Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of fenbendazole ivermectin in China. Welcome to wholesale bulk high quality fenbendazole ivermectin for sale here from our factory. Good service and reasonable price are available.
Fenbendazole Ivermectin is an oral semi‑synthetic broad‑spectrum antiparasitic derivative. It exhibits activity against most nematodes (though not all species) across multiple life cycle stages. The compound demonstrates efficacy against microfilariae of Dipetalonema reconditum, yet shows no activity against adult filarial worms. It also delivers antiparasitic effects against intestinal fecal roundworms residing within the gastrointestinal tract. Bloomtechz maintains stringent quality control over raw material synthesis and purification for this antiparasitic intermediate, ensuring consistent impurity profiles and reliable batch repeatability to support your formulation research and laboratory evaluation.
This product can also interact with chloride ion channels of other ligand valves, such as the neurotransmitter gamma aminobutyric acid (GABA). The selectivity of this product is due to the absence of glutamate chloride ion channels in some mammals, and the low affinity of avermectin for mammalian ligand chloride ion channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and roundworm like disease, as well as infections caused by hookworms, roundworms, whipworms, and pinworms.
At the same time, our company not only provides ivermectin stromectol tablets, but also cream, paste and powders. If needed, please feel free to contact us at any time.
Our product
| Product Name | Ivermectin stromectol powder | Ivermectin stromectol tablet |
| Product Type | Powder | Tablets |
| Product Purity | HPLC≥99.0% | ≥99% |
| Product Specifications | 100g/1kg/etc. | 360mg/Tablet |
| Product Package | PE/Al foil bag/ paper box for Pure powder |
100 tablets/Bottle 80 bottles/Box |
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Ivermectin Stromectol+. COA
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Certificate of Analysis |
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Compound name |
Ivermectin | |
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CAS No. |
70288-86-7 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
3kg |
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Packaging standard |
PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
202601090001 |
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MFG |
Jan 9th 2026 | |
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EXP |
Jan 8th 2029 | |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤5.0% |
0.31% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.4% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Analysis of the Mechanism and Scenarios of Combination Use of Fenbendazole and Ivermectin
Joint mechanism: molecular level collaborative strike
1. The mechanism of action of fenbendazole
Fenbendazole is a broad-spectrum antiparasitic drug belonging to the benzimidazole class of compounds. Its mechanism of action mainly includes:
Tubulin inhibition:
Fenbendazole binds to microtubules in parasite cells, inhibiting their polymerization and disrupting the parasite's microtubule system. The microtubule system plays a crucial role in cell division, material transport, and maintaining cell morphology. Its disruption leads to hindered cell division and abnormal energy metabolism in parasites, ultimately preventing their normal growth and reproduction.
Glucose metabolism interference:
Fenbendazole can also inhibit parasite uptake of glucose, causing glycogen depletion and energy metabolism obstruction, further accelerating parasite death.
Physiological structure disruption:
For certain parasites, such as tapeworms, fenbendazole can disrupt their physiological structure attached to the intestinal wall, causing them to detach from the intestinal wall and be excreted with feces.
2. The mechanism of action of ivermectin
Ivermectin is a macrolide antibiotic with broad-spectrum antiparasitic activity. Its mechanism of action mainly includes:
Neurotransmitter interference:
Ivermectin increases the release of inhibitory neurotransmitter gamma aminobutyric acid (GABA) in parasites and opens glutamate controlled chloride ion channels, enhancing the permeability of nerve membranes to chloride ions and blocking the transmission of neural signals. This kind of nerve interference can cause parasitic nerve paralysis, muscle cells lose their ability to contract, and ultimately cause the parasite to die due to inability to move.
Energy metabolism inhibition:
Ivermectin can also interfere with the energy metabolism of parasites, by inhibiting their uptake of glucose, depleting their energy reserves, and further accelerating parasite death.
