Ivermectin stromectol tablet is a new type of broad-spectrum, highly efficient, and low toxicity antibiotic antiparasitic drug, which has good killing effects on parasites, especially nematodes and arthropods, both inside and outside the body. But it is ineffective against tapeworms, flukes, and protozoa. The killing effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory neurotransmitter gamma aminobutyric acid (GABA) in the parasite, as well as to open the glutamate controlled Cl ion channel, enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, ultimately leading to nerve paralysis, causing muscle cells to lose their ability to contract, resulting in the death of the parasite.
Stromectol is another name for ivermectin, and its core physical property is a white crystalline powder with no taste. This product is in a block like physical state and is easily soluble in methanol, ethanol, acetone, and ethyl acetate. It is almost insoluble in water and has a slight hygroscopicity. Ivermectin is a macrocyclic lactone antibiotic with a sixteen membered ring. Its basic structure consists of a large ester ring at the carbon 16 position and three major substituent groups, namely hexahydrophenylpropanofuran at the C2 to C8 positions, disaccharide at the C13 position, and ketone at the C17 to C18 positions.
At the same time, our company not only provides ivermectin stromectol tablets, but also cream, paste and powders. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
| Product Name | Ivermectin stromectol powder | Ivermectin stromectol tablet |
| Product Type | Powder | Tablets |
| Product Purity | HPLC≥99.0% | ≥99% |
| Product Specifications | 100g/1kg/etc. | 360mg/Tablet |
| Product Package | PE/Al foil bag/ paper box for Pure powder |
100 tablets/Bottle 80 bottles/Box |
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Ivermectin Stromectol+. COA
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Certificate of Analysis |
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Compound name |
Ivermectin | |
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CAS No. |
70288-86-7 | |
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Grade |
Veterinary grade |
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Quantity |
339.3kg |
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Packaging standard |
25kg/drum |
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| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 9th 2025 |
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EXP |
Jan 8th 2028 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤5.0% |
0.31% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.4% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Ivermectin stromectol tablet is widely used for gastrointestinal nematodes, pulmonary nematodes, and parasitic arthropods in cattle, sheep, horses, and pigs, intestinal nematodes in dogs, ear mites, scabies mites, heartworms, and microfilaments, as well as gastrointestinal nematodes and ectoparasites in poultry.
(l) Ivermectin is administered orally or subcutaneously to cattle and sheep at a dose of 0.2mg/kg. It has a deworming rate of 97% to 100% against adult and fourth stage larvae of nematodes such as hemochromatus, Oster, Gubai, Trichomonas (including Eisenia), roundworms, upside down nematodes, fine necked nematodes, hairy head nematodes, esophageal nematodes, reticulum nematodes, and sheep Charcot worms. The above doses are also effective for arthropods, such as maggots (cowhide flies, stripe flies, sheep flies), mites (cattle scabies mites, sheep itch mites), and lice (cattle palate lice, cattle blood lice, and sheep palate lice). Ivermectin has slightly poorer therapeutic effects on chewing lice (milkworms) and sheep ticks and flies.
Ivermectin is also highly effective against ticks and flies that breed in feces. Although the drug cannot immediately kill or dismember ticks, it can affect
Eating, molting, and laying eggs can reduce reproductive ability. Subcutaneous injection of 0.2mg/kg once or daily feeding of low concentration to animals
After 5 days of medication (0.01mg/kg), the tick showed the most obvious phenomenon mentioned above. Subcutaneous injection at a dose of 0.2mg/kg also has a certain control effect on flies that reproduce in feces. After 9 days of medication in cattle, the larvae of face flies and autumn houseflies cannot develop into adults in their feces. After another 5 days, the reproduction of flies is greatly reduced due to the malformation of pupae and the obstruction of adult maturation process. The above dose is used for blood flies (blood disturbing flies), and the situation is similar after 4 weeks.
