Ambroxol Hydrochloride Powder CAS 23828-92-4

Ambroxol hydrochloride powder is usually a white or slightly yellowish crystalline powder, odorless, and has a slightly sweet taste. Molecular formula C13H19Br2ClN2O, CAS 23828-92-4, easily soluble in water, almost insoluble in organic solvents such as ethanol, acetone, and ether. The solubility in water increases with increasing temperature, making it easy to operate when preparing injection or oral solutions. There are specific absorption peaks in the UV visible and infrared spectra, which can be used for drug identification and purity analysis. By using thermal analysis techniques such as thermogravimetric analysis (TGA) and differential thermal analysis (DSC), the thermal stability and decomposition process of ambroxol hydrochloride can be studied, providing guidance for drug storage and processing. It has multiple functions and application values, and occupies an important position in the pharmaceutical field. Its pharmacological properties, including expectorant effect, improvement of respiratory function, anti-inflammatory effect, antioxidant effect, and impact on airway smooth muscle and cough reflex, make it one of the important drugs for treating respiratory diseases.

Melting point 233-234.5 ° C, Storage condition: insert atmosphere, 2-8 ° C, Solubility sparingly soluble in water, soluble in methylol, practically insoluble in methylene chloride, Morphological neat, PH value pH (10g / L, 25 ℃): 4.0 ~ 6.0, Slightly soluble in water (~ 5 mg / ml) or ethanol (~ 5 mg / ml).

Ambroxol hydrochloride powder is a widely used drug for the treatment of respiratory diseases, and its unique chemical structure and pharmacological properties make it irreplaceable in the field of medicine.
1. Expectorant effect
As an expectorant, its main function is to promote the secretion of mucous glands in the respiratory tract, reduce the secretion of mucous glands, and thus reduce the viscosity of sputum. This effect makes sputum thinner and easier to cough up, thereby relieving respiratory obstruction and discomfort. This expectorant effect is particularly important for patients with respiratory diseases such as chronic bronchitis and asthma, as it can help them more effectively remove phlegm from the respiratory tract and improve their respiratory condition.
2. Improving respiratory function

In addition to its direct expectorant effect, it can also promote the synthesis of pulmonary surfactant, increase bronchial cilia movement, and make the respiratory tract more unobstructed. These effects together improve respiratory function, allowing patients to breathe more easily and alleviate symptoms of breathing difficulties.
3. Anti inflammatory effects
It also has a certain anti-inflammatory effect, which can inhibit the release of inflammatory mediators and alleviate respiratory inflammation. This effect has a positive significance in alleviating symptoms of respiratory diseases such as coughing, wheezing, etc. By inhibiting the inflammatory response, ambroxol hydrochloride can help patients alleviate pain and improve their quality of life.
4. Antioxidant effect
In recent years, research has found that it also has certain antioxidant effects. It can eliminate free radicals in the body, alleviate oxidative stress reactions, and protect the respiratory mucosa from oxidative damage. This effect is of great significance for the prevention and treatment of respiratory diseases, as it can help patients alleviate their condition and delay disease progression.
5. Affects mucus secretion and ciliary movement

Can regulate the secretion of respiratory mucus, making it thinner and easier to excrete. At the same time, it can also promote the movement of respiratory cilia, helping sputum to be expelled from the body faster. This effect is of great significance for clearing foreign objects and pathogens in the respiratory tract, and helps maintain respiratory health.
6. The effect on airway smooth muscle
It can also directly act on the smooth muscles of the airways, causing them to relax and thereby alleviate airway spasms. This effect helps to improve the ventilation function of the respiratory tract and alleviate symptoms of breathing difficulties. For diseases such as asthma, which are mainly characterized by airway spasms, the role of ambroxol hydrochloride is particularly important.
7. Affects cough reflex
It can also affect the cough reflex, suppress the excitability of the cough center, and thus reduce the frequency and intensity of coughing. This effect is of great significance in alleviating cough symptoms and improving the quality of life of patients.
8. Synergistic effects with other drugs
When used in combination with other drugs, it can exert a synergistic effect and enhance the therapeutic effect. For example, when used in combination with antibiotics, it can enhance the concentration of antibiotics on the respiratory mucosa and improve the antibacterial effect; When used in combination with bronchodilators, it can synergistically alleviate airway spasms and improve ventilation function.

We are the supplier of Ambroxol Hydrochloride powder.

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Artificial synthesis of ethyl pyruvate: it is prepared by direct esterification of pyruvate and absolute ethanol at boiling temperature and then vacuums distillation. It can also be prepared by oxidation of ethyl lactate steam at 155 ℃ in the presence of V2O5. Add 130ml saturated potassium permanganate solution, 500ml petroleum ether (boiling point 40-60 ℃), 50g (0.42mol) ethyl lactate (99%), and 20g (0.13mol) sodium dihydrogen phosphate (NaH2PO4 · 2H2O) to the round bottom flask equipped with stirrer and thermometer. Start stirring, raise the temperature to 15 ℃, cool it with ice water, add powdered potassium permanganate in 25-30min, and continue stirring until the oxidation is complete. Keep the temperature close to 15 ℃ in the whole process. After the reaction is completed, pour out the petroleum ether, mix the slurry with 50ml petroleum ether each time, and stir and extract it three times. Combine the petroleum ether extract, dissolve it in water, and remove the petroleum ether with a short fractionation column. The residual oil is fully shaken with 2 parts of 10ml calcium chloride saturated solution, separated from the oil layer, distilled under reduced pressure, and almost evaporated to 25-27g of all products at 56-57 ℃ / 2666pa (20mmhg), with a yield of 51-54%.

The synthetic method of the drug has been reported in many kinds of literature (2-N, the main difference of each route lies in the different connection methods between the benzene ring part and trans-4-aminocyclohexanol. Among them, the method of document 010) is to replace the condensation of malic formaldehyde and trans-4-aminocyclohexanol. In Schiff base reduction, if NaBH is used; The method reported in document 4 "requires expensive LiAlH and DCC. The method is to take o-methylethyleneaniline as raw material, through benzene ring Han generation, amino diacetyl generation, and NBS non-bromination, and then condense with trans-4-aminosolanesyl cyclohexanol, and then hydrolyze and deacetylate to give 1, with an overall yield of 10.6%, We referred to the synthetic method and made some improvements. Using o-methyl aniline as the starting material, we obtained 1.5% by dianation, n-diethylation, NBS methyl Han generation, drunk condensation with the trans-4 amino ring, and hydrolysis deacetylation In the condensation reaction, absolute ethanol is used as the solvent instead of B in the literature to reduce the toxicity and cost. After the improvement, the reaction steps were reduced and the total yield was increased to 46.196. Although NBS is still used, the yield of this route is high. The operation is simple, and the succinimide precipitated after the reaction can be brominated and recycled, which is an optional industrial production method.

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