Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of kpv peptide spray in China. Welcome to wholesale bulk high quality kpv peptide spray for sale here from our factory. Good service and reasonable price are available.
KPV Peptide Spray is a topical spray preparation based on KPV (tripeptide composed of lysine proline valine), which shows unique value in the treatment of skin and mucosal inflammatory diseass. Its core mechanism of action is to inhibit the release of inflammatory mediators by binding to melanocortin receptors (MC-Rs) and block the NF - κ B signaling pathway to reduce the production of pro-inflammatory factors such as IL-1 β, thereby exerting anti-inflammatory and immune regulatory effects.In the field of skin inflammation, the spray exerts significant effects on atopic dermatitis, psoriasis and contact dermatitis.Clinical trials demonstrate that it relieves patients' itching within hours to days, reduces rash area and severity scores markedly, and lowers recurrence frequency with long-term use.Additionally, the spray shows potential in wound healing and infection prevention.
Our product
Additional information of chemical compound:
Our Product
α-MSH (11-13) (free acid)+. COA
Formulation design and advantages
1. Innovative formulation design
KPV Peptide Spray adopts spray type, which has the following advantages:
Precise local administration: spray can realize the uniform distribution of drugs in the lesion, reduce systemic absorption, and reduce the risk of adverse reactions.
Convenient to use: Patients can operate on their own and are suitable for hard to reach areas such as the scalp and back.
Rapid effect: the spray can quickly cover the skin surface and promote drug penetration.
Transdermal enhancers such as ethanol and propylene glycol may be added to the formulation to enhance the transdermal absorption efficiency of it.
2. Quality control and purity requirements
The production ofα-MSH must comply with cGMP standards, with a purity requirement of ≥ 98%. Each batch of products needs to be tested for principal component content by HPLC and validated for microbial limits, heavy metal residues, and other indicators. Stability studies have shown that the degradation rate of active ingredients in the product is less than 5% after being stored at 25 ℃/60% RH for 12 months. The uniformity of spray type, spray particle size distribution and other parameters also need to be strictly controlled to ensure the consistency of efficacy.
3. Safety and tolerability
The acute toxicity test showed that the maximum tolerated dose (MTD) of α-MSH on experimental animals was>5000 mg/kg. The human skin irritation test showed that the 0.5% concentration formulation did not cause adverse reactions such as erythema and edema after continuous use for 28 days. Local tolerance is superior to traditional glucocorticoid drugs, especially suitable for people with sensitive skin.
4. Administration route and dosage optimization
The recommended usage is 2-3 times a day, with each spray amount adjusted according to the lesion area (usually 2-3 sprays/cm ²). After a single administration, the retention time of the drug on the skin surface can reach 4-6 hours, and the transdermal absorption rate is about 30-40%. The course of treatment is usually designed for 4-8 weeks and requires dose titration in conjunction with efficacy evaluation.
Treatment of inflammatory skin diseases
1. Atopic dermatitis
Atopic dermatitis is a chronic, recurrent, inflammatoy ski diseas, often accompanied by severe itching, dry ski, and eczema like rash. α-MSH has demonstrated unique value in the treatment of atopic dermatitis. Its mechanism of action may be related to regulating the local immune response of the ski, reducing ski inflammation by inhibiting the release of pro-inflammatory cytokines.
In clinical applications, patients can experience relief of itching symptoms in a relatively short period of time after using α-MSH. Generally, within a few hours to a few days after use, the degree of itching is significantly reduced, and the patient's nighttime sleep quality is improved. At the same time, the eczema like rash on the ski gradually subsides, and the symptoms of erythema, papules, etc. decrease, and the dryness of the ski also improves. Long term use of KPV Peptide Spray can reduce the recurrence frequency of atopic dermatitis and improve the quality of life of patients.
2. Psoriasis
Psoriasis is an immune-mediated chronic, recurrent, inflammatoy ski diseas characterized by well-defined red patches on the ski, covered in silver white scales. α-MSH has a therapeutic effect on psoriasis by regulating the skin's immune microenvironment.
