Sulfadimethoxine Powder CAS 122-11-2

Sulfadimethoxine powder, its chemical name is N ^ 1- (4,6-di Methoxy group -2-pyridinesulfonyl) - N ^ 4, N ^ 4-dimethylformyl sulfonamide. Its chemical formula is C12H14N4O4S, and its Molar mass is 310.33g/mole. It is a white or almost white crystalline powder. It can form different crystal forms according to different preparation methods, such as needle like or sheet like crystals. It is soluble in common organic solvents such as methanol, ethanol and di N-Methylformamide, but it is less soluble in non-polar solvents such as Petroleum ether and n-hexane. Its solubility is related to temperature and the properties of the solvent. It is a drug that belongs to the sulfonamide class of antibiotics and is commonly used to treat bacterial infections in animals. The synthesis of Dihydrofolic acid is blocked by inhibiting Dihydrofolic acid synthase. It can be used to inhibit the synthesis of folic acid in Prokaryote. Drug resistance mechanism of Gram-positive bacteria, Gram-negative bacteria and chlamydia, change of Dihydrofolic acid synthase or alternative pathway of folate synthesis.

1. Use in animal husbandry:

Sulfadimethoxine Powder is widely used in animal husbandry to treat and prevent bacterial infections in various animals. It has antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria, including streptococcus, Escherichia coli, salmonella, etc.

The main uses include the following aspects:

-Dairy cows: Sulfadimethoxine can be used to treat diseases such as mastitis, uterine infections, and other respiratory infections.

-Pig: Sulfadimethoxine is also widely used for the treatment and prevention of respiratory infections, diarrhea, and enteritis in pigs.

-Sheep and goats: Sulfadimethoxine can be used to treat or prevent infectious arthritis, Myelitis, pneumonia and other diseases.

-Poultry: Sulfadimethoxine can be used to treat diseases such as avian influenza, Escherichia coli infection, and colitis.

2. Use in aquaculture:

In the aquaculture industry, Sulfadimethoxine is widely added to feed to prevent and treat animal infections. This addition method can ensure the uniform distribution and stable supply of drugs, thereby improving the therapeutic effect. Some common uses for breeding animals include:

-Fish farming: Sulfadimethoxine can be used to treat or prevent bacterial diseases of fish, such as red spot disease and lipid fin disease.

-Shrimp farming: Sulfadimethoxine can be used to treat or prevent bacterial infections of shrimp and other shrimp species, such as white spot disease, hemolytic disease, etc.

3. Use in pet health:

Sulfadimethoxine is also commonly used in the field of pet health, especially in animal medicine related to dogs and cats. Here are some common uses:

-Dogs and cats: Sulfadimethoxine can be used to treat and prevent respiratory tract infection, Urinary system infection and other bacterial diseases in dogs and cats.

4. Other uses:

In addition to the above applications, Sulfadimethoxine can also be used in other animal fields, such as:

-Laboratory animals: Sulfadimethoxine can be used to treat and prevent bacterial infections in laboratory animals, ensuring animal health and accuracy of experimental results.

-Wildlife protection: For injured or endangered wildlife, Sulfadimethoxine can be used by wildlife conservation agencies for anti infection treatment to improve their chances of survival.

-This product is for dog/goat/chicken and we have human pharmaceutical grade.

Melting point 200 ° C, Boiling point 265.5 ° C (rough estimate), Density 1.4006 (rough estimate), Refractive index 1.6270 (estimated), Keep in dark place, insert atmosphere, 2-8 ° C, Solubility NH4OH 1 m: 50 mg / ml, clear, fantly yellow, Morphological neat, Acidity coefficient (PKA) PKA 5.94 (H2O t = 25.0 ± 0.5 I = 0.2) (uncertain), Water solubility 46.3mg/l (37 º C), BRN 30685, Warning word, Hazard description h315-h317-h319-h335, Precautions p280-p305 + P351 + p338-p261-p264-p302 + p352 + p332 + P313 + p362 + p364-p305 + P351 + P338 + P337 + P313, Dangerous goods sign Xi, Hazard category code 36 / 37 / 38-43, Safety instructions 26-36 / 37-24 / 25-23, Dangerous goods transport No. 3249, WGK Germany 3, RTECS No. wo9030000, F 8, HazardClass 6.1(b), PackingGroup III.

The laboratory synthesis methods of Sulfadimethoxine powder are usually based on the synthesis principles and techniques of sulfa drugs.

1. Starting material:

Starting materials include p-aminobenzenesulfonyl chloride and dimethyl ethanolamine.

2. Reaction steps:

(1) First, react p-aminobenzenesulfonamide with sodium carbonate to generate sodium p-aminobenzenesulfonate.

(2) Next, under alkaline conditions, react sodium p-aminobenzenesulfonate with dimethylethanolamine to form the precursor compound of sulfadimethoxine-bis(4-methoxybenzenesulfonamide)methylamine (N^1 -(4-Methoxybenzonesulfonyl)-N^4-methylmethanamine).

