Sulfadimethoxine Powder CAS 122-11-2

Sulfadimethoxine powder, its chemical name is N ^ 1- (4,6-di Methoxy group -2-pyridinesulfonyl) - N ^ 4, N ^ 4-dimethylformyl sulfonamide. Its chemical formula is C12H14N4O4S, and its Molar mass is 310.33g/mole. It is a white or almost white crystalline powder. It can form different crystal forms according to different preparation methods, such as needle like or sheet like crystals. It is soluble in common organic solvents such as methanol, ethanol and di N-Methylformamide, but it is less soluble in non-polar solvents such as Petroleum ether and n-hexane. Its solubility is related to temperature and the properties of the solvent. It is a drug that belongs to the sulfonamide class of antibiotics and is commonly used to treat bacterial infections in animals. The synthesis of Dihydrofolic acid is blocked by inhibiting Dihydrofolic acid synthase. It can be used to inhibit the synthesis of folic acid in Prokaryote. Drug resistance mechanism of Gram-positive bacteria, Gram-negative bacteria and chlamydia, change of Dihydrofolic acid synthase or alternative pathway of folate synthesis.

Melting point 200 ° C, Boiling point 265.5 ° C (rough estimate), Density 1.4006 (rough estimate), Refractive index 1.6270 (estimated), Keep in dark place, insert atmosphere, 2-8 ° C, Solubility NH4OH 1 m: 50 mg / ml, clear, fantly yellow, Morphological neat, Acidity coefficient (PKA) PKA 5.94 (H2O t = 25.0 ± 0.5 I = 0.2) (uncertain), Water solubility 46.3mg/l (37 º C), BRN 30685, Warning word, Hazard description h315-h317-h319-h335, Precautions p280-p305 + P351 + p338-p261-p264-p302 + p352 + p332 + P313 + p362 + p364-p305 + P351 + P338 + P337 + P313, Dangerous goods sign Xi, Hazard category code 36 / 37 / 38-43, Safety instructions 26-36 / 37-24 / 25-23, Dangerous goods transport No. 3249, WGK Germany 3, RTECS No. wo9030000, F 8, HazardClass 6.1(b), PackingGroup III.

As a broad-spectrum antibacterial drug, sulfadimethoxine powder has a wide range of applications in the field of animal medicine. Its unique pharmacological properties, such as rapid oral absorption, slow excretion, long duration of action, low acetylation rate, and low risk of urinary tract damage, make it one of the commonly used antibiotics in veterinary clinical practice.

Application in dogs and cats

 

1. Treatment of coccidiosis
It has significant therapeutic effects on coccidiosis in dogs and cats. Coccidiosis is an intestinal parasitic disease caused by coccidiosis, which seriously affects the health of dogs and cats. By inhibiting the folate metabolism of coccidiosis and blocking its growth and reproduction, the therapeutic goal can be achieved. When treating coccidiosis in dogs and cats, oral administration is usually used. On the first day, use 55 mg/kg according to body weight, followed by oral administration of 27.5 mg/kg according to body weight, once a day, for 12-21 consecutive days. For dogs and cats with severe illness, subcutaneous or intravenous injection can also be used for administration. On the first day, 55 mg/kg of the medication should be taken by body weight, and then reduced to 27.5 mg/kg of the medication should be taken orally by body weight once a day for 4 consecutive days.

 

2. Treatment of toxoplasmosis
It also has good therapeutic effects on toxoplasmosis. Toxoplasma gondii is a parasitic disease caused by Toxoplasma gondii, which can infect various animals, including dogs and cats. Sulfamethoxazole inhibits the folate metabolism of Toxoplasma gondii, blocking its growth and reproduction, thereby controlling the progression of the disease. When treating toxoplasmosis in dogs and cats, it is often used in combination with anti Toxoplasma drugs such as ethambutol to enhance efficacy.
3. Other infection treatments
It can also be used to treat respiratory, digestive, and urogenital system infections caused by sensitive bacteria in dogs and cats. Its broad-spectrum antibacterial effect enables it to cope with various bacterial infections, providing protection for the health of dogs and cats.

Application in cattle and horses

 

1. Prevention and control of coccidiosis
Plays an important role in the prevention and control of coccidiosis in cattle and horses. Coccidiosis is one of the intestinal parasitic diseases in cattle and horses, which seriously affects the growth, development, and production performance of animals. By inhibiting the folate metabolism of coccidiosis and blocking its growth and reproduction, effective prevention and treatment of coccidiosis can be achieved. When treating coccidiosis in cattle and horses, medication is usually administered orally, subcutaneously, or intravenously. On the first day, use 55 mg/kg by body weight, then reduce to 27.5 mg/kg orally by body weight, once a day, for 4 consecutive days. For cows, sulfamethoxazole sustained-release pills can also be used for treatment. Take one pill per 100 kg body weight (12.5 g per pill) orally, and discard the milk within 60 hours (5 milking sessions) after the last dose.