(2) Oral administration of 0.2mg/kg Ivermectin showed high efficacy (95% to 100%) in both adult and fourth stage larvae of large and small circular nematodes; Such as large circular nematodes (common circular nematodes, horse circular nematodes, toothless circular nematodes), roundworms (horse parasitic roundworms), pinworms (horse pointed tail nematodes), stomach worms (large mouthed drassimus nematodes, soft nematode genus nematodes), small intestine nematodes (Eisenia villosa nematodes, Wechsler class roundworms), lung nematodes (Anserinopsis net tail nematodes), etc. For the three types of horse stomach maggots that have migrated or resided in the stomach, as well as the microfilaments of the disc tail silk worm that cause skin damage and the third stage larvae of stomach nematodes, although 0 The dosage of 2mg/kg is also limited, but the optimal solution is to administer the medication again at the above dosage after one month.
Of particular significance is that the recommended dose of ivermectin (0.2mg/kg) has an effective rate of approximately 99% in treating mesenteric artery damage caused by the migration of early and fourth stage larvae of common roundworms. Typically, symptoms are significantly reduced after 2 days of medication, and all damage symptoms disappear after about 28 days.
(3) Intramuscular injection of 0.3mg/kg ivermectin has broad-spectrum insecticidal activity in pigs. The expulsion rate of adult and immature worms such as pig roundworms, red pig roundworms, orchid roundworms, pig hair head nematodes, esophageal mouth nematodes, posterior roundworms, and toothed tail nematodes is 94% to 100%, and it is also highly effective against intestinal nematodes (ineffective in muscles). The above medication method also has a good control effect on pig blood lice and pig scabies mites.
Efficiency leap Precision and stability
(4) There are specialized dosage forms for dogs and cats abroad (at a dose of 6-12 μ g/kg) for the prevention and treatment of canine heartworm microfilament infection. In China, the oral administration method of 50 μ g/kg can be used to treat heartworm microfilament infection (ineffective for adults). Clinical trials have confirmed that high-dose ivermectin is highly effective against various parasites in dogs, such as subcutaneous injection of 50 μ g/kg against canine hookworm, Brazilian hookworm, European hookworm, 100 μ g/kg against canine whipworm, and 200 μ g/kg against adult and fourth stage larvae of canine roundworm. Subcutaneous injection at a dose of 200 μ g/kg has a therapeutic effect of only 69% on the lion's arch roundworm, while oral administration achieves 95%.
This product, when injected subcutaneously once, also has excellent efficacy in eliminating the airborne protozoan (200 μ g/kg) and Osler's nematode (400 μ g/kg) that parasitize the lungs of dogs. Oral or subcutaneous injection of 200 μ g/kg, repeated after two weeks, has an effective rate of 95% to 100% against intestinal fecal roundworms (excluding third stage larvae).
Ivermectin is also effective against certain arthropod infections in dogs and cats. Subcutaneous injection of 200 μ g/kg dose in dogs and cats, followed by another dose two weeks later, can eliminate infections from ear mites, scabies mites, and canine lung mites. Administer twice (with a 2-week interval) at a dose of 300 μ g/kg. It is also effective against infection by the spider mite. It is best to treat canine demodex disease by subcutaneous injection at a dose of 600 μ g/kg, with an interval of 7 days and 5 consecutive doses.
(5) Poultry are highly effective against nematodes such as roundworms and nematodes, as well as parasitic arthropods such as knee mites (mutated knee mites), when administered orally or subcutaneously at a dose of 200-300 μ g/kg. But this Ivermectin stromectol tablet is ineffective against chicken nematodes.
(6) Reindeer can be infected with Oedemagena tarandi in their cowhide by subcutaneous injection at a dosage of 200 μ g/kg for cattle.
Raw material preparation
Before producing Ivermectin Stromectol Tablets, strict inspection and pretreatment of the active ingredient Ivermectin and various excipients are required. After ensuring that the quality of the raw materials meets the standards, various raw materials are weighed in a certain proportion and mixed. The mixing process requires ensuring the uniform distribution of various raw materials to avoid the problem of uneven drug content during the tablet pressing process.
Granulation
Granulation is the process of making particles of a certain size and shape from mixed raw materials. There are various methods of granulation, commonly including wet granulation and dry granulation. In the production of Ivermectin Stromectol Tablets, wet granulation is commonly used. The specific steps are as follows:
Add the mixed raw materials into the wet granulation machine and add an appropriate amount of adhesive (such as polyvinylpyrrolidone solution) to form a moist mass of the raw materials. Then, the agglomerates are squeezed into uniformly sized particles through the sieve of the granulator. During the granulation process, it is necessary to control parameters such as the amount of adhesive, stirring speed, and screen size to ensure that the quality of the particles meets the requirements.
