Aniracetam Tablets, also known as Aniracetam tablets, are a type of brain function improving medication that belongs to the cardiovascular and cerebrovascular system and mainly acts on the nervous system. The appearance is a white tablet. It can selectively act on the central nervous system through the blood-brain barrier, improving the metabolism of brain functional neurotransmitters.
It can promote the metabolism of serotonin, effectively shorten the selective response time, promote and enhance the memory function of the brain, and improve intelligence. After oral administration in rats, the absorption is rapid, and the blood drug concentration can reach its peak within 20-40 minutes, mainly distributed in the gastrointestinal tract, kidneys, liver, brain, and blood. After 24 hours, 77-85% is excreted in urine and 4% is excreted in feces. After oral absorption by the human body, the average half-life of the original drug in the blood is 20-30 minutes, and the blood drug concentration is difficult to measure after 2 hours. It is suitable for middle-aged and elderly people with memory impairment symptoms caused by aging, and has a significant improvement effect on memory impairment caused by cerebrovascular diseases (such as cerebral hemorrhage, traumatic brain injury, cerebral thrombosis, etc.).
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
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Aniracetam COA
Production method
Aniracetam tablets are a brain function improving drug that requires strict control over the selection of raw materials, excipients, and various stages of the preparation process to ensure the quality and efficacy of the drug. The following will provide a detailed introduction to its production method:
Selection of raw materials and auxiliary materials
- Raw material selection
The main active ingredient of Aniracetam tablets is Aniracetam, with a chemical name of 1- (4-methoxybenzoyl) -2-pyrrolidone and a chemical formula of C ₁ ₂ H ₁ ∝ NO ∝. In the production process, it is necessary to choose high purity and stable quality Aniracetam raw materials, generally requiring a purity of ≥ 98% to ensure the effectiveness and safety of the drug. The raw materials should comply with relevant pharmacopoeia standards, such as the Chinese Pharmacopoeia, the United States Pharmacopoeia, etc. Strict testing should be conducted on the appearance, characteristics, identification, content determination, and related substances of the raw materials.
- Auxiliary material selection
Accessories play an important role in the production of tablets, as they can affect the formability, solubility, stability, and other properties of the tablets. The commonly used excipients for aniracetam tablets include fillers, sustained-release agents, adhesives, lubricants, etc.
Fillers: Commonly used fillers include lactose, microcrystalline cellulose, etc. Lactose has good compressibility and flowability, which can increase the volume and weight of tablets, making them form well. Microcrystalline cellulose is also a commonly used filler, which not only increases the volume of tablets, but also has a certain degree of disintegration effect, which helps the rapid disintegration of tablets in the body and the release of drugs.
Sustained release agent: The function of a sustained release agent is to control the release rate of the drug, allowing it to slowly release in the body and maintain an effective blood drug concentration for a longer period of time. Commonly used sustained-release agents include hydroxypropyl methylcellulose, carrageenan, etc. Hydroxypropyl methylcellulose is a water-soluble polymer, which can form a gel layer in the gastrointestinal tract to delay the release of drugs. Carrageenan is a natural polysaccharide substance with good sustained release effect.
Adhesive: Adhesive is used to bond raw materials and auxiliary materials together, forming particles with a certain strength. Common adhesives include polyvinylpyrrolidone K30, starch paste, etc. Polyvinylpyrrolidone K30 is a commonly used water-soluble adhesive that can quickly dissolve in water to form a uniform adhesive solution, giving the particles good adhesion. Starch slurry is a viscous liquid made by boiling starch in water, which also has a certain adhesive effect.
Lubricant: The function of lubricant is to reduce the friction between particles and the die, allowing the tablet to smoothly exit the die while preventing sticking and impact. Common lubricants include magnesium stearate, talcum powder, etc. Magnesium stearate is a commonly used lubricant with excellent lubrication performance and anti viscosity.
Preparation process flow
Pre treatment of raw materials and auxiliary materials
Crushing and sieving: Grind the Aniracetam raw material and various auxiliary materials separately to achieve a certain fineness. Generally, it is required that the raw materials and auxiliary materials pass through a 100 mesh sieve to ensure the uniformity of the mixture. The crushed material should be sealed and stored to prevent moisture and contamination.