 

2. Adenoid disease treatment
It can also be used to treat mastitis in horses. Adenosis is an acute infectious disease in horses caused by Streptococcus, characterized by high fever, swelling of the throat, and difficulty breathing. Sulfamethoxazole inhibits bacterial folate metabolism, blocks its growth and reproduction, and thus controls the progression of the disease. When treating equine glandular disease, intravenous or intramuscular injection is usually used, and the dosage is adjusted according to the animal's weight and severity of the condition.
3. Other infection treatments
It can also be used to treat respiratory, digestive, and urogenital system infections caused by sensitive bacteria in cattle and horses. Its broad-spectrum antibacterial effect enables it to cope with various bacterial infections, providing protection for the health of cattle and horses.

Application in poultry

 

1. Prevention and control of coccidiosis
Sulfadimethoxine powder has a wide range of applications in the prevention and control of coccidiosis in poultry. Coccidiosis is one of the common intestinal parasitic diseases in poultry, which seriously affects the growth, development, and production performance of poultry. By inhibiting the folate metabolism of coccidiosis and blocking its growth and reproduction, effective prevention and treatment of coccidiosis can be achieved. When treating coccidiosis in broiler chickens, hens, and turkeys, sulfamethoxazole is usually mixed with drinking water and orally administered. The commonly used dosage is 0.05% for chickens and 0.025% for turkeys, used continuously for 5 days. However, the drug is prohibited for chickens over 16 weeks of age and turkeys over 24 weeks of age, and must be banned within 5 days before slaughter to ensure the safety of animal food.

 

2. Treatment of infectious rhinitis
It can also be used to treat infectious rhinitis in poultry. Infectious rhinitis is a respiratory infectious disease in poultry caused by Haemophilus parahaemolyticus, mainly manifested as inflammation of the nasal cavity and sinuses, runny nose, sneezing and other symptoms. By inhibiting the folate metabolism of bacteria and blocking their growth and reproduction, the progression of the disease can be controlled. When treating infectious rhinitis in poultry, sulfamethoxazole is usually mixed with feed or water for administration, and the dosage is adjusted according to the animal's weight and severity of the condition.

 

3. Treatment of avian cholera
Sulfamethoxazole also has a good therapeutic effect on avian cholera. Avian cholera is an acute infectious disease in poultry caused by Pasteurella multocida, characterized by high fever, difficulty breathing, diarrhea, and neurological symptoms. Sulfamethoxazole inhibits bacterial folate metabolism, blocks its growth and reproduction, and thus controls the progression of the disease. When treating avian cholera, sulfamethoxazole is usually mixed with feed or water for administration, and the dosage is adjusted according to the animal's weight and severity of the condition.

The laboratory synthesis methods of Sulfadimethoxine powder are usually based on the synthesis principles and techniques of sulfa drugs.

1. Starting material:

Starting materials include p-aminobenzenesulfonyl chloride and dimethyl ethanolamine.

2. Reaction steps:

(1) First, react p-aminobenzenesulfonamide with sodium carbonate to generate sodium p-aminobenzenesulfonate.

(2) Next, under alkaline conditions, react sodium p-aminobenzenesulfonate with dimethylethanolamine to form the precursor compound of sulfadimethoxine-bis(4-methoxybenzenesulfonamide)methylamine (N^1 -(4-Methoxybenzonesulfonyl)-N^4-methylmethanamine).

(3) Finally, the precursor compound is subjected to a deprotection reaction to remove the protecting group to obtain the final Sulfadimethoxine product.

This is just a brief overview, and the actual synthetic method may involve more steps and reaction conditions. In addition, in the following content, I have provided two common synthetic methods in the laboratory, but it should b

This compound is an antibacterial drug mainly used to treat infections caused by sensitive bacteria. However, like all drugs, it may also cause some side effects. Here are some possible side effects:

1. Gastrointestinal reactions: This is one of the most common side effects of the compound, which may include symptoms such as nausea, vomiting, diarrhea, and loss of appetite. These reactions are usually mild and may gradually alleviate with continued treatment.
2. Allergic reactions: Some patients may experience allergic reactions to it, manifested as rash, urticaria, itching, or other skin symptoms. In rare cases, allergic reactions may be more severe, such as difficulty breathing, laryngeal edema, or shock, and immediate medical attention should be sought.
3. Hematological reactions: This compound may cause blood system reactions such as leukopenia, anemia, or thrombocytopenia. These reactions are usually rare, but once they occur, medication may need to be stopped and appropriate treatment may be required.
4. Liver and kidney function damage: Long term or excessive use of this compound may cause damage to liver and kidney function, manifested as symptoms such as elevated transaminase, hematuria, or proteinuria. Therefore, regular monitoring of liver and kidney function should be conducted when using this medication.
5. Other side effects: In addition to the aforementioned side effects, this compound may also cause discomfort symptoms such as headache, dizziness, insomnia, muscle pain, or joint pain. These reactions are usually mild and may gradually alleviate or disappear with continued treatment.

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