Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ibuprofen powder cas 15687-27-1 in China. Welcome to wholesale bulk high quality ibuprofen powder cas 15687-27-1 for sale here from our factory. Good service and reasonable price are available.
Ibuprofen powder, also known as Isobutylbenzene propionic acid, CAS 15687-27-1, white crystalline powder, odorless and tasteless. Insoluble in water, easily soluble in alcohols and many other organic solvents, stable at room temperature and pressure. It is an antipyretic, analgesic, Nonsteroidal anti-inflammatory drug. This product can inhibit Cyclooxygenase, reduce the synthesis of Prostaglandin, and produce analgesic and anti-inflammatory effects; It plays an antipyretic role through the hypothalamic Thermoregulation center. It is a Nonsteroidal anti-inflammatory drug that can relieve fever and pain. Ibuprofen, like other 2-arylpropionate derivatives (such as ketoprofen, flurbiprofen, Naproxen, etc.) α There is a chiral center in the position, so Isobutylbenzene propionic acid has two Enantiomer, which will have different effects on physiology and metabolism. In fact, (S)-(+)-Isobutylbenzene propionic acid (i.e. dextral Ibuprofen) has obvious activity in both experimental detection and clinical trials. At present, Isobutylbenzene propionic acid on the market is Racemic mixture, that is, half of the ingredients are not practical.
The products in the yellow picture below are from this series of products, and our laboratory can provide finished products or customized technology. Please email us your requirements.
|
Chemical Formula |
C13H18O2 |
|
Exact Mass |
206 |
|
Molecular Weight |
206 |
|
m/z |
206 (100.0%), 207 (14.1%) |
|
Elemental Analysis |
C, 75.69; H, 8.80; O, 15.51 |
|
|
|
Ibuprofen, as a non steroidal anti-inflammatory drug (NSAID), exerts multiple effects of antipyretic, analgesic, and anti-inflammatory by inhibiting the activity of cyclooxygenase (COX) and reducing prostaglandin synthesis.
1. Pain management
Mild to moderate pain: It is a commonly used medication for relieving non visceral pain such as headache, toothache, muscle pain, neuralgia, dysmenorrhea, etc. For example, patients with primary dysmenorrhea can achieve a pain relief rate of 70% -80% after taking ibuprofen orally. Its mechanism of action is to inhibit prostaglandin synthesis and reduce excessive contractions of uterine smooth muscle.
Postoperative pain: After minor surgery, it can effectively reduce wound pain and promote patient recovery. Its analgesic effect is comparable to opioid drugs, but it has low addiction and fewer side effects.
Chronic pain: For chronic pain such as lower back pain and neuralgia, it can be used as part of a multimodal pain management plan to improve patients' quality of life.
2. Treatment of inflammatory diseases
Rheumatoid arthritis (RA) and osteoarthritis (OA): By inhibiting the release of inflammatory mediators such as prostaglandins and leukotrienes, joint redness, pain, and morning stiffness are reduced, and joint mobility is improved. Long term use can delay joint structure damage, but attention should be paid to gastrointestinal protection.
Soft tissue inflammation, such as tendinitis and bursitis, can quickly alleviate local pain and swelling, and promote inflammation resolution.
Ankylosing spondylitis (AS): By inhibiting the inflammatory response of the spine, reducing lower back pain and stiffness, and improving spinal mobility.
3. Heat control
Infectious fever: Ibuprofen powder acts on the hypothalamic temperature regulation center to reduce the sensitivity of temperature regulation points. It is suitable for fever caused by common cold, influenza or other infections. Its antipyretic effect is comparable to acetaminophen, but the duration is longer (about 6-8 hours).
Fever after vaccination: As a preventive medication, it can reduce fever reactions after vaccination.
Mechanism of action: Multi target inhibition of inflammation and pain
1. Inhibition of prostaglandin synthesis
By non selective inhibition of COX-1 and COX-2, the production of inflammatory mediators such as prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) is reduced. Prostaglandins are key mediators of pain and inflammation, and their reduction can lower the sensitivity of pain sensing nerve endings and alleviate redness, swelling, and thermal pain caused by vasodilation and exudation.
2. Blocking the release of inflammatory mediators
It can also inhibit arachidonic acid metabolism, reduce the release of leukocyte chemokines (such as leukotriene B4), thereby inhibiting leukocyte infiltration and activation to inflammatory sites, and reducing tissue damage.
3. Intervention of temperature regulation center
Acting on the hypothalamic thermoregulatory center, promoting heat dissipation processes (such as vasodilation and sweating), suitable for low fever management, but seeking medical attention promptly if the body temperature exceeds 39 ℃ or if the fever persists.
As a common chemical substance, Ibuprofen Powder has a wide range of uses and many synthesis methods. The common chemical synthesis methods are listed below:
1. Alcohol carbonization method
Alcoholic carbonization method, namely BHC method, takes Isobutylbenzene as raw material, through Friedel Crafts acylation with Acetyl chloride, catalytic hydrogenation reduction and
Ibuprofen was synthesized by catalytic carbonization in three steps.
The synthesis route of ibuprofen by BHC method (ethanol carbonylation method) is an efficient and environmentally friendly process, which was improved by BHC company and thus won the US Green Chemistry Challenge Award. This method uses isobutyl benzene as the main starting material and introduces carbonyl groups through ethanol carbonylation reaction to construct the molecular skeleton of ibuprofen. Under the action of a catalyst, isobutyl benzene undergoes carbonylation with ethanol and carbon monoxide to produce corresponding ketone compounds, which are then converted into ibuprofen through a series of subsequent reactions.