Dry
The particles produced usually contain a certain amount of moisture and require drying treatment. The purpose of drying is to remove moisture from the particles and improve the stability and compressibility of the drug. The commonly used drying methods include hot air drying, fluidized bed drying, etc. During the drying process, it is necessary to control the drying temperature and time to avoid excessive temperature or time that may cause degradation of the active ingredients in the drug.
Tablet pressing
After sieving and shaping the dried particles, an appropriate amount of lubricant (such as magnesium stearate) is added, mixed evenly, and then compressed into tablets. The tablet pressing process requires the use of a tablet press to compress the particles into tablets with a certain shape, size, and hardness. During the tablet compression process, it is necessary to control parameters such as compression pressure, tablet weight, and hardness to ensure stable tablet quality.
Coating (optional)
In some cases, tablets may be coated to improve their appearance, taste, or stability. The coating material can be sugar coating, thin film coating, etc. Sugar coating can make the surface of tablets smooth and aesthetically pleasing, while masking the unpleasant odor of the medication; Film coating can control the release rate of drugs, improve their stability and bioavailability. The coating process requires controlling parameters such as the concentration of the coating solution, spraying speed, and drying temperature to ensure coating quality.
Quality control
Raw material inspection
During the production process, strict quality inspection must be conducted on each batch of raw materials. The inspection items include the content and purity of active ingredients, related substances, and various quality indicators of auxiliary materials. Only after passing the raw material inspection can it be put into production use.
Intermediate inspection
During the production processes of granulation, drying, and tablet pressing, it is necessary to inspect each intermediate. For example, testing indicators such as particle size distribution, moisture content, and flowability of particles; Inspect the differences in tablet weight, hardness, brittleness, and other indicators of the tablets. Through intermediate inspection, problems in the production process can be identified in a timely manner, and adjustments and improvements can be made to ensure the quality of the final product.
Finished product inspection
Finished product inspection is an important part of quality control. A comprehensive quality inspection is required for the Ivermectin Stromectol Tablet products produced. The inspection items include appearance, uniformity of content, solubility, microbial limits, etc. Content uniformity testing can ensure that the active ingredient content in each drug meets the specified requirements; Dissolution testing can simulate the dissolution process of drugs in vivo and evaluate their bioavailability; Microbial limit testing can ensure that drugs are not contaminated by microorganisms during storage and use. Only products that pass the final inspection can enter the market for sale.
Stability assessment
In order to ensure the stability of drug quality during storage, stability testing of Ivermectin Stromectol Tablets is required. Stability assessment usually includes long-term stability testing and accelerated stability testing. Long term stability testing is the process of placing a drug under specified storage conditions (such as temperature, humidity, etc.) for a certain period of time, and regularly sampling and testing the quality changes of the drug; Accelerated stability testing is the process of placing a drug under high temperature and humidity conditions for a certain period of time to accelerate the quality change of the drug and predict its shelf life. Through stability testing, the storage conditions and expiration date of drugs can be determined, providing scientific basis for the production, storage, and use of drugs.
Frequently Asked Questions
What was ivermectin originally used for?
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After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Who cannot take ivermectin?
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If you have a history of seizures, talk with your doctor about whether ivermectin is safe for you. Allergic reaction: If you've had an allergic reaction to ivermectin or any of its ingredients, your doctor will likely not prescribe ivermectin. Taking the drug could cause another allergic reaction.
What plant is ivermectin made from?
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Ivermectin is a semisynthetic, anthelminitic agent. It is an avermectin, a group of pentacyclic sixteen-membered lactones (i.e. a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent and broad-spectrum anti-parasitic agents.
What foods contain ivermectin?
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This study was the first to detect ivermectin in foods of bovine origin such as milk, meat, and liver and excretions like urine and faeces from small-scale dairy farms.
Is neem the same as ivermectin?
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Thus, Neem plant extract ( Azadirachta indica A. Juss) has been used as a natural alternative to replace Ivermectin worldwide.
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