3. Collaborative mechanism for joint use
When fenbendazole and ivermectin are used in combination, they complement each other through different mechanisms of action, forming a multi-target attack on parasites:
Expansion of deworming spectrum:
Fenbendazole has a strong killing effect on nematodes, tapeworms, and flukes, while ivermectin has a good killing effect on nematodes and arthropods (such as mites and ticks). The combination of the two can cover almost all common parasitic species in livestock and poultry, including nematodes, tapeworms, flukes, and arthropods.
Complementary mechanism of action:
Fenbendazole mainly interferes with the microtubule protein and glucose metabolism of parasites, while ivermectin mainly interferes with neurotransmitters and chloride ion channels. The complementarity of this mechanism of action allows parasites to be attacked at multiple physiological stages, greatly improving the effectiveness of deworming and reducing the possibility of parasite resistance.
Clinical Research: Empirical Efficacy and Safety
1. Animal deworming experiment
Crab eating monkey experiment: The experimental monkeys were randomly divided into four groups and received ivermectin monotherapy, fenbendazole monotherapy, combination therapy, and blank control, respectively. The results showed that the combination therapy group was significantly better than the single therapy group in terms of deworming rate and egg negative conversion rate, demonstrating a significant synergistic effect.
Treatment of pig whipworm disease: A combination therapy of ivermectin and fenbendazole was used to treat pig whipworm disease. After 3 days of medication, the pigs gradually resumed normal feeding and excreted a large amount of white worms in their feces, indicating that the combination therapy has a good therapeutic effect on pig whipworm disease.
2. Exploration of Human Applications
Anticancer potential: Preclinical studies have shown that the combination of fenbendazole and ivermectin has cytotoxic effects on cancer cells, inhibiting their proliferation and metastasis. There are case reports that combination therapy has certain therapeutic effects on cancer patients such as advanced gastric cancer and small cell lung cancer, but more clinical research is needed to verify.
Antiviral research: In vitro experiments show that fenbendazole and ivermectin can prevent the spike protein of COVID-19 from entering cells, showing potential antiviral activity.
Indications and usage scenarios
1. Core indications in the field of veterinary medicine
Combination therapy is mainly used to drive away nematode diseases, tapeworm diseases, fluke diseases, and mite diseases in animals such as pigs, cows, sheep, and poultry. The specific indications are as follows:
Cattle: It has a significant killing effect on gastrointestinal nematodes (such as blood lance nematodes and upside down nematodes) and lung nematodes in cattle, and can effectively kill external parasites such as ticks and lice.
Pet: It has a good therapeutic effect on parasitic infections such as roundworms, hookworms, and ear mites in dogs and cats.
Sheep: It can drive away internal parasites such as Moniz tapeworm and liver fluke, as well as external parasites such as scabies mite and itch mite that can kill sheep.
Pig: It can effectively drive away various internal parasites such as pig roundworms, pig hair head nematodes, and esophageal mouth nematodes, while also preventing and treating external parasites such as pig scabies mites and demodex mites.
Poultry: It can kill intestinal nematodes such as roundworms and nematodes, as well as prevent and control external parasites such as chicken skin mites and feather lice.
2. Special scenario applications
Mixed infection treatment: When animals are simultaneously infected with multiple parasites, combination therapy can avoid the toxicity problems caused by multi drug combination therapy and improve treatment effectiveness.
Response to drug-resistant strains: Parasites that develop resistance to a single drug can increase sensitivity through multi-target attacks when used in combination.
Immunodeficient animals: Combination therapy can regulate immune function and reduce the risk of secondary infections.
Comparison of the Mechanism of Action and Synergistic Mechanism between Fenbendazole and Ivermectin
Collaboration and differentiation in joint use
| Mechanism of action: | Fenbendazole | Ivermectin | Synergy point |
| Target | Microtubule system | Glucose metabolism neurotransmitters | Multi target attack on parasites |
| Complementary deworming spectrum | Taenia and flukes are effective for arthropods | while tapeworms/flukes are ineffective | Expanded Coverage |
| Metabolic pathway | Mainly metabolized by the liver | Mainly excreted by the kidneys | Reduce liver and kidney burden overlap |
The mechanism of action of fenbendazole
Microtubule Inhibition Fenbendazole suppresses the polymerization of tubulin within parasite cells, disrupting the integrity of the microtubule system. This disturbance blocks cell division and triggers aberrant energy metabolism, eventually arresting parasite growth and reproduction and resulting in parasite mortality.