(3) Finally, the precursor compound is subjected to a deprotection reaction to remove the protecting group to obtain the final Sulfadimethoxine product.

This is just a brief overview, and the actual synthetic method may involve more steps and reaction conditions. In addition, in the following content, I have provided two common synthetic methods in the laboratory, but it should b

Method 1: N-methyl p-aminobenzenesulfonamide method

Chemical formula:

C₇H₁₀N₂O₂S + C₄H₁₁NO → C₁₂H₁₈N₄O₄S + H₂O

Step 1: Synthesis of N-methyl derivatives of sulfanilamide

P-aminobenzenesulfonamide reacts with methanol to generate N-methyl p-aminobenzenesulfonamide.

Chemical formula:

C₆H₈N₂O₂S + CH₃OH → C₇H₁₀N₂O₂S + H₂O

Step 2: Synthesis of Sulfadimethoxine

The above-mentioned N-methyl p-aminobenzenesulfonamide and dimethylethanolamine are reacted in an alkaline medium to generate Sulfadimethoxine.

Method 2: Ammonolysis

Chemical formula:

C₈H₉NO₂ + C₄H₁₁NO → C₁₂H₁₈N₄O₄S + H₂O

Step 1: Synthesis of N-methyl derivatives of p-aminobenzoic acid

The reaction of p-aminobenzoic acid with methanol produces N-methyl p-aminobenzoic acid.

Chemical formula:

C₇H₇NO₂ + CH₃OH → C₈H₉NO₂ + H₂O

Step 2: Synthesis of Sulfadimethoxine

These are brief overviews of three commonly used laboratory synthesis methods for Sulfadimethoxine powder. Note that actual synthetic methods may involve more steps and reaction conditions. If you need more detailed chemical equations and synthetic methods, please refer to relevant chemical literature, professional handbooks or consult a professional chemist for accurate and detailed information.

Sulfadimethoxine powder, is a sulfonamide antibiotic that blocks the synthesis of dihydrofolate by inhibiting dihydropteroate synthase, thereby inhibiting the growth and reproduction of bacteria. It has a wide range of application cases in different fields, mainly including the following aspects:

I. Medical field
Treatment of infectious diseases: Sulfadimethoxine can broad-spectrum inhibit Gram-positive bacteria, Gram-negative bacteria and Chlamydia, these organisms can not obtain folic acid from the environment, and can only convert p-aminobenzoic acid ester (PABA) to dihydropteroic acid (an intermediate of folic acid synthesis) under the action of dihydropteroic acid synthase. Therefore, it is commonly used in the treatment of respiratory, urinary tract, intestinal and soft tissue infections. (Source: Shanghai Maokang Biotechnology Co., Ltd.)
Veterinary application: Sulfadimethoxine is also widely used in livestock and poultry breeding for the prevention and treatment of a variety of infectious diseases in animals, such as coccidiosis, infectious rhinitis and avian cholera in chickens, and toxoplasmosis in pigs. It does not affect the host's immunity to coccidia and has strong antimicrobial activity, making it suitable for co-infections of coccidia. 

2. The field of research
It also has its unique application in scientific research. For example, researchers use sulfadimethoxine monoclonal antibody technology to achieve accurate detection of sulfadimethoxine. This monoclonal antibody has a high degree of specificity and affinity, and is able to accurately recognize and bind to the target molecule, providing a powerful tool for the detection of sulfadimethoxine in samples such as food, water samples, and animal tissues.

3. The environmental field
The indiscriminate and irrational use of sulfadimethoxine has also led to the problem of its residues in the environment. These residues may not only pose a potential threat to human health, but also damage the ecological environment and cause ecological balance disorders. Therefore, the residue detection of sulfadimethoxine and its environmental impact assessment has also become an important research direction in environmental science research.

This compound is an antibacterial drug mainly used to treat infections caused by sensitive bacteria. However, like all drugs, it may also cause some side effects. Here are some possible side effects:

1. Gastrointestinal reactions: This is one of the most common side effects of the compound, which may include symptoms such as nausea, vomiting, diarrhea, and loss of appetite. These reactions are usually mild and may gradually alleviate with continued treatment.
2. Allergic reactions: Some patients may experience allergic reactions to it, manifested as rash, urticaria, itching, or other skin symptoms. In rare cases, allergic reactions may be more severe, such as difficulty breathing, laryngeal edema, or shock, and immediate medical attention should be sought.
3. Hematological reactions: This compound may cause blood system reactions such as leukopenia, anemia, or thrombocytopenia. These reactions are usually rare, but once they occur, medication may need to be stopped and appropriate treatment may be required.
4. Liver and kidney function damage: Long term or excessive use of this compound may cause damage to liver and kidney function, manifested as symptoms such as elevated transaminase, hematuria, or proteinuria. Therefore, regular monitoring of liver and kidney function should be conducted when using this medication.
5. Other side effects: In addition to the aforementioned side effects, this compound may also cause discomfort symptoms such as headache, dizziness, insomnia, muscle pain, or joint pain. These reactions are usually mild and may gradually alleviate or disappear with continued treatment.

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