Drying: For some auxiliary materials containing moisture, such as lactose, starch, etc., drying treatment is needed to reduce their moisture content. The drying temperature and time should be reasonably controlled according to the properties of the auxiliary materials. Generally, the drying temperature should not exceed 60 ℃, and the drying time should be determined based on the initial moisture content of the material and the drying equipment until the moisture content of the material meets the requirements.
mix
Preliminary mixing: Add the crushed and screened Aniracetam raw materials, fillers, slow-release agents, etc. to the mixer in a certain proportion for preliminary mixing. The mixing time is generally 15-30 minutes to ensure that all materials are thoroughly mixed evenly.
Adding adhesive to make soft materials: gradually add the prepared adhesive solution to the preliminarily mixed material, stirring while adding, to form a uniform soft material. The dryness and wetness of soft materials should be moderate, and it is advisable to "hold them lightly to form a ball and press them lightly to disperse". If the soft material is too dry, an appropriate amount of adhesive solution can be added; If the soft material is too wet, an appropriate amount of drying auxiliary material can be added for adjustment.
Granulation
Wet granulation: The prepared soft material is granulated using a swing granulator or high-speed stirring granulator. During the granulation process, choose the appropriate mesh size, usually through an 18-20 mesh sieve, to ensure uniform particle size. The wet granules after granulation should have certain fluidity and compressibility.
Drying: Spread the wet particles flat in a stainless steel tray and place them in an oven for drying. The drying temperature is generally controlled at 50-60 ℃, and the particles should be regularly flipped during the drying process to ensure uniform drying of the particles. The drying time depends on the size and moisture content of the particles, generally drying until the moisture content of the particles is below 3%.
Whole Grain&Total Mix
After drying, the particles may clump and require whole particle processing. The dried particles are processed by a granulator, usually passing through a 16-18 mesh sieve to ensure that the particle size meets the requirements. The whole particle should have good fluidity and uniformity.
Add the whole granules, lubricant, sweetener (if needed), etc. into the mixer for total mixing. The mixing time is generally 1-3 minutes to evenly distribute lubricants and other substances on the surface of the particles.
Tablet pressing
Calculate tablet weight: Calculate the theoretical tablet weight for each tablet based on the prescribed dosage and the main drug content of the particles. The formula for calculating tablet weight is: tablet weight=main drug content per tablet/percentage content of main drug in particles.
Tablet pressing: add the total mixed particles into the hopper of the tablet press, adjust the pressure, filling depth and other parameters of the tablet press, and perform tablet pressing. During the tablet pressing process, the appearance, weight difference, hardness and other indicators of the tablets should be regularly checked to ensure that the tablet quality meets the requirements. The hardness of tablets is generally controlled between 3-6kg.
Coating
Preparation of coating solution: Add the film coating premix to purified water in a certain proportion, stir evenly, and prepare a coating solution of a certain concentration. The concentration and viscosity of the coating solution should be adjusted according to the properties of the coating material and the requirements of the coating process.
Coating operation: Add the compressed tablets into the high-efficiency coating machine, start the coating machine, and continuously roll the tablets in the coating machine. The coating solution is evenly sprayed on the tablet surface through the spray system, and hot air is introduced at the same time to dry the coating solution rapidly and form a uniform film. During the coating process, the spraying speed, inlet air temperature, outlet air temperature and other parameters of the coating solution should be controlled to ensure the quality of the coating.
Frequently Asked Questions
Is aniracetam legal in the US?
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Despite its reputation as a brain enhancer, aniracetam is extremely controversial. It's approved in Europe, but it's not an approved substance in the United States. Although aniracetam lacks FDA approval, some people purchase the substance illegally through online vendors.
What is aniracetam good for?
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This compound, a member of the racetam family, is known for its potential to improve memory, learning, and overall cognitive function. Aniracetam is often utilized in studies exploring neuroprotection and the enhancement of synaptic plasticity, which is crucial for memory formation and retention.
Do I need a prescription for aniracetam?
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Aniracetam (brand names Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is a racetam which is sold in Europe as a prescription drug. It is not approved by the Food and Drug Administration for use in the United States as a prescription medication or dietary supplement.
What are the side effects of aniracetam?
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Like any other drug, Aniracetam has potential side effects, although it is generally well-tolerated. Common side effects include headaches, nausea, and gastrointestinal discomfort. These side effects are usually mild and can often be mitigated by adjusting the dosage or taking the supplement with food.
Where does aniracetam come from?
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Aniracetam is defined as a therapeutically important compound that is derived from pyrrolidine and possesses various pharmaceutical activities, including potential cognitive enhancement.
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