It can act on immune cells in the ski, inhibit excessive activation of Th17 cells, reduce the production of pro-inflammatoy factors such as IL-17, and thus alleviate ski inflammation. Clinical studies have shown that patients with psoriasis who use α-MSH experience a significant decrease in rash area and severity index (PASI) scores. After a period of use, symptoms such as redness and scales on the patient's ski significantly reduced, and the rash area gradually decreased. Moreover, α-MSH, as a topical preparation, has relatively few adverse reactions and is well tolerated by patients.
3. Contact dermatitis
Contact dermatitis is an inflammatoy reaction that occurs at or outside the contact area after the ski comes into contact with certain exogenous substances. α-MSH can be used for the treatment of contact dermatitis, reducing ski inflammatoy reactions through its anti-inflammatory and immunomodulatory effects.
When the skin comes into contact with allergens or irritants, using α-MSH can quickly relieve local skin redness, itching, and pain symptoms. It can inhibit the release of inflammatoy mediators, reduce the infiltration of inflammatoy cells, and promote the repair of skin barrier function. Generally, the early use of α-MSH after the onset of contact dermatitis can effectively shorten the course of the diseas and reduce the occurrence of complications.
Treatment of mucosal inflammatory diseass
1. Oral mucositis
Oral mucositis is an inflammatoy diseas of the oral mucosa, commonly found in cancer patients after chemotherapy and radiotherapy, as well as in immunocompromised populations. α-MSH plays an important role in the treatment of oral mucositis.
It can accelerate mucosal repair by promoting the proliferation and migration of oral mucosal epithelial cells. Meanwhile, its anti-inflammatory effect can alleviate the inflammatoy response of oral mucosa and relieve pain. For patients with oral mucosal inflammation after chemotherapy and radiotherapy, the use of α-MSH gradually reduces the ulcer area of the oral mucosa, reduces pain, and improves oral functions such as eating and speaking. Moreover, α-MSH is easy to use and can be directly sprayed on the affected areas of oral mucosa, improving patients' treatment compliance.
2. Vaginal mucosal inflammation
Vaginal mucosal inflammation is a common gynecological diseas in women, mainly caused by bacterial, fungal and other pathogenic infections. α-MSH can be used for the treatment of vaginal mucosal inflammation, regulating the local immune environment of the vagina, and inhibiting the growth and reproduction of pathogenic bacteria.
It can enhance the barrier function of vaginal mucosa, reduce the adhesion and invasion of pathogens. At the same time, it can also regulate the balance of vaginal flora and promote the growth of beneficial bacteria. Clinical applications have shown that after using α-MSH in patients with vaginal mucosal inflammation, abnormal symptoms of vaginal secretions are improved, and symptoms such as itching and odor are reduced. Regular use of α-MSH can prevent the recurrence of vaginal mucosal inflammation and maintain vaginal health.
Wound healing promotion
1. Surgical incision healing
The healing of the surgical incision is crucial for the patient's recovery after surgery. α-MSH can promote the healing of surgical incisions and reduce the occurrence of complications.
It can stimulate the proliferation of fibroblasts and the synthesis of collagen, accelerating wound contraction and epithelialization. After using α-MSH at the surgical incision site, the healing time of the incision is shortened and the risk of wound infection is reduced. Meanwhile, It can also alleviate the inflammatoy response during wound healing, reduce scar formation, and improve the aesthetic appearance of the incision.
2. Burn wound healing
The healing of burn wounds is a complex process involving multiple stages such as inflammatoy response, cell proliferation, and tissue repair. α-MSH has a positive effect in the treatment of burn wounds.
It can regulate the immune response of burn wounds, suppress excessive inflammatoy reactions, and reduce the damage of inflammation to the wound. At the same time, It promotes the proliferation and migration of cells around the wound, accelerating wound healing. For shallow burn wounds, the use of KPV Peptide Spray reduces the drying and scab formation time of the wound, and improves the quality of healing. For deep burn wounds, α-MSH can promote the formation of granulation tissue, creating conditions for further wound repair.
Antibacterial effect and infection prevention
1. Antibacterial activity against common pathogens
It have certain antibacterial effects and have inhibitory effects on various common pathogens such as Staphylococcus aureus and Candida albicans.
