Naringin Tablets

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Naringin Tablets are tablets mainly composed of naringin, belonging to the flavonoid glycoside class. The molecular formula is C27H32O14, and the molecular weight is 580.535. Its main pharmacological effects include clearing free radicals, inhibiting lipid peroxidation, and protecting cells from oxidative damage. By regulating lipid metabolism, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are reduced. Used to inhibit the NF - κ B pathway, reduce the release of inflammatory factors such as TNF - α and IL-6, induce tumor cell autophagy and apoptosis, and inhibit cancer cell proliferation.

Enhance insulin sensitivity and improve glucose metabolism disorders. Inhibit the aggregation of A β protein and protect neurons from damage. It works through multiple targets, including cytochrome P450 enzymes, DNA topoisomerase II, PI3K/Akt/mTOR pathway, etc., to regulate cell proliferation, apoptosis, and autophagy processes. It alleviates symptoms of inflammatory diseases such as rheumatoid arthritis, reduces joint swelling and pain. Regulate immune function and repair immune deficiencies caused by tumors or radiotherapy and chemotherapy.

Naringin COA

Naringin Tablets is a natural flavonoid compound widely present in the skin and flesh of Rutaceae plants such as grapefruit, orange, and citrus. Its chemical name is 4 ', 5,7-trihydroxyflavanone-7-rhamnoglucoside, and it is the main source of bitterness in citrus fruits. As a medicinal and edible active ingredient, naringin has become a research hotspot and core raw material in the fields of medicine, food, cosmetics, and health products due to its strong antioxidant, anti-inflammatory, metabolic regulation, organ protection, neuroprotection, anti-tumor and other multiple biological activities.

The application of naringin in the pharmaceutical field is the core manifestation of its value. Based on its multi-target and multi pathway pharmacological effects, it is widely used in the prevention, adjuvant treatment, and rehabilitation of cardiovascular diseases, metabolic diseases, liver diseases, neurological diseases, inflammatory diseases, tumors, kidney injuries, skin diseases, etc. Due to its natural, low toxicity, and good tolerance, it has become a key natural drug ingredient in clinical and basic research.

Prevention and treatment of cardiovascular system diseases

 

Core use: It is used for the prevention and auxiliary treatment of hypertension, hyperlipidemia, atherosclerosis, coronary heart disease, myocardial ischemia/reperfusion injury, and thrombotic diseases. Mechanism of action and application details:

Improving endothelial function: Naringin can activate endothelial nitric oxide synthase (eNOS), promote the release of nitric oxide (NO), relax vascular smooth muscle, reduce vascular resistance, and improve vascular elasticity.

Clinical studies have shown that daily supplementation of 200mg naringin can reduce systolic blood pressure by 8-15mmHg and diastolic blood pressure by 5-10mmHg in patients with primary hypertension, with an effective rate of 65% -80%.

Regulate blood lipid and anti atherosclerosis: reduce liver lipid synthesis by inhibiting fatty acid synthase and activating AMPK/SREBP-1c signaling pathway; Promote fatty acid beta oxidation, reduce serum total cholesterol, triglycerides, low-density lipoprotein (bad cholesterol), and increase high-density lipoprotein (good cholesterol).

At the same time, it inhibits macrophages from phagocytosis of oxidized low density lipoprotein (ox LDL), reduces the formation of foam cells, delays the progression of atherosclerotic plaque, stabilizes plaque, and reduces the risk of coronary heart disease and cerebral infarction.

Anti myocardial ischemia and myocardial protection: In myocardial infarction models, Naringin Tablets can reduce the size of myocardial infarction, alleviate myocardial cell apoptosis, and improve cardiac systolic and diastolic function;

Inhibit myocardial hypertrophy, myocardial fibrosis, and delay cardiac function decline.
Antithrombotic: binds to protein disulfide isomerase, inhibits its activity, regulates coagulation rate, reduces platelet aggregation, and lowers the risk of thrombosis.