Immune Modulation and Antibacterial Activity It modulates the host immune response to strengthen anti-parasitic defense, while exerting inhibitory activity against certain bacterial strains. As a broad-spectrum antiparasitic agent, it is active against roundworms, hookworms, whipworms, tapeworms and other parasites. Its metabolite, oxfendazole, helps extend the duration of pharmacological action.
Interference with Glucose Metabolism The active substance inhibits glucose uptake by parasites, causing glycogen exhaustion and collapse of energy metabolism pathways, which accelerates parasite death.
Destruction of Parasite Physiological Structure Fenbendazole damages the tissue structure of tapeworms and other intestinal-adhering parasites, detaching them from the intestinal lining so they can be expelled via feces.
Bloomtechz supplies high-purity Fenbendazole Ivermectin intermediate with tightly controlled impurity levels. We conduct systematic testing on each batch to verify active ingredient content and ensure stable pharmacological performance for your antiparasitic formulation screening and mechanism research.
The mechanism of action of ivermectin
Neurotransmitter Interference
Fenbendazole effectively interferes with parasitic nervous system conduction by boosting the endogenous release of GABA (gamma-aminobutyric acid) within parasite tissues. The excess GABA activates gated chloride ion channels on neuronal cell membranes, causing continuous chloride influx and hyperpolarization of nerve cells. This process blocks normal nerve impulse transmission, induces irreversible parasitic nerve paralysis, triggers sustained muscle relaxation and motility loss, and ultimately leads to complete parasite inactivation and death.
Energy Metabolism Inhibition
This active pharmaceutical intermediate severely disrupts the carbohydrate metabolic pathway of target parasites by competitively inhibiting transmembrane glucose absorption and transportation.
With continuous blockade of glucose intake, parasites are unable to synthesize sufficient glycogen and ATP to maintain basic physiological activities, including cell growth, reproduction, tissue repair and motor function. Progressive depletion of internal energy reserves triggers systematic metabolic collapse, severely impairs parasitic viability, and significantly accelerates the elimination and mortality of invasive parasites.
Anti-inflammatory and Immune Regulation
Beyond antiparasitic efficacy, Fenbendazole exerts prominent anti-inflammatory and immunomodulatory properties.
It suppresses excessive inflammatory responses by regulating the secretion and balance of multiple pro-inflammatory and anti-inflammatory cytokines, alleviating local tissue inflammation caused by parasitic infection.Meanwhile, it enhances the host's immune surveillance and clearance ability, assisting the body in resisting secondary infection and repairing damaged tissues.In terms of application spectrum, it presents high inhibitory efficacy against common nematodes such as roundworms and hookworms, as well as parasitic arthropods including mites, while showing negligible activity against tapeworms and flukes.
Bloomtechz provides high-purity Fenbendazole Ivermectin raw materials with stable biological activity and consistent batch performance.
Strict component calibration and impurity control ensure reliable experimental repeatability, perfectly supporting your mechanism research, pharmacological testing and formulation optimization projects.
adverse reaction
Fenbendazole Ivermectin are widely used as broad-spectrum antiparasitic drugs in veterinary and human medicine. Fenbendazole is mainly used to treat gastrointestinal nematode infections in pets such as dogs and cats, while Ivermectin is widely used in animal husbandry and the treatment of some human parasitic diseases such as filariasis and scabies due to its potent effects on various nematodes and arthropod parasites. However, with the expansion of the scope of medication, reports of adverse reactions between the two have gradually increased, especially in high-dose use or special populations (such as sensitive breeds of dogs, immunosuppressed patients), and the severity of adverse reactions has attracted attention.
Overdose constitutes the main risk factor for adverse reactions. Fenbendazole and Ivermectin have a relatively narrow safety margin, and excessive dosage may trigger toxic accumulation, especially for sensitive subjects or those with hepatic and renal impairment. For instance, the recommended Ivermectin dose for Collie dogs is 50 μg/kg, and doses exceeding 200 μg/kg raise neurotoxicity risk from 5% to 50%. Bloomtechz supplies high-purity Fenbendazole Ivermectin intermediates with consistent assay values to facilitate precise dosing studies.