In the treatment of ski and mucosal infections, α-MSH can directly kill or inhibit the growth of pathogens through its antibacterial effect. For bacterial infections on the surface of the ski, such as folliculitis, boils, etc., using α-MSH can alleviate the symptoms of infection and promote the resolution of inflammation. For fungal infections in mucosal areas, such as oral candidiasis, vaginal candidiasis, etc., α-MSH can regulate the local immune environment, inhibit fungal growth and reproduction.
2. Application of infection prevention
α-MSH can be used for infection prevention in some surgical or treatment processes that are prone to infection.
For example, before oral surgery, gynecological surgery, etc., spraying α-MSH on the surgical site can reduce the number of pathogenic bacteria in the surgical site and lower the risk of postoperative infection. In patients who have been using immunosuppressants or chemotherapy for a long time, various infections are prone to occur due to weakened immunity. Regular use of α-MSH on exposed ski and mucous membrane areas can have a certain infection prevention effect and protect the health of patients.
The manufacturing process of KPV Peptide Spray centers on four core stages: synthesis of high-purity KPV tripeptide (Lysine-Proline-Valine), formulation development, aseptic production, and quality control. The entire process adheres to GMP standards to ensure product safety, stability, and consistent efficacy.
In the raw material synthesis stage, the mainstream method is solid-phase peptide synthesis (SPPS). Using polymer-bonded resin as the solid-phase matrix, the peptide chain is extended through sequential amino acid coupling. After carboxylation with acetic acid, the resin is cleaved and deprotected using a trifluoroacetic acid (TFA) system.
The crude peptide is then precipitated with methyl tert-butyl ether (MTBE), purified by preparative HPLC (mobile phase: water-acetonitrile system), and finally obtains the product active pharmaceutical ingredient (API) with a purity of ≥99%.The API has a CAS number of 67727-97-3, a molecular formula of C18H32N4O4, and a molecular weight of 384.47 Da. Microwave-assisted technology can be applied in the synthesis process to improve efficiency, reduce solvent consumption, and achieve an overall yield of over 65%.
The formulation development and production stages focus on the sterilization and stability optimization of the spray dosage form. The API is freeze-dried into sterile lyophilized powder. For reconstitution, sterile water for injection or a dedicated buffer solution (pH 5.5–6.5, suitable for mucosal environments) is used, with biocompatible excipients such as hyaluronic acid and chitosan added to enhance mucosal adhesion and enzymatic stability.
The spray device adopts a sterile atomization system, controlling the atomized particle size at 10–50 μm to ensure uniform drug coverage on inflammatory sites and improve local penetration efficiency.The entire production process is carried out in Grade A/B clean areas. Through processes such as filtration sterilization, aseptic filling, and sealing, preservatives are avoided, and the sterile state of the product is guaranteed.
The quality control system runs through the entire process. For raw materials, purity and structural confirmation are tested by HPLC and mass spectrometry (MS). For formulations, pH, osmotic pressure, atomized particle size, sterility, and microbial limit are tested. Stability studies include accelerated testing (40℃±2℃, RH 75%±5%) and long-term testing (2–8℃) to ensure the quality stability of the product within its shelf life.
In addition, the finished product must be accompanied by a Certificate of Analysis (COA), which records various test indicators to meet the regulatory requirements for pharmaceutical-grade products.
FAQ
What is the product good for?
It naturally calms inflammatory responses in the body, particularly in the digestive system. It helps protect the gut lining and reduce discomfort associated with conditions like IBD or leaky gut, making it a reliable ally for long-term digestive health.
What is it used for?
Supports Immune Function: This peptide can enhance immune responses, potentially improving the body's ability to fend off infections and recover from illness. Promotes Wound Healing: KPV may aid in the healing of wounds and injuries by promoting tissue repair and regeneration.
How long does it take for the product to work?
How long will it take to notice results from the product? Most people start noticing shifts within 2 to 4 weeks with consistent use.
What are the side effects of the product?
Apart from its unclear safety profile, we can presume, based on our dealings with prescribers, that it administered subcutaneously can cause certain side effects that are common to most therapeutic peptide injectables: injection site reactions and mild, transient flu-like symptoms.
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