Reference information source:

1. Nutrients. 2025. A systematic review of the cardiovascular protective effects of naringin
2. Chinese Pharmacological Bulletin 2024. Research on the Cardiovascular Pharmacological Effects of Natural Flavonoids
3. ChemicalBook. 2026. Pharmaceutical Applications and Clinical Data of Naringin

Prevention and treatment of metabolic diseases

 

Core use: It is used for adjuvant treatment of type 2 diabetes, obesity, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Mechanism of action and application details:
Reduce blood sugar and improve insulin resistance: inhibit alpha glucosidase activity, delay carbohydrate absorption; Activate the insulin signaling pathway, increase the sensitivity of peripheral tissues (muscles, fat) to insulin, reduce fasting blood glucose, postprandial blood glucose, and glycated hemoglobin. Clinical trials have confirmed that 200 mg naringin per day can reduce fasting blood glucose in patients with type 2 diabetes by 15% -20%.

Anti obesity, reduce fat accumulation: inhibit adipocyte differentiation and proliferation, reduce visceral fat and subcutaneous fat accumulation; Promote energy expenditure and reduce weight gain induced by high-fat diet. Animal experiments have shown that naringin can reduce weight gain in obese rats by more than 40%.
Improving non-alcoholic fatty liver disease: reducing liver lipid deposition, inflammatory response, and oxidative stress, inhibiting hepatic stellate cell activation, and resisting liver fibrosis; Improve the ultrastructure of liver cells and restore liver function.

Reference information source:

1. Toxicology Reports. 2025. Study on the Regulation of AMPK/SREBP-1c Pathway by Naringin to Improve Fatty Liver
2. Biological communication two thousand and twenty-six Clinical study on the metabolic regulation of naringin
3. Pharmaceutical Journal two thousand and twenty-five Metabolic and pharmacological effects of natural flavonoids

Liver protection and prevention and treatment of liver disease

 

Core use: Used as an adjuvant therapy and liver protection for alcoholic liver injury, drug-induced liver injury, viral hepatitis, liver fibrosis, and cirrhosis. Mechanism of action and application details:
Anti liver injury: Clearing free radicals in the liver, increasing the activity of antioxidant enzymes such as SOD and GSH Px, reducing the level of MDA (oxidative damage marker), and alleviating liver cell damage caused by alcohol, carbon tetrachloride, acetaminophen, etc.

Anti liver fibrosis: Inhibits the activation and proliferation of hepatic stellate cells (HSCs), reduces the deposition of extracellular matrix such as collagen and fibronectin, and blocks the progression of liver fibrosis.
Promote liver cell regeneration: Upregulate the expression of hepatocyte growth factor (HGF), promote liver cell proliferation, and repair damaged liver tissue.

Reference information source:

1. Chinese Journal of Traditional Chinese Medicine 2024. Study on the hepatoprotective mechanism of naringin
2. Biological communication two thousand and twenty-five Experimental study on the anti liver fibrosis effect of naringin

Protection of the nervous system and intervention for neurodegenerative diseases

 

Core use: Used for the prevention and adjuvant treatment of Alzheimer's disease, Parkinson's disease, cerebral ischemia/reperfusion injury, cognitive dysfunction, depression, and anxiety. Mechanism of action and application details:
Anti Alzheimer's disease: easily penetrates the blood-brain barrier, inhibits the aggregation and deposition of β - amyloid protein (A β), and reduces A β production; Inhibit excessive phosphorylation of tau protein and prevent the formation of neurofibrillary tangles.Simultaneously reducing neuroinflammation, oxidative stress, protecting neurons, and improving learning and memory abilities.

Anti Parkinson's disease: Inhibits apoptosis of dopaminergic neurons, reduces alpha synuclein aggregation, and improves motor dysfunction.
Anti cerebral ischemic injury: reduces the volume of cerebral infarction, alleviates brain edema, inhibits neuronal apoptosis, and improves neurological deficits.
Antidepressant and anti anxiety: regulate the levels of monoamine neurotransmitters (serotonin, dopamine, norepinephrine), inhibit central inflammation, and improve emotional disorders.