Key steps
1. Ethanol carbonylation reaction:
Under certain pressure and temperature conditions, isobutyl benzene undergoes carbonylation reaction with ethanol and carbon monoxide using catalysts such as palladium, cobalt, and other metal catalysts, resulting in the formation of para isobutyl acetophenone. This step is the core reaction of BHC method, and its efficiency and selectivity are crucial for the success of subsequent steps.
2. Condensation reaction:
Next, a condensation reaction occurs between isobutyl acetophenone and α - chloroethyl acetate and other condensing agents under alkaline conditions, resulting in the formation of α - and β - epoxy esters. This step further enriches the molecular structure and lays the foundation for subsequent transformations.
3. Hydrolysis and decarboxylation:
Epoxy esters are hydrolyzed under acidic or alkaline conditions to remove carboxyl groups and generate corresponding aldehyde compounds. This step is a crucial step in constructing the carboxylic acid group in ibuprofen molecules.
4. Restoration and rearrangement:
Aldehydes are converted into alcohols through reduction reactions, and their molecular structures are adjusted through catalytic rearrangement reactions to ultimately obtain ibuprofen or its precursors. This step involves the selection of multiple reaction types and catalysts, which have a significant impact on the yield and purity of the product.
5. Purification:
Purification steps such as distillation and crystallization are used to remove impurities and obtain high-purity ibuprofen products. The purification process is crucial for ensuring the quality and stability of the product.
2. Olefin catalytic hydrogenation method
Zeipsen was prepared by the hydrogenation of 2- (6-neneneba methoxy-neneneea -2-tea) acrylic acid catalyzed by the pin complexes of chiral ligands, with an enantiomeric excess (ee) of 96%.
The synthesis route of ibuprofen by catalytic hydrogenation of olefins is a method of preparing ibuprofen by utilizing the catalytic hydrogenation reaction of olefins. This method mainly relies on the action of catalysts to hydrogenate and reduce unsaturated bonds (such as carbon carbon double bonds) in olefins, while combining with other chemical conversion steps, ultimately producing ibuprofen. The following is a detailed introduction to the synthesis route:
1. Selection of starting materials and catalysts
Starting materials:
In the route of catalytic hydrogenation of olefins to produce ibuprofen, compounds containing specific olefin structures are usually selected as starting materials. These olefin compounds need to be carefully designed to ensure the smooth production of key intermediates for ibuprofen in subsequent hydrogenation and conversion steps.
Catalyst selection:
Choosing the appropriate catalyst is the key to olefin catalytic hydrogenation. Common catalysts include precious metal catalysts (such as palladium, platinum, etc.) and non precious metal catalysts (such as nickel, cobalt, etc.). These catalysts can efficiently promote the hydrogenation reaction of olefins while maintaining high selectivity and stability.
Subsequent conversion steps
Conversion reaction:
After catalytic hydrogenation of olefins, the resulting product usually needs to undergo further conversion steps to produce ibuprofen. These conversion steps may include reactions such as condensation, oxidation, hydrolysis, etc., depending on the structure of the starting materials and the desired molecular structure of ibuprofen.
Purification and Separation:
After completing all conversion steps, the product needs to be purified and separated to remove impurities and improve the purity of ibuprofen. This usually includes steps such as distillation, crystallization, and filtration.
The synthesis route of ibuprofen by catalytic hydrogenation of olefins is a complex but efficient method. It relies on the selection of catalysts and optimization of reaction conditions to achieve efficient hydrogenation and subsequent conversion of olefins. Through this method, high-purity ibuprofen products can be prepared to meet the needs of the pharmaceutical industry.
melting point 77 – 78 °C , Specific rotation [ α ] D20-1 ~ + 1 ° ( c = 1, C2H5OH ) , Boiling point 157 ° C ( 4 mmHg ) , Density 1.0364 ( rough estimate ) , Refractive index 1.5500 ( estimate ) , Flash point 9 °C , Storage conditions 2-8 ° C , Practically soluble in water, freely soluble in acetone, methanol and methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates. , Acidity coefficient ( pKa ) pKa 4.45 ± 0.04 ( H2O, t = 25 ± 0.5, I = 0.15 ( KCl ) ) ( Approximate ) , Crystalline Powder , Color white to off-white , Water solubility insoluble.
pharmacology
Pharmacology
The analgesic and anti-inflammatory mechanisms of Ibuprofen powder have not been fully elucidated, and it may act locally on inflamed tissues by inhibiting the synthesis of prostaglandins or other neurotransmitters. Due to the inhibition of leukocyte activity and lysosomal enzyme release, the pain impulses in the tissue are reduced, and the sensitivity of pain receptors is lowered. The treatment of gout involves anti-inflammatory and analgesic measures, but cannot correct hyperuricemia. The mechanism of treating dysmenorrhea may be the inhibition of prostaglandin synthesis, which leads to a decrease in intrauterine pressure and a reduction in uterine contractions.
2 pharmacokinetics
Pharmacokinetics
2.1 Oral administration is easy to absorb, and absorption slows down when taken with food, but the amount absorbed does not decrease. Taking antacids containing aluminum and magnesium does not affect absorption. The plasma protein binding rate is 99%. After taking the medication, the blood drug concentration reaches its peak within 1.2-2.1 hours. The dosage is 200mg, and the blood drug concentration is 22-27 μ g/ml. When the dosage is 400mg, it is 23-45 μ g/ml, and when the dosage is 600mg, it is 43-57 μ g/ml. The half-life after a single administration is generally 1.8 to 2 hours. This product is metabolized in the liver, with 60-90% excreted through the kidneys in urine and 100% excreted within 24 hours, of which about 1% is the original form and a portion is excreted with feces.
Hot Tags: ibuprofen powder cas 15687-27-1, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, tetramisole hcl powder, Larocaine powder, epinephrine hcl powder, pure benzocaine powder, lidocaine hydrochloride powder, Iodomethane d3