Fasting administration accelerates drug disintegration and increases local irritation; postprandial dosing buffers gastric stimulation and delays gastric emptying, lowering adverse reaction risks. Data shows Fenbendazole given to dogs 3 hours after meals reduces vomiting incidence by 40% compared with the fasting group. Injectable formulations, particularly intravenous injection, bypass gastrointestinal first-pass metabolism and directly enter circulation, leading to higher allergy rates. The allergic reaction rate of Ivermectin injection (3%) is notably higher than that of oral preparations (1%). Bloomtechz offers reliable raw materials to support your formulation and administration route research.
Breeds carrying MDR1 gene mutations such as Collies are highly sensitive to the neurotoxicity of Fenbendazole and Ivermectin. Increased blood-brain barrier permeability allows drug buildup within the central nervous system. Subjects with liver or kidney dysfunction exhibit slower drug clearance, easily causing toxic accumulation. Cirrhosis patients taking Ivermectin achieve blood drug levels 2–3 times those of healthy people, with elevated neurotoxicity risk. Immunocompromised groups are more prone to hypersensitivity responses due to overactive immune status. Bloomtechz maintains strict impurity control across batches to minimize experimental variation.
reference
Campbell, W. C., & Benz, G. W. (1984). Ivermectin: A potent new antiparasitic agent. Journal of Veterinary Pharmacology and Therapeutics, 7(1), 1–16.
McKellar, Q. A., & Scott, E. W. (1990). The pharmacokinetics of fenbendazole in animals. Veterinary Research Communications, 14(5), 379–393.
Mealey, K. L. (2004). MDR1 gene mutation and ivermectin sensitivity in dogs. Journal of Veterinary Internal Medicine, 18(4), 444–451.
Lanusse, C. E., & Prichard, R. K. (1993). Gastrointestinal distribution and absorption of benzimidazole anthelmintics. Drug Metabolism Reviews, 25(4), 385–412.
Gokbulut, C. (2010). Pharmacokinetic interactions between ivermectin and benzimidazole compounds in target animal species. Parasitology Research, 107(3), 549–557.
Frequently Asked Questions
1. What makes Bloomtechz's Fenbendazole Ivermectin intermediate more suitable for pharmacological safety research?
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Our products feature high purity, low residual impurities and stable batch consistency. Since the safety and toxicity evaluation of fenbendazole and ivermectin is highly dose‑sensitive, our precisely controlled content uniformity effectively reduces experimental errors caused by raw material instability, supporting accurate safety verification, dosage screening and adverse reaction mechanism research.
2. Can you provide customized specifications for formulation and administration route research?
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Yes. Bloomtechz supports customized purity grades, particle size parameters and technical indicators for oral dosage research, injection formulation development and in vitro pharmacological testing. We can provide matching COA, HPLC detection data and technical documents to meet different experimental and industrial formulation needs.
3. Does your material support research on individual differences and gene‑related drug sensitivity?
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Absolutely. Our high‑stability Fenbendazole Ivermectin raw materials eliminate batch fluctuation interference, which is critical for studies involving MDR1 gene mutation sensitivity, liver and kidney metabolism differences, and population‑specific neurotoxicity risk assessment. Stable raw material performance ensures credible and repeatable experimental conclusions.
4. What quality documents can you provide for laboratory and project audit?
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Bloomtechz can provide complete supporting documents including COA, MSDS, HPLC purity report, heavy metal residue test and batch stability data. All files meet international laboratory standards and can be directly used for project filing, experimental data sorting and supplier qualification audit.
5. What are your advantages for long‑term bulk procurement and stable supply?
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We have standardized production and quality control systems for antiparasitic intermediates, achieving stable batch quality and sustainable large‑volume supply. For long‑term cooperative customers, we support reserved inventory, customized inspection standards and stable technical after‑sales guidance, helping customers complete continuous research and industrial scale‑up stably.
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