Reference information source:

1. Biological communication two thousand and twenty-six Study on the neuroprotective mechanism of naringin (a metabolite of naringin)
2. Journal of Ethnopharmacology. 2025. Review of the Neuropharmacological Effects of Naringin
3. Chinese Pharmacological Bulletin two thousand and twenty-four Research on the neuroprotection of flavonoids

Anti inflammatory and immune regulation (treatment of inflammatory diseases)

 

Core use: Used as an adjuvant therapy for chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, asthma, chronic obstructive pulmonary disease, skin inflammation, periodontitis, etc. Mechanism of action and application details:
Inhibit key inflammatory signaling pathways such as NF - κ B, MAPK, COX-2, iNOS, and reduce the release of pro-inflammatory factors such as TNF - α, IL-1 β, IL-6, and PGE2.

Regulate macrophage polarization, promote anti-inflammatory M2 macrophage activation, inhibit pro-inflammatory M1 macrophages, and improve the chronic inflammatory microenvironment.
Clinical application: It can alleviate joint swelling and pain in rheumatoid arthritis; Reduce symptoms of intestinal inflammation and diarrhea in inflammatory bowel disease; Improve airway inflammation and wheezing symptoms in asthma.

Reference information source:

1. Pharmaceutical Journal two thousand and twenty-five The anti-inflammatory mechanism of naringin
2. Chemical Book. 2025. Application Research of Naringin in Inflammatory Diseases

Antitumor effect (adjuvant therapy for tumors)

 

Core use: It is used for adjuvant treatment of multiple malignant tumors such as liver cancer, breast cancer, lung cancer, colon cancer, prostate cancer, thyroid cancer, etc., combined with chemotherapy and radiotherapy to increase efficiency and reduce toxicity. Mechanism of action and application details:
Inhibition of tumor cell proliferation: induces G2/M phase arrest of tumor cells and suppresses the expression of cell cycle proteins.

Inducing tumor cell apoptosis: Upregulation of pro apoptotic protein Bax, downregulation of anti apoptotic protein Bcl-2, activation of caspase apoptotic pathway.
Inhibition of tumor angiogenesis: Blocking the VEGF/VEGFR2 pathway reduces tumor angiogenesis, inhibits tumor growth and metastasis.

Chemotherapy sensitization and reversal of drug resistance: Enhance the sensitivity of chemotherapy drugs such as cisplatin, paclitaxel, and doxorubicin, inhibit the expression of multidrug resistance protein (MDR1), and reverse tumor resistance.
Reduce radiation and chemotherapy damage: antioxidant, anti-inflammatory, protect normal tissues, alleviate bone marrow suppression, gastrointestinal reactions, and liver and kidney damage caused by radiation and chemotherapy.

Reference information source:

1. Benefit Suef University Journal of Basic and Applied Sciences. 2025. Naringin targeting PKM2 against breast cancer
2. Tencent News two thousand and twenty-six Review of preclinical studies on the anti-tumor effect of naringin

Kidney protection and prevention and treatment of kidney injury

 

Core use: It is used for the protection and auxiliary treatment of acute kidney injury (AKI), chronic kidney disease, diabetes nephropathy, and drug-induced kidney injury. Mechanism of action and application details:
Inhibit the MAPK/NF - κ B inflammatory pathway and alleviate renal inflammatory response; Eliminate oxygen free radicals and alleviate oxidative damage to renal tubular epithelial cells.

Improve renal microcirculation, reduce renal interstitial fibrosis, and protect renal function.
Preclinical studies have shown significant protective effects against cisplatin and gentamicin induced acute kidney injury, reducing blood creatinine and urea nitrogen levels, and improving renal tissue pathological damage.

Reference information source:

1. Pharmaceutical Journal 2025. Study on the improvement of cisplatin induced acute kidney injury by naringin tablets

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