superficial.
Overall, it is a versatile skincare ingredient that can help to address a variety of superficial concerns. Its ability to brighten, moisturize, and protect the superficial, as well as its anti-aging and anti-inflammatory properties, make it a popular choice in many skincare products.
Decapeptide-12 is a new type of oligopeptide, which contains 2 tyrosine, 2 arginine and 3 serine in its peptide sequence. These carbohydrates have a strong inhibitory effect on tyrosinase activity. Therefore, It can inhibit the activity of tyrosinase, and then reasonably reduce the production of melanin. According to Anan Abu Ubeid and other scientific studies, it has stronger inhibition of tyrosinase in human cells than hydroquinone, and has no toxicity.
The key to skin whitening is the ability of melanocytes to produce melanin. There are melanocytes in the body cells of the basal layer of human epidermis. Its tyrosinase can oxidize tyrosine to sugar content, and then through a series of excretion processes, it can finally be converted into melanin.
The more melanin is converted into, the darker the skin will be; On the contrary, the skin will be more tender and white. Tyrosinase has a distinctive two-way catalytic effect, is an important enzyme for the production of melanin in organisms, and is closely related to human aging.
Its abnormal over-expression can cause pigmentation of the body. Tyrosinase inhibitors can treat pigmented skin diseases commonly used at this stage, such as chloasma, chloasma and senile plaques.
It is a new type of oligopeptide, which contains 2 tyrosine, 2 arginine and 3 serine in its peptide sequence. These carbohydrates have a strong inhibitory effect on tyrosinase activity. Therefore, it can inhibit the activity of tyrosinase, and then reasonably reduce the production of melanin. According to Anan Abu Ubeid and other scientific studies, it has stronger inhibition of tyrosinase in human cells than hydroquinone, and has no toxicity.
Basil et al. carried out a comparative test of that in the treatment of chloasma on five volunteers in a half-face manner, which showed that five volunteers had significantly improved chloasma. Kassim et al. showed that, compared with the patients who failed to treat with the hydroquinone tretinoin steroid cream for 6 months, the improvement of melasma on half of the face treated with it was more than 50%.
Scientific research by experts and scholars has shown that product is not easy to cause allergic or irritative dermatitis, and rarely causes mild erythema, irritability and itching.
Some experts believe that Lumixyl is rare in erythema and itching, and is not easy to cause pigmentation after inflammation. It is safe for long-term daily use and can be used as a substitute for other whitening agents. In the process of pigmentation treatment, it can complement with hydroquinone products to reduce the risk of hydroquinone related pigmentation rebound and exogenous chloasma. It has a variety of biological activities, including inhibiting melanin synthesis, stimulating colla synthesis, anti-oxidation, anti-inflammation, etc. It can affect cell function by binding to specific receptors on the cell surface.
Peptides are short chain molecules composed of amino acids connected by peptide bonds, typically consisting of 2-50 amino acids. They play important roles in organisms, such as hormones (such as insulin), neurotransmitters (such as endorphins), and cell signaling molecules (such as epidermal growth factor, EGF).
In the mid-20th century, scientists began to study the role of peptides in skin repair and anti-aging, and found that certain peptides could stimulate the production of colla or inhibit skin degrading enzymes.
In the 1980s, with the maturity of solid-phase peptide synthesis technology (SPPS), scientists were able to effectively synthesize peptides of specific sequences. This technological advancement enables researchers to design and test various bioactive peptides, laying the foundation for the discovery of Lumixyl.
At the beginning of the 21st century, the research focus in the fields of cosmetics and skin pharmacology shifted towards finding synthetic molecules that can simulate natural growth factors or signal peptides. Scientists hope to find a way:
Stimulate fibroblast proliferation
Promote the synthesis of colla and elastin
Inhibiting MMPs (such as MMP-1, MMP-3) to prevent skin matrix degradation
Researchers used high-throughput screening techniques to test the effects of hundreds of synthetic peptides on skin cells. Finally, the peptide consisting of 10 amino acids (sequence: Ac Gln Pro Arg Thr Ile Phe Gln Gly Gly Leu NH ₂) exhibited significant anti wrinkle and skin repair activity and was later named Lumixyl.
Between 2005 and 2010, multiple in vitro and clinical studies confirmed the efficacy of Lumixyl:
In 2006, an in vitro experiment showed that Lumixyl significantly increased the expression of type I colla.
In 2008, a clinical study found that skincare products containing Lumixyl reduced the depth of eye wrinkles in participants by 30% within 8 weeks.
In 2010, further research showed that the peptide could inhibit the expression of MMP-1 induced by ultraviolet (UV) radiation, thereby protecting the skin from photoaging damage.
Scope of sales channels
DecaPeptide-12 is a specific peptide with a unique amino acid sequence that endows it with various biological activities, such as inhibiting tyrosinase activity and reducing melanin production. It has important application value in whitening cosmetics, anti-aging products, and biomedical research. With the continuous growth of demand for DecaSeptide-12 in the market, its sales channels are becoming increasingly diversified.
Direct sales and customized services
Some DecaSeptide-12 suppliers adopt a direct sales model, selling their products directly to end customers. The advantage of the direct sales model is that it can reduce intermediate links, lower sales costs, and increase profit margins. At the same time, suppliers can directly communicate with customers, understand their needs and feedback, and adjust products and services in a timely manner. For example, suppliers can visit potential customers such as cosmetics companies and pharmaceutical research and development institutions through their sales teams, introduce product features and advantages, and facilitate transactions. But the direct sales model requires suppliers to have strong market development capabilities and sales teams, and the sales cycle may be longer.
Customized services
With the diversification of market demand, customized services are receiving increasing attention in DecaSeptide-12 sales. Suppliers can provide customized products and services based on specific customer requirements, such as purity, packaging specifications, formula adjustments, etc. Customized services can meet customers' personalized needs, improve customer satisfaction and loyalty. For example, some cosmetics companies may wish to blend DecaSeptide-12 with other active ingredients to develop whitening products with unique efficacy. Suppliers can provide customized solutions to customers through their own research and production capabilities. However, customized services require high technical strength and production capacity from suppliers, and the production cycle may be relatively long.
Hot Tags: decapeptide-12 cas 137665-91-9, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, dermorphin peptide, Melanotan ii powder, Cosmetic, DERMORPHIN, dermorphin in humans